sh Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3837-3852DOI: 10.1039/D4MD00426D, Research ArticleAbdrrahman Shemsu Surur, Chin Fung Chan, Frieda-Marie Bartz, Iris L. K. Wong, Van T. D. Nguyen, Lukas Schulig, Andreas Link, Tak Hang Chan, Larry M. C. Chow, Patrick J. BednarskiStructure-guided optimization of fexinidazole led to analog (S)-51, a promising lead compound with superior activity, improved metabolic stability, and enhanced hERG safetyThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
sh Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3817-3836DOI: 10.1039/D4MD00477A, Research ArticleMaha Saad, Walaa Ibrahim, Amany Helmy Hasanin, Aya Magdy Elyamany, Marwa MatboliZBiotics administration in the NASH model downregulated the RNA panel (MAPK3, EDN1, TNF, miR-6888-5p, lncRNA RABGAP1L-DT-206), restored intestinal barrier integrity, reduced hepatic inflammation, and improved lipid profiles and liver enzymes.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
sh Tamil Nadu CM Stalin to launch Phase II of nutritional intervention programme for malnourished children, mothers By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:23:48 +0530 Mothers of over 76,700 babies in the age group of zero to six months, identified as malnourished, would be covered under Phase II of the programme Full Article Tamil Nadu
sh Southern Railway refuses to share inquiry report of Perumon train tragedy By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:15:33 +0530 105 people had died in after several coaches of the Island Express fell into the Ashtamudi Lake in 1988 Full Article Tamil Nadu
sh Four Swedish companies, including IKEA, looking to set up base in Tamil Nadu: Swedish Ambassador to India By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:56:01 +0530 There are 70 Swedish companies in Tamil Nadu, employing about 25,000 people. But we want to do more, says Jan Thesleff Full Article Tamil Nadu
sh Developed nations need to triple their contribution to make climate finance credible: Avinash Persaud By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:16:07 +0530 Currently, developed nations are expected to pay $100 billion a year but they haven’t stuck to agreed targets, and this system ends next year. Full Article Business
sh New counters opened at Tirumala for issuing Srivani darshan tickets By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:45:53 +0530 Decision to open new counters taken following reports of devotees experiencing discomfort in queue at the previous counter, particularly during inclement weather, says TTD Additional EO Full Article Andhra Pradesh
sh Andhra Pradesh Budget reflects aspirations of all sections of people, say legislators By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:10:11 +0530 It has given impetus to the developmental goals outlined in the NDA’s election manifesto, say MLAs on the first day of discussion Full Article Andhra Pradesh
sh PAG report points out Andhra Pradesh govt.’s failure to disclose quantum of off-budget borrowings in Budget By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:19:16 +0530 Principal amount outstanding in 2019-20 was ₹67,171 crore, and it touched ₹1,54,797 crore in 2023-24, says the PAG report released by the I&PR Department Full Article Andhra Pradesh
sh Andhra Pradesh government deploys drones to detect ganja palnatations By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:21:37 +0530 State collaborates with NCB and Google to map and track cannabis plantations using satellite imagery technology Full Article Andhra Pradesh
sh Andhra Pradesh Govt. weighing options on how to utilise Mahila Samrakshana Karyadarshis, says Home Minister By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:30:46 +0530 Ambiguity in overall control of their duties and service matters resulted in immense distress for the MSKs, says Home Minister Full Article Andhra Pradesh
sh Andhra Pradesh govt. reaffirms commitment to ‘irrigating every acre of farmland’ in State through river-interlinking projects By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:43:13 +0530 Full Article Andhra Pradesh
sh Andhra Pradesh High Court strikes down PIL seeking to restrain police from taking action on ‘abusive content on social media’ By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:30:39 +0530 Full Article Andhra Pradesh
sh India’s office leasing soars 41% in 2024 amid rent hikes, supply crunch, and GCC growth: Cushman & Wakefield By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 09:20:06 +0530 In an interview to businessline, Cushman & Wakefield’s Veera talks about commercial space leasing outlook, trends, and rental and supply trends for the coming months Full Article Real Estate
