A heavy police presence outside a Kitchener apartment building late Friday afternoon has been linked to a homicide investigation by Windsor Police.

pncRNA-D is an irradiation-induced 602-nt long noncoding RNA transcribed from the promoter region of the cyclin D1 (CCND1) gene. CCND1 expression is predicted to be inhibited through an interplay between pncRNA-D and RNA-binding protein TLS/FUS. Because the pncRNA-D–TLS interaction is essential for pncRNA-D–stimulated CCND1 inhibition, here we studied the possible role of RNA modification in this interaction in HeLa cells. We found that osmotic stress induces pncRNA-D by recruiting RNA polymerase II to its promoter. pncRNA-D was highly m6A-methylated in control cells, but osmotic stress reduced the methylation and also arginine methylation of TLS in the nucleus. Knockdown of the m6A modification enzyme methyltransferase-like 3 (METTL3) prolonged the half-life of pncRNA-D, and among the known m6A recognition proteins, YTH domain-containing 1 (YTHDC1) was responsible for binding m6A of pncRNA-D. Knockdown of METTL3 or YTHDC1 also enhanced the interaction of pncRNA-D with TLS, and results from RNA pulldown assays implicated YTHDC1 in the inhibitory effect on the TLS–pncRNA-D interaction. CRISPR/Cas9-mediated deletion of candidate m6A site decreased the m6A level in pncRNA-D and altered its interaction with the RNA-binding proteins. Of note, a reduction in the m6A modification arrested the cell cycle at the G0/G1 phase, and pncRNA-D knockdown partially reversed this arrest. Moreover, pncRNA-D induction in HeLa cells significantly suppressed cell growth. Collectively, these findings suggest that m6A modification of the long noncoding RNA pncRNA-D plays a role in the regulation of CCND1 gene expression and cell cycle progression.

pncRNA-D is an irradiation-induced 602-nt long noncoding RNA transcribed from the promoter region of the cyclin D1 (CCND1) gene. CCND1 expression is predicted to be inhibited through an interplay between pncRNA-D and RNA-binding protein TLS/FUS. Because the pncRNA-D–TLS interaction is essential for pncRNA-D–stimulated CCND1 inhibition, here we studied the possible role of RNA modification in this interaction in HeLa cells. We found that osmotic stress induces pncRNA-D by recruiting RNA polymerase II to its promoter. pncRNA-D was highly m6A-methylated in control cells, but osmotic stress reduced the methylation and also arginine methylation of TLS in the nucleus. Knockdown of the m6A modification enzyme methyltransferase-like 3 (METTL3) prolonged the half-life of pncRNA-D, and among the known m6A recognition proteins, YTH domain-containing 1 (YTHDC1) was responsible for binding m6A of pncRNA-D. Knockdown of METTL3 or YTHDC1 also enhanced the interaction of pncRNA-D with TLS, and results from RNA pulldown assays implicated YTHDC1 in the inhibitory effect on the TLS–pncRNA-D interaction. CRISPR/Cas9-mediated deletion of candidate m6A site decreased the m6A level in pncRNA-D and altered its interaction with the RNA-binding proteins. Of note, a reduction in the m6A modification arrested the cell cycle at the G0/G1 phase, and pncRNA-D knockdown partially reversed this arrest. Moreover, pncRNA-D induction in HeLa cells significantly suppressed cell growth. Collectively, these findings suggest that m6A modification of the long noncoding RNA pncRNA-D plays a role in the regulation of CCND1 gene expression and cell cycle progression.

The Security Bureau said Police have the duty to take lawful measures for apprehending people when sufficient grounds exist.

The bureau issued the statement in response to media inquiries regarding a number of people arrested by Police today in connection with organising and participating in unauthorised assemblies.

It emphasised that under the Police Force Ordinance, Police have the duty to take lawful measures for apprehending all persons whom it is lawful to apprehend and for whose apprehension sufficient grounds exist.

The bureau noted that the relevant arrests were made based on evidence from investigations and strictly according to the laws in force.

It pointed out that in Hong Kong, everyone is equal before the law and that no one is above it nor can break it without facing consequences.

The bureau explained that if there is evidence that anyone violates the law, regardless of their status or background, they must face justice. No one has any special privileges.

