A prominent theory claims that the right temporoparietal junction (rTPJ) is especially associated with embodied processes relevant to perspective-taking. In the present study, we use high-definition transcranial direct current stimulation to provide evidence that the rTPJ is causally associated with the embodied processes underpinning perspective-taking. Eighty-eight young human adults were stratified to receive either rTPJ or dorsomedial PFC anodal high-definition transcranial direct current stimulation in a sham-controlled, double-blind, repeated-measures design. Perspective-tracking (line-of-sight) and perspective-taking (embodied rotation) were assessed using a visuo-spatial perspective-taking task that required understanding what another person could see or how they see it, respectively. Embodied processing was manipulated by positioning the participant in a manner congruent or incongruent with the orientation of an avatar on the screen. As perspective-taking, but not perspective-tracking, is influenced by bodily position, this allows the investigation of the specific causal role for the rTPJ in embodied processing. Crucially, anodal stimulation to the rTPJ increased the effect of bodily position during perspective-taking, whereas no such effects were identified during perspective-tracking, thereby providing evidence for a causal role for the rTPJ in the embodied component of perspective-taking. Stimulation to the dorsomedial PFC had no effect on perspective-tracking or taking. Therefore, the present study provides support for theories postulating that the rTPJ is causally involved in embodied cognitive processing relevant to social functioning.

SIGNIFICANCE STATEMENT The ability to understand another's perspective is a fundamental component of social functioning. Adopting another perspective is thought to involve both embodied and nonembodied processes. The present study used high-definition transcranial direct current stimulation (HD-tDCS) and provided causal evidence that the right temporoparietal junction is involved specifically in the embodied component of perspective-taking. Specifically, HD-tDCS to the right temporoparietal junction, but not another hub of the social brain (dorsomedial PFC), increased the effect of body position during perspective-taking, but not tracking. This is the first causal evidence that HD-tDCS can modulate social embodied processing in a site-specific and task-specific manner.

Although the etiology of schizophrenia is still unknown, it is accepted to be a neurodevelopmental disorder that results from the interaction of genetic vulnerabilities and environmental insults. Although schizophrenia's pathophysiology is still unclear, postmortem studies point toward a dysfunction of cortical interneurons as a central element. It has been suggested that alterations in parvalbumin-positive interneurons in schizophrenia are the consequence of a deficient signaling through NMDARs. Animal studies demonstrated that early postnatal ablation of the NMDAR in corticolimbic interneurons induces neurobiochemical, physiological, behavioral, and epidemiological phenotypes related to schizophrenia. Notably, the behavioral abnormalities emerge only after animals complete their maturation during adolescence and are absent if the NMDAR is deleted during adulthood. This suggests that interneuron dysfunction must interact with development to impact on behavior. Here, we assess in vivo how an early NMDAR ablation in corticolimbic interneurons impacts on mPFC and ventral hippocampus functional connectivity before and after adolescence. In juvenile male mice, NMDAR ablation results in several pathophysiological traits, including increased cortical activity and decreased entrainment to local gamma and distal hippocampal theta rhythms. In addition, adult male KO mice showed reduced ventral hippocampus-mPFC-evoked potentials and an augmented low-frequency stimulation LTD of the pathway, suggesting that there is a functional disconnection between both structures in adult KO mice. Our results demonstrate that early genetic abnormalities in interneurons can interact with postnatal development during adolescence, triggering pathophysiological mechanisms related to schizophrenia that exceed those caused by NMDAR interneuron hypofunction alone.

SIGNIFICANCE STATEMENT NMDAR hypofunction in cortical interneurons has been linked to schizophrenia pathophysiology. How a dysfunction of GABAergic cortical interneurons interacts with maturation during adolescence has not been clarified yet. Here, we demonstrate in vivo that early postnatal ablation of the NMDAR in corticolimbic interneurons results in an overactive but desynchronized PFC before adolescence. Final postnatal maturation during this stage outspreads the impact of the genetic manipulation toward a functional disconnection of the ventral hippocampal-prefrontal pathway, probably as a consequence of an exacerbated propensity toward hippocampal-evoked depotentiation plasticity. Our results demonstrate a complex interaction between genetic and developmental factors affecting cortical interneurons and PFC function.

