isa Big Tech opposes temporary blocking of H-1B guest worker visas because it wants to give your childrens’ jobs to cheap foreign labor By www.cpa-connecticut.com Published On :: Thu, 02 Jul 2020 14:56:08 +0000 So Apple isn't fighting for diversity. They're doing exactly what they appear to be doing: they're trying to keep wages down and keep their workers compliant by importing labor from abroad.This isn't about diversity. It's about exploitation. It always is Continue reading → Full Article Accountants CPA Hartford Articles Amazon Apple Apple's CEO Big Tech Big Tech opposes temporary blocking of H-1B guest worker visas because it wants to give your childrens' jobs to cheap foreign labor blocking guest worker visas cheap foreign labor diversity Donald Trump exploitation Google H-1B guest worker visas http://cpa-connecticut.com/barefootaccountant/big-tech-opposes-temporary-blocking-of-h-1b-guest-worker-visas-because-it-wants-to-give-your-childrens-jobs-to-cheap-foreign-labor/ India Silicon Valley STEM Tim Cook Tucker Carlson Tonight July 1 2020
isa All-time reaction to coaching ‘disaster’; Steph’s stunning clutch moment: NBA Wrap - Fox Sports By news.google.com Published On :: Wed, 13 Nov 2024 07:12:35 GMT All-time reaction to coaching ‘disaster’; Steph’s stunning clutch moment: NBA Wrap Fox SportsBike rides and Balkan music: Klay Thompson is embracing a fresh start with the Mavericks ESPN Australia10 unforgettable Klay Thompson moments with Warriors ahead of return NBA.comDub Hub: Warriors players share ‘welcome back’ messages for Klay Thompson’s return Golden State of Mind Full Article
isa NYT Spelling Bee: an archive of disallowed BrE words By separatedbyacommonlanguage.blogspot.com Published On :: Tue, 11 Apr 2023 00:34:00 +0000 Twitter has been my main internet stomping ground since 2009, but I've been withdrawing my labo(u)r from it since October, when it became much more volatile for some reason. The New York Times Spelling Bee has been my morning-coffee activity for some of those years, and since November 2020 I've been jokingly tweeting the BrE words that it hasn't accepted. These go in a thread of posts that always start: Perfectly Common BrE Words the @NYTimesGames Spelling Bee Has Denied Me: An Occasional SeriesTwitter has really degraded this week, which is making me feel a bit sad that perhaps that thread will have to die. (I'm also sad that the thread has frayed along the way—it's very difficult to read it all the way to the beginning because it splits here and there.) So as a clearly procrastinatory measure, I'm putting the list of "perfectly common BrE words" here, with a little more explanation than they tended to get on Twitter.For those who don't know the Bee: it's an anagram game where one must use the middle letter. The twist—and what makes it a superior anagram game—is that you can use any of the letters as many times as you like. Here's what it looked like on the 5th of April when I hadn't yet got to Genius level. (My goal every day is 'make it to Genius before breakfast'. It's nice to be called 'Genius' before you've started work.) The game, of course, has its own word list, which is suitably American for its New York Times home. Still, some not-usually-AmE words are playable, like FLATMATE, LORRY and PRAM. But many words that are part of my everyday vocabulary in England are not playable. And non-AmE spellings are generally not playable. There's been a lot of attention to AmE words that (orig. AmE) stump non-American players in Wordle. (Here's Cambridge Dictionary's 2022 Word of the Year post, which covers some—and includes a video in which I talk about why HOMER was a great choice for Word of the Year.) Not as much attention has been paid to the Spelling Bee, which you need to subscribe to. I'm sure British players have their own (mental) lists of American words they've had to learn in order to get "Queen Bee" status (finding all the day's words) in the game. If you're one of them, do use the comments to tell us about those weird words.So, after all that preamble, here are the "Perfectly Common BrE Words the @NYTimesGames Spelling Bee Has Denied Me" words in alphabetical order, with translations or links to other blog posts. But first, a bit more preamble. The disclaimers! Words in the puzzle must be at least four letters long, so some of these are suffixed forms for which the three-letter base word was unplayable. If there's an -ED form but not an -ING form (etc.), that'll be because the other one's letters weren't in the puzzle. Some of these would not have been allowable—regardless of their dialectal provenance—on the basis that they are "naughty" words. I include them anyway. I have checked questionable cases against the GloWbE corpus to ensure that the word really is more common in BrE than AmE.Some are Irish or Australian by origin, but they are still more common in BrE than in AmE.Sometimes my spelling is a bit liberal here. If I could find one British dictionary that allowed me the word with the given spelling, I included it. Also the phrase "perfectly common" is not meant to be taken too seriously!These words were not playable at the time when I tried to play them. The word list may have changed and some of them may be playable now. Red ones are ones that have been unsuccessfully played/tweeted about since I first started this blog list. Green ones have been added to the blog since the original post, but were tweeted-about earlier than that—I just missed them in the tangled Twitter threads when I was writing the blog post. ABATTOIR AmE slaughterhouseAGGRO aggression, aggressive behavio[u]rAITCH the letter. Less