Systemic study of pathogenic pathways and interrelationships underlying genes associated with Alzheimer's disease (AD) facilitates the identification of new targets for effective treatments. Recently available large-scale multiomics datasets provide opportunities to use computational approaches for such studies. Here, we devised a novel disease gene identification (digID) computational framework that consists of a semi-supervised deep learning classifier to predict AD-associated genes and a protein–protein interaction (PPI) network-based analysis to prioritize the importance of these predicted genes in AD. digID predicted 1,529 AD-associated genes and revealed potentially new AD molecular mechanisms and therapeutic targets including GNAI1 and GNB1, two G-protein subunits that regulate cell signaling, and KNG1, an upstream modulator of CDC42 small G-protein signaling and mediator of inflammation and candidate coregulator of amyloid precursor protein (APP). Analysis of mRNA expression validated their dysregulation in AD brains but further revealed the significant spatial patterns in different brain regions as well as among different subregions of the frontal cortex and hippocampi. Super-resolution STochastic Optical Reconstruction Microscopy (STORM) further demonstrated their subcellular colocalization and molecular interactions with APP in a transgenic mouse model of both sexes with AD-like mutations. These studies support the predictions made by digID while highlighting the importance of concurrent biological validation of computationally identified gene clusters as potential new AD therapeutic targets.

Why the American Ingenuity Award winner believes higher education should be a basic human right

Some educators are giving history classes new relevance by teaching students to be junior historians: offering engaging entry points into Canada's past and inspiring connections to the world today.

Sir Richard Branson, Jeff Ray, Jon Hirschtick, and World-Class Companies to Shine at World’s Largest Annual SolidWorks Gathering

Expanded 3D CAD curriculum gives instructors more time for individual instruction and special projects

OMers work with a Hungarian church to invest in relationships through every season.

Paul and Vivienne, volunteers from the UK, recently visited a centre for asylum seekers in one of Sweden’s large cities and share about their experiences.

Fazeen is a graduate of OM's training programme, through which God changed her life's perspective and direction.

Long-term worker teaches Transform seminar about loving Muslim women, encouraging two participants to deepen relationships with Muslim friends back home.

New sheets outlines how districts can support English-learner students, but concedes that "schools may not be able to provide all services in the same manner they are typically provided."

Native-language assessments may more fully reflect what English-language learners know and can do academically after months away from school. But not all states offer them.

Would measurement approaches based on "learning growth" resolve some of the concerns over NCLB?

Should school time be expanded to accommodate new demands? And if so, How?

A more deliberate approach to curriculum, instruction, assessment, and teacher professional development this fall could mean a better experience for students; the lack of one could turn equity gaps into chasms.

The strategy of reinforcing good behavior with praise is the least likely to be taught in teacher-prep programs, an analysis finds.

Support for in-person teaching is rising, but hybrid approaches to instruction remain the most popular, an EdWeek Research Center survey finds.

A pair of multidisciplinary faculty members at Penn State Shenango received an Advancing Equity and Inclusion Grant from the Schreyer Institute for Teaching Excellence to help fund a series of four online workshops focused on project-based learning. 

High-quality professional learning is difficult to provide in education, principal Jasmine Kullar writes. Here's a solution.

Teaching and Learning with Technology (TLT), part of Penn State University Libraries, has announced the Teaching and Learning Technologies Faculty Advisory Committee for the 2024-25 academic year. The committee is pivotal in guiding TLT on integrating technology within teaching and learning at Penn State.

Linda M. Gojak and Sara Delano Moore, two of the co-authors of "Visible Learning For Mathematics: What Works Best to Optimize Student Learning", agreed to answer a few questions about the book.

Keisha Oliver, who is pursuing a dual-title doctoral degree in art education and African American and diaspora studies, was named a fall 2024 artist-in-residence at the Penn State College of Engineering’s Learning Factory.

