This report highlights Bangladesh’s cross-border paperless trade readiness, outlines the significant legal and technical gaps it still needs to address, and provides a comprehensive action plan.

This edition of the ASEAN+3 Bond Market Guide series focuses on updates in the Republic of Korea’s (ROK) market since the publication of the previous guide for the ROK in 2018.

The Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT) has been expanded to include more patients and CT attenuation correction imaging. We present the design and initial results from the updated registry. Methods: The updated REFINE SPECT is a multicenter, international registry with clinical data and image files. SPECT images were processed by quantitative software and CT images by deep learning software detecting coronary artery calcium (CAC). Patients were followed for major adverse cardiovascular events (MACEs) (death, myocardial infarction, unstable angina, late revascularization). Results: The registry included scans from 45,252 patients from 13 centers (55.9% male, 64.7 ± 11.8 y). Correlating invasive coronary angiography was available for 3,786 (8.4%) patients. CT attenuation correction imaging was available for 13,405 patients. MACEs occurred in 6,514 (14.4%) patients during a median follow-up of 3.6 y (interquartile range, 2.5–4.8 y). Patients with a stress total perfusion deficit of 5% to less than 10% (unadjusted hazard ratio [HR], 2.42; 95% CI, 2.23–2.62) and a stress total perfusion deficit of at least 10% (unadjusted HR, 3.85; 95% CI, 3.56–4.16) were more likely to experience MACEs. Patients with a deep learning CAC score of 101–400 (unadjusted HR, 3.09; 95% CI, 2.57–3.72) and a CAC of more than 400 (unadjusted HR, 5.17; 95% CI, 4.41–6.05) were at increased risk of MACEs. Conclusion: The REFINE SPECT registry contains a comprehensive set of imaging and clinical variables. It will aid in understanding the value of SPECT myocardial perfusion imaging, leverage hybrid imaging, and facilitate validation of new artificial intelligence tools for improving prediction of adverse outcomes incorporating multimodality imaging.

SUMMARY:

The 2021 World Health Organization Classification of Tumors of the Central Nervous System (CNS5), introduced significant changes, impacting tumors ranging from glial to ependymal neoplasms. Ependymal tumors were previously classified and graded based on histopathology, which had limited clinical and prognostic utility. The updated CNS5 classification now divides ependymomas into 10 subgroups based on anatomic location (supratentorial, posterior fossa, and spinal compartment) and genomic markers. Supratentorial tumors are defined by zinc finger translocation associated (ZFTA) (formerly v-rel avian reticuloendotheliosis viral oncogene [RELA]), or yes-associated protein 1 (YAP1) fusion; posterior fossa tumors are classified into groups A (PFA) and B (PFB), spinal ependymomas are defined by MYCN amplification. Subependymomas are present across all these anatomic compartments. The new classification kept an open category of "not elsewhere classified" or "not otherwise specified" if no pathogenic gene fusion is identified or if the molecular diagnosis is not feasible. Although there is significant overlap in the imaging findings of these tumors, a neuroradiologist needs to be familiar with updated CNS5 classification to understand tumor behavior, for example, the higher tendency for tumor recurrence along the dural flap for ZFTA fusion-positive ependymomas. On imaging, supratentorial ZFTA-fused ependymomas are preferentially located in the cerebral cortex, carrying predominant cystic components. YAP1-MAMLD1-fused ependymomas are intra- or periventricular with prominent multinodular solid components and have significantly better prognosis than ZFTA-fused counterparts. PFA ependymomas are aggressive paramedian masses with frequent calcification, seen in young children, originating from the lateral part of the fourth ventricular roof. PFB ependymomas are usually midline, noncalcified solid-cystic masses seen in adolescents and young adults arising from the fourth ventricular floor. PFA has a poorer prognosis, higher recurrence, and higher metastatic rate than PFB. Myxopapillary spinal ependymomas are now considered grade II due to high recurrence rates. Spinal-MYCN ependymomas are aggressive tumors with frequent leptomeningeal spread, relapse, and poor prognosis. Subependymomas are noninvasive, intraventricular, slow-growing benign tumors with an excellent prognosis. Currently, the molecular classification does not enhance the clinicopathologic understanding of subependymoma and myxopapillary categories. However, given the molecular advancements, this will likely change in the future. This review provides an updated molecular classification of ependymoma, discusses the individual imaging characteristics, and briefly outlines the latest targeted molecular therapies.

