On today's social media platforms, people speak in code to elude algorithmic censors, an example of how improvisation reshapes language.

Dinner on Mars? Two food security experts imagine what it would take to feed a human colony on Mars in the year 2080 if we colonized the red planet. Their research offers lessons on how to improve our battered food systems here on Earth.

The dominant story in archaeology has long been that humans came to North America around 12,000 years ago. But Indigenous archaeologist Paulette Steeves points to mounting evidence suggesting human migration may have occurred closer to 130,000 ago.

Poised to open in just six years, featuring spas, concert venues and even a Ferris wheel design, this out-of-this-world hotel will be a veritable playground for the ultra rich.

Boulder County health officials said people can catch tularemia through bites from infected insects, most commonly ticks and deer flies.

Watch Dwyane Wade, Don Cheadle and more accept the honor.

Vice Chancellor Nefertiti Walker says she's investigating.

The ‘Human Library’ event will be held on Thursday, September 28th at the Bermuda National Library. A spokesperson said, “Do you want a chance to unjudge someone by having a conversation that can break down prejudices, biases and assumptions? Welcome to the Human Library, where Readers are invited to have open conversations with Books for 30 […]

The ICS Tires Cobra Puma Junior Championships are set to be played October 21st and 22nd at the Ocean View Golf Course. The age groups for this year’s tournament are girls open, boy’s 11-13, boy’s 14-16, and boy’s 17-18. The format for the tournament is individual stroke play. Related Stories Augustus Concludes Mastercard Championships Augustus […]

The ICS Tires Cobra Puma Junior Championships are being held at Ocean View Golf Course, where Bermuda’s future golf stars battled it out on the first day of the competition. The boys 14-16 age group division saw Arman Newton leading the pack with an impressive first round 3-over par 73. Hot on his heels, Sa-Qui […]

The Ocean View Golf Course was the scene for day two of the ICS Tires Cobra Puma junior championships, where 23 of Bermuda’s future golf stars returned to battle it out. The boys 14-16 age group division saw Arman Newton crowned the champion following an impressive second round 4-over par 74, to finish at 7-over […]

The dream of traversing the depths of space and planting the seed of human civilization on another planet has existed for generations. For long as we’ve known that most stars in the Universe are likely to have their own system of planets, there have been those who advocated that we explore them (and even settle …

Continue reading "Project Hyperion is Seeking Ideas for Building Humanity’s First Generation Ship"

The post Project Hyperion is Seeking Ideas for Building Humanity’s First Generation Ship appeared first on Universe Today.

Date: October 25, 2024

Location: India, United Kingdom

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Unbabel on Wednesday announced an artificial intelligence-powered translation service, adding another rival to a highly competitive space.

Philippe Reines.

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This article explores the impact of abandonment abuse and neglect, not only on children but, centrally, on the foster carers, adopters and kinship carers who parent children where it has been deemed that a return home to birth parents is not in their interests. (For purposes of simplicity we will refer to these carers as ‘parenting figures’.) In doing this we aim to provide parenting figures with support and understanding as well as reducing the feelings of isolation that is often integral to parenting ‘looked after’ children.

Hardcover – Large Print, June 8, 2023

Following Joel Schumacher’s death earlier this week, there was the inevitable return of one of nerddom’s longest-living arguments, namely the quality of the two Batman films he directed. Granted, the man directed all sorts of other movies, including at least two undeniably great ones (The Lost Boys and Tigerland), and one fascinating and questionable one […]

The clonal quaking aspen known as Pando is between 16,000 and 80,000 years old.

The Princeton professor's research follows elephants, wolves and urban lizards. He hosts the new PBS series, "Human Footprint."

Professor Wendy Laura Belcher and a primarily Ethiopian team of researchers and translators have brought new insight and access to Marian miracle stories — all now available on a website.

Modern humans and Neanderthals interacted over a 200,000-year period, says geneticist Joshua Akey.

An international team of researchers and gamers, led by Princeton’s Mala Murthy and Sebastian Seung, mapped every neuron and every synaptic connection in an adult fruit fly's brain, building a comprehensive “connectome” that represents a massive step toward understanding the human brain.

Physical chemist Giacinto Scoles, Princeton’s Donner Professor of Science, Emeritus, died in Sassenheim, the Netherlands, on Sept. 25 with his wife of nearly 60 years at his side. He was 89.

