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The application of a self-designed microfluidic lung chip in the assessment of different inhalable aerosols

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, 16,2111-2119
DOI: 10.1039/D4AY00017J, Paper
Zezhi Li, Xiang Li, Boyang Feng, Junwei Zhao, Kejian Liu, Fuwei Xie, Jianping Xie
Microfluidic-based assessment platforms have recently attracted considerable attention and have been widely used for evaluating in vitro toxic effects.
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An electrochemiluminescence microsensor based on DNA-silver nanoclusters amplification for detecting cellular adenosine triphosphate

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, 16,2019-2024
DOI: 10.1039/D4AY00212A, Paper
GuanQi Wu, Jian Chen, JinXin Dou, XiangWei He, Hai-Fang Li, Jin-Ming Lin
An ECL microsensor integrating RCA magnification and in situ DNA-templated AgNC generation for sensitive detection of cellular ATP.
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A lateral flow strip for on-site detection of homocysteine based on a truncated aptamer

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00274A, Paper
Yunqing Wu, Tianyu Huang, Xin Chen, Mingyuan Wang, Xiaoli Wang, Yuting Zhang, Nandi Zhou
A lateral flow strip based on a truncated aptamer for on-site detection of homocysteine in human serum.
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The selective extraction of dietary polyamines from chicken breast using the application of a lab-on-a-chip electromembrane and dispersive liquid–liquid microextraction followed by gas chromatography-mass spectrometry

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02172F, Paper
Fatemeh Barzegar, Samaneh Nabizadeh, Marzieh Kamankesh, Jahan B. Ghasemi, Abdorreza Mohammadi
Excessive dietary polyamines (PAs), including putrescine (PUT), spermine (SPM), and spermidine (SPD), have become a worldwide concern due to their carcinogenicity and reduced shelf life.
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Discrimination of Diptera order insects based on their saturated cuticular hydrocarbon content using a new microextraction procedure and chromatographic analysis

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00214H, Paper
Open Access
Lixy Olinda León-Morán, Marta Pastor-Belda, Pilar Viñas, Natalia Arroyo-Manzanares, María Dolores García, María Isabel Arnaldos, Natalia Campillo
The nature and proportions of hydrocarbons in the cuticle of insects is characteristic of the species and age. Chemical analysis of cuticular hydrocarbons allows species discrimination, which is of great...
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Ag-coated tetrapod gold nanostars (Au@AgNSs) for acetamiprid determination in tea using SERS combined with microfluidics

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00297K, Paper
Qian Ke, Limei Yin, Heera Jayan, Hesham R. El-Seedi, Xiaobo Zou, Zhiming Guo
The combination of highly sensitive SERS substrate core–shell Au@AgNSs and microfluidic chip featuring four circular split hybrid structures were used for quantitative detection of acetamiprid in tea. The LOD of acetamiprid was 0.048 ng mL−1.
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Statistical approaches to Raman imaging: principal component score mapping

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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00171K, Paper
Open Access
Elia Marin, Davide Redolfi Bristol, Alfredo Rondinella, Alex Lanzutti, Pietro Riello
We propose and benchmark test a universal protocol for the analysis of huge Raman imaging datasets, by applying PCA on raw, unprocessed data.
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Solvation effect enabled visualized discrimination of multiple metal ions

By pubs.rsc.org
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Anal. Methods, 2024, 16,2301-2310
DOI: 10.1039/D4AY00060A, Paper
Yang Cheng, Yuan Liu, Jiguang Li, Yudong Li, Da Lei, Dezhong Li, Xincun Dou
Highly efficient detection of environmental residual potentially toxic species is of concern worldwide as their presence in an excessive amount would greatly endanger the health of human beings as well as environmental sustainability.
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On-chip light sheet illumination for nanoparticle tracking in microfluidic channels

By pubs.rsc.org
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Anal. Methods, 2024, 16,2229-2240
DOI: 10.1039/D3AY02290K, Communication
Théo Travers, Gaétan Delhaye, Martinus H. V. Werts, Denis Gindre, Matthieu Loumaigne
A simple and inexpensive method is presented to efficiently integrate light sheet illumination in a microfluidic chip for dark-field microscopic tracking and sizing of nanoparticles.
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A new colorimetric aptasensor for paraquat detection based on the designed aptamer with multiple paraquat binding sites in combination with gold nanoparticles