SUMMARY:

The ASNR Neuroradiology Division Chief Working Group's 2023 survey, with responses from 62 division chiefs, provides insights into turnaround times, faculty recruitment, moonlighting opportunities, and academic funds. In emergency cases, 61% aim for a turnaround time of less than 45–60 minutes, with two-thirds meeting this expectation more than 75% of the time. For inpatient CT and MR imaging scans, 54% achieve a turnaround time of 4–8 hours, with three-quarters meeting this expectation at least 50% of the time. Outpatient scans have an expected turnaround time of 24–48 hours, which is met in 50% of cases. Faculty recruitment strategies included 35% offering sign-on bonuses, with a median of $30,000. Additionally, 23% provided bonuses to fellows during fellowship to retain them in the practice upon completion of their fellowship. Internal moonlighting opportunities for faculty were offered by 70% of divisions, with a median pay of $250 per hour. The median annual academic fund for a full-time neuroradiology faculty member was $6000, typically excluding license fees but including American College of Radiology and American Board of Radiology membership, leaving $4000 for professional expenses. This survey calls for further dialogue on adapting and innovating academic institutions to meet evolving needs in neuroradiology.

Background

In an evolving landscape of practices and policies, reviewing and incorporating the latest scientific evidence is necessary to ensure optimal clinical management for people with opioid use disorder. We provide a synopsis of the 2024 update of the 2018 National Guideline for the Clinical Management of Opioid Use Disorder, from the Canadian Research Initiative in Substance Matters.

Methods

For this update, we followed the United States Institute of Medicine’s Standards for Developing Trustworthy Clinical Practice Guidelines and used the Appraisal of Guidelines Research and Evaluation—Recommendation Excellence tool to ensure guideline quality. We carried out a comprehensive systematic literature review, capturing the relevant literature from Jan. 1, 2017, to Sept. 14, 2023. We drafted and graded recommendations according to the Grading of Recommendations, Assessments, Development and Evaluation approach. A multidisciplinary external national committee, which included people with living or lived experience of opioid use disorder, provided input that was incorporated into the guideline.

Recommendations

From the initial 11 recommendations in the 2018 guideline, 3 remained unchanged, and 8 were updated. Specifically, 4 recommendations were consolidated into a single revised recommendation; 1 recommendation was split into 2; another recommendation was moved to become a special consideration; and 2 recommendations were revised. Key changes have arisen from substantial evidence supporting that methadone and buprenorphine are similarly effective, particularly in reducing opioid use and adverse events, and both are now considered preferred first-line treatment options. Slow-release oral morphine is recommended as a second-line option. Psychosocial interventions can be offered as adjunctive treatment but should not be mandatory. The guideline reaffirms the importance of avoiding withdrawal management as a standalone intervention and of incorporating evidence-based harm reduction services along the continuum of care.

Interpretation

This guideline update presents new recommendations based on the latest literature for standardized management of opioid use disorder. The aim is to establish a robust foundation upon which provincial and territorial bodies can develop guidance for optimal care.

Capcom has updated its list of Platinum Titles, games that have sold over one million units as of September 30, 2024. The list includes 122 games with sales over one million units, 64 over two million units, 14 over five million units, and six over 10 million units sold.

Resident Evil 4 remake sold 400,000 units to bring lifetime sales to eight million units, Resident Evil 2 remake sold 300,000 units to bring sales to 14.5 million units, and Resident Evil 3 remake sold 200,000 units to bring lifetime sales to 9.2 million units. 

Resident Evil 7: biohazard sold 300,000 units to bring lifetime sales to 14 million units and Resident Evil Village sold 400,000 units to bring sales to 10.5 million units.

Monster Hunter Rise sold 600,000 units in the quarter to bring lifetime sales to 16 million units. Monster Hunter Rise: Sunbreak sold 400,000 units to bring lifetime sales to 8.8 million units.

