Materials and methods for treating and preventing American Foulbrood disease in honeybees, such as materials and methods for using phage lysin enzymes to lyse Paenibacillus larvae, are provided herein.

The present invention relates to the use of the miRNA expression profile, particularly of miR-199a-5p, and the target genes regulated thereby for the diagnosis, prognosis and use of miR-199a-5p inhibitors for treating fibroproliferative disorders.

The invention provides diagnostic and therapeutic targets for pulmonary disease, in particular, fibrotic lung disease. The inventors have found that a genetic variant MUC5B gene is associated with increased expression of the gene, increased risk of developing a pulmonary disease, and an improved prognosis and survival among those developing the pulmonary disease.

Provided herein are methods for the prognosis of prostate cancer progression in a patient by analyzing the gene expression in a tumor sample obtained from the patient the prognosis of prostate cancer progression in a patient by analyzing the gene expression in a tumor sample obtained from the patient. In particular, gene expression levels of GCOM1, MEX3D, TRPM4, ATPAF1, PTRF, GLYATL1, FLNA, OBSCN, STRA13, WHSCl, ARFGAP3, KDM2A, FAM83H, CLDN7, CNOT6, and B3GNT9 are measured. Kits containing means for the measurement of gene expression as described herein and methods for treatment of prostate cancer are also provided.

The present invention concerns cancer biomarkers. In particular, the invention concerns HGF as a biomarker for patient selection and patient prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.

The present invention provides methods for assessing whether a subject is at risk of developing a neurological disorder, diagnosing or confirming whether a subject is afflicted with a neurological disorder, assessing whether PD has progressed in a subject afflicted with PD, assessing whether a neurological disorder is developing in a subject who has been identified as being at risk of developing the neurological disorder, assessing whether a subject afflicted with a neurological disorder is likely to benefit from a therapy, assessing whether a subject afflicted with a neurological disorder has benefited from a therapy, treating a subject afflicted with a neurological disorder, and prophylactically treating a subject who has been identified as being at risk of developing a neurological disorder. The present invention also provides epitopes, compounds and compositions relating to these methods.

Disclosed are methods of enhancing plant growth, comprising treating seed at least one month prior to planting with an effective amount of a plant signal molecule, wherein upon harvesting the plant exhibits at least one of increased plant yield measured in terms of bushels/acre, increased root number, increased root length, increased root mass, increased root volume and increased leaf area, compared to plants harvested from untreated seed, or compared to plants harvested from seed treated with the signal molecule just prior to or within a week or less of planting.

The present invention relates to a method and arrangement for the treatment of liquid material based on organic waste products, in particular sludge from sewage disposal plants and the like, wherein the sludge material is added and mixed with chemicals, in particular sulphuric acid, nitric acid, and/or ammonia, during the vaporization and degasification of liquid from the material to increase the solids content thereof. The present invention is characterized, inter alia, in that the material is continuously introduced at the upper part of a vertical mixing vessel (1), in which the material is subject to mixing, after which the material is passed on into a reactor tank (8) for sulphuric acid treatment and at the same time, while sinking through the sulphuric acid treatment reactor tank (8), is exposed to an impact action from a number of rotary processing means (9) disposed in the reactor tank (8), after which the material is passed on into a reactor tank (14) for ammonia treatment and at the same time, while sinking through the ammonia treatment reactor tank (14), is exposed to an impact action from a number of rotary processing means (9) disposed in the reactor tank (14), after which the material is finally passed on into a drier (15) in which the material is dried until a desired solids content is achieved.

A method and system for treatment of biological wastes for preparation of fertilizers is provided. The method and system involves mixing a biological waste with a dilute sulfuric acid in a predetermined ratio. The mixture of the biological waste and the dilute sulfuric acid is then filtered to obtain an organic slurry and an acidic liquid. Thereafter, the organic slurry is thermally cracked at an elevated temperature to obtain at least one of an ammonia gas, one or more flue gases, and char and ash. The method and system further involves utilizing the ammonia gas, the char and ash, and the acidic liquid for preparation of the fertilizers.