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, 16,2340-2348
DOI: 10.1039/D4AY00053F, Paper
Pakawat Kongpreecha, Sineenat Siri
Given paraquat's environmental health risks, there is a need for a fast and simple detection method. This study presents a novel colorimetric aptasensor with a tailored aptamer, boosting sensitivity by targeting multiple paraquat binding sites.
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An immunochromatographic strip sensor for rapid and sensitive detection of candesartan, olmesartan medoxomil, and irbesartan in herbal beverages

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, 16,2359-2367
DOI: 10.1039/D4AY00151F, Paper
Dingyu Li, Aihong Wu, Liqiang Liu, Hua Kuang, Chuanlai Xu, Xiaoling Wu
Sartans, as a class of antihypertensive drugs, pose a threat to human health when illegally added to herbal beverages.
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Fading in a Page on Load with CSS & JavaScript

By www.impressivewebs.com
Published On :: Wed, 09 Dec 2020 10:59:58 +0000

When I visit a page, I get annoyed when I try to interact with elements while the website is still loading. Often stuff is moving around, fonts aren’t quite loaded, and it feels broken.

I know nowadays we’re obsessed in this industry with gaining every millisecond in page performance. But in a couple of projects that I recently overhauled, I added a subtle and clean loading mechanism that I think makes the experience nicer, even if it does ultimately slightly delay the time that the user is able to start interacting with my page.

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A Review of ipwhois.io for Reliable Geolocation Data

By www.impressivewebs.com
Published On :: Mon, 07 Feb 2022 11:00:00 +0000

[Sponsored] If you’re building an app that requires delivering a dynamic experience based on the user’s location or other location-related data, a fast and easy-to-use Geolocation API will certainly come in handy. One such option is ipwhois.io. The service, which is free for small non-commercial projects that need fewer than 10,000 requests per month, is easy to integrate with your tech stack.

As usual, it’s always best to look at a few examples so you can see it in action. Their documentation is short and easy to follow, so I’ll demonstrate using the following example request:

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How to Disable JavaScript in Almost Any Browser

By www.impressivewebs.com
Published On :: Mon, 04 Apr 2022 10:00:00 +0000

In 2022 I think it’s still important as a web developer to test your how your websites look and function when users disable JavaScript in their browser. Developing in this way used to be a cornerstone of Progressive Enhancement and can be handy on both desktop or mobile.

I still find myself wanting disabling JavaScript on pages I visit. Sometimes it’s to test a page I’m working on, but in other instances it’s simply to visit a web page that’s not functioning correctly and I want to see if JavaScript is the culprit.

The post How to Disable JavaScript in Almost Any Browser appeared first on Impressive Webs.


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​Steady but slow: On the VIPER mission, lessons for India

By www.thehindu.com
Published On :: Tue, 01 Oct 2024 00:30:00 +0530

India’s space programme needs more resources to realise its full potential


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A learning curve: On the PM Internship Scheme

By www.thehindu.com
Published On :: Mon, 07 Oct 2024 00:15:00 +0530

The outcomes of the PM Internship Scheme’s pilot project need monitoring


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​Flipping scripts: On the Haryana and J&K election results  

By www.thehindu.com
Published On :: Wed, 09 Oct 2024 00:20:00 +0530

BJP and INDIA bloc emerge clear winners in Haryana and Jammu & Kashmir


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Canadian frostbite: On the India-Canada diplomatic war

By www.thehindu.com
Published On :: Thu, 17 Oct 2024 00:20:00 +0530

India must consider the impact of its next steps on its diplomacy and image


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Culture and society: On upholding Section 6A of the Citizenship Act

By www.thehindu.com
Published On :: Tue, 22 Oct 2024 00:30:00 +0530

Supreme Court of India verdict on citizenship law for Assam helps avoid fresh problems


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Growth prescription: On the latest World Economic Outlook 

By www.thehindu.com
Published On :: Thu, 24 Oct 2024 00:20:00 +0530

The IMF’s ‘mediocre’ medium-term outlook merits policy attention


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Exploring apoptotic induction of malabaricone A in triple-negative breast cancer cells: an acylphenol phyto-entity isolated from the fruit rind of Myristica malabarica Lam.