Monster Hunter: World sold 400,000 units in the quarter to bring lifetime sales to 20.9 million units, while the Iceborne expansion sold 600,000 units for a total of 14 million units.

Dragon's Dogma 2 sold 300,000 units in the quarter to bring lifetime sales to 3.3 million units. Street Fighter 6 sold 400,000 units in the quarter to bring lifetime sales to 4.1 million units. Devil May Cry 5 sold 300,000 units to bring sales to 8.7 million units. 

Check out the complete list below:

	Release	Title	Platform	Million units
1	Jan 2018	Monster Hunter: World *Unit sales including Monster Hunter World: Iceborne Master Edition: 27.00 million units	PS4, Xbox One, PC, DL	20.90*
2	Mar 2021	Monster Hunter Rise	NSW, PS4, PS5, Xbox One, XSX, PC, DL	16.00
3	Jan 2019	Resident Evil 2	PS4, PS5, Xbox One, XSX, NSW, PC, DL	14.50
4	Jan 2017	RESIDENT EVIL 7 biohazard	PS4, PS5, Xbox One, XSX, NSW, PC, DL	14.00
5	Sep 2019	Monster Hunter World: Iceborne	PS4, Xbox One, PC, DL	14.00
6	May 2021	Resident Evil Village	PS4, PS5, Xbox One, XSX, NSW, PC, DL	10.50
7	Mar 2009	Resident Evil 5	PS3, Xbox 360, DL	9.40
8	Oct 2012	Resident Evil 6	PS3, Xbox 360, DL	9.30
9	Apr 2020	Resident Evil 3	PS4, PS5, Xbox One, XSX, NSW, PC, DL	9.20
10	Jun 2022	Monster Hunter Rise: Sunbreak	NSW, PS4, PS5, Xbox One, XSX, PC, DL	8.80
11	Mar 2019	Devil May Cry 5	PS4, Xbox One, PC, DL	8.70
12	Mar 2023	Resident Evil 4	PS4, PS5, XSX, PC, DL	8.00
13	Feb 2016	Street Fighter V	PS4、PC、DL	7.70
14	Jun 1992	Street Fighter II	SNES	6.30
15	Jan 1998	Resident Evil 2	PS	4.96
16	Dec 2010	Monster Hunter Freedom 3	PSP, DL	4.90
17	Mar 2017	Monster Hunter Generations Ultimate	3DS, NSW, DL	4.90
18	Nov 2014	Resident Evil	PS3, DL	4.50
19	Jan 2016	Resident Evil 0: HD Remaster	PS3, PS4, Xbox One, PC, DL	4.40
20	Nov 2015	Monster Hunter Generations	3DS, DL	4.30
21	Oct 2014	Monster Hunter 4 Ultimate	3DS, DL	4.20
22	Jun 2023	Street Fighter 6	PS4, PS5, XSX, PC, DL	4.10
23	Sep 2013	Monster Hunter 4	3DS, DL	4.10
24	Jul 1993	Street Fighter II Turbo	SNES	4.10
25	Apr 2013	Dragon’s Dogma: Dark Arisen	PS3, Xbox 360, DL	4.00
26	Mar 2008	Monster Hunter Freedom Unite	PSP, DL	3.80
27	Feb 2019	Phoenix Wright: Ace Attorney Trilogy	PS4, NSW, DL	3.80
28	Nov 2013	Dead Rising 3	Xbox One, DL	3.80
29	Feb 2009	Street Fighter IV	PS3, Xbox 360, DL	3.60
30	Mar 2015	Resident Evil Revelations 2	PS3, PS4, Xbox 360, Xbox One, PC, DL	3.60
31	Mar 2016	Resident Evil 6	PS4, Xbox One, DL	3.50