The invention relates to a device for the flow-through treatment of web-shaped, gas-permeable material, in particular for drying woven or non-woven fabrics, having the following characteristics: a sieving drum (5), which is rotatably supported and which is connected to a vacuum generator and which has a permeable outer circumference, wherein the material web (M) to be treated rotates around part of the outer circumference of the sieving drum (5);a treatment chamber (BH), which accommodates the sieving drum and to which the gas to be treated, preferably heated air, is supplied;inside the treatment chamber (BH), a sieving cover (SD) or corresponding flow-conducting elements, which surround the sieving drum (5) in the area around which the material web (M) is wound and by means of which the gas flowing into the treatment chamber (BH) is conducted in the direction of the sieving drum surface. According to the invention, the wall (W) of the treatment chamber (BH) facing the outer circumference of the sieving drum (S) in the area around which the material web (M) is wound has a decreasing distance (a1, a2, a3) from the surface of the sieving drum (S) in said area.

A clothes treatment apparatus and a method for controlling a clothes treatment apparatus are provided. The clothes treatment apparatus may include a drying duct, a first blower fan located in the drying duct that circulates interior air within the drying duct, and a filter located in the drying duct. The method may include sensing clogging of the filter, and switching a flow of air passing through the filter from a first direction to an opposite second direction if clogging of the filter is sensed. The method may further include a washing cycle for washing clothes, and a drying cycle for drying the clothes. An implementation time of the washing cycle may be less than an implementation time of the drying cycle.

A fabric treatment apparatus is provided. The fabric treatment apparatus includes a treatment room which can receive and hold clothes; a motor which generates a rotational force; an eccentric unit which is rotated eccentrically by the rotational force generated by the motor; a contact unit which converts the rotating motion of the eccentric unit into a reciprocating motion; a clothes rack which is disposed in the treatment room and is coupled to the contact unit so as to move reciprocally in a linear path, and on which a number of hangers can be hung; and a heating unit which supplies at least one of hot air and steam into the treatment room.

The present disclosure describes systems and methods for the treatment of obstructive sleep apnea. The system includes a mouthpiece. The mouthpiece includes a force plate that a user can press against with their tongue. Pressing the force plate enables the user to strengthen their tongue. The system also includes a control module that can measure the force applied to the force plate and provide feedback to the user about progress and the applied force.

The invention relates to the field of explosives, and more particularly relates to particles of an explosive, wherein they are in crystalline form, have a rounded shape and a majority of them contain no internal defect. Particles of an explosive in crystalline form include a volume fraction of closed pores of less than or equal to 0.05%. A method for preparing explosive particles includes preparing crystalline particles, a majority of which are without an internal defect; and rounding the crystalline particles.

A substrate treatment system for treating substrates in a continuous process includes a system chamber delimited by chamber walls, having an entry lock and an exit lock, and also at least one substrate treatment device and a transportation device inside the system chamber. The transportation device has an arrangement of transportation rollers arranged one behind the other in the transportation direction, for vertical or horizontal transportation of substrates. The rotor of the drive device is arranged under the pressure conditions prevailing in the system chamber and the stator of the drive device is arranged outside the pressure conditions prevailing in the system chamber.

A method of thermally processing a tobacco material is provided, the method including the steps of (i) mixing a tobacco material, water, and an additive selected from the group consisting of lysine, glycine, histidine, alanine, methionine, glutamic acid, aspartic acid, proline, phenylalanine, valine, arginine, di- and trivalent cations, asparaginase, saccharides, phenolic compounds, reducing agents, compounds having a free thiol group, oxidizing agents, oxidation catalysts, plant extracts, and combinations thereof, to form a moist tobacco mixture; (ii) heating the moist tobacco mixture at a temperature of at least about 60° C. to form a heat-treated tobacco mixture; and (iii) incorporating the heat-treated tobacco mixture into a tobacco product. Heat-treated tobacco composition prepared according to the method are also provided, such as heat-treated smokeless tobacco composition comprising a tobacco material, water, flavorant, binder, and filler, the heat-treated smokeless tobacco composition having an acrylamide content of less than about 2000 ppb.