As teacher strikes sweep the nation, Marc Tucker compares the trajectory of teaching to that of the nursing profession, one of high standards of entry and rigorous preparation.

Public libraries are moving deeper into digital learning, often in partnership with schools and other institutions, to help prepare students for the skills they'll need for college and careers.

U.S. Department of Education money will help public television develop projects promoting math and literacy for children ages 2 to 8.

Summer programs that use multimedia may improve student literacy, numeracy, phonics skills, and math vocabulary, according to a study released by WestEd, a nonprofit education research organization. The report examines the Electric Company's Summer Learning Program, which is sponsored by the Sesame

Leaders at DREAM's REAL Kid's New York summer academic and baseball program decided early on to move the program online. To do that, they relied on their core principle: the value of being on a team.

Penn State Berks took learning out of the classroom in early October when 14 students, faculty and staff visited "Field of Screams," a haunted Halloween attraction in Lancaster, Pennsylvania. The event was organized as an experiential learning activity for humanities, arts and social sciences courses (such as "Rhetoric of American Horror Films" and "Transformative Texts") that deal with topics related to horror and monstrosity within popular cultural texts. 

Erna Neufeld teaches sewing skills and shares the Gospel with women in a small Albanian town.

When it comes to parenting students with learning differences, every family's experience is unique. And that reality has never been more true than it is now as millions of students are out of school due to the coronavirus pandemic.

Nearly 30 disability rights and education advocacy organizations have launched a new resource hub and online network designed to help special educators during the coronavirus crisis.

A new digital guide aims to identify students missing out on special education services and supports during distance learning.

The strategy of reinforcing good behavior with praise is the least likely to be taught in teacher-prep programs, an analysis finds.

Mica Pollack and her colleagues from UCSD share new research about the importance of teachers in blended learning environments that highlights the strengths and limits of online tools.

Innovative professional development initiatives infuse technology with in-person learning to enhance learning experiences for teachers.

We talk a lot about blended learning opportunities in my district, asking ourselves whether we are offering the most beneficial learning opportunities for both staff and students. We're looking to provide quality online learning resources to students when they are outside of our classrooms, as well

The new "question-of-the-week" is:

Computer programs may help predict students' grades in school as well as determine successful pathways for completing assignments, finds a new Stanford University study.

Using online editing sessions does not affect student scores on standardized writing and reading exams, according to a forthcoming study.

Even great innovations can fail. Will blended learning be one of them? These five factors may help us determine if the new educational model has reached a tipping point.

Modern classrooms are slowly taking a new approach to imparting wisdom and knowledge to the upcoming generation. Traditional classroom teaching techniques are giving way to a new system of blended learning.

Technology-enhanced instruction can make learning personalized, student-centered, and available anytime, anywhere.

Quiz yourself: How much do you know about how educators are navigating hybrid instruction and planning content for in-person and remote instruction?

To avoid the frustrations and mistakes of last spring, see our tips, checklists, best practices, and expert advice on how to make teaching and learning at home engaging, productive, and equitable.

A more deliberate approach to curriculum, instruction, assessment, and teacher professional development this fall could mean a better experience for students; the lack of one could turn equity gaps into chasms.

Four educators share their experiences of blended learning. They suggest elements needed to make it work in remote teaching such as emphasizing relationship-building and minimizing the number of online tools.

Three educators share how they are adapting the principles of "blended learning" to the COVID-19 environment, including through involving community members and using a "flipped" classroom.

Penn State’s Teaching and Learning with Technology (TLT), part of Penn State University Libraries, has welcomed five University instructors across three campuses into its Faculty Fellows cohort for 2024-26 and started collaborating on a new collection of projects. Faculty chosen for the Faculty Fellows program team up with TLT on innovative technology projects, with past endeavors spanning a broad spectrum from learning spaces to virtual reality/immersive experiences to data-empowered learning.

A long-term worker shares how learning Arabic has impacted her life and friendships in the Arabian Peninsula.