For visually guided navigation, the use of environmental cues is essential. Particularly, detecting local boundaries that impose limits to locomotion and estimating their location is crucial. In a series of three fMRI experiments, we investigated whether there is a neural coding of navigational distance in the human visual cortex (both female and male). We used virtual reality software to systematically manipulate the distance from a viewer perspective to different types of a boundary. Using a multivoxel pattern classification employing a linear support vector machine, we found that the occipital place area (OPA) is sensitive to the navigational distance restricted by the transparent glass wall. Further, the OPA was sensitive to a non-crossable boundary only, suggesting an importance of the functional constraint of a boundary. Together, we propose the OPA as a perceptual source of external environmental features relevant for navigation.

SIGNIFICANCE STATEMENT One of major goals in cognitive neuroscience has been to understand the nature of visual scene representation in human ventral visual cortex. An aspect of scene perception that has been overlooked despite its ecological importance is the analysis of space for navigation. One of critical computation necessary for navigation is coding of distance to environmental boundaries that impose limit on navigator's movements. This paper reports the first empirical evidence for coding of navigational distance in the human visual cortex and its striking sensitivity to functional constraint of environmental boundaries. Such finding links the paper to previous neurological and behavioral works that emphasized the distance to boundaries as a crucial geometric property for reorientation behavior of children and other animal species.

Autism spectrum disorder (ASD) is characterized partly by atypical attentional engagement, reflected in exaggerated and variable responses to sensory stimuli. Attentional engagement is known to be regulated by the locus ceruleus (LC). Moderate baseline LC activity globally dampens neural responsivity and is associated with adaptive deployment and narrowing of attention to task-relevant stimuli. In contrast, increased baseline LC activity enhances neural responsivity across cortex and widening of attention to environmental stimuli regardless of their task relevance. Given attentional atypicalities in ASD, this study is the first to evaluate whether, under different attentional task demands, individuals with ASD exhibit a different profile of LC activity compared with typically developing controls. Males and females with ASD and age- and gender-matched controls participated in a one-back letter detection test while task-evoked pupillary responses, an established correlate for LC activity, were recorded. Participants completed this task in two conditions, either in the absence or presence of distractor auditory tones. Compared with controls, individuals with ASD evinced atypical pupillary responses in the presence versus absence of distractors. Notably, this atypical pupillary profile was evident despite the fact that both groups exhibited equivalent task performance. Moreover, between-group differences in pupillary responses were observed specifically in response to task-relevant events, providing confirmation that the group differences most likely were specifically associated with distinctions in LC activity. These findings suggest that individuals with ASD show atypical modulation of LC activity with changes in attentional demands, offering a possible mechanistic and neurobiological account for attentional atypicalities in ASD.

SIGNIFICANCE STATEMENT Individuals with autism spectrum disorder (ASD) exhibit atypical attentional behaviors, including altered sensory responses and atypical fixedness, but the neural mechanism underlying these behaviors remains elusive. One candidate mechanism is atypical locus ceruleus (LC) activity, as the LC plays a critical role in attentional modulation. Specifically, LC activity is involved in regulating the trade-off between environmental exploration and focused attention. This study shows that, under tightly controlled conditions, task-evoked pupil responses, an LC activity proxy, are lower in individuals with ASD than in controls, but only in the presence of task-irrelevant stimuli. This suggests that individuals with ASD evince atypical modulation of LC activity in accordance with changes in attentional demands, offering a mechanistic account for attentional atypicalities in ASD.

The latest edition of The State of Food Security and Nutrition in the World will be launched on Monday 15 July 2019 during a special event on the [...]