Police will handle the case in a fair, just and impartial manner in accordance with the law, it added.

pncRNA-D is an irradiation-induced 602-nt long noncoding RNA transcribed from the promoter region of the cyclin D1 (CCND1) gene. CCND1 expression is predicted to be inhibited through an interplay between pncRNA-D and RNA-binding protein TLS/FUS. Because the pncRNA-D–TLS interaction is essential for pncRNA-D–stimulated CCND1 inhibition, here we studied the possible role of RNA modification in this interaction in HeLa cells. We found that osmotic stress induces pncRNA-D by recruiting RNA polymerase II to its promoter. pncRNA-D was highly m6A-methylated in control cells, but osmotic stress reduced the methylation and also arginine methylation of TLS in the nucleus. Knockdown of the m6A modification enzyme methyltransferase-like 3 (METTL3) prolonged the half-life of pncRNA-D, and among the known m6A recognition proteins, YTH domain-containing 1 (YTHDC1) was responsible for binding m6A of pncRNA-D. Knockdown of METTL3 or YTHDC1 also enhanced the interaction of pncRNA-D with TLS, and results from RNA pulldown assays implicated YTHDC1 in the inhibitory effect on the TLS–pncRNA-D interaction. CRISPR/Cas9-mediated deletion of candidate m6A site decreased the m6A level in pncRNA-D and altered its interaction with the RNA-binding proteins. Of note, a reduction in the m6A modification arrested the cell cycle at the G0/G1 phase, and pncRNA-D knockdown partially reversed this arrest. Moreover, pncRNA-D induction in HeLa cells significantly suppressed cell growth. Collectively, these findings suggest that m6A modification of the long noncoding RNA pncRNA-D plays a role in the regulation of CCND1 gene expression and cell cycle progression.

Late Thursday, Georgia father and son Gregory McMichael and Travis McMichael were arrested in connection with the death of Ahmaud Arbery, a 25-year-old black man.

'Organised crime has many faces. The trafficking of cultural goods is one of them. It is not a glamorous business run by flamboyant gentlemen forgers, but by international criminal networks'

[News24Wire] Minister of Police Bheki Cele has revealed that a police officer accused of making blasphemous comments while arresting a group of Muslim men at a mosque last month, has been cleared of wrongdoing.

Governor Nyesom Wike of Rivers State, on Friday arrested 14 persons hidden in two trailers conveying cattle from Adamawa State to Port Harcourt, the State’s capital. Wike told reporters that the trailers were intercepted following a tip-off from well-meaning Nigerians, who told the State authorities that some Northerners were making their way into Port Harcourt. […]

COVID-19 lockdown: Rivers Govt arrests 14 persons, to auction 2 truckload of cows

The Nigerian military has arrested 28 suspected spies leaking operational secrets to the Boko Haram and Islamic State in West Africa Province (ISWAP) terrorists. The suspects, both local and foreign nationals are currently under investigation. The arrest followed attacks this week by ISWAP on the military post in Diffa, Niger Republic, located along a border […]

Boko Haram/ISWAP: Nigerian military arrests 28 local, foreign spies

Hong Kong’s police chief has reacted with fury over the “dishonour brought to the force” by the arrest of 18 officers for various offences over the past three weeks, including nine detained on Friday in connection with actions against street sleepers.Commissioner of Police Chris Tang Ping-keung said the behaviour of the officers concerned had brought disgrace to the force and dealt a severe blow to its credibility and nullified efforts achieved over the years.“As commissioner, I am not just…

Hundreds of protesters gathered in front of a Georgia courthouse on Friday to decry the killing of an unarmed black man in February and the delay in charging two white men in a shooting captured on video that was released earlier this week. This report produced by Jillian Kitchener.

Hundreds of protesters gathered in front of a Georgia courthouse on Friday to decry the killing of an unarmed black man in February and the delay in charging two white men in a shooting captured on video that was released earlier this week.

Hundreds of protesters gathered in front of a Georgia courthouse on Friday to decry the killing of an unarmed black man in February and the delay in charging two white men in a shooting captured on video that was released earlier this week. This report produced by Jillian Kitchener.

Title: Out-of-Hospital Cardiac Arrests On the Rise During COVID-19 Crisis
Category: Health News
Created: 4/30/2020 12:00:00 AM
Last Editorial Review: 5/1/2020 12:00:00 AM

Hundreds of protesters gathered in front of a Georgia courthouse on Friday to decry the killing of an unarmed black man in February and the delay in charging two white men in a shooting captured on video that was released earlier this week.

