ANIMAL Crossing New Horizons became a welcome break from the coronavirus pandemic last month when Nintendo's most ambitious second-life game debuted to critical acclaim. Since release, the developers have added a string of updates, one of which included sly art seller Redd.

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Randal Taylor, who became police chief last week, has felt the grief that lies behind every shooting in Indianapolis.

Purdue coach Matt Painter met with the media Tuesday to discuss a wide range of subjects

BBC Sport looks at the path La Liga is following to allow top-flight football to resume safely in Spain.

The public has been warned to avoid emergency rooms because of coronavirus cases. But staying home undoubtedly made my son-in-law's condition worse.

Hundreds of thousands of families live in overcrowded homes. What is lockdown life like for them?

BBC Sport looks at the path La Liga is following to allow top-flight football to resume safely in Spain.

A chronology of key events

Key facts, figures and dates

In keeping with the best video game remakes, “Black Mesa” is a perfect complement to your rose-tinted memories, with modern-day graphics and extensive level design tweaks.

Artists are creating social-distancing versions of Vermeer, da Vinci, Michelangelo and more.

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Madrid, Spain

Andalusia, Southern Spain

Barcelona, Spain

Valencia, Spain

The Amateur Traveler talks to Ben Dixon about biking the route of the Camino di Santiago in northern Spain. The Camino di Santiago is a an ancient pilgrim trail that runs across northern Spain from the border with France to Santiago di Compostella. The cathedral in Santiago di Compostella reputedly holds the remains of St. James. Modern day pilgrims are sometimes drawn by faith and sometimes just drawn by the journey itself to trek for a month across the varied landscapes of northern Spain. As an American, Ben did not have a month of vacation but rather than be one of those pilgrims who only traverses the very end of the trail he chose to take on the pilgrim route on a bicycle. Along the way he stayed in the hostels that house the many pilgrims where he met people who had been walking from far beyond the border with France. Through countryside, cities and picturesque towns he rode in both sunshine and driving rain, but the highlight of the trip might not be what you think.

The Amateur Traveler talks to Vicente Perez about his home city of Pamplona, Spain. Pamplona is best known for the festival of San Fermin and of course for the running of the bulls. Vicente tells us more about that colorful festival, of which, the running of the bulls is actually a very small part. From the Txupinazo, the ceremonial firing of a rocket on July 6th until July 14th the population of Pamplona swells with celebrants. Processions of giant figures (the Comparsa), music, bull fights and lots and lots of partying fill the days and nights. But Vicente also tells of some of the other features of Pamplona and the Navarre region that can be enjoyed any time of year including wonderful food, beautiful mountains, castles, and the nearby cave of Zugarramurdi (Known for the Basque witch trials).

The Amateur Traveler talks to Gary Arndt of Everything-Everywhere.com about his recent trip to the Canary Islands. The Canary Islands are tropical volcanic islands that are part of Spain but are located off the coast of Northwestern Africa.They are not named after birds.

    The first thing that struck me when I got off the plane was how much the weather was like Hawaii and I have heard a lot of people call it Europe's Hawaii. It is a part of Spain. There are two provinces that constitute the Canary Islands. One with its capital on Grand Canaria Island and the other on the island of Tenerife. Columbus's last stop over was in the Canary Islands. Each of the islands, and there are 7 main islands, have a very different character.

The Amateur Traveler talks to Photographer Ralph Velasco about two of his favorite cities in Spain, Toledo and Segovia. Both Toledo and Segovia are a short distance from Madrid and both offer interesting and historically significant cities with UNESCO World Heritage sites.

The Amateur Traveler talks to Sherry Ott about Costa Brava Spain. Costa Brava is in Catalonia north of Barcelona on the rugged coastline of Spain. It also extends as far inland as the Pyrenees and includes farming country and medieval towns.

Hear about travel to Extremadura in Spain as the Amateur Traveler talks to Sam from indefiniteadventure.com about living and working there. Extremadura is a lesser known region in southwest Spain on the border with Portugal and adjacent to Andalusia, Madrid and Castilla. Sam lived in the city of Medira for 3 months teaching English.

Hear about travel to the Andalucia region of Spain as the Amateur Traveler talks to Crawford Hill from Chill Expeditions about his adopted home in Southern Spain. Crawford traveled in that area and then fell in love and bought a second home here.

Hear about travel to Seville, Spain as the Amateur Traveler talks to Cat Gaa from sunshineandsiestas.com about life in her adopted city. Hear about what to see, do and eat in Seville. 

Hear about hiking the Camino de Santiago (the Way of St. James) in northern Spain as the Amateur Traveler talks to Linda Martin from The Indie Travel Podcast.