The USS Silversides is patrolling the Pacific during WWII when it finds itself in a terrifying situation: one of its torpedoes has jammed

The USS Barb had an unusual target in its sights in 1945 - one that wasn't even in the water. It was a Japanese supply train on the island of Karafuto

It's June 1945 and the USS Barb has just launched an unprecedented attack on the factories of the Japanese island of Shari

But will that keep susceptible populations safe?

The bacterial strain can break down some of the toxic components of polyurethane plastic

The two NASA astronauts will lift off from historic launch pad 39A, used for the Apollo and space shuttle missions

Two years before the Carthaginian general crossed the Alps, he won a decisive victory at the Battle of the Tagus

Nearly 2,000 years ago, women who rode horseback and practiced archery may have roamed the steppes of Mongolia

The government of the Northwest Territories is releasing $8.7 million in federal funding to five airlines in the N.W.T. offering schedule-based passenger service.

<span class="topsy_trackback_comment"><span class="topsy_twitter_username"><span class="topsy_trackback_content">FCC Launches New Round of Audits of Radio Station EEO Performance http://bit.ly/anoP3q</span></span>

The National Book Festival Presents series was created to provide a book festival experience to lovers of the event on a year-round basis. Because these programs can no longer be held at the Library, we are offering a virtual multipart series, with authors who have written books about widespread diseases and the worldwide response to them.

Press release about the Basel Committee launching the consolidated Basel Framework, 16 December 2019.

Press release "Governors and Heads of Supervision announce deferral of Basel III implementation to increase operational capacity of banks and supervisors to respond to Covid-19", 27 March 2020

BCBS Press release "Basel Committee and IOSCO announce deferral of final implementation phases of the margin requirements for non-centrally cleared derivatives", 3 April 2020

For those working in CHSLDs — the province's long-term care homes which are the site of the most serious outbreaks — the bonus will amount to as much as $1,000 per month.

Quebecers, like the rest of the world, are growing accustomed to the uncertainty that's accompanied the pandemic. But they may not appreciate their government adding to that already hefty burden.

With Mother's Day only a few days away, businesses are coming up with creative ways to help your family celebrate. Everything from brunch in a box to colourful bouquets and home delivered chocolate.

Voters have elected a new mayor in Flint, Michigan, where recovery from a lead-contaminated water crisis remains a major issue.

The Chicago Bulls announced Marc Eversley as their new general manager on Friday, making him the first Canadian GM in NBA history.

Acclaimed jigger Ryan Richard, from Sandy Bay First Nation, is calling all dancers to showcase their skills in an online jigging competition.

Kiuna College hopes to play an active role in the emergence of the next generation of Indigenous filmmakers and creators.

Hate crimes against Vancouver's Asian communities have increased since the early days of the outbreak and the #Elimin8hate campaign is an effort to combat that and comfort victims.

Five members of Calgary city council use a name in their political life that doesn't always line up with their birth certificate.

It will be a difficult road back to any kind of normal living.

Mayor John Tory, Dr. Eileen de Villa, the city's medical officer of health, and Toronto Fire Chief Matthew Pegg, head of the city's emergency response team, spoke at a city hall news conference Thursday afternoon.

Team Homan, Canada’s 2018 Olympic women’s curling team and the 2017 World Women’s Curling Champions have announced that the team has parted ways with lead Lisa Weagle. 

The time was right for Lisa Weagle to join forces with Olympic champion Jennifer Jones. Jones told CBC Sports' Anastasia Bucsis that the latest addition to her five-person rink "was like the clouds parted and the sun came out."

The post Announcing the SOLIDWORKS xDesign SAE Challenge appeared first on SOLIDWORKS Education Blog.

Bank of Finland Research Discussion Papers by Gene Ambrocio

On the fourth day of NCAA Division III Week on Thursday, April 16, the Allegheny Mountain Collegiate Conference released its All-Sportsmanship teams for winter and spring sports. Between winter and spring sports, a total of nine Penn State Altoona student-athletes were selected as representatives to the teams.

