DSSP stands as a foundational tool in the domain of protein secondary structure prediction, yet it encounters notable challenges in accurately annotating irregular structures, such as β-turns and γ-turns, which constitute approximately 25%-30% and 10%-15% of protein turns, respectively. This limitation arises from DSSP's reliance on hydrogen-bond analysis, resulting in annotation gaps and reduced consensus on irregular structures. Alternatively, PROMOTIF excels at identifying these irregular structure annotations using phi-psi information. Despite their complementary strengths, previous methodologies utilised DSSP and PROMOTIF separately, leading to disparate prediction methods for protein secondary structures, hampering comprehensive structure analysis crucial for drug development. In this work, we bridge this gap using an annotation fusion approach, combining DSSP structures with beta, and gamma turns. We introduce IRNN-SS, a model employing deep inception and bidirectional gated recurrent neural networks, achieving 77.4% prediction accuracy on benchmark datasets, outpacing current models.

This paper aims to share the author's vision on possible research directions for big knowledge-based AI. A renewed definition of big knowledge (BK) and big knowledge systems (BKS) is first introduced. Then the first BKS model, called cloud knowledge social intelligence (CKEI) is provided with a hierarchy of knowledge as a service (KAAS). At last, a new semantics, the big-and-broad step axiomatic structural operational semantics (BBASOS) for applications on BKS is introduced and discussed with a practical distributed BKS model knowledge graph network KGN and a mini example.

Understanding of social network structure and user behavior has important implications for site design, applications (e.g., ad placement policies), accurate modeling for social studies, and design of next-generation infrastructure and content distribution systems. Currently, characterizations of social networks have been dominated by topological studies in which graph representations are analyzed in terms of connectivity using techniques such as degree distribution, diameter, average degree, clustering coefficient, average path length, and cycles. The problem is that these parameters are not completely satisfactory in the sense that they cannot account for individual events and have only limited use, since one can produce a set of synthetic graphs that have the exact same metrics or statistics but exhibit fundamentally different connectivity structures. In such an approach, a node drawn as a small circle represents an individual. A small circle reflects a black box model in which the interior of the node is blocked from view. This paper focuses on the node level by considering the structural interiority of a node to provide a more fine-grained understanding of social networks. Node interiors are modeled by use of six generic stages: creation, release, transfer, arrival, acceptance, and processing of the artifacts that flow among and within nodes. The resulting description portrays nodes as comprising mostly creators (e.g., of data), receivers/senders (e.g., bus boys), and processors (re-formatters). Two sample online social networks are analyzed according to these features of nodes. This examination points to the viability of the representational method for characterization of social networks.

KUALA TERENGGANU: A crane driver and two tow truck operators pleaded not guilty in the Magistrate’s Court here today to charges of abducting a man last week.

The accused, Mohd Sabri Zakarya, 42, Muhamad Hafiz Hasbullah, 35, and Hairudin Sabri Abas, 40, claimed trial after the charges were read before Magistrate Noor Mazrinie Mahmood.

According to the charge, the three men were accused of forcibly abducting a 53-year-old man with the intent to confine him secretly and unlawfully in the motorcycle parking area in front of Bank Islam at a hypermarker here at around 2 pm on Nov 7.

They were charged under Section 365 of the Penal Code read together with Section 34 of the same code, which carries a prison sentence of up to seven years and a fine upon conviction.

Prosecuting officer Insp Ahmad Fitri Mohamed Kamal offered bail at RM10,000 for each accused, while lawyer Ghazali Ismail requested a lower bail amount, citing the financial circumstances of his three clients.

Ghazali noted that Mohd Sabri, who works as a crane driver, and Muhamad Hafiz and Hairudin Sabri, both tow truck operators, earn between RM2,000 to RM2,500 per month and support their respective families.

Magistrate Noor Mazrinie subsequently granted bail at RM6,000 for each accused and ordered them not to disturb or contact the victim until the case is resolved. The case was set for mention on Dec 12 for document submission.

