Jay Collins is Vice Chairman Banking, Capital Markets and Advisory, Citigroup*

The post Only Sustainable Investment & Global Cooperation Can Counter COVID’s Blow to SDGs appeared first on Inter Press Service.

The rest of Japan is scheduled to get theirs by the end of the month — when the emergency is set to end.

As the United States has taken a step back from world affairs to focus on an unprecedented health crisis at home, China has made full use of its massive military power to promote itself as a leader in the global fight against Covid-19.In the latest of a slew of recent overseas aid efforts carried out by the People’s Liberation Army (PLA), a Chinese medical team put the finishing touches to a testing laboratory in Yangon, Myanmar’s largest city, which they had helped to build from the ground up…

To offset the declining benefits of manufacturing, governments must increase the productivity of the services sector. This will boost growth and offer employment opportunities.

Despite the global outcry against animal sacrifice in Nepal, the tradition persists.

A total of 34 coronavirus infections was registered by Lebanon’s Health Ministry Thursday, raising the number of detected cases in the country to 784.

The auction of commercial properties held by the Chandigarh Housing Board flopped with just two booths finding any takers on Wednesday. A total of 145 booths, bay shops and a restaurant site were to go under the hammer. The two properties that were auctioned fetched a little over the reserve price. The CHB auction of booths held in 2009 had also flopped with no property being auctioned. Among the booths that were auctioned was one in Sector 38 (West). This fetched Rs 61.13 lakh, just Rs 25,000 more than the reserve price. Another booth in Manimajra fetched Rs 60.25 lakh, which was Rs 27,000 more than the reserve price. The […]

This pink manta ray, nicknamed Clouseau, has resurfaced off Australia’s coast. No one knows why it has a bubble-gum pink underside or if there are others out there

If big rocks fall far enough they can explode with more energy than any non-nuclear bomb – and the ensuing shockwave can snap large trees half a kilometre away

Just how humans evolved the stiff feet that allow us to walk and run has been something of a mystery, but now researchers say a bony arch structure is the key

Title: Health Food Stores Often Promote Adult-Only Supplements to Teens
Category: Health News
Created: 4/26/2015 12:00:00 AM
Last Editorial Review: 4/27/2015 12:00:00 AM

Title: Many Manly Men Avoid Needed Health Care
Category: Health News
Created: 4/28/2016 12:00:00 AM
Last Editorial Review: 4/29/2016 12:00:00 AM

Title: Bystander CPR Not Only Saves Lives, It Lessens Disability: Study
Category: Health News
Created: 5/4/2017 12:00:00 AM
Last Editorial Review: 5/5/2017 12:00:00 AM

Title: Benlysta Approved for Children With Lupus
Category: Health News
Created: 4/29/2019 12:00:00 AM
Last Editorial Review: 4/30/2019 12:00:00 AM

Title: Many With Dog Allergies Might Only Be Allergic to Male Dogs
Category: Health News
Created: 1/7/2020 12:00:00 AM
Last Editorial Review: 1/8/2020 12:00:00 AM

Access to services related to reproductive and sexual health is critical to the health of women but has been threatened in recent years. Family physicians are trained to provide a range of women’s health care services and are an essential part of the health care workforce in rural and underserved areas, where access to these services may be limited.

Phosphoglycerate kinase 1 (PGK1) plays important roles in glycolysis, yet its forward reaction kinetics are unknown, and its role especially in regulating cancer cell glycolysis is unclear. Here, we developed an enzyme assay to measure the kinetic parameters of the PGK1-catalyzed forward reaction. The Km values for 1,3-bisphosphoglyceric acid (1,3-BPG, the forward reaction substrate) were 4.36 μm (yeast PGK1) and 6.86 μm (human PKG1). The Km values for 3-phosphoglycerate (3-PG, the reverse reaction substrate and a serine precursor) were 146 μm (yeast PGK1) and 186 μm (human PGK1). The Vmax of the forward reaction was about 3.5- and 5.8-fold higher than that of the reverse reaction for the human and yeast enzymes, respectively. Consistently, the intracellular steady-state concentrations of 3-PG were between 180 and 550 μm in cancer cells, providing a basis for glycolysis to shuttle 3-PG to the serine synthesis pathway. Using siRNA-mediated PGK1-specific knockdown in five cancer cell lines derived from different tissues, along with titration of PGK1 in a cell-free glycolysis system, we found that the perturbation of PGK1 had no effect or only marginal effects on the glucose consumption and lactate generation. The PGK1 knockdown increased the concentrations of fructose 1,6-bisphosphate, dihydroxyacetone phosphate, glyceraldehyde 3-phosphate, and 1,3-BPG in nearly equal proportions, controlled by the kinetic and thermodynamic states of glycolysis. We conclude that perturbation of PGK1 in cancer cells insignificantly affects the conversion of glucose to lactate in glycolysis.

Treating malaria in HIV-coinfected individuals should consider potential drug-drug interactions. Artemether-lumefantrine is the most widely recommended treatment for uncomplicated malaria globally. Lumefantrine is metabolized by CYP3A4, an enzyme that commonly used antiretrovirals often induce or inhibit. A population pharmacokinetic meta-analysis was conducted using individual participant data from 10 studies with 6,100 lumefantrine concentrations from 793 nonpregnant adult participants (41% HIV-malaria-coinfected, 36% malaria-infected, 20% HIV-infected, and 3% healthy volunteers). Lumefantrine exposure increased 3.4-fold with coadministration of lopinavir-ritonavir-based antiretroviral therapy (ART), while it decreased by 47% with efavirenz-based ART and by 59% in the patients with rifampin-based antituberculosis treatment. Nevirapine- or dolutegravir-based ART and malaria or HIV infection were not associated with significant effects. Monte Carlo simulations showed that those on concomitant efavirenz or rifampin have 49% and 80% probability of day 7 concentrations <200 ng/ml, respectively, a threshold associated with an increased risk of treatment failure. The risk of achieving subtherapeutic concentrations increases with larger body weight. An extended 5-day and 6-day artemether-lumefantrine regimen is predicted to overcome these drug-drug interactions with efavirenz and rifampin, respectively.

BACKGROUND AND PURPOSE:

Endovascular embolization only has been advocated for treatment of brain arteriovenous malformations in recent trials. Our aim was to evaluate the results of embolization only in a cohort of patients who were enrolled in the A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA) study at 39 clinical sites in 9 countries.

The UK government has pledged to make smart motorways safer by rolling out a radar detection system within the next three years, but New Scientist can reveal that just 7 per cent of the roads are protected by the measure today

Get an all day breakfast on a pizza before you go on your killing spree. Only psychopaths will order this, is what I'm saying.

We may not have found alien life yet, but new methods and the discovery of exoplanets and extreme life on Earth is revolutionising the hunt, says the doyenne of SETI research

Strange blasts from space called fast radio bursts continue to puzzle astronomers with their odd behaviour, as they seem to come from a variety of galaxies

Today we learn the difference between Nier and far. Then we take out a mortgage for a collector’s edition. We then brush up our reading...