need to spell it as a word in AmE. See this old post.ANAEMIA / ANAEMIC AmE anemia/anemicANNEXE minority spelling in BrE; usually, as in AmE, it's annexAPNOEA AmE apneaAPPAL AmE appall; old post on double LsARDOUR old post on -or/-ourARGYBARGY this is a bit of a joke entry because it's usually spelled/spelt ARGY-BARGY (a loud argument), but the Squeeze album has no hyphen. ARMOUR -or/-ourBALLACHE something annoying or tedious (usually hyphenated, but some dictionaries include the closed-up version)BIBBED I don't know why this shows up more in BrE data, but it does, just meaning 'wearing a bib'BINMAN / BINMEN AmE garbage man (among other terms); old post on binBINT derogatory term for a womanBITTY having lots of unconnected parts, often leaving one feeling unsatisfied; for example, this blog post is a bit bittyBLAG covered in this old postBLUB / BLUBBING to sob (= general English blubbering)BOAK retch, vomit, throw up a bit in the mouth. That was gross. Sorry.BOBBLY having bobbles BOBBY I think this one might be playable now. Informal term for police officer. In AmE, found in bobby pins. BODGE / BODGED make or fix something badlyBOFFIN see this old postBOLLOCK / BOLLOCKED reprimand severelyBOLLOX This one's more common in Irish English than BrE. To screw something up.BOKE see BOAK BONCE the head (informal)BOYO a boy/man (Welsh informal)BRILL short for brilliant, meaning 'excellent'; also a kind of European flatfishBROLLY umbrella (informal)BUNG / BUNGING to put (something) (somewhere) quickly/carelessly. People cooking on television are always bunging things in the oven. BUTTY see this old postCAFF a café, but typically used of the kind that is analogous to an AmE diner (that is to say a café is not as fancy in BrE as it would be in AmE)CAWL a soupy Welsh dish (recipe); also a kind of basketCEILIDH a Scottish social dance (event)CHANNELLED post on double LsCHAPPIE a chap (man)CHAV / CHAVVY see this old post and/or this oneCHICANE a road arrangement meant to slow drivers down; see this old postCHILLI see this old postCHIMENEA / CHIMINEA the 'e' spelling is considered etymologically "correct" but the 'i' spelling seems to be more common in UK; I think these kinds of outdoor fireplaces are just more trendy in UK than in US?CHIPPIE alternative spelling of chippy, informal for a (fish and) chip shop"cholla" at a UK online supermarketCHOC chocolate (informal, countable)CHOLLA a spelling of challah (the bread) CLAG mud; more common is claggy for 'having a mud-like consistency'COLOUR -or/-ourCONNEXION this is a very outdated spelling of connection. Not actually used in UK these days, but wouldn't it be nice to be able to play it?COOTCH a hiding place, a shed or similar (from Welsh cwtch)COUNCILLOR post on double LsCRAIC it's really an Irish one (a 'good time'), but it qualifies here because it's used more in BrE than AmE (and understood pretty universally in UK)CRIM criminalCUTTY short (in some UK dialects)DADO as in dado rail, what's often called a chair rail in AmE (here's a picture)DEFENCE AmE defenseDEMOB /DEMOBBED de-mobilize(d); that is, released from the (BrE) armed forces / (AmE) militaryDENE a valley (esp. a narrow, wooded one) or a low sand dune near the sea (regional)DEVILLED post on double LsDIALLING post on double LsDIDDY small (dialectal); see this old postDOBBED / DOBBING actually Australian, dob = to inform on someone; see this old post on the BrE equivalent grass (someone) upDODDLE it's a doddle = (orig. AmE) it's a piece of cake (very easy)DOOLALLY out of one's mindEQUALLED post on double LsFAFF / FAFFING one of the most useful BrE words. See this old post. FARL a kind of (AmE) quick bread, usually cut into triangles; can be made of various things, but here's a recipe for a common kind, the potato farlFAVOUR -or/-ourFILMIC cinematic, relating to filmFITMENT = AmE fixture, i.e. a furnishing that is fit(ted) in placeFLANNELETTE = AmE flannel old post on flannelsFLAVOUR -or/-ourFLAVOURFUL -or/-ourFOETAL AmE (and BrE medical) fetalFOOTMAN a servant or (formerly soldier (of a particular rank)FUELLED post on double LsFULFIL post on double LsGADGIE / GADGE guy, man, boy (regional)GAMMON this post covers the meat meaning, but lately it's also used as an insult for Brexiteers and their political similarsGAMMY (of a body part) not working well; e.g., I have a gammy kneeGANNET a type of sea bird, but also BrE slang for a greedy personGAOL now less common spelling for jailGIBBET gallows; to hang (a person) [not really in current use]GIGGED / GIGGING to perform at a gig [playable as of May 2023]GILET covered at this clothing post and also at this pronunciation postGIPPING form of gip, a synonym of BOAK (see above)GITE French, but used in English for a type of holiday/vacation cottageGOBBED / GOBBING form of gob, which as a noun means 'mouth', but as a verb means 'spit'GOBBIN waste material from a mineGOBBY mouthyGOOLY (more often GOOLIE, GOOLEY) a testicle (informal, see GDoS)getting gunged/slimedGUNGE any unpleasant soft or slimy substance; also used as a verb for having such stuff poured over one's head on a children's show (= AmE slime)GURN / GURNING see this old postHAITCH = AITCH, but pronounced differently See this old post.HALLO old-fashioned hello HENCH strong, fit (like a weightlifter)HOLDALL a duffel bag or similar heavy-duty bag; often spelled with a hyphen (hold-all), but at least some places don't. HOOPOE a kind of bird (mostly African), which sometimes makes it to EnglandHOGMANAY it is a proper noun, but I wanted to include it anywayHOICK / HOIK to lift/pull abruptlyHOTCHPOTCH AmE hodgepodgeINNIT invariant tag question: isn't it? INVIGILATING