[…] occurred to me – but Karen Blakeman has posted this advice – SEASONAL OPENING TIMES – NEVER TRUST GOOGLE’S ANSWERS (OR BING’S) (Dec 29) – information about open and closed times of shops might not be right – always […]

Voting in the UK election has finished and the results are in, but the dust has most definitely not settled. It looks as we in the UK are in for interesting times ahead. It would help those of us researching the various political parties and policies if Google could at least get the basics right, … Continue reading Another example of Google’s Knowledge Graph getting it wrong →

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Hackers target Bengal cat enthusiasts in Australia, who were targeted by cybercriminals using SEO poisoning and Gootloder. This threat is significant enough that Sophos issued an https://news.sophos.com/en-us/2024/11/06/bengal-cat-lovers-in-australia-get-psspsspssd-in-google-driven-gootloader-campaign/official warning advising people to avoid searching for Bengal cat information altogether, highlighting the scale of the issue. ''GootLoader campaigns are increasingly targeting niche interests to stay under the radar. These campaigns illus...

When should you give your Social Security number and when should you not? Giving out your Social Security number is something you shouldn’t do unless you know it’s absolutely, positively required for what you’re doing. Companies and institutions ask for our Social Security numbers all the time. Unfortunately, they do a mediocre-to-terrible job of securing […]

The post Do Not Give Your Social Security Number at These Places appeared first on Clark Howard.

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Actor maintains filmmaker is close to his heart

Actor was previously married to former model Aliza Sultan until 2022

Pakistan is the only country in the world where 90% of them are deprived of old-age benefits

An undated image shows students playing at the Darlington Public School in Chippendale, Sydney, Australia. — Instagram/@fjcstudio

A small suburban school in Chippendale, Sydney in Australia beat iconic skyscrapers, museums and airport terminals to be crowned...

A girl receives polio vaccine drops, during an anti-polio campaign, in a low-income neighborhood in Karachi on July 20, 2020. — Reuters First case in Chagai district confirmed. Lab detects Poliovirus Type-1 .Genetic sequencing of samples underway.

Pakistan...

A female polio health worker administers polio drops to a child during the anti-polio vaccination campaign aimed at eradicating polio in the provincial capital. — AFPThis is second polio case reported from Qila Saifullah in 2024.Pakistan one of only two polio endemic countries in...

A girl receives polio vaccine drops, during an anti-polio campaign, in a low-income neighborhood in Karachi, July 20, 2020. — Reuters

The trailer has left people feeling confused, somewhat surprised and also overjoyed. For me, it's disappointment.

Disney seems increasingly uninspired and creatively vacant, relying on the powers of nostalgia to draw in an audience.

Posts circulating on social media claim that politician and lawyer Aitzaz Ahsan has accused two senior Supreme Court judges, Justice Mansoor Ali Shah and Justice Munib Akhtar, of facilitating a political party.

The claim is false.

On October 23, a user on X posted a...

A representational image shows an illustration of the WhatsApp logo. — Unsplash

WhatsApp is set to revamp its feature for muting notifications from group chats in an upcoming update, making it simpler for users to better understand how this feature works.

Coldplay updates music lovers with another exciting announcement

Coldplay recently announced an exciting show in Ahmedabad, India.

The boy-band, who is set to in the Indian cities next year in January, declared that the show will take place at the Narendra Modi Stadium in Ahmedabad...

I was convinced that if my time is not up, this virus can never kill me

The report further showed that the additional SHO had been previously found guilty of framing a man in a fake case

Privacy: Ross Ulbricht handed in his appeal to the U.S. Supreme Court last week, highlighting an important Analog Equivalent Privacy Right in the process: Just because you’re using equipment that makes a third party aware of your circumstances, does that really nullify any expectation of privacy?

In most constitutions, there’s a protection of privacy of some kind. In the European Charter of Human Rights, this is specified as having the right to private and family life, home, and correspondence. In the U.S. Constitution, it’s framed slightly differently, but with the same outcome: it’s a ban for the government to invade privacy without good cause (“unreasonable search and seizure”).

