People with rheumatoid arthritis often take medicines that can have damaging side-effects, but a system that uses red light to deliver drugs exactly where they are needed could help

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Key Points

Cinnamaldehyde (Cin), a bioactive cinnamon essential oil from traditional Chinese medicine herb Cinnamomum cassia, has been reported to have multipharmacological activities including anti-inflammation. However, its role and molecular mechanism of anti-inflammatory activity in musculoskeletal tissues remains unclear. Here, we first investigated the effects and molecular mechanisms of Cin in human synoviocyte cells. Then in vivo therapeutic effect of Cin on collagen-induced arthritis (CIA) also studied. Cell Counting Kit ‎CCK-8 assay was performed to evaluate the cell cytotoxicity. Proinflammatory cytokine expression was evaluated using quantitative polymerase chain reaction and ELISA. Protein expression was measured by western blotting. The in vivo effect of Cin (75 mg/kg per day) was evaluated in rats with CIA by gavage administration. Disease progression was assessed by clinical scoring, radiographic, and histologic examinations. Cin significantly inhibited interleukin (IL)-1β–induced IL-6, IL-8, and tumor necrosis factor-α release from human synoviocyte cells. The molecular analysis revealed that Cin impaired IL-6–induced activation of Janus kinase 2 (JAK2), signal transducer and activator of transcription 1 (STAT1), and STAT3 signaling pathway by inhibiting the phosphorylation of JAK2, STAT1, and STAT3, without affecting NF-B pathway. Cin reduced collagen-induced swollen paw volume of arthritic rats. The anti-inflammation effects of Cin were associated with decreased severity of arthritis, joint swelling, and reduced bone erosion and destruction. Furthermore, serum IL-6 level was decreased when Cin administered therapeutically to CIA rats. Cin suppresses IL-1β–induced inflammation in synoviocytes through the JAK/STAT pathway and alleviated collagen-induced arthritis in rats. These data indicated that Cin might be a potential traditional Chinese medicine–derived, disease-modifying, antirheumatic herbal drug.

People with rheumatoid arthritis often take medicines that can have damaging side-effects, but a system that uses red light to deliver drugs exactly where they are needed could help

The first study to report use of the rheumatoid arthritis drug anakinra to treat COVID-19 patients found that high-dose anakinra was safe and was associated with respiratory improvements and reduced signs of cytokine storm [1] in 72% (21/29) of patients, according to results from patients studied for 21 days (enrolled from 17 to 27 March 2020) in a Milan hospital, published in The Lancet Rheumatology journal.

(MedPage Today) -- Triple therapy -- with methotrexate, hydroxychloroquine, and sulfasalazine -- is little used for the treatment of rheumatoid arthritis (RA) in the U.S. today, and clinical outcomes showed less efficacy than regimens combining...

Novartis has revealed that the European Commission has moved to approve Cosentyx (secukinumab) for the treatment of active non-radiographic axial spondyloarthritis (nr-axSpA) in adult patients.

Noel Wayne Jhagroo, 47, pleaded guilty to conspiracy to commit health care fraud before U.S. District Judge Vanessa Gilmore in the U.S. District Court in Houston. 

Bassey Monday Idiong, Linda Eteimo Ere Kendabie and Modupe Babanumi each pleaded guilty today in connection with their roles in an "arthritis kit" Medicare fraud scheme.

Rolondae Mitchell-Straughter and Ana Quinteros each pleaded guilty yesterday in connection with their roles in an "arthritis kit" Medicare fraud scheme.

GlaxoSmithKline is hard at work with partner Sanofi in getting a vaccine tested for COVID-19, but this morning it said it was now also entering the race to treat patients already hit with the disease.

People with rheumatoid arthritis often take medicines that can have damaging side-effects, but a system that uses red light to deliver drugs exactly where they are needed could help

Eating yogurt may help reduce chronic inflammation, a factor in bowel disease, arthritis and asthma, according to a study. The research, published in the Journal of Nutrition, explored the hypothesis that yogurt may help reduce inflammation by improving the integrity of the intestinal lining. This could help prevent endotoxins - pro-inflammatory molecules produced by gut microbes - from crossing into the blood stream.

"I wanted to look at the mechanism more closely and look specifically at yogurt," said Brad Bolling, an assistant professor at the University of Wisconsin-Madison in the US. While anti-inflammatory medications like aspirin, naproxen, hydrocortisone and prednisone can help mitigate the effects of chronic inflammation, each comes with its own risks and side effects.

