The Program in Visual Arts presents an exhibition of recent work created by students in the fall course, "Painting I," taught by Pam Lins and Colleen Asper. Gallery Hours: Weekdays, 7 AM-8:30 PM; Weekends, 9 AM-8:30 PM.

The Program in Visual Arts presents an exhibition of recent work created by students in the fall course, "Painting I," taught by Pam Lins and Colleen Asper. Gallery Hours: Weekdays, 7 AM-8:30 PM; Weekends, 9 AM-8:30 PM.

The Program in Visual Arts presents an exhibition of recent work created by students in the fall course, "Painting I," taught by Pam Lins and Colleen Asper. Gallery Hours: Weekdays, 7 AM-8:30 PM; Weekends, 9 AM-8:30 PM.

The Program in Visual Arts presents an exhibition of recent work created by students in the fall course, "Painting I," taught by Pam Lins and Colleen Asper. Gallery Hours: Weekdays, 7 AM-8:30 PM; Weekends, 9 AM-8:30 PM.

The Program in Visual Arts presents an exhibition of recent work created by students in the fall course, "Painting I," taught by Pam Lins and Colleen Asper. Gallery Hours: Weekdays, 7 AM-8:30 PM; Weekends, 9 AM-8:30 PM.

The Program in Visual Arts presents an exhibition of recent work created by students in the fall course, "Painting I," taught by Pam Lins and Colleen Asper. Gallery Hours: Weekdays, 7 AM-8:30 PM; Weekends, 9 AM-8:30 PM.

The Program in Visual Arts presents an exhibition of recent work created by students in the fall course, "Painting I," taught by Pam Lins and Colleen Asper. Gallery Hours: Weekdays, 7 AM-8:30 PM; Weekends, 9 AM-8:30 PM.

The Program in Visual Arts presents an exhibition of recent work created by students in the fall course, "Painting I," taught by Pam Lins and Colleen Asper. Gallery Hours: Weekdays, 7 AM-8:30 PM; Weekends, 9 AM-8:30 PM.

The Program in Visual Arts presents an exhibition of recent work created by students in the fall course, "Painting I," taught by Pam Lins and Colleen Asper. Gallery Hours: Weekdays, 7 AM-8:30 PM; Weekends, 9 AM-8:30 PM.

The Program in Visual Arts presents an exhibition of recent work created by students in the fall course, "Painting I," taught by Pam Lins and Colleen Asper. Gallery Hours: Weekdays, 7 AM-8:30 PM; Weekends, 9 AM-8:30 PM.

The Program in Visual Arts presents an exhibition of recent work created by students in the fall course, "Painting I," taught by Pam Lins and Colleen Asper. Gallery Hours: Weekdays, 7 AM-8:30 PM; Weekends, 9 AM-8:30 PM.

The Program in Visual Arts presents an exhibition of recent work created by students in the fall course, "Painting I," taught by Pam Lins and Colleen Asper. Gallery Hours: Weekdays, 7 AM-8:30 PM; Weekends, 9 AM-8:30 PM.

The Program in Visual Arts presents an exhibition of recent work created by students in the fall course, "Painting I," taught by Pam Lins and Colleen Asper. Gallery Hours: Weekdays, 7 AM-8:30 PM; Weekends, 9 AM-8:30 PM.

The Program in Visual Arts presents an exhibition of recent work created by students in the fall course, "Painting I," taught by Pam Lins and Colleen Asper. Gallery Hours: Weekdays, 7 AM-8:30 PM; Weekends, 9 AM-8:30 PM.

The Program in Visual Arts presents an exhibition of recent work created by students in the fall course, "Painting I," taught by Pam Lins and Colleen Asper. Gallery Hours: Weekdays, 7 AM-8:30 PM; Weekends, 9 AM-8:30 PM.

The Program in Visual Arts presents an exhibition of recent work created by students in the fall course, "Painting I," taught by Pam Lins and Colleen Asper. Gallery Hours: Weekdays, 7 AM-8:30 PM; Weekends, 9 AM-8:30 PM.

Patterns of lines and dots associated with specific animal species in cave art may point to an early writing system.

From the horror of the Holocaust to the struggles that the cousins face in the modern day, the movie is about the overall pains of life, film star Jennifer Grey iterated.

Satellite images and on-the-ground photos show the scale of destruction caused by the floods.

For 15 years, David Gilliver has been a pioneer in the technique of painting with light.