U.S. Courts have long held, that if you have voluntarily given up some part of your digitally-stored privacy to a third party, then you can no longer expect to have privacy in that area. When looking at analog equivalence for privacy rights, this doctrine is atrocious, and in order to understand just how atrocious, we need to go back to the dawn of the manual telephone switchboards.

At the beginning of the telephone age, switchboards were fully manual. When you requested a telephone call, a manual switchboard operator would manually connect the wire from your telephone to the wire of the receiver’s telephone, and crank a mechanism that would make that telephone ring. The operators could hear every call if they wanted and knew who had been talking to whom and when.

Did you give up your privacy to a third party when using this manual telephone service? Yes, arguably, you did. Under the digital doctrine applied now, phonecalls would have no privacy at all, under any circumstance. But as we know, phonecalls are private. In fact, the phonecall operators were oathsworn to never utter the smallest part of what they learned on the job about people’s private dealings — so seriously was privacy considered, even by the companies running the switchboards.

Interestingly enough, this “third-party surrender of privacy” doctrine seems to have appeared the moment the last switchboard operator left their job for today’s automated phone-circuit switches. This was as late as 1983, just at the dawn of digital consumer-level technology such as the Commodore 64.

This false equivalence alone should be sufficient to scuttle the doctrine of “voluntarily” surrendering privacy to a third party in the digital world, and therefore giving up expectation of privacy: the equivalence in the analog world was the direct opposite.

But there’s more to the analog equivalent of third-party-service privacy. Somewhere in this concept is the notion that you’re voluntarily choosing to give up your privacy, as an active informed act — in particular, an act that stands out of the ordinary, since the Constitutions of the world are very clear that the ordinary default case is that you have an expectation of privacy.

In other words, since people’s everyday lives are covered by expectations of privacy, there must be something outside of the ordinary that a government can claim gives it the right to take away somebody’s privacy. And this “outside the ordinary” has been that the people in question were carrying a cellphone, and so “voluntarily” gave up their right to privacy, as the cellphone gives away their location to the network operator by contacting cellphone towers.

But carrying a cellphone is expected behavior today. It is completely within the boundaries of “ordinary”. In terms of expectations, this doesn’t differ much from wearing jeans or a jacket. This leads us to the question; in the thought experiment that yesterday’s jeans manufacturers had been able to pinpoint your location, had it been reasonable for the government to argue that you give up any expectation of privacy when you’re wearing jeans?

No. No, of course it hadn’t.

It’s not like you’re carrying a wilderness tracking device for the express purpose of rescue services to find you during a dangerous hike. In such a circumstance, it could be argued that you’re voluntarily carrying a locator device. But not when carrying something that everybody is expected to carry — indeed, something that everybody must carry in order to even function in today’s society.

When the only alternative to having your Constitutionally-guaranteed privacy is exile from modern society, a government should have a really thin case. Especially when the analog equivalent — analog phone switchboards — was never fair game in any case.

People deserve Analog Equivalent Privacy Rights.

Until a government recognizes this and voluntarily surrenders a power it has taken itself, which isn’t something people should hold their breath over, privacy remains your own responsibility.

Privacy: We’ve seen how our digital children’s privacy is violated in everything they buy with cash or credit, in a way our analog parents would have balked at. But even worse: our digital children’s privacy is also violated by tracking what they don’t buy — either actively decline or just plain walk away from.

Amazon just opened its first “Amazon Go” store, where you just pick things into a bag and leave, without ever going through a checkout process. As part of the introduction of this concept, Amazon points out that you can pick something off the shelves, at which point it’ll register in your purchase — and change your mind and put it back, at which point you’ll be registered and logged as having not purchased the item.

Sure, you’re not paying for something you changed your mind about, which is the point of the video presentation. But it’s not just about the deduction from your total amount to pay: Amazon also knows you considered buying it and eventually didn’t, and will be using that data.

Our digital children are tracked this way on a daily basis, if not an hourly basis. Our analog parents never were.