32	Sep 1999	Resident Evil 3 Nemesis	PS	3.50
33	May 2018	Street Fighter 30th Anniversary Collection	PS4, Xbox One, NSW, PC, DL	3.40
34	Jun 2016	Resident Evil 5	PS4, Xbox One, DL	3.30
35	Aug 2016	Resident Evil 4	PS4, Xbox One, DL	3.30
36	Mar 2024	Dragon’s Dogma 2	PS5, XSX, DL	3.30
37	Sep 2010	Dead Rising 2	PS3, Xbox 360, PC, DL	3.20
38	Jan 2013	DmC Devil May Cry	PS3, Xbox 360, DL	3.10
39	Jan 2008	Devil May Cry 4	PS3, Xbox 360, DL	3.00
40	Feb 2014	Resident Evil 4: Ultimate HD Edition	PC, DL	3.00
41	Jun 2015	Devil May Cry 4 Special Edition	PS4, Xbox One, DL	2.80
42	Mar 1996	Resident Evil	PS	2.75
43	May 2013	Resident Evil Revelations	PS3, Xbox 360, Wii U, PC, DL	2.70
44	Mar 2012	Resident Evil: Operation Raccoon City	PS3, Xbox 360, DL	2.70
45	Dec 2011	Monster Hunter 3 Ultimate	3DS, DL	2.60
46	Oct 2017	Dragon’s Dogma: Dark Arisen	PS4, Xbox One, DL	2.50
47	Dec 2017	Okami HD	PS4, Xbox One, NSW, DL	2.50
48	Feb 2021	Capcom Arcade Stadium	DL (PS4, Xbox One, NSW, PC)	2.40
49	Feb 2007	Monster Hunter Freedom 2	PSP	2.40
50	Feb 2010	Resident Evil 5: Gold Edition	PS3, Xbox 360, DL	2.40
51	Jul 1999	Dino Crisis	PS	2.40
52	Sep 2017	Marvel vs. Capcom: Infinite	PS4, Xbox One, PC, DL	2.30
53	Dec 2005	Resident Evil 4	PS2	2.30
54	Aug 2014	Ultra Street Fighter IV	PS3, Xbox 360, PC, DL	2.20
55	Feb 2011	Marvel vs. Capcom 3: Fate of Two Worlds	PS3, Xbox 360	2.20
56	May 2010	Lost Planet 2	PS3, Xbox 360, DL	2.20
57	Aug 2001	Devil May Cry	PS2	2.16
58	Mar 2002	Onimusha 2: Samurai’s Destiny	PS2	2.10
59	Jan 2001	Onimusha: Warlords	PS2	2.02
60	Jul 2021	Monster Hunter Stories 2: Wings of Ruin	NSW, PS4, PC, DL	2.00
61	Mar 2017	Ultimate Marvel vs. Capcom 3	PS4, Xbox One, DL	2.00
62	May 2007	Resident Evil 4 Wii edition	Wii, DL	2.00
63	Mar 2018	Devil May Cry HD Collection	PS4, Xbox One, DL	2.00
64	Jun 1994	Super Street Fighter II	SNES	2.00
65	Aug 2009	Monster Hunter Tri	Wii	1.90
66	Oct 2018	Mega Man 11	PS4, Xbox One, NSW, DL	1.90
67	Apr 2010	Super Street Fighter IV	PS3, Xbox 360, DL	1.90
68	Mar 2012	Street Fighter X Tekken	PS3, Xbox 360, DL	1.90
69	Aug 2006	Dead Rising	Xbox 360, DL	1.80
70	Jul 2022	Capcom Arcade 2nd Stadium	DL (PS4, Xbox One, NSW, PC)	1.80
71	Dec 2006	Lost Planet Extreme Condition	Xbox 360, DL	1.70
72	Nov 2013	DuckTales: Remastered	PS3, Xbox 360, Wii U, DL	1.70
73	Jan 2003	Devil May Cry 2	PS2	1.70
74	Sep 1993	Street Fighter II’ Special Champion Edition	MD	1.65
75	Jun 1986	Ghosts’n Goblins	NES	1.64