The Tanner Lectures on Human Values are presented annually at a select list of universities around the world. The University Center serves as host to these lectures at Princeton, in which an eminent scholar from philosophy, religion, the humanities, sciences, creative arts or learned professions, or a person eminent in political or social life, is invited to present a series of lectures reflecting upon scholarly and scientific learning relating to “the entire range of values pertinent to the human condition." Tanner Lectures on Human Values: Randall L. Kennedy (Harvard Law School): "In Praise of Racial Liberalism: Lecture II-How Can We Achieve It?" Randall Kennedy's lectures will posit the ends and means suitable currently for advancing the cause of racial justice in America. Lecture one will focus on aims: what should racial "justice" mean today? Lecture two will focus on strategy: what are optimal ways of proceeding in a polarized polity in which racial prejudices and resentments constitute significant impediments to needed reforms. Lecture II: How Can We Achieve It? About the speaker Randall L. Kennedy is Michael R. Klein Professor of Law, Harvard Law School. He attended Princeton University, '77, and Yale Law School. He clerked for Judge J. Skelly Wright and for Justice Thurgood Marshall. A member of the bars of the District of Columbia and the United States Supreme Court, he is also a member of the American Academy of Arts and Sciences and the American Philosophical Society. He is the author of several books, the most recent of which is "Say it Loud! On Race, Law, Culture and History." Commentators: Olúfẹ́mi O. Táíwò, Associate Professor of Philosophy, Georgetown University

The Tanner Lectures on Human Values are presented annually at a select list of universities around the world. The University Center serves as host to these lectures at Princeton, in which an eminent scholar from philosophy, religion, the humanities, sciences, creative arts or learned professions, or a person eminent in political or social life, is invited to present a series of lectures reflecting upon scholarly and scientific learning relating to “the entire range of values pertinent to the human condition." Tanner Lectures on Human Values: Randall L. Kennedy (Harvard Law School): "In Praise of Racial Liberalism: Lecture I: What Does Racial Justice Mean Today?" Randall Kennedy's lectures will posit the ends and means suitable currently for advancing the cause of racial justice in America. Lecture one will focus on aims: what should racial "justice" mean today? Lecture two will focus on strategy: what are optimal ways of proceeding in a polarized polity in which racial prejudices and resentments constitute significant impediments to needed reforms. Lecture I: What Does Racial Justice Mean Today? About the speaker Randall L. Kennedy is Michael R. Klein Professor of Law, Harvard Law School. He attended Princeton University, '77, and Yale Law School. He clerked for Judge J. Skelly Wright and for Justice Thurgood Marshall. A member of the bars of the District of Columbia and the United States Supreme Court, he is also a member of the American Academy of Arts and Sciences and the American Philosophical Society. He is the author of several books, the most recent of which is "Say it Loud! On Race, Law, Culture and History." Commentators: Elizabeth Anderson, John Dewey Distinguished Professor of Philosophy, University of Michigan Elizabeth Hinton, Professor of History, African American Studies & Law, Yale University

Footprints in New Mexico’s White Sands National Park challenge scientists’ timeline of when humans first came to North America.

Earth’s natural satellite could be a jumping-off point for future space exploration.

A new study shows just what dolphins get out of cooperating with fishers in Brazil (besides lunch).

Stories of brilliant innovations and inventions by the world’s greatest minds.

A pimenta, a cúrcuma e outras especiarias são frequentemente citadas como tendo benefícios para a nossa saúde ou até mesmo a capacidade de 'estimular nosso sistema imunológico'. Mas será que elas realmente oferecem algum benefício à nossa saúde ou nos ajudam a prevenir doenças?

DR Congo-born Dikembe Mutombo has been hailed for his humanitarian work across Africa following his death aged 58 from brain cancer.

United Nations Secretary-General Antonio Guterres told world leaders at the COP29 summit on Tuesday to "pay up" to prevent climate-led humanitarian disasters, and said time was running out to limit a destructive rise in global tempera

Botswana's new president Duma Boko used his inauguration on Friday to tell the world that he and his government were ushering in a "new political dawn".