When we’re shopping for anything online, there are even simple plugins for the most common merchant solutions with the business terms “funnel analysis” — where in the so-called “purchase funnel” our digital children choose to leave the process of purchasing something — or “cart abandonment analysis”.

We can’t even simply walk away from something anymore without it being recorded, logged, and cataloged for later use against us.

But so-called “cart abandonment” is only one part of the bigger issue of tracking what we’re interested in in the age of our digital children, but didn’t buy. There is no shortage of people today who would swear they were just discussing a very specific type of product with their phone present (say, “black leather skirts”) and all of a sudden, advertising for that very specific type of product would pop up all over Facebook and/or Amazon ads. Is this really due to some company listening for keywords through the phone? Maybe, maybe not. All we know since Snowden is that if it’s technically possible to invade privacy, it is already happening.

(We have to assume here these people still need to learn how to install a simple adblocker. But still.)

At the worst ad-dense places, like (but not limited to) airports, there are eyeball trackers to find out which ads you look at. They don’t yet change to match your interests, as per Minority Report, but that’s already present on your phone and on your desktop, and so wouldn’t be foreign to see in public soon, either.

In the world of our analog parents, we weren’t registered and tracked when we bought something.

In the world of our digital children, we’re registered and tracked even when we don’t buy something.

Pakistan Cricket Board headquarters in Lahore. — PCB websitePCB ready to withdraw from playing in ICC events in India: sources.Board determined to reject "hybrid model" for Champions Trophy.Pakistan will host mega-tournament in February-March next year.

LAHORE: The...

Qudus Wahab scored 19 points and grabbed 15 rebounds against his former team, Ace Baldwin Jr. had 17 points and 11 assists to help Penn State beat Maryland 85-69 Sunday night in the regular season finale for both teams.

"Election Day is Tuesday, Nov. 5 -- but that doesn't mean we'll know who won the election on that date. With each passing election, more and more Americans are casting mail-in ballots, which take longer to count than in-person votes because they need to be opened and verified. That means that finding out the winner on election night may be a thing of the past," advises ABC News in a brief analysis.

Alex Bono finished with seven saves for D.C. United, Roman Celentano stopped four shots for FC Cincinnati and the two clubs played to a scoreless draw on Sunday.

The iconic Notre Dame Cathedral is ringing its bells once more, five years after a devastating fire nearly destroyed the Paris landmark.

Hungarian Foreign Minister Peter Szijjarto argues in an exclusive interview that his country remains the only NATO nation to avoid sending weapons to Ukraine because such a step, he believes, would only prolong a war with Russia that it is increasingly evident neither side can win.

The Liberian government is mounting a sustained campaign against corruption to win trust and new international investments, whether they come from the U.S. or China, Liberian President Joseph Boakai said in an interview.

With thinner margins in a strengthened and expanded conference along with Maryland's struggle to limit penalties, Friday night's home game with Northwestern is now a keystone to get to bowl eligibility.

Red Bull driver Max Verstappen has received a five-place grid penalty at the Brazilian Grand Prix after he again decided to change his engine.

Free college tuition. New cars. Complimentary passes to government gyms. And cold, hard cash. Militaries all over the world are at war right now. And they're getting creative with pay and benefits to lure in potential recruits and to keep battle-hardened veterans in their uniforms for another round.

Tom Homan, President-elect Donald Trump's new border czar, delivered a stern warning to sanctuary cities on Monday by telling them to "get the hell out of the way" as the next administration comes for illegal immigrants.

It's been a week since President-elect Donald Trump's landslide reelection, and some Democrats are using words such as "realignment," "self-reflection" and "regret."

World leaders are converging Tuesday at the United Nations annual climate conference in Baku, Azerbaijan although the big names and powerful countries are noticeably absent, unlike past climate talks which had the star power of a soccer World Cup.

The temptation is great among conservatives to get back at the leftists who used government power to harass and imprison their opponents for nearly four years.

As you pack up your things, Joe and Kamala, I just wanted to take the time to thank you for taking such good care of middle- and lower-middle-class Americans these past four years.