Apple's first product to integrate Mini LED display technology might see a later-than-expected launch timeline due to setbacks caused by the coronavirus pandemic, according to new research from TF Securities analyst Ming-Chi Kuo.

Following in the footsteps of Apple Card, and in the shadow of a rumored debit card solution from Google, Samsung on Thursday announced plans to field a physical debit card product in partnership with finance company SoFi.

Apple has now launched a new shop front online which is expressly for making it easier to buy, and get technical help, from home.

Apple has refreshed the 13-inch MacBook Pro with Magic Keyboard, the start of Apple's online WWDC has been announced, the iPad Pro Smart Keyboard gets a teardown, and your hosts provide a massive roundup of HomeKit and smart home devices.

Washington, D.C. Newsroom, May 8, 2020 / 03:10 pm (CNA).- The Diocese of Springfield, Illinois, said that the Church must return to “normal life” after the governor announced plans to ban large gatherings until a COVID-19 vaccine or treatment is available.

Earlier in the week, the state’s Governor JB Pritzker unveiled a five-phase “Restore Illinois” plan that bans gatherings of more than 50 people until a vaccine or treatment is available, or the virus has stopped spreading for a sustained period of time. Health officials have said that a vaccine for the new coronavirus (COVID-19) might not be available for 12 to 18 months. 

Currently, people in the state are allowed to attend religious services of 10 or fewer people, but no gatherings of more than 10 people are permitted until phase 4 of Pritzker’s plan, and the state wouldn’t even be able to “advance” to phase 3 until May 29.

“The Church has certainly done her part in making great sacrifices to slow the spread of this virus,” Andrew Hansen, director of communications for the diocese of Springfield, Illinois, told CNA on Friday.

“That said, the Church must return to her normal life of liturgy and communal worship,” Hansen said, while emphasizing precautions such as social distancing “will likely be the appropriate path longer term for the return to some version of normalcy for the Church.”

Previously, in-person or drive-in religious services were banned in the state. The Thomas More Society filed a lawsuit on behalf of a church in Lena, Ill., on April 30. Later that evening a paragraph was added to the governor’s executive order allowing for people to leave their homes to attend religious services of ten or fewer people, the society’s president Peter Breen told CNA.

The next day, May 1, the archdiocese of Chicago announced it would be resuming public Masses with 10 or fewer people.

According to the “Restore Illinois” plan, there could not be any gathering of between 11 and 50 people in size until phase 4 of the plan—“Revitalization.”

That phase can start only when certain conditions have been met: the positivity rate of COVID tests is at or under 20% and doesn’t rise by more than 10 points over 14 days; hospital admissions don’t increase for 28 days; and hospitals have at least 14% “surge capacity” in ICU beds, medical and surgical beds, and ventilators.

Pitzker clarified in a Wednesday press conference that religious services would be part of this 50-person limit in phase 4, and schools would not be allowed to reopen until then, raising questions of how tuition-dependent Catholic schools might fare in the fall if remote learning is still widely utilized.

The state’s superintendent of education has said that at least some schools might have to begin the new school year with remote learning, or with students attending classes in-person only on certain days.

“So we continue to hope and pray schools will reopen next school year. Certainly, when our schools reopen, new measures and precautions will be in place,” Hansen told CNA.

The president of DePaul University, located in Chicago, announced earlier this week that the university already plans to “minimize our footprint on campus this fall,” and that an announcement of the fall plans could happen by June 15.

Hailed as transitional by local observers, the latest polls were expected to usher in a new type of leadership in FRELIMO, with Filipe Nyussi being the first non-liberation northern leader in a southern dominated elite; they would also see opposition parties RENAMO and MDM alter their strategies and become more politically relevant; and would possibly be the last polls before the country became a mass resource-producing economy. However, the Presidential and parliamentary elections of 15 October have made the political setting, the prospects for improved governance and wealth redistribution more opaque, and the implementation of the new peace agreement harder.