I’m still digging through some of the pieces I posted at the now defunct NewCo Shift, and found this piece, adapted from a talk I gave at the Thrival Humans X Tech conference in Pittsburgh back in September of 2018. I was alarmed by trends that I saw intensifying – a push by the tech … Continue reading "Technology, Humanity, and the Existential Test"

Michal Bassani-Sternberg
Mar 1, 2015; 14:658-673
Research

Ivan Matic
Jan 1, 2008; 7:132-144
Research

Lawrence E. Ostrowski
Jun 1, 2002; 1:451-465
Research

William M. Old
Oct 1, 2005; 4:1487-1502
Research

Mathias Uhlén
Dec 1, 2005; 4:1920-1932
Research

N. Leigh Anderson
Nov 1, 2002; 1:845-867
Reviews/Perspectives

Linn Fagerberg
Feb 1, 2014; 13:397-406
Research

Despite its major importance in human health, the metabolic potential of the human gut microbiota is still poorly understood. We have recently shown that biosynthesis of Ruminococcin C (RumC), a novel ribosomally synthesized and posttranslationally modified peptide (RiPP) produced by the commensal bacterium Ruminococcus gnavus, requires two radical SAM enzymes (RumMC1 and RumMC2) catalyzing the formation of four Cα-thioether bridges. These bridges, which are essential for RumC's antibiotic properties against human pathogens such as Clostridium perfringens, define two hairpin domains giving this sactipeptide (sulfur-to-α-carbon thioether–containing peptide) an unusual architecture among natural products. We report here the biochemical and spectroscopic characterizations of RumMC2. EPR spectroscopy and mutagenesis data support that RumMC2 is a member of the large family of SPASM domain radical SAM enzymes characterized by the presence of three [4Fe-4S] clusters. We also demonstrate that this enzyme initiates its reaction by Cα H-atom abstraction and is able to catalyze the formation of nonnatural thioether bonds in engineered peptide substrates. Unexpectedly, our data support the formation of a ketoimine rather than an α,β-dehydro-amino acid intermediate during Cα-thioether bridge LC–MS/MS fragmentation. Finally, we explored the roles of the leader peptide and of the RiPP precursor peptide recognition element, present in myriad RiPP-modifying enzymes. Collectively, our data support a more complex role for the peptide recognition element and the core peptide for the installation of posttranslational modifications in RiPPs than previously anticipated and suggest a possible reaction intermediate for thioether bond formation.

Independent Thinking: Humanitarian disaster in Syria and Turkey Audio NCapeling 16 February 2023

Episode 15 of our weekly podcast examines the far-reaching consequences of the earthquakes which struck Turkey and Syria on the region’s fragile geopolitics.

With thousands killed and international aid flooding in, what hope is there for the many thousands of people in Syria and Turkey caught between the groups and governments involved in conflict for more than a decade.

The panel aslo discusses the political impact within Turkey, as fears grow that President Recep Tyap Erdogan may postpone the upcoming election amid outcries over corruption and the devastating loss of life.

Joining Bronwen this week is Lina Sinjab, Syrian filmmaker and BBC journalist covering the Middle East, Charles Lister, senior fellow and director of the Syria programme at the Middle East Institute, and Ziya Meral, senior associate fellow on Turkey at the Royal United Services Institute (RUSI).

About Independent Thinking

A weekly podcast hosted by Chatham House director Bronwen Maddox, in conversation with leading policymakers, journalists, and Chatham House experts providing insight on the latest international issues.

Synapse loss is associated with motor and cognitive decline in multiple neurodegenerative disorders, and the cellular redistribution of tau is related to synaptic impairment in tauopathies, such as Alzheimer's disease and frontotemporal dementia. Here, we examined the cellular distribution of tau protein species in human tau overexpressing line 66 mice, a transgenic mouse model akin to genetic variants of frontotemporal dementia. Line 66 mice express intracellular tau aggregates in multiple brain regions and exhibit sensorimotor and motor learning deficiencies. Using a series of anti-tau antibodies, we observed, histologically, that nonphosphorylated transgenic human tau is enriched in synapses, whereas phosphorylated tau accumulates predominantly in cell bodies and axons. Subcellular fractionation confirmed that human tau is highly enriched in insoluble cytosolic and synaptosomal fractions, whereas endogenous mouse tau is virtually absent from synapses. Cytosolic tau was resistant to solubilization with urea and Triton X-100, indicating the formation of larger tau aggregates. By contrast, synaptic tau was partially soluble after Triton X-100 treatment and most likely represents aggregates of smaller size. MS corroborated that synaptosomal tau is nonphosphorylated. Tau enriched in the synapse of line 66 mice, therefore, appears to be in an oligomeric and nonphosphorylated state, and one that could have a direct impact on cognitive function.