A doctor leaves the calm of home to work in the charged atmosphere of the hospital where sober conversations abound about the possibility of being overrun with COVID-19 cases.

The Kings' rebuilding phase is underway and includes some former-player reunions like Saturday, when two generations of Kings players were on display

Hollywood is eager to get back to work after the coronavirus outbreak, but union officials, studio executives and others must first agree on new protocols to make filming safe again.

"If I wanna party, it's a party of one," Mick Jagger sings on the Rolling Stones' "Living in a Ghost Town," surprise-released on Thursday amid the COVID-19 pandemic.

TESCO, Asda, Sainsbury's and Waitrose customers are among those being warned of an urgent product recall, because an item which has been sold by the aforementioned retailers is at risk of potentially containing small pieces of metal.

Celtic legend Chris Sutton has bitten back Robbie Savage on Twitter, as the Hoops finished the week top of the Scottish Premiership table, after Rangers’ 1-1 draw against Hearts.

MICHAEL COLLINS made a candid confession over his role in the Moon landings after 50 years, admitting he "had some regrets" about the way things played out.

TESCO, Asda, Sainsbury's and Waitrose customers are among those being warned of an urgent product recall, because an item which has been sold by the aforementioned retailers is at risk of potentially containing small pieces of metal.

Danville senior Ella Collier is Hendricks County's all-time leading scorer. And it didn't happen by accident.

Indiana Congressman Trey Hollingsworth says it's a false choice between accepting widespread casualties or reopening the economy.

Michael Jordan spent the spring of 1984 in Bloomington before he became Michael Jordan

These restaurants are turning Indiana's ban on dining in restaurants to their favor by throwing back to olden days with drive-up service.

IndyStar went inside IU Health Methodist Hospital for an exclusive look at its COVID-19 units in the midst of the coronavirus pandemic.

The fire broke out shortly after 2 a.m. in medium brush between Gaviota State Beach and the Hollister Ranch guard gate.

Montreal Police are investigating the cause of the collision but say the car driver is in critical condition.

A 16-year-old boy suffers life-threatening injuries in an apparent double hit-and-run, police say.

The human MASTL (Microtubule-associated serine/threonine kinase-like) gene encodes an essential protein in the cell cycle. MASTL is a key factor preventing early dephosphorylation of M-phase targets of Cdk1/CycB. Little is known about the mechanism of MASTL activation and regulation. MASTL contains a non-conserved insertion of 550 residues within its activation loop, splitting the kinase domain, and making it unique. Here, we show that this non-conserved middle region (NCMR) of the protein is crucial for target specificity and activity. We performed a phosphoproteomic assay with different MASTL constructs identifying key phosphorylation sites for its activation and determining whether they arise from autophosphorylation or exogenous kinases, thus generating an activation model. Hydrogen/deuterium exchange data complements this analysis revealing that the C-lobe in full-length MASTL forms a stable structure, whereas the N-lobe is dynamic and the NCMR and C-tail contain few localized regions with higher-order structure. Our results indicate that truncated versions of MASTL conserving a cryptic C-Lobe in the NCMR, display catalytic activity and different targets, thus establishing a possible link with truncated mutations observed in cancer-related databases.

There has been an outpouring of grief following the death of legendary Jamaican singer Millicent Dolly May Small, popularly known as Millie Small. She died in the United Kingdom today at the age of 73 after suffering a stroke. The voice...

The second round of results from the ADA Health Policy Institute poll on the impact of COVID-19 on dental practices showed significant financial impact, with collections for the vast majority of dentists less than 5% of what is typical in their practice.

The third round of results from the ADA Health Policy Institute poll on the impact of COVID-19 on dental practices was released April 27, with 79% of dentists reporting their practices are closed except for emergencies and 17% are closed completely.

One hundred forty-three years ago, women's suffrage advocate Elizabeth Cady Stanton faced a conundrum: With the Civil War over, Stanton had to decide whether to support the 14th and 15th amendments to the Constitution, which enabled black men to vote -- at a time when white women such as herself...

Before the coronavirus pandemic, bioengineer Jim Collins and his team combined the power of AI with synthetic biology in an effort to combat a different looming crisis: antibiotic-resistant superbugs. Collins explains how they pivoted their efforts to begin developing a series of tools and antiviral compounds to help fight COVID-19 -- and shares their plan to discover seven new classes of antibiotics over the next seven years. (This ambitious plan is a part of The Audacious Project, TED's initiative to inspire and fund global change.)

A read of California's news outlets makes clear that the state is not going to accept President-elect Donald Trump's policies without a fight, particularly those on immigration.

Bookbinders -- Fiction.

Women -- South Australia -- Biography.

Stuttgart : Enke, 1896.

Jena : H. Dufft, 1876.

Viennæ : Typis Christiani Friderici Wappler, 1788-92.

Wien : A. Pichlers Witwe, 1904.