Linda says, "the thing about the Camino is that it is as long as you wanted to be."

Hear about travel to Barcelona, Spain as the Amateur Traveler talks to Lauren Aloise from devourspain.com about traveling to this capital of the region of Catalan. 

Hear about travel to Madrid, Spain as the Amateur Traveler talks to James Blick from DevourTours.com and Yolanda Martin from TheFlamencoGuide.com about their city.

Hear about hiking the Camino Ronda in Northern Spain as the Amateur Traveler talks to Sherry Ott about her trek along the coastline of the Costa Brava region.

Hear about travel to the Basque Region of Spain as the Amateur Traveler talks to David Bumstead about his adopted country and region.

Hear about travel to Valencia, Spain as the Amateur Traveler talks to Jason Jenkins from AnEpicEducation.com about the 2 years his family lived in Spain's 3rd largest city.

Invitation Only Research Event

Event participants

Dr Tedros Adhanom Ghebreyesus, Director-General, World Health Organization 

Activation of microglia and astrocytes secondary to inflammatory processes contributes to the development and perpetuation of pain with a neuropathic phenotype. This pain state presents as a chronic debilitating condition and affects a large population of patients with conditions like rheumatoid arthritis and diabetes, or after surgery, trauma, or chemotherapy. Here, we review the regulation of lipid rafts in glial cells and the role they play as a key component of neuroinflammatory sensitization of central pain signaling pathways. In this context, we introduce the concept of an inflammaraft (i-raft), enlarged lipid rafts harboring activated receptors and adaptor molecules and serving as an organizing platform to initiate inflammatory signaling and the cellular response. Characteristics of the inflammaraft include increased relative abundance of lipid rafts in inflammatory cells, increased content of cholesterol per raft, and increased levels of inflammatory receptors, such as toll-like receptor (TLR)4, adaptor molecules, ion channels, and enzymes in lipid rafts. This inflammaraft motif serves an important role in the membrane assembly of protein complexes, for example, TLR4 dimerization. Operating within this framework, we demonstrate the involvement of inflammatory receptors, redox molecules, and ion channels in the inflammaraft formation and the regulation of cholesterol and sphingolipid metabolism in the inflammaraft maintenance and disruption. Strategies for targeting inflammarafts, without affecting the integrity of lipid rafts in noninflammatory cells, may lead to developing novel therapies for neuropathic pain states and other neuroinflammatory conditions.

Most of Europe may be on lockdown, but there is still reason to look forward to SumeRR, in Spain. Originally from Jamaica, the singer relocated to the European country three years ago, chasing love and record deal dreams. The dreams came true,...

Activation of microglia and astrocytes secondary to inflammatory processes contributes to the development and perpetuation of pain with a neuropathic phenotype. This pain state presents as a chronic debilitating condition and affects a large population of patients with conditions like rheumatoid arthritis and diabetes, or after surgery, trauma, or chemotherapy. Here, we review the regulation of lipid rafts in glial cells and the role they play as a key component of neuroinflammatory sensitization of central pain signaling pathways. In this context, we introduce the concept of an inflammaraft (i-raft), enlarged lipid rafts harboring activated receptors and adaptor molecules and serving as an organizing platform to initiate inflammatory signaling and the cellular response. Characteristics of the inflammaraft include increased relative abundance of lipid rafts in inflammatory cells, increased content of cholesterol per raft, and increased levels of inflammatory receptors, such as toll-like receptor (TLR)4, adaptor molecules, ion channels, and enzymes in lipid rafts. This inflammaraft motif serves an important role in the membrane assembly of protein complexes, for example, TLR4 dimerization. Operating within this framework, we demonstrate the involvement of inflammatory receptors, redox molecules, and ion channels in the inflammaraft formation and the regulation of cholesterol and sphingolipid metabolism in the inflammaraft maintenance and disruption. Strategies for targeting inflammarafts, without affecting the integrity of lipid rafts in noninflammatory cells, may lead to developing novel therapies for neuropathic pain states and other neuroinflammatory conditions.

​ Builders will continue to build, and White folk dumpster dive,  In the winter anyway, In red, And blue overalls, scavenge – Scavenger, Some for profit, others fun, and I Cannot be a predator, I Cannot carry luggage, I Am dying, and Perhaps giving things away, a book or something will relive the pain, lord […]

I remember her detail, How she looked, how she talked to her husband, I just stood on the pavement and cried, I’ll Never see her again, not here, That’s it. Whatever came, came for a moment and then left, we were Going to live forever. I don’t get in touch with anyone anymore, It scares […]