Sterilization and cleaning of an escalator hand rail are performed. A sterilization and cleaning device including a hand rail; a plasma source for irradiating the hand rails with ions or radicals or UV light; an enclosure for housing the plasma source; a power source for generating plasma; a fan for generating relatively negative pressure in the enclosure; filter units for removing removed bacteria, viruses, and organic matters such as hand marks; and filter plates located backward and forward of a moving direction of the hand rail in the enclosure along the hand rail is provided.

A device for preventing jamming of a fibrous material subject to a compressive treatment in a stuffing chamber defined by a feed roll and a retard roll. The device includes an impact blade and a stabilizing apparatus. The impact blade is rigid and interchangeable. The stabilizing apparatus stabilizes the impact blade against moving away from the feed roll to prevent the jamming of the fibrous material between the feed roll and the impact blade during the compressive treatment of the fibrous material.

A machine and a method for treating fabrics, comprise in combination a step of inducing substantially vertical vibrations in a quantity of fabric in the form of a substantially compact mass and a simultaneous step of drying the rest of the fabric in opened-out form.

The present document describes methods of use of photo activated compositions for oral disinfection and/or treatments which comprise at least one oxidant, at least one photoactivator capable of activating the oxidant, and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin, in association with a pharmacologically acceptable carrier.

The tool for treatment of interdental surfaces includes a strip (10) having an abrasive field (12) on at least one of its longitudinal sides (11). The field is situated at a distance (A) from the apical edge (11a) of the longitudinal side, the latter being blank between the apical edge and the field.

An oral treatment device that includes a mouthpiece and an electromagnetic radiation source. In one aspect, the oral treatment device includes a mouthpiece comprising a curved wall having a concave inner surface and a bite platform extending from the concave inner surface of the curved wall to a distal end, the distal end of the bite platform extending continuously in a non-interrupted manner from a first end of the bite platform to a second end of the bite platform; an electromagnetic radiation source configured to emit electromagnetic radiation from the curved wall; and wherein the bite platform comprises a collapsible region such that the mouthpiece is alterable between: (1) a biased state in which the curved wall has a first curvature; and (2) a flexed state in which the curved wall has a second curvature that is different than the first curvature.

An oral treatment device that emits light onto surfaces of a user's teeth. In one aspect, the oral treatment device includes an intraoral mouthpiece. The mouthpiece comprises a lamp support structure comprising a lamp support surface and is formed of a first material. A flexible lamp is mounted to the lamp support surface so that a light emitting surface of the flexible lamp assumes a concave curvature, thereby forming a lamp assembly. A guard component is overmolded to the lamp assembly. The guard component is formed of an elastomeric material having a hardness that is less than a hardness of the first material. In one embodiment, the oral treatment device may be a teeth whitening device.

An oral treatment device that emits light onto surfaces of a user's teeth. In one aspect, the oral treatment device includes an intraoral mouthpiece comprising: a lamp support surface; and a lamp. When the lamp is mounted to the lamp support surface, a first contact surface of the lamp contacts a first contact surface of a first electrical contact element of the lamp support surface; and (2) a second contact surface of the lamp contacts a second contact surface of a second electrical contact element of the lamp support surface.

An oral treatment device that emits light onto surfaces of a user's teeth. In one aspect, the oral treatment device includes an intraoral mouthpiece. The mouthpiece may comprise a lamp support structure comprising a lamp support surface; first and second lamps, each of the first and second lamps comprising a plurality of light emitters that generate light which is emitted from a rear surface of the lamp; each of the first and second lamps mounted to the lamp support surface, thereby forming a lamp assembly, each of the first and second lamps operably coupled to a control circuit having a power source; and a lamp retaining component coupled to the lamp support structure, a lower portion of the first lamp and an upper portion of the second lamp retained between the lamp retaining component and the lamp support surface of the lamp support structure.