sh Affordable generics will stay relevant amid a premiumisation trend: Bhushan Akshikar By www.thehindu.com Published On :: Wed, 13 Nov 2024 10:50:51 +0530 GSK will keep its existing portfolios while entering areas like oncology, said company officials at its centenary celebrations Full Article Health
sh Millions of Nigerians go hungry as floods compound hardship By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:07:00 +0530 Torrential rains and floods in 29 of Nigeria's 36 states this year have destroyed more than 1.5 million hectares of cropland, affecting more than nine million people Full Article Environment
sh Karnataka bypolls: Channapatna, Shiggaon and Sandur constituencies witness overall turnout of 76.9% till 5 p.m. By www.thehindu.com Published On :: Wed, 13 Nov 2024 10:37:35 +0530 A total of 45 candidates are in the fray in these byelections Full Article Karnataka
sh Satish Jarkiholi supporter to lead Belagavi DCC bank By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:13:34 +0530 Before the election, the three Jarkiholi brothers — Satish (Congress MLA), Ramesh (BJP MLA), and Balachandra (BJP MLA) — met in a private hotel in Belagavi to discuss the names of candidates Full Article Karnataka
sh Karnataka bypolls: A few residents of Savanur boycott polling in Shiggaon Assembly constituency By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:31:09 +0530 Some families at Dandinpet in Savanur boycotted the bypolls over not being given record of occupancy rights to them. Full Article Karnataka
sh Illegal export of iron ore from Belekeri port: Karnataka High Court suspends sentence and grants bail to MLA Satish Sail and five other convicts By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:21:10 +0530 Full Article Karnataka
sh FIR registered against Snehamayi Krishna By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:21:22 +0530 Full Article Karnataka
sh Union and State governments should set up Sanatana Board, demand seers By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:27:24 +0530 Full Article Karnataka
sh Three youths go missing after coracle overturns in Sharavathi backwaters in Sagar taluk By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:01:17 +0530 Full Article Karnataka
sh 80.48% voter turnout recorded in Shiggaon By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:51:07 +0530 The polling for the byelection to Shiggaon Legislative Assembly Constituency in concluded peacefully with large number of voters turning up at 241 polling stations in the assembly segment to exercise their franchise on Wednesday Full Article Karnataka
sh Pakistan should stop playing cricket with India, says Rashid Latif By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:49:54 +0530 The Pakistan Cricket Board (PCB) has written to ICC asking for written confirmation from the BCCI for India's inability to travel to Pakistan for the tournament Full Article Cricket
sh I've found ways and means to break it down: Ashwin on Smith's batting By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:21:04 +0530 The two seasoned campaigners would face off during the Border-Gavaskar Trophy starting November 22 in Perth Full Article Cricket
sh Shambala and Kimiko impress By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:34:17 +0530 Full Article Races
sh Comeback man Shami hogs the spotlight as MP takes honours on opening day against Bengal By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:38:38 +0530 Full Article Sport
sh Sharandeep grinds out a half-century on a slow-moving opening day By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:43:55 +0530 The Jharkhand opener exhibits ample patience and a tight defence Full Article Cricket
sh Pacers Koushik, Vidyadhar run through Uttar Pradesh By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:46:00 +0530 Duo shares eight wickets to roll the opposition over for 89; debutant Shrijith’s unbeaten 68 steadies a rocking ship for the visitors as they eke out a 38-run lead Full Article Cricket
sh Ranji Trophy | Tamil Nadu has Railways under the cosh with dominant show By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:18:55 +0530 CRICKET | Skipper Jagadeesan’s decision to field pays off handsomely as Ajith Ram and Gurjapneet take quick wickets; Ahuja, Saif and Merai hold out with half centuries Full Article Cricket
sh Siddhant Banthia sails past Siddharth Vishwakarma in ITF men’s tennis tournament By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:37:44 +0530 Siddhant Banthia broke serve dropping one point, and served out at love in the next game, to gain a stranglehold over the proceedings. He ran up a 5-1 lead in the second set before closing it out without any trouble Full Article Sport