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3558-3575
DOI: 10.1039/D4MD00391H, Research Article
Pothiyil S. Vimalkumar, Neethu Sivadas, Vishnu Priya Murali, Daisy R. Sherin, Madhukrishnan Murali, Anuja Gracy Joseph, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Malabaricone A isolated from Myristica malabarica induces apoptosis in triple-negative breast cancer cells through intrinsic and extrinsic pathways, which is validated through in vitro and in silico studies and resembles a potent phyto-entity.
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Sidechain structure–activity relationships of cyclobutane-based small molecule αvβ3 antagonists

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3616-3624
DOI: 10.1039/D4MD00306C, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Adam Throup, Manar Saleh Zraikat, Andrew Gordon, Shohreh Jafarinejad Soumehsaraei, Kathrin D. Haase, Laurence H. Patterson, Patricia A. Cooper, Katherine Hanlon, Paul M. Loadman, Mark Sutherland, Steven D. Shnyder, Helen M. Sheldrake
Cyclobutanes provide a versatile scaffold for the synthesis of small molecule integrin antagonists with good metabolic stability and in vivo tolerability.
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A novel, glutathione-activated prodrug of pimasertib loaded in liposomes for targeted cancer therapy

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00517A, Research Article
Open Access
Arianna Amenta, Susanna Comi, Marcelo Kravicz, Silvia Sesana, Antonia Antoniou, Daniele Passarella, Pierfausto Seneci, Sara Pellegrino, Francesca Re
A novel, glutathione-activated prodrug of pimasertib (PROPIMA) has been developed. PROPIMA showed ability to inhibit tumour cell migration and proliferation controlled over time, while also achieving a high incorporation rate into liposomes.
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Design, synthesis, and structure–activity relationship studies of 6H-benzo[b]indeno[1,2-d]thiophen-6-one derivatives as DYRK1A/CLK1/CLK4/haspin inhibitors

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00537F, Research Article
Open Access
Abdelfattah Faouzi, Alexandre Arnaud, François Hallé, Jean Roussel, Mandy Aymard, Vincent Denavit, Cong Viet Do, Angélique Mularoni, Mohamed Salah, Ahmed ElHady, Thanh-Nhat Pham, Alexandre Bancet, Marc Le Borgne, Raphaël Terreux, Roland Barret, Matthias Engel, Thierry Lomberget
A series of sulfur-containing tetracycles was designed and evaluated for their ability to inhibit protein kinase DYRK1A, a target known to have several potential therapeutic applications including cancers, Down syndrome or Alzheimer's disease.
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Design, synthesis, and evaluation of benzhydrylpiperazine-based novel dual COX-2/5-LOX inhibitors with anti-inflammatory and anti-cancer activity

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00471J, Research Article
Poorvi Saraf, Bhagwati Bhardwaj, Akash Verma, Mohammad Aquib Siddiqui, Himanshu Verma, Pradeep Kumar, Samridhi Srivastava, Sairam Krishnamurthy, Saripella Srikrishna, Sushant Kumar Shrivastava
Screening piperazine derivatives via ChEMBL database led to the design and synthesis of novel dual COX-2/5-LOX inhibitors with strong anti-inflammatory, analgesic, and anti-cancer activity.
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Modulating polybasic character of galactose-based glycosylated antitumor ether lipids for enhanced cytotoxic response

By pubs.rsc.org
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00662C, Research Article
Rajat Arora, Ayan Mukherjee, Gilbert Arthur, Mark W. Nachtigal, Frank Schweizer
We describe the multi-step synthesis of different dibasic and tribasic galactosamine-based glycosylated antitumor ether lipids (GAELs) and their cytotoxic response in comparison to doxorubicin and cisplatin.
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Amides of moronic acid and morolic acid with the tripeptides MAG and GAM targeting antimicrobial, antiviral and cytotoxic effects

