ani Editors’ Picks: Kitchen Organizers By feedproxy.google.com Published On :: Thu, 30 Apr 2020 14:30:26 +0000 An organized kitchen doesn't have to be super minimal; it just has to function well. These editor-approved kitchen organizers help make the tools and ingredients in your kitchen more visible and accessible, so you can cook with more ease and joy! Continue reading "Editors’ Picks: Kitchen Organizers" » Full Article Cleaning and Organizing Editors' Picks Kitchen Tools
ani velocityconf: RT @oreillyanimals Vote Instant Wild's Digital Eyes & Ears for Wildlife Protection to win Google Global Impact Award http://t.co/Z0EetiQshZ By feedproxy.google.com Published On :: Thu, 23 May 2013 17:35:35 +0000 velocityconf: RT @oreillyanimals Vote Instant Wild's Digital Eyes & Ears for Wildlife Protection to win Google Global Impact Award http://t.co/Z0EetiQshZ Full Article
ani velocityconf: RT @OReillyAnimals Advice, please! Elephant Listening Project asks for ideas/solutions/help with 3 practical problems http://t.co/Y90YP3maoz By feedproxy.google.com Published On :: Tue, 04 Jun 2013 03:15:10 +0000 velocityconf: RT @OReillyAnimals Advice, please! Elephant Listening Project asks for ideas/solutions/help with 3 practical problems http://t.co/Y90YP3maoz Full Article
ani News24.com | Qassem Soleimani: Arya should stick to facts on Iran By www.news24.com Published On :: Mon, 27 Jan 2020 12:32:01 +0200 In the wake of Soleimani's death, a group of 60 American ethicists, including some notable Catholic theologians, released a statement stating that "the drone killing of Iranian General Qassem Soleimani on January 3rd by the United States was not morally justified…" Full Article
ani AT#51 - Travel to Tanzania as a tourist By traffic.libsyn.com Published On :: Sun, 30 Jul 2006 18:47:00 +0000 Tanzania, Africa as a tourist Full Article
ani AT#52 - Travel to Tanzania as a guest By traffic.libsyn.com Published On :: Sun, 06 Aug 2006 06:12:00 +0000 Tanzania, Africa as a guest Full Article
ani AT#113 - Theme Cruise to Panama (Shakespeare at Sea / MacMania) By traffic.libsyn.com Published On :: Sat, 17 Nov 2007 21:13:00 +0000 Theme Cruise to Panama (Shakespeare at Sea / MacMania) Full Article
ani AT#139 - Travel to Lancaster County Pennsylvania By traffic.libsyn.com Published On :: Sat, 14 Jun 2008 21:20:00 +0000 Lancaster County Pennsylvania Full Article
ani AT#161 - Travel to Transylvania in Romania By traffic.libsyn.com Published On :: Sat, 22 Nov 2008 16:55:00 +0000 The Amateur Traveler talks to Shawn about his trip to Transylvania in Romania. We talk, of course, about Vlad III the Impaler (Dracula) but also about the green rolling hills, walled towns, castles and people of this beautiful country. Full Article
ani AT#164 - Travel to Zanzibar in Tanzania By traffic.libsyn.com Published On :: Sat, 13 Dec 2008 19:54:38 +0000 The Amateur Traveler talks to Tadzio about his trip to Zanzibar in Tanzania, off the east coast of Africa. Tadzio worked as a ranger on Chumbe then toured Stonetown, the northern beaches, the Jozani forest, and Pemba. Hear about the food, the people, the snorkeling, the swimming, the beaches and the history of this tropical island paradise. Full Article
ani AT#259 - Travel to Pittsburgh, Pennsylvania By usa.amateurtraveler.com Published On :: Sat, 18 Dec 2010 15:00:00 +0000 The Amateur Traveler talks to Chris Bogdon who talks to us about his hometown of Pittsburgh, Pennsylvania. This former steel capital has undergone a renaissance since its steel business went away and Chris tells us some of the reasons to visit this city at the headwaters of the Ohio River. Pittsburgh boasts both historic Fort Pitt and nearby Fort Necessity where George Washington made a name for himself. It is the home to many different ethnic neighborhoods which it celebrates with food and festivals and commemorates in an Immigration Museum in the Carnegie Library of the University of Pittsburgh. The town now hosts students in greater numbers than steelworkers. It is near Frank Lloyd Wright's Fallingwaters and a wine region. Chris also talks about side trips to Bethlehem, PA and Jim Thorpe, PA. Full Article
ani AT#268 - Travel to Albania By europe.amateurtraveler.com Published On :: Sat, 19 Feb 2011 15:00:00 +0000 The Amateur Traveler talks to Francis Tapon from WanderLearn.com about Albania which has gone from a totally closed society 20 years ago to a destination that Lonely Planet ranked as the #1 destination for travel this year (that was before some of the recent protests. Francis says the because it was isolated for so long it created an exotic and unique culture. Abandoned bunkers still line the country from back when their fear of invasion had nothing to do with tourists. He recommends we start in the capital of Tirana and from there go to Krujë and its legendary Skanderbeg castle. Full Article
ani AT#323 - Travel to Lithuania By europe.amateurtraveler.com Published On :: Sat, 21 Apr 2012 17:52:00 +0000 The Amateur Traveler talks to Katie Aune from KatieGoingGlobal.com about her recent trip to Lithuania. Katie visited Lithuania as part of a year traveling through countries that were part of the former U.S.S.R. She spent much of her time in and around Vilnius, the capital. Full Article
ani AT#355 - Solo (International) Travel as a Woman with Janice Waugh By amateurtraveler.com Published On :: Tue, 31 Jul 2012 16:14:31 +0000 The Amateur Traveler talks to Janice Waugh from Solo Traveler about solo travel as a woman, particularly solo international travel. Janice did not set out to be a solo traveler but after the death of her husband she gained her courage to travel again. Full Article
ani AT#369 - Travel to Bucharest, Romania By europe.amateurtraveler.com Published On :: Sat, 27 Apr 2013 12:30:00 +0000 Hear about travel to Bucharest as the Amateur Traveler talks to Wandering Earl about visiting and living in that city. Earl calls Bucharest one of the most under-rated cities in all of Europe, certainly eastern Europe. Full Article
ani AT#411 - Travel to Arctic Manitoba By canada.amateurtraveler.com Published On :: Sat, 15 Mar 2014 18:09:38 +0000 Hear about travel to Arctic Manitoba as the Amateur Traveler talks to Marybeth Bond from GutsyTraveler.com about her recent trip to Churchill Manitoba to see polar bears. Full Article