76	Aug 2015	Mega Man Legacy Collection	PS4, Xbox One, DL	1.60
77	Dec 2016	Dead Rising 4	Xbox One, PC, DL	1.60
78	Jan 2005	Resident Evil 4	GC	1.60
79	Feb 2004	Onimusha 3: Demon Siege	PS2	1.52
80	Dec 1988	Mega Man 2	NES	1.51
81	Sep 2016	Dead Rising	PS4, Xbox One, DL	1.50
82	Jun 2013	Remember Me	PS3, Xbox 360, PC, DL	1.50
83	Nov 2017	Resident Evil Revelations Collection	NSW, DL	1.50
84	Feb 2014	Strider	DL（PS3, PS4, Xbox 360, Xbox One, PC）	1.50
85	Oct 2010	Dead Rising 2 Off The Record	PS3, Xbox 360, DL	1.50
86	Dec 1990	Final Fight	SNES	1.48
87	Dec 2003	Resident Evil Outbreak	PS2	1.45
88	Mar 2001	Resident Evil Code: Veronica X	PS2, DC	1.40
89	Jul 2009	Marvel vs. Capcom 2: New Age Of Heroes	DL (PS3, Xbox 360)	1.40
90	Sep 2014	Dead Rising 3 Apocalypse Edition	PC, DL	1.40
91	Mar 2015	DmC Devil May Cry Definitive Edition	PS4, Xbox One, DL	1.40
92	Mar 2002	Resident Evil	GC	1.35
93	Dec 2003	Mega Man Battle Network 4	GBA	1.35
94	Jul 2018	Mega Man X Legacy Collection	PS4, Xbox One, NSW, DL	1.30
95	Jun 2009	Bionic Commando	PS3, Xbox 360, PC, DL	1.30
96	May 2012	Dragon’s Dogma	PS3, Xbox 360	1.30
97	Feb 2011	Super Street Fighter IV 3D Edition	3DS, DL	1.30
98	Dec 2005	Monster Hunter Freedom	PSP, DL	1.30
99	Mar 2012	Resident Evil 4	DL（PS3, Xbox 360）	1.30
100	Nov 2007	Resident Evil: The Umbrella Chronicles	Wii	1.30
101	Feb 2005	Devil May Cry 3	PS2	1.30
102	Nov 2002	Resident Evil 0	GC	1.25
103	Jun 2011	Super Street Fighter IV Arcade Edition	PS3, Xbox 360, DL	1.20
104	Sep 2000	Dino Crisis 2	PS	1.20
105	Nov 2011	Ultimate Marvel vs. Capcom 3	PS3, Xbox 360, DL	1.20
106	Mar 2012	Devil May Cry HD Collection	PS3, Xbox 360, DL	1.20
107	Apr 2019	Dragon’s Dogma DARK ARISEN	NSW, DL	1.20
108	Sep 2016	Dead Rising 2 Off The Record	PS4, Xbox One, DL	1.20
109	Aug 1998	Resident Evil Director’s Cut Dual Shock	PS	1.20
110	Dec 1993	Mega Man X	SNES	1.16
111	Feb 2000	Resident Evil Code: Veronica	DC	1.14
112	Sep 1986	Commando	NES	1.14
113	Sep 1997	Resident Evil Director’s Cut	PS	1.13
114	Aug 2017	Resident Evil Revelations	PS4, Xbox One, DL	1.10
115	Jul 2021	The Great Ace Attorney Chronicles	PS4, NSW, DL	1.10
116	Oct 1991	Super Ghouls’n Ghosts	SNES	1.09
117	Sep 1990	Mega Man 3	NES	1.08
118	May 1993	Final Fight 2	SNES	1.03
119	Oct 2019	Resident Evil 6	DL (NSW)	1.00
120	Dec 1998	Street Fighter Alpha 3	PS	1.00
121	Jul 2018	Megaman X Anniversary Collection 2	PS4, Xbox One, NSW, DL	1.00
122	Feb 2006	Devil May Cry 3 Special Edition	PS2	1.00