Detectives investigating a gang responsible for trafficking young women from Brazil to work in brothels in north London have made two arrests.

Police have arrested six people and seized about £1m in assets from brothels in Westminster as part of a major crackdown operation.

An average of 100 people a day are being arrested for domestic violence offences during the coronavirus lockdown in London, Scotland Yard has revealed.

Hosam Maher Husein Smadi, 19, has been arrested and charged in a federal criminal complaint with attempting to use a weapon of mass destruction.

A criminal complaint, unsealed today, charged Dani Nemr Tarraf with conspiring to acquire anti-aircraft missiles (FIM-92 Stingers) and conspiring to possess machine guns (approximately 10,000 Colt M4 Carbines).

429 individuals in 16 states were arrested as part of Project Deliverance, which targeted the transportation infrastructure of Mexican drug trafficking organizations in the United States, especially along the Southwest border.

"Today, more than 800 federal, state and local law enforcement officials have arrested over 110 individuals, including dozens of La Cosa Nostra members and associates."

Approximately 1,985 individuals have been arrested on narcotics-related charges as part of a 20-month multi-agency law enforcement investigation known as “Project Delirium,” which targeted the La Familia Michoacana drug cartel.

Noting that African-American and Hispanic males are arrested at disproportionately high rates, U.S. Attorney General Eric Holder said Monday that the Justice Department will seek to collect data about stops, searches and arrests as part of a larger effort to analyze and reduce the possible effect of bias within the criminal justice system.

The Kandivli police have arrested the father of an 18-year-old girl after she allegedly accused him of constantly molesting and sexually harassing her for two years. In her written complaint,  the girl has alleged that her father has been molesting her since 2016. She also said that she mustered courage and filed a complaint against him after he tried to 'touch her inappropriately' on the eve of September 11.

"On Monday, she came to the police station accompanied by an older woman from her neighbourhood. She said that over the last two years, her father has made several inappropriate comments and actions. And that he would also often make lewd gestures in front of her and try to make her uncomfortable in various ways,” said an official from the Kandivali police as reported in Mumbai Mirror.

Since the girl was facing and dealing with the abuse for a long time, the Kandivli police have booked the father under the Protection of Children from Sexual Offences (POCSO) Act, along with the relevant
sections of the Indian Penal Code (IPC). Post the arrest of her father on Monday evening, the girl’s mother lashed out at her, accusing her own daughter of falsely implicating her father, the police sources said.

"The mother believes that the daughter is doing this under the influence of someone. She thinks that with the father in prison, it will give her the necessary freedom to do what she wants and scare her parents from taking any disciplinary action against her” said an official elaborating on the mother’s statement. 

In another incident, the parents of a four-year-old girl lodged a police complaint against a woman teacher from a Kandivli school on Monday for molesting their child during the school hours. The Kandivli police have booked the teacher under the stringent POSCO (Protection of Children from Sexual Offences) act. The police are probing the case and till now no arrests have been made.

The minor child, who is in junior KG, complained to her parents after returning from school on Monday that the teacher had touched her inappropriately. When the parents of the minor girl approached the school, the management informed the parents that the school premises are entirely covered by cameras, except inside the washrooms. The police were summoned and the CCTV footage was shown to the parents as well as cops. "Nothing concrete has been found in the CCTV footage." the police officer said. 

Also Read: Watch Video: Woman Steals Mobile-Phone From Mulund Shop

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The Amboli police on Tuesday arrested the main accused in the 20 kg ephedrine seizure case. On New Year's Eve, the Amboli police seized 20 kg ephedrine worth Rs 3 crore from Jogeshwari. Two people were arrested earlier. Now, Amboli police have also nabbed the main accused in the case.

The accused has been identified as Shankar Narsaiyya Madderla (49), who is the owner of Venus chemical and drugs Pvt Ltd, based in Karnataka. He was arrested from Hyderabad by the team lead by PI Daya Nayak. Before this, in 2013, the accused was arrested for possessing 250 kg ephedrine which was seized by the Narcotics Control Bureau.

On New Year Eve, the Amboli Police busted a drug haul which was supposed to be supplied at high profile parties across the city. Around 20 kg ephedrine worth more than 3 crores has been seized and the two suppliers were arrested on the same day.