sh Swiggy pre-open trade: Shares jump in trading debut after $1.4-billion IPO By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 10:02:08 +0530 The stock listed at ₹420 on India's National Stock Exchange, compared to its issue price of ₹390 Full Article Companies
sh Daylight assault on doctor inside Chennai hospital leaves medical fraternity in shock By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:20:29 +0530 The attacker, Vignesh, was reportedly frustrated over the treatment given to his mother, who was diagnosed with Hodgkin’s Lymphoma in an advanced stage Full Article Chennai
sh Comeback man Shami makes a quiet return to action By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:33:23 +0530 Aryan and Khejroliya pick up four wickets apiece as Madhya Pradesh bowls out Bengal for 228; host batters build on advantage Full Article Sport
sh Kunnummal, Akshay score resolute half-centuries By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:43:49 +0530 Kerala ends the opening day against the home team Haryana at 138 for two with pacer Kamboj claiming both the wickets to fall Full Article Cricket
sh Sharandeep grinds out a half-century on a slow-moving opening day By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:59:37 +0530 The opener exhibits ample patience and a tight defence as Jharkhand reached 136 for three in the 55 overs that were possible after the start of play was delayed by two hours Full Article Cricket
sh Tilak’s maiden ton, Abhishek’s 50 fire India to 219/6 against South Africa in 3rd T20I By www.thehindu.com Published On :: Thu, 14 Nov 2024 01:34:36 +0530 Tilak Varma got ample backing from Abhishek Sharma who made a brisk 50 after SA skipper Aiden Markram invited the visitors to bat first. Full Article Cricket
sh Sindhu movers to pre-quarters, Lakshya bows out of Kumamoto Masters Japan By www.thehindu.com Published On :: Thu, 14 Nov 2024 06:10:19 +0530 Full Article Sport
sh Additional Central forces rushed to Manipur; abducted women, children remain untraced By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:58:02 +0530 More than 48 hours on, the three women and three children who were allegedly abducted from Jiribam district by armed miscreants were yet to be rescued or traced, a senior government official said Full Article India
sh Cochin Shipyard funding for climate tech company By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:11:23 +0530 Full Article Kerala
sh Kozhikode Corporation to rehabilitate traders evicted from shop rooms below CH Flyover By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:31:59 +0530 Around 40% of evicted traders find alternative locations; Deputy Mayor urges others to wait for funds to be allocated, while traders offer to build shops themselves Full Article Kerala
sh Six men held for online share trading scam By www.thehindu.com Published On :: Thu, 14 Nov 2024 00:01:05 +0530 Full Article Chennai
sh U-shaped flyover on IT corridor nearing completion By www.thehindu.com Published On :: Thu, 14 Nov 2024 00:01:19 +0530 Full Article Tamil Nadu
sh The impact of Pradhan Mantri Ujjwala Yojana in Jammu and Kashmir By www.thehindu.com Published On :: Thu, 14 Nov 2024 00:57:59 +0530 Expanding the network of LPG distribution points in rural areas and extending financial support for refills could further increase clean fuel adoption Full Article Comment
sh L-G approves proposal to deploy former bus marshals on anti-pollution duties By www.thehindu.com Published On :: Thu, 14 Nov 2024 01:08:11 +0530 Full Article Delhi
sh After Uddhav Thackeray calls EC biased for checking his bags, Eknath Shinde releases videos of his bags being checked By www.thehindu.com Published On :: Thu, 14 Nov 2024 02:21:50 +0530 Eknath Shinde’s luggage was being checked at the Palghar police ground helipad as part of Standard Operating Procedures (SOPs) Full Article Mumbai
sh Encroachments along Vrishabhavathi: HC pulls up officials for ‘sitting tight and hoodwinking court’ By www.thehindu.com Published On :: Thu, 14 Nov 2024 05:53:00 +0530 The court gave authorities time till November 22 for demonstrating concrete action on removal of encroachments Full Article Bengaluru
sh Congress hindering tourism development in Karkala by meddling with Parashuram statue issue, says Sunil Kumar By www.thehindu.com Published On :: Thu, 14 Nov 2024 07:00:00 +0530 Sculptor had disassembled statue only to introduce minor alignment corrections as suggested by NITK, the MLA claims Full Article Mangaluru
sh Mother, sister arrested for suicide of 32-year-old Pakshikere resident seek bail By www.thehindu.com Published On :: Thu, 14 Nov 2024 07:00:00 +0530 Full Article Mangaluru