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463020/capcom-updates-its-best-sellers-list-monster-hunter-world-at-209m-re4-remake-at-8m-more/

Enshrouded has received what developers Keen Games are calling the survival game's "most sizable" update yet, sizable being an appropriate word for mountains. Expect a new playable area, the Alabaneve Summits, with its own enemies, resources, non-threatening wildlife and quests. The maximum character level has risen to 35! There are new townsfolk to find and place in your poorly built houses! You can tame animals, and make them live in poorly built houses too! You can get hypothermia!

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Steam's built-in game recording feature has been usable in beta since the summer, but it has now been properly launched for every user, following a client update to Steam yesterday. It's basically another method of capturing funny ragdoll glitches and posting them on the "lol-games-are-dumb" channel of your friend's Discord. Or for posting that flukey knife throw in Call Of Duty to Twitter, as if you really meant to kill the man from across the map all along. Or saving a clip for your personal records, like the footage of that time you yeeted an innocent citizen off the 50-foot wall of a castle town in Dragon's Dogma 2. We all do that, right? Right?

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My strongest and most enduring memory of Grand Theft Auto will always be creasing into complete hysterics watching my mate pile into a crumpled police officer with a wooden baseball bat in GTA 3 after school one time. Young’uns these days just don’t appreciate how revolutionary it was to be able to hit a cop with a thing after he’d already fallen over. Suffice it to say I’ve got good memories of the open world series’ nascent forays into 3D, though never enough to tempt me into revisiting them, especially given the poor reception to Grand Theft Auto: The Trilogy - The Definitive Edition. I can sympathise. I’m annoyed just having to type a semicolon and a dash in the same game name.

If you’re in a similarly non-fussed position (I will never not be annoyed that ‘nonplussed’ doesn’t mean what it sounds like it should mean) I can’t imagine a lighting update that’s been available on the mobile versions for a while is enough to tempt you back. But what is a reporter's job if not pathetically treading water between chunklets of Grand Theft Auto news, upon the publishing of which Graham presses the button to release the nutritious pellets on which we all wholly subsist? I hope he doesn’t read that last sentence. I don’t get my pellet if the syntax becomes too convoluted. Moving swiftly on.

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An updated Android trojan called FakeCall hijacks bank calls. Tech expert Kurt “CyberGuy" Knutsson says Android phone manufacturers and Google need to step up their game on security.

New design facilitates extended graphics card compatibility and customisable options.

The U.S. Food and Drug Administration has published the 2022 Food Code Supplement. The Supplement updates the 2022 Food Code with recommendations from regulatory officials, industry, academia, and consumers at the 2023 Biennial Meeting of the Conference for Food Protection.  The Food Code and its Supplement provide the government and industry with... Continue Reading

Home users can opt in for a single year of updates at $30 per PC—not 3 years.

Other Windows Insider updates include new CPU instructions for Prism x86 emulator.

We spoke to the Conservative MP and former army officer Tom Tugendhat, who served in Iraq and Afghanistan.

Following its announcement a few weeks ago, the final major update for Dead Cells titled The End is Near, version …

Continue reading "Dead Cells’ Final Major Update 35 ‘The End Is Near’ Is Now Available on PC and Consoles, No Word on Mobile Yet"

Back in May, Dysmantle ($9.99) from 10tons Ltd. got its final major content update on Steam. Dysmantle version 1.4.0 titled …

Continue reading "Dysmantle’s Final Major Update Is Now Live on iOS Bringing In Ark Level 4, Night Terrors, Link Towers, and Much More"

Last week, Gameloft announced the next major and free Disney Dreamlight Valley update for PC and consoles alongside Disney Dreamlight …

Continue reading "‘Disney Dreamlight Valley’ Dapper Delights Update Now Available for Apple Arcade, Consoles, and PC"

Following yesterday’s big Disney Dreamlight Valley update on Apple Arcade and other platforms, a few more notable games on Apple’s …

Continue reading "Apple Arcade Weekly Round-Up: New Content and Feature Updates Are Now Live for TMNT Splintered Fate, Temple Run: Legends, Vampire Survivors, Simon’s Cat, and More"

Back in October last year, Feral Interactive announced that cross platform multiplayer was in the works for Company of Heroes …

Continue reading "‘Company of Heroes’ Mobile Multiplayer Beta Announced for Next Week on Android, Full Update Coming to iOS and Switch As Well"

HoYoverse has begun pre-installation for the major Genshin Impact (Free) version 5.0 “Flowers Resplendent on the Sun-Scorched Sojourn" update for …

Continue reading "‘Genshin Impact’ Version 5.0 Update Pre-Installation Now Live, New Trailer Released"

Hello everyone, and welcome to the week! It’s time once again for our look back at the noteworthy updates of …

Continue reading "Best iPhone Game Updates: ‘TMNT Splintered Fate’, ‘Subway Surfers’, ‘Another Eden’, and More"