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00742E, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Uladzimir Bildziukevich, Lucie Cerna, Jana Trylčová, Marie Kvasnicova, Lucie Rárová, David Šaman, Petra Lovecká, Jan Weber, Zdenek Wimmer
A series of amides of the selected plant triterpenoids, moronic acid and morolic acid, with the tripeptides MAG and GAM was designed and synthesized. Two required tripeptides 5 and 10...
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S-MGBs bearing amidine tail groups are potent, selective antiplasmodial agents

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00619D, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Marina Perieteanu, Tayner Rodriguez Garzon, Leah M. C. McGee, Abedawn I. Khalaf, Colin J. Suckling, Rebecca Beveridge, Vicky M. Avery, Fraser J. Scott
25 S-MGBs, including those bearing an amidine tail group, were investigated for their antiplasmodial, in vitro activity against 3D7 and Dd2 strains of P. falciparum. Several potent, and selective, hit compounds were identified.
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Miniaturized click chemistry and direct screening facilitate the discovery of triazole piperazine SARS-CoV-2 Mpro inhibitors with improved metabolic stability

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00555D, Research Article
Shenghua Gao, Letian Song, Bing Ye, Mianling Yang, Junyi Li, Manyu Gu, Ann E. Tollefson, Karoly Toth, Peng Zhan, Xinyong Liu
The continuous mutational nature of SARS-CoV-2 and its inter-species' similarities emphasize the urgent need to design and develop more direct-acting antiviral agents against highly infectious variants.
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A novel approach for the synthesis of the cyclic lipopeptide globomycin

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00685B, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Samantha J. Bann, Stephen A. Cochrane
Lipid swapping: a new approach for the synthesis of globomycin that allows for facile lipid diversification.
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Design, synthesis, and biological evaluation of pyrazole–ciprofloxacin hybrids as antibacterial and antibiofilm agents against Staphylococcus aureus

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00623B, Research Article
Ojaswitha Ommi, Priyanka Sudhir Dhopat, Shashikanta Sau, Madhu Rekha Estharla, Srinivas Nanduri, Nitin Pal Kalia, Venkata Madhavi Yaddanapudi
A series of pyrazole–ciprofloxacin hybrids were designed, synthesized, and tested for antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis, aiming to combat antibiotic resistance.
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Metal-free synthesis of N-fused quinazolino-quinazoline-diones as a MALAT1 RNA triple helix intercalator

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00614C, Research Article
Vijay Babu Pathi, Pranotosh Das, Abhyuday Guin, Manish Debnath, Biswadip Banerji
The development of chemical scaffolds that target highly conserved MALAT1 RNA received attention due to its significance in splicing, nuclear organization, and gene expression in disease progression pathways.
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3-Thio-3,4,5-Trisubstituted-1,2,4-Triazoles: High Affinity Somatostatin Receptor-4 Agonist Synthesis and Structure-Activity Relationships

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00597J, Research Article
Albert Michael Crider, Audrey Hospital, Karin Sandoval, William Neumann, Stephen Kukielski, Lejla Garic, Kristen Ingold, Matthew Dunahoo, Khush Srabony, Rafael Frare, Olivia Slater, Nathan Peel, Maria Kontoyianni, Ken Witt
Somatostatin receptor-4 (SST4) is a therapeutic target for several conditions, including Alzheimer’s disease, seizures, neuropsychiatric disorders, and pain. Our previous work on 1,2,4-triazole derivatives led to enhanced SST4 binding affinity,...
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Frequent traffic snarls pose hardship to motorists in Tiruchi

By www.thehindu.com
Published On :: Tue, 05 Nov 2024 17:45:36 +0530

It is common to see vehicles lining up for a long distance from the traffic signal near Cauvery bridge to Anna Statue.


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Tiruchi district SHGs compete to prepare healthy millet-based recipes at food festival

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 07:51:25 +0530

Women entrepreneurs urged to take advantage of social media platforms to advertise and market their products to a wider customer base


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553: TypeScript, DX, GripeScript, and Astro v2 with Fred Schott

By shoptalkshow.com
Published On :: Mon, 20 Feb 2023 10:37:22 +0000

Fred Schott stops by to talk about TypeScript, what DX means in 2023, a bit of GripeScript, and being transparent about what Astro is good at, and what it's not.