There were no immediate reports of casualties after heavy rain on Thursday.

Two weeks after flash floods devastated eastern Spain, several areas are on alert again.

Daniel James says his Euros penalty heartache is behind him as he aims to make up for lost time with Craig Bellamy’s Wales.

Spanish football writer Guillem Balague talks to former Barcelona and Spain midfielder Andres Iniesta about his plans after retiring.

1. 'There's a guy in Indian team whose Test average is 63...': Tim Paine wants Rohit and Gambhir to open their eyes  Hindustan Times
2. EXCLUSIVE | Dhruv Jurel can be the X-factor India are looking for in Australia, says Suresh Raina  The Times of India
3. Former Australia captain tips India youngster to shine Down Under  ICC Cricket
4. Not Rishabh Pant or Yashasvi Jaiswal; Ex- Australian captain backs this Indian young player to impress everyone in Border-Gavaskar Trophy, says 'class above all his teammates on this tour'  SportsTak
5. Why India should play Jurel as a specialist batsman at Perth  The Indian Express

It's all over but the crying for a campaign that was supposed to be characterized by 'joy'. There will be no concession speech tonight. At little before 1 am, Kamala is running like a scared rabbit.

The post Cowardly Kamala Pulls A Hillary — Refuses To Concede As Trump Paints The Country Red appeared first on Clash Daily.

The human cardiovascular system has adapted to function optimally in Earth's 1G gravity, and microgravity conditions cause myocardial abnormalities, including atrophy and dysfunction. However, the underlying mechanisms linking microgravity and cardiac anomalies are incompletely understood. In this study, we investigated whether and how calpain activation promotes myocardial abnormalities under simulated microgravity conditions. Simulated microgravity was induced by tail suspension in mice with cardiomyocyte-specific deletion of Capns1, which disrupts activity and stability of calpain-1 and calpain-2, and their WT littermates. Tail suspension time-dependently reduced cardiomyocyte size, heart weight, and myocardial function in WT mice, and these changes were accompanied by calpain activation, NADPH oxidase activation, and oxidative stress in heart tissues. The effects of tail suspension were attenuated by deletion of Capns1. Notably, the protective effects of Capns1 deletion were associated with the prevention of phosphorylation of Ser-345 on p47phox and attenuation of ERK1/2 and p38 activation in hearts of tail-suspended mice. Using a rotary cell culture system, we simulated microgravity in cultured neonatal mouse cardiomyocytes and observed decreased total protein/DNA ratio and induced calpain activation, phosphorylation of Ser-345 on p47phox, and activation of ERK1/2 and p38, all of which were prevented by calpain inhibitor-III. Furthermore, inhibition of ERK1/2 or p38 attenuated phosphorylation of Ser-345 on p47phox in cardiomyocytes under simulated microgravity. This study demonstrates for the first time that calpain promotes NADPH oxidase activation and myocardial abnormalities under microgravity by facilitating p47phox phosphorylation via ERK1/2 and p38 pathways. Thus, calpain inhibition may be an effective therapeutic approach to reduce microgravity-induced myocardial abnormalities.

When a scuba diver comes up from the deep too quickly, the rapid decrease in pressure can give them a case of "the bends" or decompression sickness. It is caused by bubbles of gas building up in the body, causing pain. It can also be fatal....

The cornea is densely innervated, mainly by sensory nerves of the ophthalmic branch of the trigeminal ganglia (TG). These nerves  are important to maintain corneal homeostasis, and nerve damage can lead to a decrease in wound healing, an increase in corneal ulceration and dry eye disease (DED), and neuropathic pain. Pathologies, such as diabetes, aging, viral and bacterial infection, as well as  prolonged use of contact lenses and surgeries to correct vision can produce nerve damage. There are no effective therapies to alleviate DED (a multifunctional disease) and several clinical trials using -3 supplementation show unclear and sometimes negative results. Using animal models of corneal nerve damage, we show that treating corneas with pigment epithelium-derived factor (PEDF) plus docosahexaenoic acid (DHA) increases nerve regeneration, wound healing, and tear secretion. The mechanism involves the activation of a calcium-independent phospholipase A2 (iPLA2) that releases the incorporated DHA from phospholipids and enhances the synthesis of docosanoids neuroprotectin D1 (NPD1) and a new resolvin stereoisomer  RvD6i. NPD1 stimulates the synthesis of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and of semaphorin 7A (Sema7A).  RvD6i treatment of injured corneas modulates gene expression in the TG resulting in enhanced neurogenesis; decreased neuropathic pain and increased sensitivity. Taken together, these results represent a promising therapeutic option to re-establish the homeostasis of the cornea.