ani AT#418 - Travel to Winnipeg, Manitoba By canada.amateurtraveler.com Published On :: Sat, 03 May 2014 15:30:00 +0000 Hear about travel to Winnipeg, Manitoba as the Amateur Traveler talks to return guest Michael Soncina of Sonchy’s Adventures about this city on the great plains of Canada. Full Article
ani AT#426 - Travel to Tasmania, Australia By australia.amateurtraveler.com Published On :: Sat, 28 Jun 2014 19:00:12 +0000 Hear about travel to Tasmania in Australia as the Amateur Traveler talks to Robert Reid, the Offbeat Observer for National Geographic Traveler, about his recent trip to Van Diemen’s Land. Full Article
ani AT#462 - Travel to Philadelphia, Pennsylvania By usa.amateurtraveler.com Published On :: Sat, 04 Apr 2015 20:10:24 +0000 Hear about travel to Philadelphia, Pennsylvania as the Amateur Traveler talks to Larissa and Michael Milne of changesinlongitude.com. They recently authored the "Philadelphia Liberty Trail" book. Full Article
ani AT#488 - Travel to Northern Romania By europe.amateurtraveler.com Published On :: Sat, 31 Oct 2015 13:57:01 +0000 Hear about travel to Northern Romania as the Amateur Traveler talks to Ralph Velasco of photoenrichment.com about the region that he visited leading a recent photo tour. We talk about the regions of Maramureş and Bukovina, north of Transylvania. Full Article
ani AT#517 - Travel to the Danube Delta, Romania By europe.amateurtraveler.com Published On :: Sat, 04 Jun 2016 13:00:00 +0000 Hear about travel to the Danube Delta in Romania as the Amateur Traveler talks to Christian Cummins about traveling to this UNESCO biosphere in Europe. Full Article
ani AT#524 - Hiking the Peaks of the Balkans (Albania, Kosovo, Montenegro) By europe.amateurtraveler.com Published On :: Sat, 13 Aug 2016 14:00:00 +0000 Hear about hiking the Peaks of the Balkans trail in Albania, Kosovo, and Montenegro as the Amateur Traveler talks to Dan and Audrey from uncorneredmarket.com about this off the beaten track route in Europe. Full Article
ani AT#575 - Travel to Albania By europe.amateurtraveler.com Published On :: Sat, 16 Sep 2017 14:00:00 +0000 Hear about travel to Albania as the Amateur Traveler talks to Dina Rabiner about her visit to the country where she originally went as a Peace Corps volunteer. Full Article
ani AT#621 - Travel to Pittsburgh and Western Pennsylvania By amateurtraveler.com Published On :: Sat, 25 Aug 2018 14:00:00 +0000 Hear about travel to Pittsburgh and Western Pennsylvania as the Amateur Traveler talks to Tom Shaner about his hometown. Full Article
ani Five Challenges Companies Must Overcome to Make Use of All Their Data By feedproxy.google.com Published On :: Tue, 29 Aug 2017 22:48:11 +0000 Full Article Industry Perspectives
ani Pentagon Opens Probe Into Sexual Abuse by U.S. Allies in Afghanistan By feedproxy.google.com Published On :: Wed, 28 Oct 2015 15:52:51 EST The Defense Department's Inspector General has opened an investigation into whether U.S. troops were discouraged from reporting the rape and sexual abuse of children by their Afghan allies. Full Article
ani ISIS in Afghanistan: School of Jihad By feedproxy.google.com Published On :: Sun, 01 Nov 2015 08:51:48 EST The emergence of ISIS in Afghanistan has introduced a new level of brutality to the conflict, beyond what has been practiced by the Taliban. Full Article
ani “The Most Risky … Job Ever.” Reporting on “ISIS in Afghanistan” By feedproxy.google.com Published On :: Tue, 17 Nov 2015 13:59:43 EST Najibullah Quraishi has covered the war in Afghanistan for more than a decade, but embedding with ISIS fighters who've recently emerged there "was the most risky and dangerous job ever I've done in my life," he says. Full Article
ani ISIS is in Afghanistan, But Who Are They Really? By feedproxy.google.com Published On :: Tue, 17 Nov 2015 18:13:51 EST It appears ISIS-allied fighters are gaining a foothold in Afghanistan, but just how similar are they to the group's branches in Iraq and Syria? Full Article
ani The Simplest Hack to Be Your Most Organized Self By feedproxy.google.com Published On :: Wed, 06 May 2020 12:30:19 +0000 Finding a good system to be organized can be intimidating. There are so many options! Useful tips on how to get your life together are all over the internet. From minimalist planners to detailed systems, something is bound to draw you in. Choosing the best system to use will be the biggest decision you’ll have […] The post The Simplest Hack to Be Your Most Organized Self appeared first on Dumb Little Man. Full Article Lifehacks Productivity
ani Working remotely builds organizational resiliency By feedproxy.google.com Published On :: Fri, 27 Mar 2020 14:37:37 +0000 For many, moving from everyone’s-working-from-the-office to everyone’s-working-at-home isn’t so much a transition as it is a scramble. A very how the fuck? moment. That’s natural. And people need time to figure it out. So if you’re in a leadership position, bake in time. You can’t expect people to hit the ground running when everything’s different.… keep reading Full Article Uncategorized
ani Video: Organic or not? By www.bbc.co.uk Published On :: 2008-02-26T16:20:00 Part of the Food for thought promo for the BBC UK Homepage Full Article
ani ‘Schiff in Panic Mode’: Sources Say Russia Probe Transcripts Affirm Officials Found Nothing on Collusion By 100percentfedup.com Published On :: Thu, 07 May 2020 13:44:13 +0000 The following article, ‘Schiff in Panic Mode’: Sources Say Russia Probe Transcripts Affirm Officials Found Nothing on Collusion, was first published on 100PercentFedUp.com. Transcripts of House Intelligence Committee interviews have been cleared for release, and Adam Schiff is reportedly in panic mode. Unfortunately for Schiff, top law enforcement and intel officials said they saw no evidence of collusion between the Trump campaign and Russia in the transcripts. Republicans sought and got approval for the release of the transcripts […] Continue reading: ‘Schiff in Panic Mode’: Sources Say Russia Probe Transcripts Affirm Officials Found Nothing on Collusion ... Full Article Breaking Featured Politics
ani Overnight snow expected in areas of Southern Manitoba By winnipeg.ctvnews.ca Published On :: Fri, 8 May 2020 17:07:00 -0600 Environment Canada has issued a special weather statement for the southwestern area of Manitoba. Full Article