AmE proctoring; old postJAMMY lucky; old post KIRK church (Scotland)KIPPING form of kip, to take a napLAIRY (esp. of a person) unpleasantly loud, garish LAMBING form of to lamb, give birth to lambs. Often heard in lambing time or lambing seasonLAMPED form of to lamp, to hit a person very hardLARKING form of to lark, 'to behave in a silly way for fun'LAYBY AmE turnout (and other synonyms/regional terms); a place where a car can move out of the flow of traffic (usually has a hyphen lay-by, but I found one dictionary that doesn't require it)LIDO an outdoor public swimming pool; there's some debate about how to pronounce it LILO a blow-up mattress for floating on in a poolLINO short for linoleumLOLLY lollipop or (AmE) popsicle (especially in ice lolly)LOVAGE a(n) herb that Americans don't see very often [has been added! Played successfully on 3 May 2023]LUPIN AmE lupine, a flowerLURGI / LURGY see this old postMEDIAEVAL the less common spelling of medievalMILLIARD (no longer really used) a thousand million, i.e. a billion MILORD address term for a noblemanMINGE a woman's pubic hair/area (not flattering) MINGING foul, bad smelling, ugly (rhymes with singing!)MODELLED post on double LsMOGGY a cat (informal)MOOB man boobMOULT AmE molt (related to -or/-our)MOZZIE mosquitoMUPPET in its lower-case BrE sense: 'idiot; incompetent person'NAFF this has come up in posts about 'untranslatables' and about a study that identified common BrE words Americans don't knowNAPPY AmE diaperNAVVY a manual labo(u)rer (old-fashioned)NEEP Scottish English for what the English call a swede and what Americans call a rutabaga (old post on the latter two)NELLY in the BrE phrase not on your nelly (= AmE not on your life)NIFFY unpleasant-smellingNOBBLE to unfairly influence an outcome; steal NOBBLY alternative spelling of knobbly (which is more common in both AmE & BrE)NONCY adjective related to nonce (sex offender, p[a]edophile) NOWT nothing (dialectal)ODOUR -or/-ourOFFENCE AmE offenseOFFIE short for BrE off-licence; AmE liquor store (discussed a little in this old post) ORACY the speaking version of literacy; in US education, it's called oralityPACY having a good or exciting pace (e.g. a pacy whodunnit)PAEDO short for pa(e)dophilePANTO see this postPAPPED / PAPPING from pap, to take paparazzi picturesPARLOUR -or/-ourPARP a honking noisePEDALLED post on double LsPELMET another one from the study that identified common BrE words Americans don't knowPENG slang for 'excellent' PIEMAN / PIEMEN this one is usually two words (pie man), but I was able to find a dictionary that allowed it as a single word, so I added it to the listPIPPED / PIPPING pip = to defeat by a small amount; often heard in to be pipped at the post PITTA another spelling for pita, more in line with the BrE pronunciation of the wordPLAICE another one from the study that identified common BrE words Americans don't knowPLUMMY see this postPODGY chubbyPOMMY another Australian one, but English people know it because it's an insult directed at them, often in the phrase pommy bastardPONCE / PONCY see this postPONGING horrible-smellingPOOED / POOING see this post for the poo versus poop storyPOOTLE to travel along at a leisurely speedPOPPADOM / POPPADUM anything to do with Indian food is going to be found more in UK than USPORRIDGY like porridge, which in AmE is oatmealPUFFA full form: puffa jacket; a kind of quilted jacket; it is a trademark, but used broadly; I did find it in one dictionary with a lower-case pPUNNET see this old postRAILCARD you buy one and it gives you discounts on train ticketsRANCOUR -or/-ourRUMOUR -or/-ourTANNOY AmE loudspeaker, public address system (originally a trademark, but now used generically)TARTY dressed (etc.) in a provocative mannerTELLY (orig.) AmE tvTENCH a Eurasian fishTHALI another Indian menu word THICKO stupid personTIDDY small (dialectal) TIFFIN usually referring to chocolate tiffin (recipe)TINNING AmE canningTITBIT see this postTITCH a small person TIZZ = tizzy (to be in a tizz[y])TOFF an upper-class person (not a compliment)TOMBOLA see this postTOTTED / TOTTING see this post TOTTY an objectifying term for (usually) a womanTRUG a kind of basket; these days, often a handled rubber container TUPPENCE two penceTWIGGED, TWIGGING form of twig 'to catch on, understand'UNEQUALLED post on double LsUNVETTED related to my 2008 Word of the Year VALOUR -or/-ourVIVA an oral exam (short for viva voce)WANK / WANKING my original Word of the Year (2006!)WEEING AmE peeingWELLIE / WELLY a (BrE) wellington boot / (AmE) rubber bootWHIN a plant (=furze, gorse)WHINGE AmE whine (complain)WILLIE / WILLY penisWOAD a plant used to make blue dyeWOLD a clear, upland area (mostly in place names now)WOOLLEN post on double LsYOBBO / YOBBY hooligan / hooliganishYODELLED post on double Ls Full Article games spelling
isa SoftwareOne reports "disappointing" Q3 results By biztoc.com Published On :: Wed, 13 Nov 2024 06:29:45 GMT SoftwareOne Holding sales increased during its third quarter by 1.4%, the company said on Wednesday, adding that discussions about taking it private were progressing but were "challenging". Group revenues increased to 236.7 million Swiss francs ($268.06 million), while adjusted core operating… Full Article
isa Is Social Marketing Forcing Business Websites to Disappear? By linkworxseo.wordpress.com Published On :: Tue, 15 Jan 2013 18:15:34 +0000 Why do you Place Social Buttons on a Website? During a discussion on LinkedIn, a gentleman posed the question about not being able to understand the reason social media buttons are on main business websites. I thought it might be nice to cover some of the main purposes of social media strategies and what can […] Full Article SOCIAL MEDIA MARKETING (SMO) business-marketing share-buttons social-marketing social-media social-media-marketing social-optimization website-marketing