There is nothing quite like the excitement of discovery in science—of finding something no one else knew and seeing a story unfold. One has to be part of an emerging picture to feel the elation. These moments in a lifetime are few and far between, but they fuel enthusiasm and keep one going. They are embedded in struggles and joys of everyday life, years of establishing what Louis Pasteur called “the prepared mind,” working with mentors, trainees, and colleagues, failures and successes. This article recalls 1) how I got to be a biochemist; 2) my contributions as an educator and researcher, especially regarding meprin metalloproteases; and 3) my participation in communities of science. Perhaps my reflections will help an aspiring scientist see how fulfilling a career in science can be.

Virtual yoga can be a successful and accessible way to manage chronic low back pain -- a common ailment with major consequences, a new study suggests.

It has incredible psychological and physiological power.

More layoffs and damaging cuts loom as districts move deeper into the school year with their budgets depleting and Congress stalemated over emergency relief.

Freshman had a season-high 13 points off bench while contributing to Spartans' win over Eastern Michigan.

Laura Medlock
Apr 13, 2022; 42:3133-3149
Systems/Circuits

Fadel Zeidan
Nov 18, 2015; 35:15307-15325
BehavioralSystemsCognitive

We recently demonstrated that transient attenuation of Toll-like receptor 4 (TLR4) in dorsal root ganglion (DRG) neurons, can both prevent and reverse pain associated with chemotherapy-induced peripheral neuropathy (CIPN), a severe side effect of cancer chemotherapy, for which treatment options are limited. Given the reduced efficacy of opioid analgesics to treat neuropathic, compared with inflammatory pain, the cross talk between nociceptor TLR4 and mu-opioid receptors (MORs), and that MOR and TLR4 agonists induce hyperalgesic priming (priming), which also occurs in CIPN, we determined, using male rats, whether (1) antisense knockdown of nociceptor MOR attenuates CIPN, (2) and attenuates the priming associated with CIPN, and (3) CIPN also produces opioid-induced hyperalgesia (OIH). We found that intrathecal MOR antisense prevents and reverses hyperalgesia induced by oxaliplatin and paclitaxel, two common clinical chemotherapy agents. Oxaliplatin-induced priming was also markedly attenuated by MOR antisense. Additionally, intradermal morphine, at a dose that does not affect nociceptive threshold in controls, exacerbates mechanical hyperalgesia (OIH) in rats with CIPN, suggesting the presence of OIH. This OIH associated with CIPN is inhibited by interventions that reverse Type II priming [the combination of an inhibitor of Src and mitogen-activated protein kinase (MAPK)], an MOR antagonist, as well as a TLR4 antagonist. Our findings support a role of nociceptor MOR in oxaliplatin-induced pain and priming. We propose that priming and OIH are central to the symptom burden in CIPN, contributing to its chronicity and the limited efficacy of opioid analgesics to treat neuropathic pain.

Seven guest collaborators bring new eyes to a Smithsonian museum founder’s collection of American art

Rome/New York – Queen Letizia of Spain will join international efforts against hunger and [...]

Artist Michael Kirby spent four days painting an image from "Falnama: The Book of Omens" in front of the Arthur M. Sackler Gallery. Read more at: https://www.smithsonianmag.com/smithsonian-institution/muralist-uses-the-sidewalk-outside-the-sackler-gallery-as-canvas-20678724/

Filmed by the famous photographer during the Spanish Civil War, this clip debuted at the 2010 Orphan Film Symposium

Read more at http://www.smithsonianmag.com/arts-culture/Arcimboldos-Feast-for-the-Eyes.html The Hapsburg Dynasty's court painter's unique style of portraiture, using fruits, vegetables and animals to compose his faces -- has fascinated artists and the general public for centuries.

Officials in Extremadura are hoping to attract digital nomads and tech workers in a bid to boost the region's shrinking population

Archaeologists unearthed a series of mudbrick rooms filled with religious tributes, soldiers' personal effects, engraved weaponry and animal bones

The artist's cityscapes, once dismissed as too masculine, would later influence the floral artworks that became central to her iconic style