A team of firefighters worked tirelessly for three hours to rescue a horse named Duchess who had fallen into a ditch in Great Horkesley, near Colchester on the Friday of bank holiday.

PETER HITCHENS: We will not escape from this misery until the Government has been forced to admit that it made a foolish mistake and over-reacted wildly to Covid-19.

An Australian woman attempted to clean her microwave using the lemon in water trick. But she missed the vital step of putting the citrus fruit in water, which resulted in heavily burnt lemons.

The former Real Housewives of Orange County star and her husband, Botched doctor Terry Dubrow, own a lavish mansion in Southern California.

The Vlogger, 19, was left petrified by the 3am raid on her Brighton home two weeks ago, but revealed that her training schedule has left exhausted enough to go to bed.

This Tuesday, the Bitcoin is expected to undergo a 'halving'. Will it offer a new opportunity for investors to make a profit? Or as legendary investor Warren Buffett believes, is it no more than 'rat poison'?

DANNY MURPHY: As a footballer, my instinct was always to play. I played in the Champions League for Liverpool v Boavista on the night of 9-11. There weren't any dissenting voices among the players.

Before this season, few Premier League campaigns had been more barmy than 2004-05, when conventions were ripped up and troublemaking footballers hit the front pages as well as the back.

Mary Pratt, believed to be one of the last surviving members of the women's baseball league which was celebrated in the Hollywood film "A League of Their Own," has died. She was 101. The baseball icon Pratt pitched in the 1940s for the Rockford Peaches, one of the original teams in the All-American Girls Professional Baseball League. She was the last surviving member of the Peaches. She died peacefully in her sleep at the John Scott Nursing home in Quincy, Massachusetts. "We are terribly sad to report that former Rockford Peaches and Kenosha Comets pitcher, Mary Pratt passed away on May 6th. She was 101 years old," the AAGPBL wrote on its Twitter account. "Mary was the last known original Peaches player that played on the 1943 team. Her stories, her energy will be missed for a long time." The league was immortalized in the 1992 film which was directed by Penny Marshall and starred Tom Hanks and Geena Davis. Born in 1918 in Bridgeport, Connecticut, Pratt joined the inaugural season of

Former New Zealand head coach and current England defence chief John Mitchell believes some good may come for rugby union from the coronavirus if it creates "greater professionalism" thanks to a concentration of talent at fewer clubs worldwide, including Super Rugby. Even before COVID-19 saw this year's edition of Super Rugby suspended after seven rounds in March, there was a widespread view the southern hemisphere's now 15-string premier club tournament had become increasingly unattractive for fans and broadcasters alike, with talent spread too thinly. The pandemic has already had a huge financial impact on rugby and there are concerns current club structures won't survive the outbreak fully intact. England's Rugby Football Union has lost ?15 million ($19 million) so far due to the crisis, with Twickenham chiefs forecasting a total loss of ?107 million if the autumn internationals are cancelled. Meanwhile Rugby Australia, already reeling after reaching a multi-million dollar ...

Several user reports and news websites mentioned that after the installation process the handset showed an error prompting users to plug it to iTunes on a PC. On connecting, another error cropped up which read, “There is a problem with the iPhone 'iPhone' that requires it to be updated or restored.”

இந்தியாவின் முன்னணி தனியார் வங்கிகளான ஐடிசி மற்றும் ஆக்சிஸ் வங்கிகளில் மத்திய அரசு வைத்திருக்கும் பங்குகளை மொத்தமாக விற்பனை செய்ய முடிவு செய்துள்ளது மோடி தலைமையிலான அரசு. இந்தப் பங்கு விற்பனை மூலம் சுமார் 22,000 கோடி ரூபாய் அளவிலான நிதியைத் திரட்ட மத்திய அரசு முடிவு செய்துள்ளது. தற்போது எடுக்கப்பட்டுள்ள முடிவுகளின் படி ஐடிசி மற்றும்

Migrants complain officials are delaying their entry citing silly reasons and technical formalities

ITC scam a pre-meditated loot of public money: HC

A simple and robust tool for spatio-temporal overlap of THz and XUV pulses in in-vacuum pump–probe experiments is presented. The technique exploits ultrafast changes of the optical properties in semiconductors (i.e. silicon) driven by ultrashort XUV pulses that are probed by THz pulses. This work demonstrates that this tool can be used for a large range of XUV fluences that are significantly lower than when probing by visible and near-infrared pulses. This tool is mainly targeted at emerging X-ray free-electron laser facilities, but can be utilized also at table-top high-harmonics sources.