An oral treatment device that emits light onto a user's teeth. The oral treatment device includes an intraoral mouthpiece comprising: a lamp comprising: a flexible sheet body having a front surface and a rear surface; and a plurality of light emitting diodes embedded within the flexible sheet body that generate light which is emitted from the rear surface of the flexible sheet body. The flexible sheet body comprises: a flexible lens plate formed of a biocompatible material. The plurality of light emitting diodes are printed to the front surface of the flexible lens plate, the rear surface of the flexible lens plate forming the rear surface of the flexible sheet body. The rear surface of the flexible sheet body of the lamp having a concave curvature and being exposed so as to form a light emitting surface of the mouthpiece.

An oral treatment device that emits light onto surfaces of a user's teeth. In one aspect, the oral treatment device includes an intraoral mouthpiece. The mouthpiece comprises: a first light emitting surface configured to emit light onto a user's maxillary teeth, the first light emitting surface having a concave curvature; a second light emitting surface configured to emit light onto a user's mandibular teeth, the second light emitting surface having a concave curvature; the first and second light emitting surface located on opposite sides of a horizontal reference plane; the first light emitting surface inclined so that a first acute angle is formed between with the first light emitting surface and the horizontal reference plane; and the second light emitting surface inclined so that a second acute angle is formed between with the second light emitting surface and the horizontal reference plane.

Systems and methods for treating small elongated fibrous and particles of certain materials, e.g., PTFE materials in a suspension are presented. In some instances, high-intensity ultrasound (or acoustical energy) is applied to a sample of the material, through a fluid coupling medium or suspension, to achieve a material transformation in the sample. In various embodiments, fibrillation of particles of PTFE or similar materials is accomplished, or the formation of extended structures of these materials is caused or enhanced. Also, the ability to separate long fiber samples by ultrasonic or acoustic cavitation action is provided.

A pressure steam treatment apparatus according to the invention includes a pressure steam treatment chamber and labyrinth sealing chambers. The labyrinth sealing chambers are respectively arranged on a fiber bundle inlet and on a fiber bundle outlet of the steam treatment apparatus, having a running path of the fiber bundle in a horizontal direction and having plural labyrinth nozzles on top and bottom of the running path. The difference between a maximum value and a minimum value of the distance in the perpendicular direction of the top and bottom side labyrinth nozzles, of a pair of opposing labyrinth nozzles is 0.5 mm or smaller when the ambient temperature of the labyrinth sealing chamber is 140° C. This structure ensures that the energy cost can be reduced, the deformation of the apparatus and also, the raise of fuzz on the fiber bundle and fiber bundle breakage can be prevented at the same time.

Burner for an oven for reheating siderurlogical products such as billets, blooms or slabs, or for heat treatment oven, which is equipped with a fuel injection device and with an oxidant feed body feeding feed orifices with oxidant, the burner having an axial direction; the injection device is designed to provide a central injection of fuel via an orifice in, or parallel to, the axial direction of the burner; the oxidant feed body includes two sets of four oxidant feed orifices, each set including two orifices situated above a horizontal plane passing through the axial direction of the burner, and two orifices situated below this plane, the orifices of a second set being further away from the horizontal plane than those of the first set, the geometric axes of the orifices of the two sets making angles of inclination with respect to the axial direction of the burner.

