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Unorthodox Parenteral {beta}-Lactam and {beta}-Lactamase Inhibitor Combinations: Flouting Antimicrobial Stewardship and Compromising Patient Care [Commentary]

In India and China, indigenous drug manufacturers market arbitrarily combined parenteral β-lactam and β-lactamase inhibitors (BL-BLIs). In these fixed-dose combinations, sulbactam or tazobactam is indiscriminately combined with parenteral cephalosporins, with BLI doses kept in ratios similar to those for the approved BL-BLIs. Such combinations have been introduced into clinical practice without mandatory drug development studies involving pharmacokinetic/pharmacodynamic, safety, and efficacy assessments being undertaken. Such unorthodox combinations compromise clinical outcomes and also potentially contribute to resistance development.




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Assessment of Apparent Internal Carotid Tandem Occlusion on High-Resolution Vessel Wall Imaging: Comparison with Digital Subtraction Angiography [EXTRACRANIAL VASCULAR]

BACKGROUND AND PURPOSE:

Not all tandem occlusions diagnosed on traditional vascular imaging modalities, such as MRA, represent actual complete ICA occlusion. This study aimed to explore the utility of high-resolution vessel wall imaging in identifying true ICA tandem occlusions and screening patients for their suitability for endovascular recanalization.

MATERIALS AND METHODS:

Patients with no signal in the ICA on MRA were retrospectively reviewed. Two neuroradiologists independently reviewed their high-resolution vessel wall images to assess whether there were true tandem occlusions and categorized all cases into intracranial ICA occlusion, extracranial ICA occlusion, tandem occlusion, or near-occlusion. DSA classified patient images into the same 4 categories, which were used as the comparison with high-resolution vessel wall imaging. The suitability for recanalization of occluded vessels was evaluated on high-resolution vessel wall imaging compared with DSA.

RESULTS:

Forty-five patients with no ICA signal on MRA who had available high-resolution vessel wall imaging and DSA images were included. Among the 34 patients (34/45, 75.6%) with tandem occlusions on DSA, 18 cases also showed tandem occlusions on high-resolution vessel wall imaging. The remaining 16 patients, intracranial ICA, extracranial ICA occlusions and near-occlusions were found in 2, 6, and 8 patients, respectively, on the basis of high-resolution vessel wall imaging. A total of 20 cases (20/45, 44.4%) were considered suitable for recanalization on the basis of both DSA and high-resolution vessel wall imaging. Among the 25 patients deemed unsuitable for recanalization by DSA, 11 were deemed suitable for recanalization by high-resolution vessel wall imaging.

CONCLUSIONS:

High-resolution vessel wall imaging could allow identification of true ICA tandem occlusion in patients with an absence of signal on MRA. Findings on high-resolution vessel wall imaging can be used to screen more suitable candidates for recanalization therapy.




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Parenting Tips: जिद्दी बच्चे को समझदार बनाने के लिए अपनाएं ये तरीके

मां-बाप अपने बच्चों की खुशियों के लिए कई तरह के छोटे बड़े त्याग करते रहते हैं। बच्चों की हर जिद्द पूरी करते हैं। ऐसे में बच्चे ज्यादा जिद्दी होते जाते हैं।




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'Terrible twos' not inevitable: With engaged parenting, happy babies can become happy toddlers

Parents should not feel pressured to make their young children undertake structured learning or achieve specific tasks, particularly during lockdown. A new study of children under the age of two has found that parents who take a more flexible approach to their child's learning can - for children who were easy babies - minimize behavioral problems during toddlerhood.




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Lori Loughlin, other parents lose bid to dismiss U.S. college scam charges

A federal judge on Friday declined to dismiss the charges against "Full House" actress Lori Loughlin and other wealthy parents awaiting trial in the U.S. college admissions scandal after they accused investigators of fabricating evidence.




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Welcoming a newborn in a pandemic proves bittersweet for new parents

“It’s like life is on hold — everything is on hold,” one new mother said.




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Parents of NHS nurse from New Zealand who treated Boris Johnson 'exceptionally proud' of daughter

Follow our live updates here Coronavirus: the symptoms




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Prince Harry chats to 'super-parents' of seriously ill children during 30-minute video call for WellChild charity

Read our live coronavirus updates HERE




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Parents challenged over 70-mile trip to beach during coronavirus lockdown said children needed 'change of air'

A group of parents who were challenged by police over a trip to the beach during the coronavirus lockdown claimed their children needed a "change of air".




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Parents' joy as three-week-old baby recovers from coronavirus

A three-week-old girl has recovered from coronavirus to the delight of her parents.