Tannerella forsythia is an oral dysbiotic periodontopathogen involved in severe human periodontal disease. As part of its virulence factor armamentarium, at the site of colonization it secretes mirolysin, a metallopeptidase of the unicellular pappalysin family, as a zymogen that is proteolytically auto-activated extracellularly at the Ser54–Arg55 bond. Crystal structures of the catalytically impaired promirolysin point mutant E225A at 1.4 and 1.6 Å revealed that latency is exerted by an N-terminal 34-residue pro-segment that shields the front surface of the 274-residue catalytic domain, thus preventing substrate access. The catalytic domain conforms to the metzincin clan of metallopeptidases and contains a double calcium site, which acts as a calcium switch for activity. The pro-segment traverses the active-site cleft in the opposite direction to the substrate, which precludes its cleavage. It is anchored to the mature enzyme through residue Arg21, which intrudes into the specificity pocket in cleft sub-site S1'. Moreover, residue Cys23 within a conserved cysteine–glycine motif blocks the catalytic zinc ion by a cysteine-switch mechanism, first described for mammalian matrix metallopeptidases. In addition, a 1.5 Å structure was obtained for a complex of mature mirolysin and a tetradecapeptide, which filled the cleft from sub-site S1' to S6'. A citrate molecule in S1 completed a product-complex mimic that unveiled the mechanism of substrate binding and cleavage by mirolysin, the catalytic domain of which was already preformed in the zymogen. These results, including a preference for cleavage before basic residues, are likely to be valid for other unicellular pappalysins derived from archaea, bacteria, cyanobacteria, algae and fungi, including archetypal ulilysin from Methanosarcina acetivorans. They may further apply, at least in part, to the multi-domain orthologues of higher organisms.

Transforming growth factor β-1 (TGFβ-1) is a secreted signalling protein that directs many cellular processes and is an attractive target for the treatment of several diseases. The primary endogenous activity regulatory mechanism for TGFβ-1 is sequestration by its pro-peptide, latency-associated peptide (LAP), which sterically prohibits receptor binding by caging TGFβ-1. As such, recombinant LAP is promising as a protein-based therapeutic for modulating TGFβ-1 activity; however, the mechanism of binding is incompletely understood. Comparison of the crystal structure of unbound LAP (solved here to 3.5 Å resolution) with that of the bound complex shows that LAP is in a more open and extended conformation when unbound to TGFβ-1. Analysis suggests a mechanism of binding TGFβ-1 through a large-scale conformational change that includes contraction of the inter-monomer interface and caging by the `straight-jacket' domain that may occur in partnership through a loop-to-helix transition in the core jelly-roll fold. This conformational change does not appear to include a repositioning of the integrin-binding motif as previously proposed. X-ray scattering-based modelling supports this mechanism and reveals possible orientations and ensembles in solution. Although native LAP is heavily glycosylated, solution scattering experiments show that the overall folding and flexibility of unbound LAP are not influenced by glycan modification. The combination of crystallography, solution scattering and biochemical experiments reported here provide insight into the mechanism of LAP sequestration of TGFβ-1 that is of fundamental importance for therapeutic development.

The bacterial flavin adenine dinucleotide (FAD)-dependent glucose dehydrogenase complex derived from Burkholderia cepacia (BcGDH) is a representative molecule of direct electron transfer-type FAD-dependent dehydrogenase complexes. In this study, the X-ray structure of BcGDHγα, the catalytic subunit (α-subunit) of BcGDH complexed with a hitchhiker protein (γ-subunit), was determined. The most prominent feature of this enzyme is the presence of the 3Fe–4S cluster, which is located at the surface of the catalytic subunit and functions in intramolecular and intermolecular electron transfer from FAD to the electron-transfer subunit. The structure of the complex revealed that these two molecules are connected through disulfide bonds and hydrophobic interactions, and that the formation of disulfide bonds is required to stabilize the catalytic subunit. The structure of the complex revealed the putative position of the electron-transfer subunit. A comparison of the structures of BcGDHγα and membrane-bound fumarate reductases suggested that the whole BcGDH complex, which also includes the membrane-bound β-subunit containing three heme c moieties, may form a similar overall structure to fumarate reductases, thus accomplishing effective electron transfer.

Just as people use airplanes to fly overseas, marine snails may use birds to fly over land,” said Mark Torchin, staff scientist at the Smithsonian.

The post Hitchhiking snails fly from ocean to ocean appeared first on Smithsonian Insider.

For three years—2001, 2002 and 2008—on Teopa Beach in Jalisco, Mexico, researchers examined the shell, neck and flippers of female turtles that had come out onto the beach to nest, collecting and carefully documenting all the organisms—known as epibionts—they found.

The post Sea turtle “hitchhikers” ID’d in survey appeared first on Smithsonian Insider.

A rising spike in West Nile virus is taking health officials across the country by surprise as this year more than 2,600 people in 45 states and the District of Columbia, have been stricken with severe symptoms of this mosquito-transmitted disease.

The post As robins disperse, West Nile mosquitoes switch diet to humans: Q&A with Smithsonian ornithologist Peter Marra appeared first on Smithsonian Insider.

When some of the world’s largest mammals come your way, most animals steer clear. Not the genet. The small cat-like carnivore was captured on film […]

The post Maybe it’s safer riding a rhino. Genet expert poses new ideas on the mammal’s hitchhiking behavior appeared first on Smithsonian Insider.