ani Manitoba’s unemployment rate nearly doubled in April: Statistics Canada By winnipeg.ctvnews.ca Published On :: Fri, 8 May 2020 07:32:00 -0600 Manitoba’s unemployment rate nearly doubled between March and April, according to the monthly report from Statistics Canada released Friday morning. Full Article
ani May snowstorm buries southwest Manitobans By winnipeg.ctvnews.ca Published On :: Sat, 9 May 2020 10:46:00 -0600 Instead of May flowers, Manitobans in the southwest part of the province received a blanketing of snow for Mother's Day weekend. Full Article
ani UK General Election 2019: What the Political Party Manifestos Imply for Future UK Trade By feedproxy.google.com Published On :: Mon, 25 Nov 2019 15:50:01 +0000 Research Event 4 December 2019 - 12:30pm to 1:30pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Michael Gasiorek, Professor of Economics, University of Sussex; Director, Interanalysis; Fellow, UK Trade Policy Observatory, University of SussexJulia Magntorn Garrett, Research Officer, UK Trade Policy Observatory, University of SussexProf Jim Rollo, Deputy Director, UK Trade Policy Observatory, University of Sussex; Associate Fellow, Global Economy and Finance Department, Chatham HouseNicolo Tamberi, Research Officer in the Economics of Brexit, University of SussexL. Alan Winters, Professor of Economics, Director, UK Trade Policy Observatory, University of Sussex The upcoming UK general election is arguably a 'Brexit election', and as such, whoever wins the election will have little time to get their strategy for Brexit up and running to meet the new Brexit deadline of 31 January 2020. But what are the political parties’ policies for the UK's future trade? This event will present and discuss what the five main parties’ manifestos imply for future UK trade. Each manifesto will be presented and analysed by a fellow of the UK Trade Policy Observatory (UKTPO) and will be followed by a Q&A session. Department/project Global Economy and Finance Programme, UK Trade Policy Observatory Michela Gariboldi Research Assistant, Global Economy and Finance Programme 02073143692 Email Full Article
ani Mechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2 [Signal Transduction] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 The protein-tyrosine phosphatase SHP2 is an allosteric enzyme critical for cellular events downstream of growth factor receptors. Mutations in the SHP2 gene have been linked to many different types of human diseases, including developmental disorders, leukemia, and solid tumors. Unlike most SHP2-activating mutations, the T507K substitution in SHP2 is unique in that it exhibits oncogenic Ras-like transforming activity. However, the biochemical basis of how the SHP2/T507K variant elicits transformation remains unclear. By combining kinetic and biophysical methods, X-ray crystallography, and molecular modeling, as well as using cell biology approaches, here we uncovered that the T507K substitution alters both SHP2 substrate specificity and its allosteric regulatory mechanism. We found that although SHP2/T507K exists in the closed, autoinhibited conformation similar to the WT enzyme, the interactions between its N-SH2 and protein-tyrosine phosphatase domains are weakened such that SHP2/T507K possesses a higher affinity for the scaffolding protein Grb2-associated binding protein 1 (Gab1). We also discovered that the T507K substitution alters the structure of the SHP2 active site, resulting in a change in SHP2 substrate preference for Sprouty1, a known negative regulator of Ras signaling and a potential tumor suppressor. Our results suggest that SHP2/T507K's shift in substrate specificity coupled with its preferential association of SHP2/T507K with Gab1 enable the mutant SHP2 to more efficiently dephosphorylate Sprouty1 at pTyr-53. This dephosphorylation hyperactivates Ras signaling, which is likely responsible for SHP2/T507K's Ras-like transforming activity. Full Article
ani Prominins control ciliary length throughout the animal kingdom: New lessons from human prominin-1 and zebrafish prominin-3 [Cell Biology] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 Prominins (proms) are transmembrane glycoproteins conserved throughout the animal kingdom. They are associated with plasma membrane protrusions, such as primary cilia, as well as extracellular vesicles derived thereof. Primary cilia host numerous signaling pathways affected in diseases known as ciliopathies. Human PROM1 (CD133) is detected in both somatic and cancer stem cells and is also expressed in terminally differentiated epithelial and photoreceptor cells. Genetic mutations in the PROM1 gene result in retinal degeneration by impairing the proper formation of the outer segment of photoreceptors, a modified cilium. Here, we investigated the impact of proms on two distinct examples of ciliogenesis. First, we demonstrate that the overexpression of a dominant-negative mutant variant of human PROM1 (i.e. mutation Y819F/Y828F) significantly decreases ciliary length in Madin–Darby canine kidney cells. These results contrast strongly to the previously observed enhancing effect of WT PROM1 on ciliary length. Mechanistically, the mutation impeded the interaction of PROM1 with ADP-ribosylation factor–like protein 13B, a key regulator of ciliary length. Second, we observed that in vivo knockdown of prom3 in zebrafish alters the number and length of monocilia in the Kupffer's vesicle, resulting in molecular and anatomical defects in the left-right asymmetry. These distinct loss-of-function approaches in two biological systems reveal that prom proteins are critical for the integrity and function of cilia. Our data provide new insights into ciliogenesis and might be of particular interest for investigations of the etiologies of ciliopathies. Full Article