The present invention relates to a column (1) for thermal treatment of fluid mixtures, having a cylindrical, vertically aligned column body (2) which forms a column cavity (3), having a sequence of vertically spaced-apart dual-flow mass transfer trays (8) which are mounted in the column cavity (3) and which have orifices for passage of liquid and gas in countercurrent, and having at least one gas entry orifice (5) disposed below the lowermost of the sequence of dual-flow mass transfer trays (8). It is a characteristic feature of the column of the invention that a gas distribution tray (9) which is disposed between the lowermost of the sequence of dual-flow mass transfer trays (8) and the gas entry orifice (5) has orifices (32) for vertical passage of gas which can be introduced into the column cavity (3) via the gas entry orifice (5), the orifices (32) being formed so as to bring about equal gas distribution over the column cross section. The invention further relates to a process for thermal treatment of fluid mixtures in such a column (1).

An inflatable dummy target comprising a chassis of inflatable ducts wrapped with a sheet. The chassis of inflatable ducts can include one or more ring shaped ducts and one or more elongate ducts. The chassis can include at least two ring shaped ducts interconnected by one or more elongate ducts. The dummy target can include several attached axi-symmetrical sections, each section have a chassis of inflatable ducts. Each section can be conical, frustoconical or cylindrical, thereby achieving a concave or convex dummy target geometry.

A device used to smooth a material's surface with abrasion. More specifically, the device is in the form of a glove or mitten with an abrasive layer that is placed over, and secured on, a user's hand to protect the user's hand and to provide an agile and flexible range of motion while sanding a material's surface.

Physical treatment garment for aiding in treatment and healing of injured or strained muscles. Garment is made of flexible material that can be pulled up around the waist, such as compression shorts or full length tights or leggings, and the garment has one or more pockets in the thigh and/or hamstring area to hold cold packs or heat packs and have a fastener apparatus at the top. The garment has fastening apparatuses on or about the hip area and on or about just above the knee. Using a flexible or compression wrap with the compatible fastening apparatuses, the compression wrap is wrapped around the leg and/or groin area and secured using the fastening apparatuses. Pockets for ice or heat treatment are similarly located in the front or rear of the tights or leggings with fastening connections to hold ice or heat packs for treatment of the applicable injury.

A breathable gas inlet control device permits flow regulation at the inlet of a flow generator for a respiratory treatment apparatus such as a ventilator or continuous positive airway pressure device. The device may implement a variable inlet aperture size based on flow conditions. In one embodiment, an inlet flow seal opens or closes the inlet to a blower in accordance with changes in pressure within a seal activation chamber near the seal. The seal may be formed by a flexible membrane. A controller selectively changes the pressure of the seal activation chamber by controlling a set of one or more flow control valves to selectively stop forward flow, prevent back flow or lock open the seal to permit either back flow or forward flow. The controller may set the flow control valves as a function of detected respiratory conditions based on data from pressure and/or flow sensors.

In certain example embodiments, a system and/or method of guiding transitions between therapy modes in connection with the treatment and/or diagnosis of a patient for a respiratory disorder is/are provided. Respiratory disorder treatment according to a first therapy mode is provided. Input indicating a second therapy mode to be transitioned to following provision of the first therapy mode is received, with the second therapy mode being different from the first therapy mode. At least one default treatment parameter suitable for the second therapy mode is assigned or calculated. Each default treatment parameter of the second therapy mode is presented, with each default treatment parameter being adjustable by an operator during the presenting. Transitioning from the first therapy mode to the second therapy mode is performed by providing respiratory disorder treatment in accordance with the second therapy mode and each default treatment parameter and any adjustments made thereto prior to the transitioning. Advantageously, the chances of a patient being disturbed by transitioning from mode-to-mode are reduced.

To provide a liquid crystal display device, in which the vertical alignment property of the liquid crystal is high, favorable transparency when no voltage is applied and favorable scattering property when a voltage is applied are achieved, and the adhesion between the liquid crystal layer and the vertical liquid crystal alignment film is high. A liquid crystal display device, which comprises a liquid crystal layer formed by disposing a liquid crystal composition containing a polymerizable compound which undergoes a polymerization reaction by ultraviolet rays, between a pair of substrates provided with an electrode, and irradiating the liquid crystal composition with ultraviolet rays and curing it in such a state that the liquid crystal composition partly or entirely shows liquid crystallinity, and at least one of the substrates being provided with a liquid crystal alignment film to vertically align a liquid crystal, wherein the liquid crystal alignment film is a liquid crystal alignment film obtained from a liquid crystal aligning agent containing a polymer having a first side chain structure and a second side chain structure.