Researchers who examined thousands of migratory birds arriving in the United States from Central and South America have determined that three percent carry ticks species […]

The post Disease carrying ticks hitchhike into U.S. on migratory birds appeared first on Smithsonian Insider.

Many animals change sex at some point in their lives, often after reaching a certain size. Snails called slipper limpets begin life as males, and […]

The post The Power of Touch: Sex-changing snails switch sooner when together appeared first on Smithsonian Insider.

Part 1 – Public Programs Coordinator Gloria Kenyon demonstrates crafting for the next Handi Hour program at the Renwick Gallery of the Smithsonian American Art […]

The post Handi-hour crafting – Cross Stitch Embroidery appeared first on Smithsonian Insider.

For the first time researchers from the Smithsonian, South Dakota State University and the University of Nebraska described the immature stages of the switchgrass moth, first collected in Denver in 1910.

The post Potential biofuel pest, the switchgrass moth, under renewed scrutiny of entomologists appeared first on Smithsonian Insider.

For many Californians, last year’s wet winter triggered a case of whiplash. After five years of drought, rain from October 2016 to February 2017 broke […]

The post In San Francisco, one wet winter can switch up Bay’s invasive species appeared first on Smithsonian Insider.

“One cannot think well, love well, sleep well if one has not dined well,” Virginia Woolf once said. Woolf’s sentiment is one that the staff […]

The post Behind the scenes in the restaurant kitchen that feeds the National Zoo’s residents appeared first on Smithsonian Insider.

One of the essential components of molecular electronic circuits are switching elements that are stable in two different states and can ideally be switched on and off many times. Here, distinct buckminsterfullerenes within a self-assembled monolayer, forming a two-dimensional dodecagonal quasicrystal on a Pt-terminated Pt3Ti(111) surface, are identified to form well separated molecular rotational switching elements. Employing scanning tunneling microscopy, the molecular-orbital appearance of the fullerenes in the quasicrystalline monolayer is resolved. Thus, fullerenes adsorbed on the 36 vertex configuration are identified to exhibit a distinctly increased mobility. In addition, this finding is verified by differential conductance measurements. The rotation of these mobile fullerenes can be triggered frequently by applied voltage pulses, while keeping the neighboring molecules immobile. An extensive analysis reveals that crystallographic and energetic constraints at the molecule/metal interface induce an inequality of the local potentials for the 36 and 32.4.3.4 vertex sites and this accounts for the switching ability of fullerenes on the 36 vertex sites. Consequently, a local area of the 8/3 approximant in the two-dimensional fullerene quasicrystal consists of single rotational switching fullerenes embedded in a matrix of inert molecules. Furthermore, it is deduced that optimization of the intermolecular interactions between neighboring fullerenes hinders the realization of translational periodicity in the fullerene monolayer on the Pt-terminated Pt3Ti(111) surface.

UATP has partnered the payment technology company

A look at what’s going beyond the scenes in one of the largest software bot deployments in the world.

What drives people to behave in more environmentally friendly ways? A new study explores factors that affect Dutch motorists’ intentions to switch to electric vehicles. The authors found that they could reliably predict the intention to switch by applying a theoretical framework—Protection Motivation Theory—based on perceptions of the threat of environmental damage.

Planning future sustainable water management in cities is a challenge. A recent study describes a new computer tool that enables quick comparisons of different water management options in cities, to help develop future strategies for effective integrated urban water management.

A recent study suggests that blocking ditches originally dug in peatlands to drain water is an effective restoration method, but is influenced by local conditions. Restoration efforts should therefore be monitored over long periods of time at the landscape level to fully evaluate their impacts.

Dishwashing is responsible for over half of tap water used in the kitchen, according to the results of a new study, which also suggest that people who live alone consume double the water per person that those that live in a four or five-person household. Although relatively few households were studied, this research could prove useful in helping develop consumer advice for saving water.

The future of oyster farming in Europe is threatened by disease. However, a recent study highlights the risk of importing oysters to improve or replace lost stock, as this could accidentally bring further disease and invasive species.

The effect on bats of the replacement of mercury lamps with light-emitting diodes (LEDs) in street lighting has been investigated in a recent study. Artificial light affects bat species differently and the activity of species normally more sensitive to light were affected less by the new LED street lamps than by traditional mercury lamps. Use of LEDs may, therefore, help to reduce the impacts of outdoor lighting on light-sensitive bats, if used at an appropriate level.

Pesticides used on agricultural land can leach into nearby surface water; this is called run-off and can harm aquatic ecosystems. This study evaluated the potential of ditches to reduce run-off, using Italy’s Po Valley as a case study. Grassy ditches were able to significantly reduce the concentration of herbicides, even during extreme flooding. The researchers therefore suggest that the promotion of vegetated ditches via agri-environment schemes would be beneficial for pesticide mitigation.

Traffic could be worse than before the COVID-19 pandemic as people feel safer in cars than catching trains and buses, transport experts have warned.

Plans are also underway for initiatives that expand oil export capacity.