ani How the Soleimani Assassination Will Reverberate Throughout the Middle East By feedproxy.google.com Published On :: Mon, 06 Jan 2020 12:59:23 +0000 6 January 2020 Dr Sanam Vakil Deputy Director and Senior Research Fellow, Middle East and North Africa Programme @SanamVakil Dr Renad Mansour Senior Research Fellow, Middle East and North Africa Programme; Project Director, Iraq Initiative @renadmansour Dr Lina Khatib Director, Middle East and North Africa Programme @LinaKhatibUK Regional experts examine how Iran benefits from the fallout of the killing, the implications for politics in Iraq and how Tehran might respond with its proxies in the region. 2020-01-06-Soleimani.jpg Protesters hold up an image of Qassem Soleimani during a demonstration in Tehran on 3 January. Photo: Getty Images. An unexpected bounty for IranSanam VakilThe assassination of Qassem Soleimani has been an unexpected bounty for the Islamic Republic at a time when Iran was balancing multiple economic, domestic and regional pressures stemming from the Trump administration’s maximum pressure campaign.Coming on the heels of anti-Iranian demonstrations in Iraq and Lebanon, and following Iran’s own November 2019 protests that resulted in a brutal government crackdown against its own people, the Soleimani killing has helped the Iranian government shift the narrative away from its perceived regional and domestic weaknesses to one of strength. The massive funeral scenes in multiple Iranian cities displaying unending waves of mourners chanting against the United States has provided the Islamic Republic with a unique opportunity to showcase its mobilizing potential. This potential is not limited to Iran but also extends to Iraq and Lebanon, where Tehran’s transnational summoning power has also been visible. The Iraqi parliamentary vote to end the American military presence is one early negative consequence. While the region awaits Iran’s response, further anti-American rallying cries will continue to reverberate. Domestically, Soleimani’s death and President Donald Trump’s continued provocations on Twitter, including threats to attack 52 Iranian cultural sites, are being used as a nationalist rallying cry. This sentiment should not be seen solely as Islamic or ideological, but rather an opportunity for the state to pivot to an Iranian-based nationalism that is more inclusive and empowering for much of the country’s disgruntled youth.Iran’s notoriously divided political factions have also unified in the face of this crisis. With parliamentary elections looming in February and turnout previously expected to be low, the political establishment is likely to use this crisis to mobilize voters in favour of conservative candidates. How Tehran chooses to respond to Qassem Soleimani’s death will very much determine its ability to continue to control the narrative and manage its swell of domestic and regional support. For these benefits to continue to manifest, it is important for Tehran to balance the mix of public sympathy and international anxiety and not overplay its hand in its quest for revenge.A reset for Iraqi politicsRenad MansourThe US strike which killed Qassem Soleimani and Abu Mehdi al-Muhandis has grave implications for Iraq. The act jeopardizes Iraq’s recently stabilized security situation, and threatens to reshape the country’s political environment, moving backwards to the days of anti-Americanism and sect-based mobilization. If Baghdad loses relations with the US and other diplomatic representations, it risks turning into a pariah state. Over the past few years, and notably since October 2019, young Iraqis have taken to the streets demanding reform and the downfall of the political establishment, and its main external backer Iran. The political establishment, including political parties and militias close to Tehran, failed to appease or suppress these protests. Now, these political elites are using the deaths of Muhandis and Soleimani to (re)gain popularity from their own population, by drawing on the old tool of anti-Americanism. Following the attacks, Shia populist cleric Muqtada al-Sadr – who until recently had called for an end to Iranian and pro-Iranian militia influence in Iraq – has called to revamp the Mehdi Army that he led until 2008 and is calling for ‘Islamic resistance’ to the US. In seeking to regain control of his former movement, he is coming closer to former Shia foes.For years, pro-Iranian groups attempted to push the US out of Iraq. Their calls often fell on deaf ears, as public opinion in Iraq did not consider the US as a threat and some even supported the US and international effort against ISIS. Following the attacks, however, anti-American voices have gained more ammunition.A complete American withdrawal would not only have direct security implications but force other countries and organizations, from European states to NATO, to reconsider their positions and role.Limited options for ‘revenge’ in the LevantLina KhatibIran’s use of Lebanon and Syria as spaces for revenge against the US is unlikely.On Sunday, Hezbollah leader Hassan Nasrallah vowed revenge for Soleimani’s death by singling out American soldiers as a target. However, Hezbollah’s options are limited. Lebanon is in the middle of wide-ranging protests against the country’s ruling political class, of which Nasrallah is a key figure.Unlike in 2006, when Hezbollah’s military actions against Israel rallied the public around it, today there is no public appetite for dragging Lebanon into a war. Were Hezbollah to instigate one, it would incur public anger, if only for the economic repercussions that would exacerbate an already severe financial crisis in Lebanon. Lebanon also does not have any US military bases that could be a target for Hezbollah.In theory, Hezbollah or other Iranian-backed groups could attack American bases in Syria. But these bases are staffed by multinational forces from the international anti-ISIS coalition. Attacking them would therefore put Iran in confrontation with other countries besides the US, which is not in Iran’s interest.Attacking US soldiers in northeast Syria would also go against Kurdish interests because it would weaken the anti-ISIS coalition front of which Kurdish forces are part. It would, furthermore, anger Arab tribes in the area, opening up possibilities for ISIS to take advantage of public dissent to stage a comeback. Iran would then find itself fighting on several fronts at once, which it does not have the capacity to handle. More likely, Iran’s allies and proxies in the Levant are going to engage in strong rhetoric without taking hasty actions. When a key Hezbollah leader, Imad Mughniyeh, was assassinated in Damascus on 2008, there were strong words and public vows to seek revenge for his killing, but ultimately there was no response. Full Article