Both of them had previous records of supplying drugs for high profile parties. One of them was a class 4 custom officer who was fired in 2013 after he was found smuggling drugs. Cops believed that this is a gang which mostly operates for big events, especially New Year.

The accused, who were arrested earlier, have been identified as Mohammed Ismail Gulamhusaind, 45, who hails from Hyderabad and Dayanand Manik Muddanar, 32, who was a resident of Vasai. 

An officer from Amboli Police said, "The accused arrested from Hyderabad has supplied drugs to the accused who have already been arrested earlier. We are probing as to where the drugs were supposed to be delivered. The accused has been arrested under various sections of the NDPS Act."

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Almost two weeks since the lynching of the three men from Mumbai in Palghar, no fresh arrests have been made in the case, as the tribals involved in the crime continue to give the police the slip. The investigating team says a few of them are hiding in the hills and pelt stones at the police whenever they inch closer to them.

Some others, the police say, have taken shelter in the houses of relatives in Jawhar forest division, while some have crossed the border to hide in Dadra and Nagar Haveli.

While the police continue to hunt for the culprits, many of them are a demotivated lot, as three more personnel were suspended for 'dereliction of duty' in the lynching case. Some of them claim police personnel were also beaten up by the mob and are being suspended and transferred for no fault of theirs.

Police on the hunt for the tribals

Fled with food and family
After lynching the trio – Chikne Maharaj, 70, Sushil Giri, 35, and their cab driver Nilesh Tilghate, 30 - on the night of April 16, and before the police crackdown next morning, almost all the inhabitants of Gadchinchale village and nearby hamlets took off with food and family members including kids, said Sonudaji Borsa, a watchman at the forest post and a witness to the barbaric incident.

Helped by other villagers?
Police sources have not ruled out the possibility that residents of other hamlets in the forest supply food and other essentials to the tribals in the night, when the police team scales down the hills. Police sources told mid-day that they have received inputs that a few of the tribals have taken shelter at distant relatives' houses in Jawhar forest division and some went to Dadra and Nagar Haveli.

"The villagers are aware of the geography of the jungle and hilly regions of Palghar and Dahanu. On April 17, most of them managed to run towards the dense forest and climb the hills. Chances are very high that they have crossed the area bordering Dadra and Nagar Haveli as they know the internal jungle routes," said a police officer.

The investigating team under the supervision of Atulchandra Kulkarni, Additional Director General of Police (CID), Maharashtra Police has also retrieved the dumb data (mobile locations etc) of the lynching site to track those who were present at the spot either to instigate the mob, or kill the trio, or out of curiosity. Till now the Palghar police have arrested 110 people including nine juveniles in connection with the mob lynching. A total of three FIRs have been registered at Kasa police station and the complainants are API Anandrao Kale, PSI Sudhir Katare and SDPO Bhagwat Sonawane of Jawhar division.

At least 19 arrests across border
The fourth FIR was registered at Khanvel police station after the reinforcement coming from Talasari via Dadra and Nagar Haveli was stopped by a mob of 250 people and the Additional SP was attacked. The superintendent of police of Dadra and Nagar Haveli, Sharad Darade told mid-day that 19 accused have been arrested under sections of IPC, Disaster Management Act and Prevention of Damage to Public Property Act. "All are residents of Chisda in Khanvel," said Darade, who added that the matter is being investigated considering all the angles including the Maoist link.

Tribals were jobless
The tribals work in the brick factories in Bhiwandi. "The tribals go to Bhiwandi with their wives and children to work there. They remain there for four months and return in June and work for the cultivation of paddy. But due to the lockdown, all the workers in these factories were sent back home in March. Had there been no lockdown, all the people would have been working in the brick factories in Bhiwandi," said a retired police officer.

Three more policemen suspended

Three more policemen have been suspended for 'dereliction of duty' in connection with the mob lynching.

They include Assistant Sub-Inspector Ravindra Salunkhe and Head Constables Santosh Mukane and Naresh Dodi.

"Salunkhe, who is set to retire next year, is the policeman seen in the video with Chikne Maharaj. Those commenting and making decisions based on the video must know that he (Salunkhe) too was beaten and threatened by the mob on April 16," said a Palghar police officer.

"It is really discouraging that the policemen are being suspended and transferred for no fault of theirs. Transfers and suspensions are very easy for senior police officers. But show us the courage to tackle a frenzied mob of 2,500 with a handful of policemen," challenged a policeman.