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David Walliams in new campaign to help parents teach children IT skills at home




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Parents told not to feel guilty if they stray from school timetable

Parents of young children should stop trying to follow a strict nursery routine during lockdown and allow them to use technology, the head of a group of London preschools said.




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Switzerland lets children under 10 to visit grandparents as they 'can't pass on coronavirus'




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Parents warned to look out for signs of online radicalisation during coronavirus lockdown

Parents, relatives and friends were today urged to raise the alarm if they fear that children are being radicalised during the lockdown as the Met warned that tip-offs about suspected extremists have plummeted.




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Parents of Harry Dunn urge Dominic Raab to concede position on suspected killer's diplomatic immunity

Teenager's parents criticise Foreign Secretary Dominic Raab's comments on son's death as "misleading"




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Parents urged to remain vigilant as nearly 100 children are targeted by predators online in first month of lockdown

Nearly 100 children who were being targeted online by child abusers were saved by police in London during the first four weeks of the lockdown, Scotland Yard revealed today.




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Most parents don't want to send children back to school immediately after coronavirus lockdown lifts, survey shows

Most parents don't want to send their children back to school as soon as the coronavirus lockdown is lifted, a new study has found.




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Five-year-old boy found driving parents' car on highway gets free ride in Lamborghini from kind stranger

A five-year-old boy who was caught behind the wheel of his parents' car "driving to California to buy a Lamborghini" has been given a ride in his dream car by a kind stranger.




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The Tie That Binds These Grandparents In Isolation? TikTok

NPR's reporter in Nairobi finds his parents connecting with his kids through TikTok. Formerly the realm of Gen Z, the app's now a family board game where Grandma and Grandpa reveal their silly selves.





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Both my parents are doctors and got coronavirus. I've never been so scared

Some weeks ago my main worries were around my GCSEs. Now I hear every day about deaths from Covid-19

It is the sixth week of lockdown, and for many people things are getting progressively more intense. Most families are physically distancing at home. People are only leaving the house for their weekly shop – and spending a lot of that time waiting in the queue – or to exercise once a day.

In my family things are a bit different. Our driveway is usually empty during the day as my parents, who are doctors, go in to work. It is difficult to imagine how only some weeks ago my main worries were around my GCSEs. Now every day, I hear about deaths from coronavirus. I cannot help but feel a surge of fear for my parents as I watch these updates with my brother. I’m painfully aware of the many healthcare workers who have lost their lives.

Continue reading...




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Tips for home-schooling parents during a pandemic: First, trust yourself and teachers.

We shouldn't expect a normal level of learning right now and teachers are prepared to catch kids up this fall. Their message to parents: Leave it to us.

      




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Robert Jenrick defends coronavirus lockdown breach allegations after visiting his parents

Coronavirus: the symptoms Follow our live coronavirus updates here Who is Robert Jenrick?




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Jeffrey Tambor apologises again about Transparent sexual harassment allegations

'Never, ever, ever, ever intended to make anyone feel uncomfortable – ever. It's just not who I am'




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Stranger Things star Maya Hawke thinks her parents' generation 'really f***ed us over'

Actor also spoke about how she feels the traditional image of the Hollywood movie star has faded in recent years




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Pandemic nesters: what it's like to move back with your parents during lockdown

Some people have found returning to the family home a blessing, but for others it has been anything but smooth sailing

Covid-19 has reshaped geographic boundaries. It has left many financially distressed. Expatriates have returned from overseas for indefinite periods of time, and vulnerable people require more help than usual. For all these reasons, and many more, adult children have found themselves doing something that might previously have been unthinkable: moving back in with their parents.

Some are finding the experience transformative. One woman, who left New York for her parent’s rural home, told me that the space and country air have made her reconsider whether she will ever return to the city. But there are also downsides. “I’m craving male attention more than I ever have before,” she confessed. When flirting over apps stopped cutting it, she wound up ordering a vibrator in an unmarked box, and fended off her younger siblings in order to retrieve it from the mailbox.

Continue reading...




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Mark Strong: Growing up without a father has made me take parenthood 'really seriously'

The actor's father left the family home shortly after he was born




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Giovanna Fletcher on parenting during lockdown and her candid interview with the Duchess of Cambridge

Happy Mum, Happy Baby's Giovanna Fletcher on how she's keeping three boys under six entertained during lockdown and her anxiety about the now-famous interview with the Duchess of Cambridge




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Divorce, solo parenting and crowded flatshares: 5 tales of self-isolation around the capital

From the now-trapped together couple who had just decided to divorce, to a cramped houseshare of ten people... Londoners on their new lockdown lives




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Peppy: the health app connecting anxious new parents with specialists in new NHS initiative

New parent looking for some health support? Peppy is on hand to help




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How does coronavirus affect newborns and what guidelines are in place for new parents?