Usually, updates for premium priced ports on mobile are good to have for optimization or compatibility reasons, but Capcom’s newest …

Continue reading "Capcom Updates ‘Resident Evil 4', ‘Resident Evil Village’, and ‘Resident Evil 7’ on iOS With Online DRM"

JOYCITY has launched an exciting new update for Pirates of the Caribbean: Tides of War, inviting everyone to join in …

Continue reading "‘Pirates of the Caribbean: Tides of War’ Adds Cross-Server Battles in Latest Empire Invasion Update"

Following pre-installation going live earlier in the week, HoYoverse has just released the major Genshin Impact (Free) version 5.0 “Flowers …

Continue reading "‘Genshin Impact’ Version 5.0 Update Is Now Available Worldwide on iOS, Android, PC, PS5, and More"

Yesterday during the Nintendo Indie World Partner Direct whatever it is called for the double feature, Red Nexus Games’ pachinko …

Continue reading "The Huge ‘Peglin’ 1.0 Update Is Now Live on iOS, Android, and Steam Following Switch Launch Yesterday"

This week, Apple Arcade sees a major game update for Apple Vision Pro and a few notable updates. Castle Crumble …

Continue reading "Castle Crumble for Apple Vision Pro Is Now Available on Apple Arcade Alongside Big Updates for Puyo Puyo Puzzle Pop, Crayola Adventures, and More"

HoYoverse’s Honkai Star Rail (Free) version 2.5 update titled “Flying Aureus Shot to Lupine Rue" was just showcased during a …

Continue reading "‘Honkai Star Rail’ Version 2.5 “Flying Aureus Shot to Lupine Rue” Update Releases on September 10th, New Trailer Showcased During Livestream"

Hello everyone, and welcome to the week! It’s time once again for our look back at the noteworthy updates of …

Continue reading "Best iPhone Game Updates: ‘Peglin’, ‘Brawl Stars’, ‘Genshin Impact’, ‘Royal Match’, and More"

Summer holidays might be over, but fans of Gunship Battle: Total Warfare are still in for a treat as Joycity …

Continue reading "‘Gunship Battle: Total Warfare’ Launches Massive Sky Ace Update"

Beginning today, Apple will have released one new Apple Vision Pro game, one App Store Great, and upgrading an App …

Continue reading "NFL Retro Bowl 25, Monster Train+, and Puzzle Sculpt Release Today on Apple Arcade Alongside Major Game Updates This Week"

Company expects to be cash flow positive in the next two quarters.

If you have an iPhone that can run iOS 18, you can now download and install the public beta of iOS 18.2. One of the most useful new features is the capability to share the location of a lost item connected to Apple's Find My network with a third party. You can already share an item's location with people in your contacts list, but Apple says this could help in instances wherein you have to rely on the help of a stranger.

When you choose "Share Item Location" in the Find My app on iPhone, iPad or Mac, you'll get the option to share a link that shows the location of your missing item. The link's recipient will be able to open it on any device, and they'll also be able to see your Apple account email and/or phone number so that they can get in touch with you. You'll be able to see how many people visited the link, which expires after you're reunited with your lost belonging or after a week if you haven't found it by then.

Along with benevolent strangers, you'll be able to share the locations of misplaced AirTags and Find My accessories with select airlines. Apple has worked with several of them to integrate this feature into their systems. Only a small number of airline staff can access each Share Item Location link, and Apple says they'll first need to authenticate themselves with an Apple Account or partner email address.

Apple

More than 15 airlines will start supporting this feature in the coming months, including Aer Lingus, Air Canada, Air New Zealand, Austrian Airlines, British Airways, Brussels Airlines, Delta Air Lines, Eurowings, Iberia, KLM Royal Dutch Airlines, Lufthansa, Qantas, Singapore Airlines, Swiss International Air Lines, Turkish Airlines, United, Virgin Atlantic and Vueling. Apple says that more airlines will get involved over time to help track down mishandled or delayed bags.

Air transport tech company SITA is also incorporating Share Item Location into WorldTracer, its baggage-tracing system. According to Apple, this is used by more than 500 airlines and ground handlers at more than 2,800 airports.