isa The Bipartisan Infrastructure Law By www.eschatonblog.com Published On :: Tue, 12 Nov 2024 18:30:00 +0000 I don't think you have to be a commie trot to observe that calling it that is stupid. Full Article
isa 8 Easy Friendsgiving Games That Will Not Disappoint By www.apartmenttherapy.com Published On :: Tue, 12 Nov 2024 09:30:00 -0500 They take no time at all to learn to play. READ MORE... Full Article Life Edit Shopping entertaining Entertaining at Home Entertainment & Fun friends games holiday Shopping
isa What helps women who have learning disabilities get checked for cervical cancer? By lx.iriss.org.uk Published On :: Monday, September 7, 2015 - 13:47 This is a paper produced as part of the PROP2 (Practitioner Research: Outcomes and Partnership) programme, a partnership between the Centre for Research on Families and Relationships (CRFR) at the University of Edinburgh and IRISS that was about health and social care in Scotland. This paper was written by Elaine Monteith from ENABLE Scotland who participated in the PROP2 programme. What this research paper explores: All women are asked to go to the doctor every few years to get a check for cancer but women who have a learning disability don’t go for these checks as often as other women. The paper explore what barriers there are for women attending for checks and also looks at what could be done to encourage women them to attend. Full Article
isa Scottish Consortium for Learning Disabilities (SCLD) By lx.iriss.org.uk Published On :: Friday, November 27, 2015 - 10:06 SCLD brings together some of the most respected practitioners and thinkers from across the learning disability sector who work alongside people who have learning disabilities and their families and carers.The team at SCLD is focused on delivering real change through influencing policy, identifying and sharing evidence and good practice and challenging public attitudes. SCLD aims to be a knowledge hub – offering support, information and new ideas about learning disability in Scotland. Full Article
isa British Institute of Learning Disabilities By lx.iriss.org.uk Published On :: Friday, November 27, 2015 - 10:55 British Institute of Learning Disabilities services help develop the organisations who provide services, and the people who give support. Full Article
isa Scottish Council for Voluntary Organisations (SCVO) By lx.iriss.org.uk Published On :: Friday, November 27, 2015 - 14:21 The Scottish Council for Voluntary Organisations (SCVO) is the membership organisation for Scotland's charities, voluntary organisations and social enterprises. Full Article
isa Natural Disasters Aren’t Gender Neutral – Hurricanes Milton and Helene Prove It By feminist.org Published On :: Thu, 24 Oct 2024 16:18:20 +0000 Photo by NASA Natural disasters don’t just ravage landscapes—they also expose and deepen systemic inequalities. Recent hurricanes, Milton and Helene, tore through Florida, Georgia, and the Carolinas, destroying homes, businesses, and the lives built across generations. While governments rush to repair infrastructure and restore housing, they often overlook the people most impacted in the long term—especially […] The post Natural Disasters Aren’t Gender Neutral – Hurricanes Milton and Helene Prove It appeared first on Feminist Majority Foundation. No related posts. Full Article Climate Change climate change hurricanes news
isa Lisa Simpson Replaces Bart in Detention in ‘The Simpsons’ Latest Episode By www.cracked.com Published On :: Mon, 11 Nov 2024 13:10:00 -0800 By JM McNab Published: November 11th, 2024 Full Article
isa CISA Alerts to Active Exploitation of Critical Palo Alto Networks Vulnerability By thehackernews.com Published On :: Fri, 08 Nov 2024 10:47:00 +0530 The U.S. Cybersecurity and Infrastructure Security Agency (CISA) on Thursday added a now-patched critical security flaw impacting Palo Alto Networks Expedition to its Known Exploited Vulnerabilities (KEV) catalog, citing evidence of active exploitation. The vulnerability, tracked as CVE-2024-5910 (CVSS score: 9.3), concerns a case of missing authentication in the Expedition migration tool that Full Article
isa ISRAEL DISARMED By www.backwoodshome.com Published On :: Tue, 15 Oct 2024 13:00:00 +0000 Mark Smith is a brilliant attorney, gun-focused and one of our most articulate spokespersons for firearms owners civil rights. Check out his blog called The Four Boxes Diner. That’s a reference to Boxes of Liberty: the soapbox, the ballot box, the jury box, and finally the cartridge box. You also want to check out his […] Full Article Uncategorized
isa Usenix LISA is no more. Here's my retrospective. By everythingsysadmin.com Published On :: Sat, 12 Nov 2022 11:34:18 -0500 The Usenix LISA conference is no more. After 35 years, I have a lot of good (and some not good) memories of the conference. It was a big part of my career and I'm sad to see it go. However I'm proud of what LISA accomplished. I wrote my personal reflections on the conference in a new article published on the Usenix website. Warning: this article includes some over-sharing. Read it here: LISA made LISA obsolete (That's a compliment!) Full Article History LISA Usenix