In one example embodiment, a system for treating a tissue site is disclosed comprising a dressing adapted to contact the tissue site and provide a fluid seal between a therapeutic environment and a local external environment, and a solution source fluidly coupled to the dressing and adapted to deliver an antimicrobial solution comprising a peroxy α-keto carboxylic acid, such as peroxy pyruvic acid, to the tissue interface. The system may further comprise a negative-pressure source fluidly coupled to the dressing and adapted to provide negative pressure to the therapeutic environment after delivery of the antimicrobial fluid to the therapeutic environment. In another example embodiment, a method for treating a tissue site is disclosed comprising positioning a tissue interface to contact the tissue site, covering the tissue interface and the tissue site with a drape to provide a fluid seal between the therapeutic environment and the local external environment, and delivering an antimicrobial solution comprising peroxy α-keto carboxylic acid to the therapeutic environment before providing negative pressure to the therapeutic environment.

A medical treatment system including a treatment chamber, a source of an aqueous mist containing a medication, a source of an oxygen-enriched gas, and a control system adapted to alternately surround a human body part with a mist containing a medication and the oxygen enriched gas, which can be used to treat various skin disorders including infected lesions, bacterial infections such as acne (i.e. Propionibacterium acnes), fungal infections such as Athlete's foot (i.e. fungal genus Trichophyton), conditions associated with hair loss including alopecia as well as ulcerations and frostbite resulting from poor circulation. A method of treating skin disorders is also disclosed, that includes providing a mist containing a medication and enriched oxygen gas to the site being treated as well as providing oxygen to the patient during treatment.

Systems and methods for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and treating hyperglycemia, Alzheimer's disease, sleep disorders, Parkinson's disease, Attention Deficit Disorder and nicotine addiction involve synchronizing and tailoring the administration of nutraceuticals, medications and other substances in accordance with the body's natural circadian rhythms, meal times and other factors. Improved control of blood glucose levels, extended alertness, and weight control, and counteracting of disease symptoms when they are at their worst are possible. An automated, pre-programmable transdermal administration system is used to provide pulsed doses of medications, pharmaceuticals, hormones, neuropeptides, anorexigens, pro-drugs, stimulants, nutraceuticals, phytochemicals, phytonutrients, enzymes, antioxidants, essential oils, fatty acids, minerals, vitamins, amino acids, coenzymes, or other physiological active ingredient or precursor. The system can utilize a pump, pressurized reservoir, a system for removing depleted carrier solution, or other modulated dispensing actuator, in conjunction with porous membranes or micro-fabricated structures.

An ultrasound catheter with a lumen for fluid delivery and fluid evacuation, and an ultrasound source is used for the treatment of intracerebral or intraventricular hemorrhages. After the catheter is inserted into a blood clot, a lytic drug can be delivered to the blood clot via the lumen while applying ultrasonic energy to the treatment site. As the blood clot is dissolved, the liquefied blood clot can be removed by evacuation through the lumen.

The present disclosure provides one embodiment of an IC method. First pattern densities (PDs) of a plurality of templates of an IC design layout are received. Then a high PD outlier template and a low PD outlier template from the plurality of templates are identified. The high PD outlier template is split into multiple subsets of template and each subset of template carries a portion of PD of the high PD outlier template. A PD uniformity (PDU) optimization is performed to the low PD outlier template and multiple individual exposure processes are applied by using respective subset of templates.