The study enrolled 120 premenopausal women, half obese and half non-obese. Half of the participants were assigned to eat 12 ounces of low-fat yogurt every day for nine weeks; a control group ate non-dairy pudding for nine weeks. Bolling and his team took fasting blood samples from participants and evaluated an assortment of biomarkers that scientists have used over the years to measure endotoxin exposure and inflammation.

The results showed that while some of the biomarkers remained steady over time, the yogurt-eaters experienced significant improvements in certain key markers, such as TNF, an important inflammation-activating protein. "The results indicate that ongoing consumption of yogurt may be having a general anti-inflammatory effect," said Bolling.

The research focuses on a different aspect of the study. Participants were also involved in a high-calorie meal challenge at the beginning and end of their nine-week dietary intervention. The challenge, meant to stress an individual's metabolism, started with either a serving of yogurt or non-dairy pudding followed by a large high-fat, high-carb breakfast meal. "It was two sausage muffins and two hash browns, for a total of 900 calories. But everybody managed it. They'd been fasting, and they were pretty hungry," Bolling said.

For both challenges, blood work showed that the yogurt "appetizer" helped improve some key biomarkers of endotoxin exposure and inflammation as participants digested the meal over the ensuing hours. It also helped improve glucose metabolism in obese participants, by speeding the reduction of post-meal blood glucose levels.

"Eating eight ounces of low-fat yogurt before a meal is a feasible strategy to improve post-meal metabolism and thus may help reduce the risk of cardiovascular and metabolic diseases," said Ruisong Pei, a postdoctoral researcher at UW-Madison.

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Gum disease bacterium was found to travel throughout the body, exuding toxins linked to Alzheimer's disease, rheumatoid arthritis and aspiration pneumonia, reported new findings.

New mobile app can help relieve osteoarthritis pain by notifying you to complete a few simple physical exercises every day, and also provide reliable

A small French study has found that severely ill coronavirus patients given tocilizumab, a drug used to treat rheumatoid arthritis, were less likely to be put on life support and less likely to die.

Dr Giorgio Gentile gave Leonard Whitehurst, being treated at Royal Cornwall Hospital, the drug tocilizumab as a last ditch attempt to save his life. He had heard promising results from early trials.

A new study from San Raffaele Hospital in Milan, Italy, found that 72% of 29 coronavirus patients given anakinra, an arthritis drug, had improved respiratory health and markers of inflammation.

Doctors at Leeds General Infirmary, who treated the unidentified patient and reported the strange case in a medical journal, said the shigella flexneri bacteria caused his reactive arthritis. (stock)

JONATHAN GORNALL: There are two things you can do to avoid osteoarthritis or keep it at bay once joints start to stiffen and feel painful: stay active and watch your weight.

Dr Imran Sharief, a pulmonologist from Santa Ana California, gave tocilizumab, a drug used to treat rheumatoid arthritis, to severely ill coronavirus patients who were on ventilators.

Retired receptionist Lynn Moore, 75, from Crosby, Liverpool, told FEMAIL she suffered excruciating pain in both her feet for 18 years after she broke both of them within seven months of each other.

Drug otilimab - in which GSK acquired rights from German biotech firm Morphosys in 2013 - may possibly ease the devastating effect of the virus on the lungs, while not suppressing the virus directly, a company spokesman said.

This week we hear stories on a big jump in U.S. rates of knee arthritis, some science hits and misses from past eclipses, and the link between a recently discovered thousand-year-old Viking fortress and your Bluetooth earbuds with Online News Editor David Grimm. Sarah Crespi talks to Daniel Apai about a long-term study of brown dwarfs and what patterns in the atmospheres of these not-quite-stars, not-quite-planets can tell us. Listen to previous podcasts. [Image: NASA/JPL-Caltech; Music: Jeffrey Cook]  

New study explores whether dampening IL-6 could address serious coronavirus infections

Interview with Maria E Suarez-Almazor, MD, PhD, author of Risk of Malignancies in Patients with Rheumatoid Arthritis Treated with Biologic Therapy: A Meta-analysis

Interview with Timothy McAlindon, DM, MPH, author of Effect of Vitamin D Supplementation on Progression of Knee Pain and Cartilage Volume Loss in Patients With Symptomatic Osteoarthritis: A Randomized Controlled Trial

Interview with Kim L. Bennell, PhD, author of Effect of Physical Therapy on Pain and Function in Patients With Hip Osteoarthritis: A Randomized Clinical Trial