isa "Eclipse" - Scrappy Improvisational Quilt By beadlust.blogspot.com Published On :: Tue, 16 Jan 2018 05:22:00 +0000 When my brother, Thom Atkins, visited last fall, he showed me (and a few quilting buddies) his new method for designing and constructing "scrappy improv wall quilts," a technique that turned out to be a lot of fun for me, especially given my long history with an improvisational, intuitive approach to bead embroidery. Basically, what we did was to empty our bags or boxes of scraps onto a large table and start pawing through them, pulling out ones that appealed to us at that moment. For me it was all about color - red, magenta, fuchsia, with hints of pink, golden-yellow, orange, lavender, and dark green. All of the fabrics were in my scrap box. We had two days of Thom's demonstrations and guidance. During that time, each of us in our small group produced a unique and very pleasing "piece" or "block," measuring roughly 18 x 21 inches, the size of a fat quarter. One of my red scraps, cut in a nice arc at one end, was the start of it all because I liked the shape and the color. Next I picked up a small strip of yellow, and held it behind the arc of red. Ooooh! Nice enough to repeat. The scrap of orange/red batik was large enough to cut a similar arc, and the strip of yellow was long enough to go behind that one too. These two arcs formed the basis of my piece. You can see the two arcs above; the lower right was the first. The yellow strip was only about 3" wide, not enough to go all the way around the arcs, but I cut two shapes that would echo the top of each of the arcs. I layered the remaining scraps from that on top of the arcs along the vertical edges of the design. Then I put a dark green scrap behind the arcs and the yellow, which set them off nicely. The rest was just filling to the edges of the quilt with more scraps, including fussy-cut leaves and flowers. The next step was to glue it all together along the 1/4" seam overlap, working in layers from bottom to top, and cutting away the excess fabric from the underside after each piece is glued. Cutting away the excess fabric leaves a double layer of fabric only at the seams; the rest is a single layer. The glue is Elmer's School Glue, Disappearing Purple, as shown below. It is an organic stick glue, relatively easy to sew through, repositionable, (in case you change your mind), and purple when first applied, drying to transparent (so you can see where exactly you are putting it). Thom's method is a type of raw edge applique, typically accomplished with heat-fusible web, such as "wonder under." The typical method, given a complex, layered design such as mine, would have resulted in a thick, stiff, multi-layer surface, which would be difficult to quilt, even with a machine. In Thom's method, there is no web, and in most places only one or two layers of fabric. Like all raw edge techniques, the raw edges must be sewn down, and the resulting quilts are not very suitable for bed quilts unless there is heavy stitching over the raw edges (for example, dense, zig-zag, machine stitching). After gluing my original (shown above) quilt top, I assembled the quilt, using a spray glue to layer the backing, batting and top. The next step was to stitch along the "seams," the overlapping, glued edge of each piece. From there, it was up to each of us as to how to finish the quilt, perhaps with machine quilting, such as stippling or contour stitches, or perhaps with beading, all of which Thom does on his quilts. A couple of months went by after getting to the unfinished stage shown above. I liked it, but didn't know what to do with it, until one day when I was at our Senior Center, getting foot care from a trained nurse who comes a couple times a week to help those who need it. Her treatment room, about the size of a walk-in closet, has no windows. Her client faces the door to the room, a plain, wooden door. "That door needs a quilt," I told her. The rest is history; my scrappy improv quilt, Eclipse, hangs there now. Only first I had to finish it. Above is the finished quilt, Eclipse. Below I'll tell you some of the finishing steps and about how I transformed it from looking flat and ordinary to sharp and textured using embroidery embellishments. Please click on the photo so you can see the details! You might have noticed that the finished quilt is longer (better suited for hanging on a door) than the original piece. That was a challenge, although less than you might expect, because Thom had demonstrated for us how he sometimes extends the size of his quilts. In short, I roughly planned out the addition, the mock-up shown below, then created it using the same process and scraps as the original piece. I used fusible "tape" made for butt-joining pieces of batting, to add a new piece of batting to the bottom edge of batting on the original (upper) part of the quilt. The horizontal strip of striped fabric overlaps the two parts of the quilt and the joined batting underneath. As you can see below, I added a fussy-cut flower over the striped fabric to break up the horizontal strip and visually join the two parts. Confession time... I'm not good at machine quilting, and don't even have a proper quilting foot for my old machine (1972 Pfaff). I tried stitching around the fussy cut flowers to secure the glued edges, but failed miserably. What to do? Ah, hand-sew with embroidery stitches and floss? Yes! It took a few tries, but eventually I found stitch and thread combinations that worked. It looked so good that I decided to add stitching and knots to the yellow arcs next. Wow! That popped the eclipse look! In the photo below, you can see bits of all the embroidery stitches I added. Not only does the embroidery provide embellishment and emphasis, it also further quilts the piece. Click the photo to see the detail and better read the stitch identification. Here are two more detail photos of the finished quilt (without the text boxes). Lots of fun, and I like the results! Will I do another one? Well, right now I've finally returned to my hexie project, where I'm likely to remain for many months, but after that, scrappy improv may be just what I need! Full Article applique art quilts fabric collage fabric scraps finishing techniques improv improvisation intuitive raw edge applique scrappy quilts Thom Atkins thread embroidery tutorial
