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Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety

RSC Med. Chem., 2024, 15,3837-3852
DOI: 10.1039/D4MD00426D, Research Article
Abdrrahman Shemsu Surur, Chin Fung Chan, Frieda-Marie Bartz, Iris L. K. Wong, Van T. D. Nguyen, Lukas Schulig, Andreas Link, Tak Hang Chan, Larry M. C. Chow, Patrick J. Bednarski
Structure-guided optimization of fexinidazole led to analog (S)-51, a promising lead compound with superior activity, improved metabolic stability, and enhanced hERG safety
The content of this RSS Feed (c) The Royal Society of Chemistry




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Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway

RSC Med. Chem., 2024, 15,3817-3836
DOI: 10.1039/D4MD00477A, Research Article
Maha Saad, Walaa Ibrahim, Amany Helmy Hasanin, Aya Magdy Elyamany, Marwa Matboli
ZBiotics administration in the NASH model downregulated the RNA panel (MAPK3, EDN1, TNF, miR-6888-5p, lncRNA RABGAP1L-DT-206), restored intestinal barrier integrity, reduced hepatic inflammation, and improved lipid profiles and liver enzymes.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Tamil Nadu CM Stalin to launch Phase II of nutritional intervention programme for malnourished children, mothers

Mothers of over 76,700 babies in the age group of zero to six months, identified as malnourished, would be covered under Phase II of the programme




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Southern Railway refuses to share inquiry report of Perumon train tragedy

105 people had died in after several coaches of the Island Express fell into the Ashtamudi Lake in 1988




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Four Swedish companies, including IKEA, looking to set up base in Tamil Nadu: Swedish Ambassador to India

There are 70 Swedish companies in Tamil Nadu, employing about 25,000 people. But we want to do more, says Jan Thesleff




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Developed nations need to triple their contribution to make climate finance credible: Avinash Persaud

Currently, developed nations are expected to pay $100 billion a year but they haven’t stuck to agreed targets, and this system ends next year.




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New counters opened at Tirumala for issuing Srivani darshan tickets

Decision to open new counters taken following reports of devotees experiencing discomfort in queue at the previous counter, particularly during inclement weather, says TTD Additional EO




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Andhra Pradesh Budget reflects aspirations of all sections of people, say legislators

It has given impetus to the developmental goals outlined in the NDA’s election manifesto, say MLAs on the first day of discussion




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PAG report points out Andhra Pradesh govt.’s failure to disclose quantum of off-budget borrowings in Budget

Principal amount outstanding in 2019-20 was ₹67,171 crore, and it touched ₹1,54,797 crore in 2023-24, says the PAG report released by the I&PR Department




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Andhra Pradesh government deploys drones to detect ganja palnatations

State collaborates with NCB and Google to map and track cannabis plantations using satellite imagery technology




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Andhra Pradesh Govt. weighing options on how to utilise Mahila Samrakshana Karyadarshis, says Home Minister 

Ambiguity in overall control of their duties and service matters resulted in immense distress for the MSKs, says Home Minister




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Andhra Pradesh govt. reaffirms commitment to ‘irrigating every acre of farmland’ in State through river-interlinking projects




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Andhra Pradesh High Court strikes down PIL seeking to restrain police from taking action on ‘abusive content on social media’




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India’s office leasing soars 41% in 2024 amid rent hikes, supply crunch, and GCC growth: Cushman & Wakefield

In an interview to businessline, Cushman & Wakefield’s Veera talks about commercial space leasing outlook, trends, and rental and supply trends for the coming months




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Affordable generics will stay relevant amid a premiumisation trend: Bhushan Akshikar

GSK will keep its existing portfolios while entering areas like oncology, said company officials at its centenary celebrations




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Millions of Nigerians go hungry as floods compound hardship

Torrential rains and floods in 29 of Nigeria's 36 states this year have destroyed more than 1.5 million hectares of cropland, affecting more than nine million people




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Karnataka bypolls: Channapatna, Shiggaon and Sandur constituencies witness overall turnout of 76.9% till 5 p.m.

A total of 45 candidates are in the fray in these byelections




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Satish Jarkiholi supporter to lead Belagavi DCC bank

Before the election, the three Jarkiholi brothers — Satish (Congress MLA), Ramesh (BJP MLA), and Balachandra (BJP MLA) — met in a private hotel in Belagavi to discuss the names of candidates




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Karnataka bypolls: A few residents of Savanur boycott polling in Shiggaon Assembly constituency

Some families at Dandinpet in Savanur boycotted the bypolls over not being given record of occupancy rights to them.