As Carrie Symonds and Boris Johnson welcome a baby boy just one month after the Prime Minister was diagnosed with COVID-19, we examine what to do if you have a new baby in the time of coronavirus




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Apps for parents: track feeding times and connect with other parents with these smart apps

Log on to lockdown lifelines for parents




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Your ultimate guide to parenting in lockdown by the Scummy Mummies

Ellie Gibson and Helen Thorn from Scummy Mummies podcast give us their sage - and realistic - advice...




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Down’s Syndrome student wins compensation after school sent letter to parents detailing violent behaviour



  • topics:things/primary-education
  • structure:news
  • topics:organisations/high-court
  • topics:things/non-coronavirus-stories
  • structure:news/uk-news
  • storytype:standard

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Planned Parenthood Exits Federal Family Planning Program Over Abortion Gag Rule

Planned Parenthood is leaving the federal government’s Title X program, which funds family planning services for low-income people, due to...




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Working parents are struggling to take care of themselves. Here's how we can fix that

Two-thirds of working mums and dads are struggling to look after themselves physically and mentally, according to a new report. The findings are pretty depressing. But what can parents actually do about it?




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‘You’re the worst parent’

UK TV host Piers Morgan tore into the mother who sent another mum a bill for damage to her daughter’s expensive shoes — reducing her to tears.




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White House Apparently Not Following Social Distancing Rules



Trump Administration not sticking to its own order.




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Noggin Hosts Special To Help Parents Manage COVID Issues



It's called 'Navigating the New Normal: Parents Edition.'




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Google, Facebook offer paid leave to parents amid coronavirus school closures

The Silicon Valley giants have often led the field in employee benefits—but the new policy doesn't extend to contract workers




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Many parents of young children will be in greater debt after pandemic – report

Half of parents with young children will struggle to make ends meet in the next three months, study suggests.




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'My child won't be a lab rat!': Danish parents threaten to boycott end of school lockdown

Parents say there are too many unknowns about COVID-19 for it to be safe to expose their children to the risk of contagion.




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Not all teachers and parents are happy about a return to ACT schools amid coronavirus

The ACT Education Minister's decision to cut short remote learning in favour of returning students to class has caught many parents and teachers off-guard, with some calling the decision "deeply disappointing and stupid".




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Parents’ plea for SA man facing death

THE parents of an Adelaide man who may face the death penalty after being arrested for allegedly selling drugs in the Philippines have issued a plea for help to save their son.




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Anderson Cooper is co-parenting baby Wyatt with a former partner

Anderson Cooper says he and ex-partner Benjamin Maisani are not back together, but they will co-parent new baby Wyatt Morgan Cooper.




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Attorney General Holder, Secretary Duncan Meet with Youth Leaders, Parents on Teen Dating Violence

“We must engage the broadest spectrum of community partners in order to stem youth violence, and a cornerstone of that partnership is young people themselves,” said Attorney General Holder. “The Department of Justice is committed to working with young people to develop innovative solutions to help prevent teen dating abuse.”



  • OPA Press Releases

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Parent Company of Two New Jersey Hospitals to Pay U.S. $7.95 Million to Settle False Claims Act Allegations

Our Lady of Lourdes Health Care Services Inc., the parent company of two New Jersey hospitals, has agreed to pay the United States $7.95 million to resolve allegations that the hospitals defrauded Medicare.



  • OPA Press Releases

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Wife of Convicted Felon Thomas Parenteau Sentenced in Ohio to 33 Months in Prison for Money Laundering Conspiracy

Marsha Parenteau of Dublin, Ohio, has been sentenced for conspiring to commit money laundering, the Justice Department and Internal Revenue Service (IRS) announced.



  • OPA Press Releases

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Justice Department Files Lawsuit Against Maryland Man for FACE Act Violation at a Planned Parenthood

The Justice Department today filed a civil complaint in the U.S. District Court for the District of Columbia against Richard Retta for violating the Freedom of Access to Clinic Entrances Act (FACE Act).



  • OPA Press Releases

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Man Pleads Guilty to Civil Rights Violations in Connection with Arson at Planned Parenthood and Vandalism of Mosque in Madera, California

Donny Eugene Mower of Madera, Calif., pleaded guilty in federal court today to one count of arson, one count of damaging religious property and one count of violating the Freedom of Access to Clinic Entrances (FACE) Act.



  • OPA Press Releases