isa Hisashi Kobayashi, former Princeton engineering dean and data storage pioneer, dies at 84 By www.princeton.edu Published On :: Fri, 21 Apr 2023 09:03:35 -0400 Hisashi Kobayashi, whose steady leadership as dean guided Princeton's School of Engineering and Applied Science through a rapid expansion of programs and facilities in the late 1980s and early 1990s, died on March 9. He was 84. Full Article
isa Euphoric Whispers: Improvisations for Tanbur and Percussion By www.princeton.edu Published On :: Mon, 25 Nov 2024 17:30:00 -0500 Euphoric Whispers This event is free, but a ticket is required to attend. To reserve a ticket, use the University Ticketing website. This concert features a rare NJ appearance of Ali Akbar Moradi and Pejman Hadadi, two of Iran’s most renowned musicians. Moradi is the greatest living master of the tanbour, an ancient 2-stringed long-necked fretted lute traditionally used in religious ceremonies. Hadadi is the innovative percussionist (tombak, daf) who has been a member of the Dastan Ensemble for over 20 years and has collaborated with countless master musicians in Persian and world traditions. They will perform ecstatic and trance-inducing Kurdish music from western Iran – music that is little known in the US. Featured are meditative improvisations based on the repertoire of the Yarsan people, and the beauty and complexities of the art of this region. “Love, spirituality, intoxication with the divine and the power of music…With one string providing a drone, everything else rides on a single string of the tanbour, and in Mr. Moradi’s hands, that string encompasses an expressive universe.” - New York Times "The masterful Hadadi delivers an astonishing array of sounds." - Los Angeles Times Aliakbar Moradi Aliakbar Moradi, often hailed as “the best tanbour player alive” (Songlines Magazine, Issue 26, 2004), was born in 1957 in Guran, near Kermanshah, the central city of Kermanshah Province, Iran. Encouraged by his grandfather and father, he began studying the Tanbur at the age of six. Under the guidance of masters such as Sayyed Hachem Kafashyan, Sayed Mahmoud Alavi, Ali Mir Darvishi, Allah Morad Hamidi, and Sayyed Vali Hosseyni, he not only mastered the instrument but also delved deeply into the Kurdish maqam repertoire. Moradi gave his first recital at the age of 14 in Kermanshah. A year later, he established the first Tanbur group within the cultural department of Kermanshah. He then embarked on tours across Iran and later co-founded the renowned Shams Tanbur Ensemble. In 1991, he won first prize at the String Instrument Festival. Starting in 1992, he conducted extensive research on the ancient maqams of the Tanbur, resulting in a significant publication: a set of four CDs and a booklet released in 2002 by Maison des Cultures du Monde. Over the years, Moradi has published more than 23 recordings and books. He has collaborated with numerous esteemed musicians, including Shahram Nazeri, Kaykhosro Pournazeri, Kayhan Kalhor, Ardeshir and Bijan Kamkar, Pejman Hadadi, Erdal Erzincan, Ulaş Özdemir, Pezhham Akhavass, Mehdi Bagheri, and Arash and Kourosh Moradi. In addition to his research, recordings, and performances, Moradi teaches Tanbur in Tehran and Kermanshah. Currently residing in Kurdistan, Iran, he founded the cultural center The House of Tanbur in Guran. This center offers year-round music classes and hosts annual Tanbur and Kurdish music festivals to preserve and promote the rich cultural heritage of the region. Pejman Hadadi Pejman Hadadi, a renowned percussionist from Tehran, Iran, began his musical journey at age 10, studying under Master Tombak player Assadollah Hejazi. Influenced by greats like Bahman Rajabi and Hossein Tehrani, he later mastered the Daf, inspired by Bijan Kamkar’s recordings. Moving to the US in 1989, Pejman began his professional career in 1991, collaborating with notable musicians such as Hossein Alizadeh, AliAkbar Moradi, Kayhan Kalhor, Shahram Nazeri, and joining the Dastan Ensemble in 1995. He co-founded ZARBANG, the pioneering Iranian percussion ensemble, in 2000. Pejman’s innovative techniques on the Tombak, including tunable frame drums, and his partnership with REMO to develop synthetic-skin Dafs, have significantly expanded the instruments’ global reach. Dedicated to education, he established Neyreez World Music Institute and has received the Durfee Foundation Master Musician Award twice. Pejman’s compositions span dance and film, including soundtracks for Prince of Egypt and Prince of Persia. Full Article
isa Princeton Disability Awareness Carnival By www.princeton.edu Published On :: Sun, 17 Nov 2024 12:15:00 -0500 Princeton Disability Awareness Carnivals provides Princeton students the opportunity to spend the day with kids with disabilities during a fun day of carnival games and activities. Full Article
isa Princeton Disability Awareness Carnival By www.princeton.edu Published On :: Sun, 17 Nov 2024 12:15:00 -0500 Carnival for Princeton students to spend time with children with disabilities at a day of fun. Full Article
isa Princeton Disability Awareness Carnival By www.princeton.edu Published On :: Sun, 17 Nov 2024 12:15:00 -0500 Carnival Full Article