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Illegal export of iron ore from Belekeri port: Karnataka High Court suspends sentence and grants bail to MLA Satish Sail and five other convicts




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FIR registered against Snehamayi Krishna




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Union and State governments should set up Sanatana Board, demand seers




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Three youths go missing after coracle overturns in Sharavathi backwaters in Sagar taluk




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80.48% voter turnout recorded in Shiggaon

The polling for the byelection to Shiggaon Legislative Assembly Constituency in concluded peacefully with large number of voters turning up at 241 polling stations in the assembly segment to exercise their franchise on Wednesday




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Pakistan should stop playing cricket with India, says Rashid Latif

The Pakistan Cricket Board (PCB) has written to ICC asking for written confirmation from the BCCI for India's inability to travel to Pakistan for the tournament




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I've found ways and means to break it down: Ashwin on Smith's batting

The two seasoned campaigners would face off during the Border-Gavaskar Trophy starting November 22 in Perth




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Shambala and Kimiko impress




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Comeback man Shami hogs the spotlight as MP takes honours on opening day against Bengal




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Sharandeep grinds out a half-century on a slow-moving opening day

The Jharkhand opener exhibits ample patience and a tight defence




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Pacers Koushik, Vidyadhar run through Uttar Pradesh

Duo shares eight wickets to roll the opposition over for 89; debutant Shrijith’s unbeaten 68 steadies a rocking ship for the visitors as they eke out a 38-run lead




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Ranji Trophy | Tamil Nadu has Railways under the cosh with dominant show

CRICKET | Skipper Jagadeesan’s decision to field pays off handsomely as Ajith Ram and Gurjapneet take quick wickets; Ahuja, Saif and Merai hold out with half centuries




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Siddhant Banthia sails past Siddharth Vishwakarma in ITF men’s tennis tournament

Siddhant Banthia broke serve dropping one point, and served out at love in the next game, to gain a stranglehold over the proceedings. He ran up a 5-1 lead in the second set before closing it out without any trouble




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Swiggy pre-open trade: Shares jump in trading debut after $1.4-billion IPO

The stock listed at ₹420 on India's National Stock Exchange, compared to its issue price of ₹390




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Daylight assault on doctor inside Chennai hospital leaves medical fraternity in shock

The attacker, Vignesh, was reportedly frustrated over the treatment given to his mother, who was diagnosed with Hodgkin’s Lymphoma in an advanced stage




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Comeback man Shami makes a quiet return to action

Aryan and Khejroliya pick up four wickets apiece as Madhya Pradesh bowls out Bengal for 228; host batters build on advantage




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Kunnummal, Akshay score resolute half-centuries

Kerala ends the opening day against the home team Haryana at 138 for two with pacer Kamboj claiming both the wickets to fall




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Sharandeep grinds out a half-century on a slow-moving opening day

The opener exhibits ample patience and a tight defence as Jharkhand reached 136 for three in the 55 overs that were possible after the start of play was delayed by two hours




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Tilak’s maiden ton, Abhishek’s 50 fire India to 219/6 against South Africa in 3rd T20I

Tilak Varma got ample backing from Abhishek Sharma who made a brisk 50 after SA skipper Aiden Markram invited the visitors to bat first.




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Sindhu movers to pre-quarters, Lakshya bows out of Kumamoto Masters Japan




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Additional Central forces rushed to Manipur; abducted women, children remain untraced

More than 48 hours on, the three women and three children who were allegedly abducted from Jiribam district by armed miscreants were yet to be rescued or traced, a senior government official said




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Cochin Shipyard funding for climate tech company




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Kozhikode Corporation to rehabilitate traders evicted from shop rooms below CH Flyover

Around 40% of evicted traders find alternative locations; Deputy Mayor urges others to wait for funds to be allocated, while traders offer to build shops themselves




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Six men held for online share trading scam 




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U-shaped flyover on IT corridor nearing completion




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The impact of Pradhan Mantri Ujjwala Yojana in Jammu and Kashmir

Expanding the network of LPG distribution points in rural areas and extending financial support for refills could further increase clean fuel adoption




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L-G approves proposal to deploy former bus marshals on anti-pollution duties




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After Uddhav Thackeray calls EC biased for checking his bags, Eknath Shinde releases videos of his bags being checked

Eknath Shinde’s luggage was being checked at the Palghar police ground helipad as part of Standard Operating Procedures (SOPs)




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Encroachments along Vrishabhavathi: HC pulls up officials for ‘sitting tight and hoodwinking court’

The court gave authorities time till November 22 for demonstrating concrete action on removal of encroachments




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Congress hindering tourism development in Karkala by meddling with Parashuram statue issue, says Sunil Kumar

Sculptor had disassembled statue only to introduce minor alignment corrections as suggested by NITK, the MLA claims




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Mother, sister arrested for suicide of 32-year-old Pakshikere resident seek bail