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572: Text Sqwunch Property, Figma Developer Mode, Stripe Elements

By shoptalkshow.com
Published On :: Mon, 03 Jul 2023 08:24:15 +0000

Show DescriptionDave reports back from the Figma Conference, how to build a better developer to designer bridge, do clients really want to update their website, using Stripe in 2023, permissions and sharing, and are you feeling overwhelmed by CSS in 2023? Listen on Website →Links Config 2023 | Figma’s Annual Conference Figma Visual Studio Code […]


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584: Community, Partnerships, Images, and Astro with Fred K. Schott

By shoptalkshow.com
Published On :: Mon, 25 Sep 2023 07:02:00 +0000

Fred K. Schott stops by to talk about building community, open source and sponsorship, building on partnerships in the dev community, WordPress + Astro, view transitions, using Discord for support, and leaking secret Astro Studio details.


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593: Beep & Texts, Tumblr, JavaScript & Web Components, & Cool Blog Post Ideas

By shoptalkshow.com
Published On :: Mon, 27 Nov 2023 09:00:10 +0000

Thoughts on smashing all communication messaging apps together, what's happened to Tumblr under Automattic, what the situation is with native web components and JavaScript, and looking at a list of types of blog posts.


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594: Wiping Your Laptop, UX of Password Codes, and :Has Tips and Tricks

By shoptalkshow.com
Published On :: Mon, 04 Dec 2023 09:15:20 +0000

In this episode we're discussing making tech videos, website tinkering, :has tricks, SVG path commands, and the complexities of CSS & JavaScript logic.


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603: Deno, React Alternatives, and Copilot Concerns with Triple Threat Josh Collinsworth

By shoptalkshow.com
Published On :: Mon, 19 Feb 2024 09:22:07 +0000

Josh (or Jsoh) stops by to talk about his work at Deno, recent blog posts on Copilot, why Svelte is awesome and React is not, Apple and PWA, and building word games on the web.


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610: TypeScript in 2024, Signals, Productivity Sniped, and Follow Up

By shoptalkshow.com
Published On :: Mon, 08 Apr 2024 08:38:19 +0000

Dave's about to be eclipsed, the state of TypeScript in 2024, signals stage zero proposal, corrections on accessibility in frameworks (thanks!), web apps for better collaborative writing, getting productivity sniped, the problem with email may be you, indieweb follow up, and ultimate guitar tab apps.


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611: React! TypeScript! Jobification! Drupal!

By shoptalkshow.com
Published On :: Mon, 15 Apr 2024 08:30:37 +0000

Dave & Chris and thoughts on career advice that worked 3 years ago but isn't as helpful now, marking tests with ChatGPT, is taking a Drupal job in 2024 a good idea, Chris got #gear sniped, P3 color follow up, the confusing File System APIs, and where did all the lightboxes go?


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625: CarTalk, Ownership of A Book Apart, and URL Shorteners

By shoptalkshow.com
Published On :: Mon, 22 Jul 2024 18:28:00 +0000

Dave's putting together a platform for his presidential bid and workshops his policies, discussing vehicle options for a family in 2024, Chris and other authors get ownership of their A Book Apart books back, and the ramifications and reasoning behind Google killing a URL shortener.


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Why we need lane discipline

By www.thehindu.com
Published On :: Fri, 18 Dec 2015 12:49:08 +0530

Stick to the left lane when making a turn, even in smaller lanes


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Catalysing Indian IP creation 

By www.thehindubusinessline.com
Published On :: Sun, 20 Oct 2024 21:48:42 +0530

How policy support and monetisation can rev up India’s innovation ecosystem


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  • Science and Technology
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Attempts to douse Alipur warehouse fire continue on second day

By www.thehindu.com
Published On :: Tue, 05 Nov 2024 01:00:26 +0530


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Delhi women to get monthly stipend of ₹1,000 soon: Kejriwal

By www.thehindu.com
Published On :: Tue, 05 Nov 2024 01:13:29 +0530


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Chhath Puja: Devotees take dip in Yamuna even as toxic foam floats over river  

By www.thehindu.com
Published On :: Wed, 06 Nov 2024 00:35:50 +0530


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Kejriwal gives clarion call to sarpanchs in Punjab to wipe out curse of drugs

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 20:56:50 +0530

Opposition says AAP government has ‘mishandled and mismanaged’ every aspect of State administration


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