isa Does Oman Have A Specific Digital Nomad Visa Program? By www.geekytraveller.com Published On :: Wed, 21 Feb 2024 06:00:15 +0000 Oman, otherwise officially known as the Sultanate of Oman, is within the southeastern portion of the Arabian Peninsula. The country is surrounded by two sea bodies including the Arabian Sea in the southeast and the Sea of Oman in the northeastern portion. A larger body of water, the Indian Ocean, is also near Oman in the southeastern area like the Arabian Sea. Americans, Canadians, and other digital nomads from various countries can easily assimilate as digital nomads since English is a widely used language besides the official language, Arabic. While there is no digital nomad visa program in Oman, you can opt to apply for an employment visa. If you are a digital nomad, you will have to apply for various eVisas depending on where you are going, such as an eVisa Ethiopia. How To Apply for An Employment Visa in Oman Applying for an employment visa in Oman takes six steps with an overall turnaround time of up to 9 weeks long depending on individual processing time. The first step is the initiation process where you have to contact Fakhoury Global Immigration and send in the appropriate documents to start applying for the employment visa. This initial step only takes about 24-72 hours. The second step involves filling out the labor permit application and waiting for that to be approved within 3 to 4 weeks. For step 3, you must fill out the employment visa application and provide the mandated documents. Take everything to the closest Royal Oman Police location for full processing within 1 week to a month. The fourth step involves entering Oman where you can begin your digital nomad endeavors once this happens. For step 5, you need to have a health exam at one of the entity’s supported clinics. You will need a chest X-ray, blood tests to be sure you don’t have any bad diseases, as well as pee and poop samples for a full health profile. The final step is applying for and receiving a residential ID card from the Directorates General of Civil Status. The Benefits of Being A Digital Nomad In Oman Your day can be filled with exploring what Oman has to offer in between getting your work done on your laptop. You can have breakfast at Tr.Eat Cafe and get your work done with nearby free Wi-Fi. Then, you can take a break and explore the Sultan Qaboos Grand Mosque in the afternoon before grabbing dinner at Theatrum Restaurant. Plan your itinerary in Oman around your work schedule so that you can still have fun where you are temporarily living while getting your work done. Locating yourself in Muscat would be your best bet as it is the most popular part of Oman with the most free Wi-Fi spots so you can have a variety of places to work. Work can get boring if you are working in the same place every day. Instead of purchasing expensive home Internet, you can plan your day to be located near free Wi-Fi spots to get your work done. No Internet access at home can help you to stay connected to yourself with non-tech activities like reading a book or embarking on a hobby before you go back to being a digital nomad exploring Oman the next day. Where Can I Get Free Wi-Fi in Oman? According to WiFi Map, the top 5 places with free Wi-Fi in Oman are Muscat, Seeb, Salalah, Sohar, and Matrah. Muscat is the most popular region of Oman with free Wi-Fi spots, featuring 2,883 locations to connect with your laptop to complete your workload. When you first enter Muscat or another popular region in Oman with Wi-Fi spots, you can download WiFi Map to your smartphone so you are informed of all the nearby spots where you can get connected. Local hotels, cafes, restaurants, and other businesses could have free Wi-Fi for their patrons. Maybe you want to explore a part of Oman that you have not seen yet. Book a few days at a local hotel and you can utilize the free Wi-Fi there. Whenever you stop at a cafe or restaurant for a meal, you can get some work done after eating before you go to your next destination. Become A Digital Nomad in Oman Today! Oman has so much to offer such as opera houses, mosques, delightful eateries, and forts like the Jibreen Castle. Wadi Bani Khalid is a desert retreat with a mountainous landscape and clear green waters for swimming. When you have to stay connected to work, you can stop by one of the most popular Wi-Fi spots in Muscat. When you want to explore Oman’s attractions and eateries, you can put away your work and enjoy life. Being a digital nomad in Oman can change your life so start the employment visa process today! Author Bio: Cathy Slater is an experienced content writer. She is associated with many renowned travel blogs as a guest author where she shares her valuable travel tips with the audience. The post Does Oman Have A Specific Digital Nomad Visa Program? appeared first on Geeky Traveller. Full Article Travel Blog cultural exploration digital nomad digital nomad lifestyle employment visa expat life explore Oman Fakhoury Global Immigration free Wi-Fi in Oman Jibreen Castle Middle East Oman Oman digital nomad visa Omani attractions remote work Sultanate of Oman Travel Guide travel insights travel inspiration travel lifestyle travel tips visa process Wadi Bani Khalid Wi-Fi spots in Muscat work and travel work in Oman work remotely work-life balance
isa Vida em lua de Urano? As revelações de nova pesquisa sobre condições do planeta By www.bbc.com Published On :: Tue, 12 Nov 2024 11:26:12 GMT Dados enviados pela Voyager 2 em 1986 mostravam que as luas de Urano eram completamente diferente do resto do Sistema Solar Full Article