In a case implicating the use of schools as voting locations as well as free speech in education, the justices said Minnesota went too far.

Rockville, Maryland : National Institute on Drug Abuse, 1986.

The superior colliculus (SC) is arguably the most important visual structure in the mouse brain and is well known for its involvement in innate responses to visual threats and prey items. In other species, the SC plays a central role in voluntary as well as innate visual functions, including crucial contributions to selective attention and perceptual decision-making. In the mouse, the possible role of the SC in voluntary visual choice behaviors has not been established. Here, we demonstrate that the mouse SC of both sexes plays a causal role in visual perceptual decision-making by transiently inhibiting SC activity during an orientation change detection task. First, unilateral SC inhibition-induced spatially specific deficits in detection. Hit rates were reduced, and reaction times increased for orientation changes in the contralateral but not ipsilateral visual field. Second, the deficits caused by SC inhibition were specific to a temporal epoch coincident with early visual burst responses in the SC. Inhibiting SC during this 100-ms period caused a contralateral detection deficit, whereas inhibition immediately before or after did not. Third, SC inhibition reduced visual detection sensitivity. Psychometric analysis revealed that inhibiting SC visual activity significantly increased detection thresholds for contralateral orientation changes. In addition, effects on detection thresholds and lapse rates caused by SC inhibition were larger in the presence of a competing visual stimulus, indicating a role for the mouse SC in visual target selection. Together, our results demonstrate that the mouse SC is necessary for the normal performance of voluntary visual choice behaviors.

SIGNIFICANCE STATEMENT The mouse superior colliculus (SC) has become a popular model for studying the circuit organization and development of the visual system. Although the SC is a fundamental component of the visual pathways in mice, its role in visual perceptual decision-making is not clear. By investigating how temporally precise SC inhibition influenced behavioral performance during a visually guided orientation change detection task, we identified a 100-ms temporal epoch of SC visual activity that is crucial for the ability of mice to detect behaviorally relevant visual changes. In addition, we found that SC inhibition also caused deficits in visual target selection. Thus, our findings highlight the importance of the SC for visual perceptual choice behavior in the mouse.

What do cucumbers, mustard, almonds and alfalfa have in common? On the surface it appears to be very little. However, there is one thing they do share: They all owe their existence to the service of bees. There is more to the tiny striped helper than sweet honey and a painful sting. For millennia, it has carried out its service [...]

“It’s a bee!” someone screams as they jump up from their picnic blanket, knocking over their apple juice and flailing their arms, trying to get away from this flying creature. Does this scene sound familiar?  

A 17-year-old boy from Riverview, N.B., has died after the small motorbike he was riding collided with a minivan in Lower Coverdale, a settlement southeast of Moncton. 

Spring has arrived. While some of us may have an opportunity to carefully step outside and view blossoms in our own neighborhood, others may not. Wherever you are, you can take a virtual stroll among the shoots and blossoms planted among the collections of the Prints & Photographs Division. Many images of gardens can be […]

Application deadline: 17 May 2020 | Banking Settlements Centre | Location: Basel, Switzerland

Remarks by Mr Olli Rehn, Governor of the Bank of Finland, at the Reinventing Bretton Woods Committee Panel Discussion on "The world economy transformed: Reflections on policy responses and the future post pandemic monetary architecture", in the context of the virtual IMF Spring Meetings, Washington DC, 17 April 2020.

OPP are investigating a fatal crash that took place in Lakeshore Thursday night.

During the OM's Ride 2 Transform 2017 cycle tour, 17 cyclists biked 550 kilometres around southern Malawi, distributing AudioBibles and praying.

In conjunction with the soft launch, Apple uploaded 10 YouTube videos that explain how consumers can apply for the credit card and use it. Sign up in the iPhone's Wallet app.

The Rolling Stones have released their first new song in eight years. Unlike everything else they've done in the last three decades, it's bang up to date. It even references the coronavirus crisis.

Many studies have demonstrated that the built environment is related to both collision risk and walking to school. However, little research examines the influence of the built environment on the relationship between walking to school and pedestrian collision risk.

Increased walking was not associated with increased pedestrian collision once the effects of the built environment and socioeconomic status were modeled. Safety was related primarily to the built environment and specifically features related to road crossing. (Read the full article)

Recent concussion research has examined the role of impact location (ie, the area on the head to which impact occurred); however, no studies exist regarding impact location’s association with concussion outcomes (eg, symptomatology, symptom resolution time, return to play).

This study is the first to examine the association of impact location and concussion outcomes in young athletes. Our findings suggest that impact location, as assessed by sideline observers/player report, is likely of little use in predicting clinical outcomes. (Read the full article)

Source: www.reuters.com - Saturday, May 09, 2020
Little Richard, the self-proclaimed "architect of rock 'n' roll" who built his ground-breaking sound with a boiling blend of boogie-woogie, rhythm and blues and gospel, died on Saturday at the age of 87, Rolling Stone magazine reported.