Earlier PSI Katare and API Kale were suspended and 35 policemen attached to Kasa police station were transferred.

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The CBI has arrested two Goods and Services Tax (GST) superintendents here in Maharashtra for allegedly demanding and accepting a bribe of Rs one lakh for settling service tax liability of complainant.

A case has been registered against the two superintendents of GST, Pune, under section 120-B (Punishment of criminal conspiracy) of the IPC and section 7 of the Prevention of Corruption Act, 1988 (as amended in 2018), the CBI stated in a release on Tuesday.

The accused duo had demanded a bribe of Rs 3 lakh from the complainant for settling the Service Tax liability for the Financial Year 2016-17, it stated. The duo were caught when they were accepting Rs one lakh as the first instalment of the total bribe amount, the CBI said. The Central agency then conducted searches at the office and residential premises of the accused superintendents in Pune.

During the searches, documents regarding acquisition of movable and immovable properties, gold jewelleries, cash, computer hard disks and other incriminating documents were recovered, it said. The accused are being produced before special judge for the CBI cases.

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The Central Bureau of Investigation (CBI) on Tuesday arrested two superintendents posted at the Goods and Service Tax (GST) office for allegedly demanding and accepting a bribe.

Those arrested have been identified as Vivek Dekate and Sanjeev Kumar. A complaint was registered against two under Section 7 of the Indian Penal Code (IPC).

The two accused were produced before the Special CBI Judge, who remanded them to three-day CBI custody.

The officers were caught red-handed while accepting a bribe of Rs 1 lakh from the complainant. The amount has been recovered from their possession.

The complainant alleged that the accused demanded Rs 3 lakh in order to settle the service tax liability for the financial year 2016-17. Further probe is on.

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Vera Zinger was pulled over in Barangaroo on November 29 and police searched her car where they allegedly found two grams of drugs and $2,150 in cash.

Miguel Federico Ajqui-Ajtzalam was picked up by Immigration and Customs Enforcement on Monday after originally being arrested in New York last Thursday. NYPD released him despite ICE detainer.

CBP agents intercepted a Mexican national with 41.4 pounds of cocaine and 5.3 pounds of fentanyl in California. The confiscated fentanyl was enough to kill 1.2 million people.

Immigration officials said it will delay the majority of its arrests of illegal immigrants due to the coronavirus pandemic except for those who pose a risk or have committed serious criminal acts.

Iranian president Hassan Rouhani (pictured) today called for a special court to be set up to probe the 'painful and unforgivable' mistake which killed 176 people including dozens of Iranians.

Both third-year students were detained by Egyptian authorities in Cairo and later released. The university said all nine of students in the city have either now returned or are 'in the process of leaving'.

A PIL was filed in the Delhi High Court seeking an SIT or CBI investigation in the incident of "Bois Locker Room", an Instagram group in which obscene messages and morphed pictures of underage girls were shared, and demanded arrest the offenders. The participants of the chat room were mostly young teenage boys from Delhi who allegedly shared lewd and objectionable content pertaining to minor girls. The chat room was used to make comments and share compromising and allegedly morphed images of minor girls. The plea is likely to come up for hearing on May 13. Petitioner Dev Ashish Dubey also sought protection for the girls and women who have highlighted the crime of Delhi school students so that they cannot be harmed by the members of the group. "Since the issue is related to the offence committed against girls and women by the group members of Instagram group named as 'Bois Locker Room', which was created by school students mainly staying in South Delhi. Hence the petitioner preferred ..

CPI(M) leader Brinda Karat has approached the Delhi High Court seeking an early hearing in her plea for directions to police to make public the list of people arrested in connection with communal violence in northeast Delhi in February this year. The application for preponing the date of hearing of the petition is likely to be listed on May 12. The main petition, which has sought that a list of those arrested be put up outside police control room and police stations in the district, should be updated on a case-by-case basis. It is listed for hearing on June 16. The application for early hearing said the country is suffering from the COVID-19 pandemic and the Ministry of Home Affairs (MHA) has declared nationwide lockdown due to which people are not allowed to go out except for essential services. However, Delhi Police has continued its probe in connection with certain FIRs related to the Delhi violence and as per media reports, the MHA has directed police to ensure that the probe does