ani COVID-19 and the Iranian Shadows of War By feedproxy.google.com Published On :: Wed, 08 Apr 2020 13:24:47 +0000 8 April 2020 Dr Sanam Vakil Deputy Director and Senior Research Fellow, Middle East and North Africa Programme @SanamVakil Coronavirus has plunged Iran into the country’s biggest crisis since its war with Iraq. More than 30 years later, the lingering effects of the war are shaping Iran’s reaction to the pandemic. 2020-04-08-Iran-COVID-Tehran Spraying disinfectant at Tajrish bazaar in Tehran, Iran, during the coronavirus pandemic in March 2020. Photo by Majid Saeedi/Getty Images. In the face of the COVID-19 pandemic, many global leaders have invoked war analogies – from the Pearl Harbor attack to the collective spirit on display during the Second World War – to highlight past lessons learned or rally their populations.For Iran’s leadership, more recent war analogies hold resonance and help explain the ideological and political conundrum limiting an effective COVID-19 response. While the Islamic Republic has weathered a multitude of challenges, COVID-19 is putting unprecedented strain on Iran’s already fragile, heavily-sanctioned economy and further exposing domestic political fissures amid ongoing international tensions.Iran has been identified as the regional epicentre of the pandemic with a steadily rising number of deaths, including several of the country’s political and military elite. Yet the Iranian government has not evoked the collective memory of the war as an opportunity for national resistance and mobilization.Sluggish and poorly managedThis is unsurprising, because thus far the Iranian government’s response to COVID-19 has been sluggish and poorly managed. After an initial slow response, Iran then attempted to downplay the impact of the virus, covering up the number of cases and deaths and blaming the United States, before implementing a poorly coordinated action plan marred by government infighting.For the Iranian leadership, the Iran-Iraq war has been the single most influential and defining period – it has impacted its political ideology, domestic and security policies and international relations. More than half a million Iranians died, and a paranoid worldview and sense of isolation was cemented among many elite leaders such as Supreme Leader Ali Khamenei.The war created a valiant culture of leadership from Qassem Soleimani to presidents Mahmoud Ahmadinejad and Hashemi Rafsanjani and, over time, has resulted in the development of Iran’s asymmetrical defense capabilities.The war enabled a dark purge of political opponents and the gradual birth of Iran’s reformist faction, all while the ethos of sacrifice and martyrdom was linked to the collective notions of resistance.These would be carried forward in other resistance campaigns both regional and economic. Most defining was Ayatollah Khomeini’s infamous 1988 decision to ‘drink the poisoned chalice’ and end the long war. Three decades later, Iran continues to contend with those outcomes.To acknowledge that the COVID-19 crisis could have equally profound consequences would add further pressure to the Islamic Republic at a time of incomparable vulnerability. Even before this crisis, the Iranian government linked sanctions to economic warfare, making future negotiations conditional on sanctions relief.Iranian hardliners used the opportunity to promote Iran’s subsistence-based resistance economy designed to insulate Iran’s economy from external shocks such as sanctions. While both groups recognize the economic urgency, their contending strategies help explain the muddled government response and the ongoing ideological competition between the political elites.Rouhani has argued that a full lockdown of the Iranian economy is impossible because it is already under significant strain from sanctions - the Iranian economy experienced a 9.5% contraction in 2019 and is expected to worsen in the coming year.That said, through Iran’s New Year holidays the government did take action to slow the spread of the virus, discouraging travel and shutting schools, pilgrimage sites and cancelling Friday prayers. Finally, on 4 April, after receiving permission from Khamenei to do so, Rouhani withdrew $1 billion from Iran’s National Development Fund and is distributing the money through loans and credits to 23 million households.Aid from a number of Iran’s parastatal agencies was also announced. Conversely, in his annual New Year’s speech the supreme leader securitized the crisis by laying blame on the United States for spreading the virus as a form of biological terrorism. Iran’s army chief of staff Major General Bagheri was tasked with building hospitals and the Islamic Revolution Guard Corps given authority to clear the streets.The recent expulsion of Médecins Sans Frontières from Iran highlights the mix of paranoia and resistance culture still on display. US sanctions on Iran have significantly weakened Iran’s economy and limited Tehran’s ability to purchase much needed medical supplies and equipment. Unable to access its foreign reserves due to sanctions, the Rouhani government has applied for a $5 billion loan from the IMF.European countries alongside a number of US members of congress have appealed to the Trump administration to ease sanctions on humanitarian grounds. While Washington continues to pursue its steadfast approach, referring to Iran’s campaign as a ‘sanctions relief scam’, Germany, France, and the UK have offered $5 million in aid and launched INSTEX – a trading mechanism designed to circumvent sanctions to allow non-sanctioned humanitarian trade.The impact of coronavirus on Iranian society remains to be seen. But the impact of sanctions has placed heavy economic and psychological burden on the people. Feeling abandoned by the Iranian state and the United States could produce a mix of contradictory nationalistic and independent impulses.The social contract – already fragile amid protests and government repression – reveals declining trust. Without national mobilization and calls for unity reminiscent of the war period, Iranians have stepped in, highlighting the continued resilience of civil society. Support for the medical establishment has been celebrated throughout the country and on social media. Charities, the private sector - through one initiative known as Campaign Nafas (Breathe) - and diaspora groups have initiated fundraising drives and