Of course, installing beta software does have its downsides. There's a higher chance of running into bugs, and some apps or features might still not work as Apple had intended. If you don't mind and want to test iOS 18.2, you'll have to enable Beta Updates under Software Updates in your device's Settings menu. Apple is expected to roll out iOS 18.2 proper in December.

Meanwhile, as luck would have it, there's an early Black Friday deal on AirTags at the time of writing. You can scoop up a four-pack for a record low of $70.

Update, November 5 2024, 9:10AM ET: This story has been updated to clarify that these new features are in the developer beta of iOS 18.2. The public beta for that software isn't available just yet.

Update, November 11, 2024, 3:12PM ET: This story has been updated to include details of the airline integration and to note that a public beta of iOS 18.2 is now available.

This article originally appeared on Engadget at https://www.engadget.com/mobile/apples-latest-find-my-update-makes-it-easier-to-find-lost-items-133049512.html?src=rss

This week, I’m rerunning some popular posts while we put the finishing touches on DCI’s new 2024-25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors.

Last week, the Federal Trade Commission (FTC) released the redacted version of administrative complaint against the three largest pharmacy benefit managers (PBMs). The FTC rightly calls out how the gross-to-net bubble can raise patients’ out-of-pocket costs, while also acknowledging how rebates can reduce a plan's (but not the patient’s) costs. Apparently, the FTC believes that PBMs’ customers are pretty dumb, because PBMs are able to prevent plans from “appreciating” such healthcare financing dynamics.

Section V.E. of the complaint (starting on page 23) focuses on the PBMs’ alleged unlawful conduct related to preferring high-list/high-rebate insulin products over versions with lower list prices. I thought it would therefore be fun to take the Wayback Machine to November 2021, when I wrote about this specific topic.

Below, you can review my commentary about the warped incentives behind Viatris’ dual-pricing strategy for its interchangeable biosimilar of Lantus. Much of the FTC’s description of the drug channel aligns with my commentary. But before you fist pump too hard for Ms. Khan’s FTC, you should pause to reflect on the agency’s legal theories in light of plans’ revealed preferences.

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The Food & Drug Administration (FDA) recently approved the first interchangeable biosimilar insulin product: the insulin glargine-yfgn injection from Viatris. Read the FDA’s press release.

Alas, I’m sad to report that the warped incentives baked into the U.S. drug channel will limit the impact of this impressive breakthrough.

Viatris is being forced to launch both a high-priced and a low-priced version of the biosimilar. However, only the high-list/high-rebate, branded version will be available on Express Scripts’ largest commercial formulary. Express Scripts will block both the branded reference product and the lower-priced, unbranded—but also interchangeable—version. Meanwhile, Prime Therapeutics will place both versions on its formularies, leaving the choice up to its plan sponsor clients.

Consequently, many commercial payers will adopt the more expensive product instead of the identical—but cheaper—version. As usual, patients will be the ultimate victims of our current drug pricing system.

Below, I explain the weird economics behind this decision, highlight the negative impact on patients, and speculate on what this all could mean for biosimilars’ future. Until plan sponsors break their addiction to rebates, today’s U.S. drug channel problems will remain.
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Eeek! It's time for Drug Channels’ Halloween roundup of terrifying tales to share with your ghoulish fiends. This month’s tricks and treats:

• Spooky! Blue Shield of California frightens away the gross-to-net bubble with its Humira biosimilar strategy

• Vampiric! Prior authorization sinks its fangs into providers’ time

• Wicked! How the IRA will put a stake through specialty physician practices

• Eerie! Google’s monstrous AI podcasts leave me petrified

• Zoinks! Join the vampire hunters at Drug Channels Institute

Plus, Dr. Glaucomflecken tells us a frightening tale of copayments.

P.S. Stretch out your arms and join the ever-growing zombie horde who shamble after me on LinkedIn. You’ll find my ghostly rantings along with commentary from the undead hordes in the DCI community.
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<p>On 3^&nbsp;June 2024,&nbsp;Resolution&nbsp;RDC No. 876 was published in Brazil in the Official Journal of the Union (DOU)[1],&nbsp;modifying the current regulations regarding the post-registration of biological products (RDC 413/2020).</p>