A method for obtaining diesel fuel from vegetable or animal oils through the addition of hydrogen in the presence of catalysts under suitable temperature and pressure conditions is described. The method is different from other similar methods in that it involves the use of space velocities of between 5.1 h-1 and 9 h-1, thereby enabling a reduction in the size of the reactor and in hydrogen consumption, as well as lowering construction and operating costs. The invention also relates to the products obtained using said method, which have demonstrated that in additions, even below 10%, they improve the performance of diesel engines, thereby lowering fuel consumption.

A ballast water treatment device attached to a vessel provided with: a line (1) through which drawn treatment target water flows; and a ballast tank (5) connected to a downstream side of the line (1). The ballast water treatment device is provided with: a filter (3) which is disposed in the line (1) and which filters the treatment target water; and a controller (7). The controller (7) causes the treatment target water to be discharged outboard from an upstream side of the filter (3) in an early stage of drawing of the treatment target water, until water quality is stabilized, and, when the water quality of treatment target water has stabilized, causes the filter (3) to filter the treatment target water. Thus, ballast water filtering can be efficiently performed.

Ozonated washing water is generated by injecting an ozone gas into pressurized washing water that is filtered water obtained by membrane filtration of untreated water and that is to be used at the time of backwashing, and the ozonated washing water is supplied to a membrane from the filtration secondary side to thereby remove a fouling substance inside the membrane, while causing ozone-containing bubbles to emerge in the filtration primary side to thereby remove a fouling substance on a membrane surface in the filtration primary side.

A thermo-sensitive water absorbent is used as a draw material in production of fresh water by a forward osmosis process. The thermo-sensitive water absorbent has a cloud point, and coagulates when heated, the thermo-sensitive water absorbent being a block copolymer containing at least a hydrophobic part and a hydrophilic part, having a glycerin structure as a basic structure, and including an ethylene oxide group and a group consisting of propylene oxide and/or butylene oxide.

A water treatment apparatus includes a membrane in a contact with a soil structure, a hollow elongated member being passed through membrane and being mounted vertically within a vertical well with the bottom end of the elongated member being configured to expel treated water into the soil structure, a filtration member mounted stationary or for a linear reciprocal movement so as to filter the water prior to entry into a hollow interior of the elongated member, a trash rack positioned on the membrane and surrounding an upper portion of the elongated member and a barrier positioned adjacent and/or on said peripheral side wall of said trash rack, said barrier configured to reduce flow of the water and/or absorb a portion of the contaminant(s) prior to the water entering said filtration member.

The present invention relates to in vitro methods of assessing the susceptibility or responsiveness of a subject to the treatment with an epidermal growth factor receptor (EGFR) inhibitor/antagonist, wherein the subject has been diagnosed or suspected of suffering from inflammation-associated. These methods comprise determining the level of expression of EGFR in myeloid cells in a sample from the subject, wherein an expression of EGFR in the myeloid cells is indicative of the subject being susceptible to the treatment with an EGFR inhibitor/antagonist. The invention also relates to EGFR inhibitors/antagonists for use in the treatment or amelioration of inflammation-associated cancer. The invention furthermore provides in vitro methods of prognosing the survival time, progression-free survival time or disease course of a subject that has been diagnosed or suspected of suffering from from inflammation-associated cancer. In addition thereto, the invention relates to in vitro diagnostic methods of assessing the proneness of a subject to develop inflammation-associated cancer in which the expression of EGFR is determined in myeloid cells from the subject.

The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.

A method to detect prostate cancer comprising contacting a sample of prostate cells from the patient with a set of detectably labeled probes under hybridization conditions and determining the presence of chromosomal abnormalities in prostate tumor tissue, PIN (intra-epithelial neoplasia), histologically benign tissue and benign prostatic hyperplasia (BPH); a method to combine immunofluorescence and FISH (IF-FISH) to facilitate the assessment of chromosomal abnormalities; a set of probes; and a kit comprising the set of probes and instructions for diagnosing prostate cancer in a patient.