assistance measures.Iran’s relations with the international community, and specifically the United States, remain an unresolved consequence of the war. The 2015 Iranian nuclear agreement was the closest Tehran and Washington came to resolving decades of tensions, containment and sanctions.COVID-19 has further heightened the trajectory of tensions between Tehran and Washington suggesting that any new deal, while necessary, is not on the cards. Tit-for-tat military exchanges have been on the rise in Iraq and Yemen while American and Iranian leaders issue threats and warnings of potential escalation.Abdullah Nasseri, an advisor to Iran’s reformists, recently stated that in order to manage the coronavirus crisis, the Iranian government needed to make a decision akin to the 1988 United Nations resolution 598 that ended war hostilities. Ayatollah Khomeini famously commented on that ceasefire, stating: ‘Happy are those who have departed through martyrdom. Unhappy am I that I still survive.… Taking this decision is more deadly than drinking from a poisoned chalice. I submitted myself to Allah's will and took this drink for His satisfaction’. While a similar compromise today might appear deadly to the political establishment, it is clear that a paradigm shift away from the shadows of Iran’s last war is urgently needed to manage the challenges stemming from COVID-19. Full Article
ani First ever global analysis of refugees’ energy use: High costs and poor supply undermine humanitarian assistance By feedproxy.google.com Published On :: Tue, 17 Nov 2015 11:50:49 +0000 11 November 2015 20151119MovingEnergyInitiative.jpg A migrant girl looks at a light illuminating a camp site of refugees and migrants on the Greek island of Lesbos, 4 October 2015. Photo: Getty Images. About 90 per cent of refugees living in camps have no access to electricity and many lack any form of lighting at night, says a Chatham House report for the Moving Energy Initiative. Energy poverty in refugee settlements is not on the radar of international initiatives and humanitarian agencies are ill-equipped to deal with the scale of need. Heat Light and Power for Refugees: Saving Lives, Reducing Costs zooms in on the energy needs of refugees and displaced people worldwide, and presents the first ever estimates of the volume and costs of what they use.'The problem goes beyond electricity. 80 per cent of those in camps rely on firewood for cooking and, as a result, we estimate that some 20,000 people die prematurely each year due to the pollution from indoor fires. Exposure to extremes of cold and heat are also killers for people living in flimsy, temporary shelter,' says Glada Lahn, senior research fellow at Chatham House. 'The current lack of provision for energy undermines the fundamental aims of humanitarian assistance,' she adds.There are nearly 60 million forcibly displaced people in the world, and they pay staggering costs for energy. The 83,277 households living in Dadaab in Kenya, the world’s largest refugee settlement, spent an estimated $6.2 million on firewood last year, which accounts for approximately 24 per cent of their overall household income. (The average UK household spent 4 per cent of its income on energy in 2011.) In Uganda, almost half of refugee households surveyed by the UNHCR skip meals because they do not have enough fuel to cook with.'The imperative is to find humane, creative and cost-effective ways to respond to the needs of so many individuals, most of whom are women and children. Improving access to clean, safe and sustainable energy offers a promising way forward,' says Kofi Annan in the report’s foreword.The report calls for an overhaul in the way that heat, light and power are delivered in humanitarian crises. It makes the case for new partnerships between humanitarian agencies and private providers to increase clean energy access in refugee settlements. Investment in energy infrastructure will also benefit host communities in some of the world’s poorest countries.'As refugee households spend approximately $2.1 billion on energy each year, developing local markets for energy services could be part of a mix of solutions,' adds Lahn. 'Using green, culturally appropriate technologies could save lives, reduce CO2 emissions by 11 million tonnes per year and radically improve living standards. Introducing even the most basic solutions, such as improved cookstoves and basic solar lanterns, could save $323 million a year in fuel costs.' Other findings include:Rape and violence against women is common in many unlit camps. Only 4 per cent of women and girls in households in the Goudoubo camp in Burkina Faso would go out after dark due to the lack of streetlights.Wood equalling around 49,000 football pitches worth of forest (64,700 acres) is burned by displaced families living in camps each year, mainly in countries suffering severe deforestation, because they have no alternative sources of energy.Firewood consumption emits nearly twice as much CO2 as liquid petroleum gas and produces little energy in comparison to its carbon intensity.International Development Minister Grant Shapps said:‘Across sub-Saharan Africa, hundreds of millions of people still do not have access to electricity. Women and girls are at risk of violence after dark, families are forced to inhale toxic kerosene fumes, and energy remains unaffordable for many.‘With the technology in place and investors coming on board, the time to act is now. The UK's Energy Africa campaign is already kick-starting a solar revolution across the continent.‘Supporting the Moving Energy Initiative is another way Britain can help boost access to clean, reliable and affordable energy. This will transform people’s lives and help achieve the UN’s goal of universal energy access by 2030.’ Editor's notes Read Heat Light and Power for Refugees: Saving Lives, Reducing Costs by Glada Lahn and Owen Grafham.To link back to the report in an article, please use this landing page for the final report.The Moving Energy Initiative (MEI) is a collaboration between GVEP International, Chatham House, Practical Action Consulting, the Norwegian Refugee Council (NRC) and the United Nations High Commissioner for Refugees (UNHCR). The report is supported by the UK Department for International Development through the Humanitarian Innovation and Evidence Programme.The number of refugee households in Dadaab, Kenya is as of May 2015.Chatham House will host a press briefing with MEI programme board member Michael Keating and authors Glada Lahn and Owen Grafham on Thursday 12 November at 10:30-11:30 GMT. To register, or for interview requests, please contact the press office.All figures are original and based on estimations and calculations prepared for the Moving Energy Initiative. Chatham House designed a model offering the first estimates of the scale and cost of energy use and CO2 emissions among forcibly displaced households worldwide, not including people affected by natural disasters. For more details on the populations considered in the report and used in the model, contact the authors.The authors are available to answer questions from the media. Please contact the press office. 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ani New Coronavirus Outbreak: Concern Is Warranted, Panic Is Not By feedproxy.google.com Published On :: Thu, 23 Jan 2020 12:03:21 +0000 23 January 2020 Professor David Heymann CBE Distinguished Fellow, Global Health Programme Lara Hollmann Research Assistant, Global Health Programme @lara_hollmann LinkedIn Whenever there is a new infection in humans, such as the novel coronavirus, it is appropriate to be concerned because we do not know enough about its potential. Explainer: Coronavirus - What You Need to Know World-renowned global health expert Professor David Heymann CBE explains the key facts and work being done on the Coronavirus outbreak. When it comes to emerging infectious diseases – those newly recognized in humans or in new locations – it is not only what we know that matters but also what we do not know.An outbreak of a new coronavirus first reported in Wuhan, China, which has so far led to more than 500 confirmed cases and multiple deaths across five countries (and two continents) has prompted the question from several corners of the world: Should we be worried?Although expert teams coordinated by the World Health Organization (WHO) are working on key questions to get answers as soon as possible, the level of uncertainty is still high.We do not yet know exactly how deadly the disease is, how best to treat those who get sick, precisely how it is spreading, nor how stable the virus is. It is thought that the virus spread from an animal source, but the exact source is yet to be confirmed and the disease is now in human populations and appears to be spreading from human to human.It is such uncertainty, inherent in emerging infectious disease outbreaks, that warrants concern. Until they are resolved, it is appropriate for the world to be concerned. It is useful to remember that most established scourges of humanity such as HIV, influenza and tuberculosis likely started as emerging infectious diseases that jumped the species barrier from animals to humans.Shortly after the Chinese authorities reported the first cases of ‘mystery pneumonia’ in Wuhan, China, to WHO, the virus causing the disease was isolated and identified as being part of the coronavirus family. It belongs to the same virus family as SARS, a highly contagious and life-threatening coronavirus that caused a nine-month epidemic in 2003 that affected 26 countries and resulted in more than 8,000 infections and nearly 800 deaths.A second novel coronavirus that emerged in 2012 and persists today – MERS, or Middle East Respiratory Syndrome – is less contagious (spread by close contact rather than coughing and sneezing).The differences between the SARS coronavirus and the MERS coronavirus highlight that, despite belonging to the same virus family, pathogens do not necessarily behave in the same way. It is as yet unknown whether the new virus is, or will turn out to be, more like SARS or MERS, or neither. Chinese authorities have confirmed that there is human-to-human transmission. However, it is not yet established whether it is sustained, which would make the outbreak more difficult to control. As of 23 January, the number of cases range from 500 confirmed cases up to an estimated 1,700 cases, according to a disease outbreak model by Imperial College London.Likewise, we do not know to what extent the virus is able to mutate and if so, how rapidly. Generally, coronaviruses are known to be able to mutate, with the risk that a less contagious form of the virus becomes highly contagious. This could have an impact not only on the transmission pattern and rate but also the death rate. The virus could change in either direction, to become either more or less of a threat.It is important to take a precautionary approach while uncertainty persists. It is also important not to overreact and for measures to be scientifically sound. Concern over this outbreak is due, but panic is not.Three virtual networks of experts supporting the response – one of virologists, one of epidemiologists and one of clinicians – are working on the key pieces of the jigsaw puzzle: watching the virus, watching the transmission patterns, and watching the people who have been infected. It is crucial to maintain the ongoing investigation of the disease, stay focused on the science and to keep sharing the necessary information. Full Article
ani Strongly anisotropic type II blow up at an isolated point By www.ams.org Published On :: Tue, 10 Mar 2020 10:59 EDT Charles Collot, Frank Merle and Pierre Raphaël J. Amer. Math. Soc. 33 (2020), 527-607. Abstract, references and article information Full Article
ani Highly Selective Enrichment of Phosphorylated Peptides from Peptide Mixtures Using Titanium Dioxide Microcolumns By feedproxy.google.com Published On :: 2005-07-01 Martin R. LarsenJul 1, 2005; 4:873-886Technology Full Article
ani ABC transporters control ATP release through cholesterol-dependent volume-regulated anion channel activity [Signal Transduction] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 Purinergic signaling by extracellular ATP regulates a variety of cellular events and is implicated in both normal physiology and pathophysiology. Several molecules have been associated with the release of ATP and other small molecules, but their precise contributions have been difficult to assess because of their complexity and heterogeneity. Here, we report on the results of a gain-of-function screen for modulators of hypotonicity-induced ATP release using HEK-293 cells and murine cerebellar granule neurons, along with bioluminescence, calcium FLIPR, and short hairpin RNA–based gene-silencing assays. This screen utilized the most extensive genome-wide ORF collection to date, covering 90% of human, nonredundant, protein-encoding genes. We identified two ABCG1 (ABC subfamily G member 1) variants, which regulate cellular cholesterol, as modulators of hypotonicity-induced ATP release. We found that cholesterol levels control volume-regulated anion channel–dependent ATP release. These findings reveal novel mechanisms for the regulation of ATP release and volume-regulated anion channel activity and provide critical links among cellular status, cholesterol, and purinergic signaling. Full Article
ani Mechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2 [Signal Transduction] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 The protein-tyrosine phosphatase SHP2 is an allosteric enzyme critical for cellular events downstream of growth factor receptors. Mutations in the SHP2 gene have been linked to many different types of human diseases, including developmental disorders, leukemia, and solid tumors. Unlike most SHP2-activating mutations, the T507K substitution in SHP2 is unique in that it exhibits oncogenic Ras-like transforming activity. However, the biochemical basis of how the SHP2/T507K variant elicits transformation remains unclear. By combining kinetic and biophysical methods, X-ray crystallography, and molecular modeling, as well as using cell biology approaches, here we uncovered that the T507K substitution alters both SHP2 substrate specificity and its allosteric regulatory mechanism. We found that although SHP2/T507K exists in the closed, autoinhibited conformation similar to the WT enzyme, the interactions between its N-SH2 and protein-tyrosine phosphatase domains are weakened such that SHP2/T507K possesses a higher affinity for the scaffolding protein Grb2-associated binding protein 1 (Gab1). We also discovered that the T507K substitution alters the structure of the SHP2 active site, resulting in a change in SHP2 substrate preference for Sprouty1, a known negative regulator of Ras signaling and a potential tumor suppressor. Our results suggest that SHP2/T507K's shift in substrate specificity coupled with its preferential association of SHP2/T507K with Gab1 enable the mutant SHP2 to more efficiently dephosphorylate Sprouty1 at pTyr-53. This dephosphorylation hyperactivates Ras signaling, which is likely responsible for SHP2/T507K's Ras-like transforming activity. Full Article
ani Roles of active-site residues in catalysis, substrate binding, cooperativity, and the reaction mechanism of the quinoprotein glycine oxidase [Enzymology] By feedproxy.google.com Published On :: 2020-05-08T03:41:14-07:00 The quinoprotein glycine oxidase from the marine bacterium Pseudoalteromonas luteoviolacea (PlGoxA) uses a protein-derived cysteine tryptophylquinone (CTQ) cofactor to catalyze conversion of glycine to glyoxylate and ammonia. This homotetrameric enzyme exhibits strong cooperativity toward glycine binding. It is a good model for studying enzyme kinetics and cooperativity, specifically for being able to separate those aspects of protein function through directed mutagenesis. Variant proteins were generated with mutations in four active-site residues, Phe-316, His-583, Tyr-766, and His-767. Structures for glycine-soaked crystals were obtained for each. Different mutations had differential effects on kcat and K0.5 for catalysis, K0.5 for substrate binding, and the Hill coefficients describing the steady-state kinetics or substrate binding. Phe-316 and Tyr-766 variants retained catalytic activity, albeit with altered kinetics and cooperativity. Substitutions of His-583 revealed that it is essential for glycine binding, and the structure of H583C PlGoxA had no active-site glycine present in glycine-soaked crystals. The structure of H767A PlGoxA revealed a previously undetected reaction intermediate, a carbinolamine product-reduced CTQ adduct, and exhibited only negligible activity. The results of these experiments, as well as those with the native enzyme and previous variants, enabled construction of a detailed mechanism for the reductive half-reaction of glycine oxidation. This proposed mechanism includes three discrete reaction intermediates that are covalently bound to CTQ during the reaction, two of which have now been structurally characterized by X-ray crystallography. Full Article
ani Webinar: International Humanitarian Law Amid Coronavirus By feedproxy.google.com Published On :: Thu, 07 May 2020 09:20:01 +0000 Members Event Webinar 15 May 2020 - 1:00pm to 2:00pmAdd to CalendariCalendar Outlook Google Yahoo Emanuela-Chiara Gillard, Associate Fellow, International Law Programme, Chatham HouseChair: Chanu Peiris, Programme Manager, International Law Programme, Chatham HouseFurther speakers to be announced. In April 2020, UN Secretary General Antonio Guterres called for a global ceasefire in order for communities and states to focus efforts on responding to the coronavirus outbreak. The consequences of armed conflict – including displacement, detention, lack of access to health services and disrupted social infrastructures – mean that those in conflict-ridden areas are amongst the most vulnerable to the virus. Observing international humanitarian law (IHL) could be one way of safeguarding against, at least, the provision of vital medical supplies and personnel for vulnerable groups. Against the backdrop of a growing health and economic emergency that is otherwise dominating government agendas, how do we emphasise the importance of humanitarian action and guarantee - or improve - compliance?The panellists will discuss the remit and limitations of international humanitarian law and how the pandemic might complicate compliance. What is the framework for humanitarian action under international humanitarian law? What are the challenges to delivering relief? And how has COVID-19 impacted humanitarian action in conflict-ridden areas?This event is for Chatham House members only. Not a member? Find out more. Full Article
ani Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth By feedproxy.google.com Published On :: 1980-07-01 MS BrownJul 1, 1980; 21:505-517Reviews Full Article