isa £30,000 limit on disabled adaptions grants reviewed By www.bbc.com Published On :: Fri, 01 Nov 2024 15:11:42 GMT A court challenge means the government will look again at the cap on the Disabled Facilities Grant. Full Article
isa Titan sub disaster: Five key questions that remain By www.bbc.com Published On :: Sun, 15 Sep 2024 01:08:06 GMT A public hearing is set to examine the events surrounding the catastrophic failure of Oceangate’s submersible. Full Article
isa Boss Lewis '100% disagrees' England not fit enough By www.bbc.com Published On :: Tue, 12 Nov 2024 12:50:48 GMT England head coach Jon Lewis rejects accusations some of his players are not fit enough. Full Article
isa 'This generation's Thierry Henry' - how good is Isak? By www.bbc.com Published On :: Sun, 10 Nov 2024 23:55:03 GMT BBC MOTD2 pundit and former Arsenal forward Theo Walcott explains why Newcastle striker Alexander Isak's all-round game makes him a player who could get in any team. Full Article
isa 'Disappointed but proud' - Arteta on Chelsea draw By www.bbc.com Published On :: Sun, 10 Nov 2024 19:41:06 GMT Arsenal boss Mikel Arteta praises his side's performance against Chelsea in the Premier League, but says that getting results is "what is missing" at the moment. Full Article
isa 'It's down to me' - Postecoglou takes responsibility for 'hugely disappointing' defeat By www.bbc.com Published On :: Sun, 10 Nov 2024 16:59:19 GMT Tottenham boss Ange Postecoglou accepts responsibility for his side's 2-1 Premier League defeat at home by a previously winless Ipswich. Full Article
isa News24 | COP29: Pay up or face climate-led disaster for humanity, warns UN chief By www.news24.com Published On :: Tuesday Nov 12 2024 19:30:14 United Nations Secretary-General Antonio Guterres told world leaders at the COP29 summit on Tuesday to "pay up" to prevent climate-led humanitarian disasters, and said time was running out to limit a destructive rise in global tempera Full Article
isa News24 | OPINION | Lisa Otto: Isolationism vs hegemony... and the contradictions of Trump's America By www.news24.com Published On :: Wednesday Nov 13 2024 06:18:13 America and Americans must decide what the US' place in the world is and then accept what comes with that, writes Lisa Otto. Full Article
isa Current State of the Evidence: Examining the Effects of Orton-Gillingham Reading Interventions for Students With or at Risk for Word-Level Reading Disabilities By www.readingrockets.org Published On :: Tue, 11 Oct 2022 10:40:37 EDT Over the past decade, parent advocacy groups led a grassroots movement resulting in most states adopting dyslexia-specific legislation, with many states mandating the use of the Orton-Gillingham (OG) approach to reading instruction. Orton-Gillingham is a direct, explicit, multisensory, structured, sequential, diagnostic, and prescriptive approach to reading for students with or at risk for word-level reading disabilities (WLRD). Evidence from a prior synthesis and What Works Clearinghouse reports yielded findings lacking support for the effectiveness of OG interventions. Full Article
isa News24 | Lottoland wins Google battle, Mogale City sewage disaster: Today's top 7 stories in 7 minutes By www.news24.com Published On :: Tuesday Nov 12 2024 18:32:16 News24 brings you the top stories of the day, summarised into neat little packages. Read through quickly or listen to the articles via our customised text-to-speech feature. Full Article
isa News24 | WASTE LAND | Mogale City sewage disaster sees faeces-laden river water testing 100 times above legal limit By www.news24.com Published On :: Tuesday Nov 12 2024 04:45:19 Scientific tests confirm rivers and dams have been poisoned by the raw sewage dumped by the municipality in the Bloubankspruit and Crocodile Rivers, killing aquatic life and destroying businesses and livelihoods. Full Article
isa Another emulation project disappears amid Nintendo crackdown By boingboing.net Published On :: Wed, 02 Oct 2024 13:53:28 +0000 Nintendo is cracking down on emulators of its hardware and media depicting their use. First Yuzu was taken down with a lawsuit, and now departs Ryujinx, a similar project that had sought to avoid the legal landmines Yuzu stepped on. — Read the rest The post Another emulation project disappears amid Nintendo crackdown appeared first on Boing Boing. Full Article Post copyright gadgets lawsuits retrogaming tech
isa 16 Fun Things to Do in Pisa, Italy By www.adventurouskate.com Published On :: Sat, 09 Nov 2024 12:28:00 +0000 There’s so much more to Pisa than the Leaning Tower. There are so many cool things to do in Pisa — this is a big, bustling city with a mind and attitude of its own! So many travelers swoop in on a day trip from Florence to take photos with the Leaning Tower of Pisa. And […] The post 16 Fun Things to Do in Pisa, Italy appeared first on Adventurous Kate. Full Article Italy
isa Sport | Key dying minutes of Tests: Boks have been demons, England disasters By www.news24.com Published On :: Tuesday Nov 12 2024 10:06:14 In his latest Rucking with Rob newsletter, Rob Houwing argues that for England to have any hopes of beating the Springboks, they'll have to be on the ball in the final stages. Full Article
isa Sport | Makgopa's rise evidence of Broos' Bafana impact: 'You don't want to disappoint such a person' By www.news24.com Published On :: Wednesday Nov 13 2024 05:00:31 Evidence Makgopa wore a sheepish smile when Bafana Bafana coach Hugo Broos showered him with praise before literally patting the forward on the back, making him blush at Dobsonville Stadium. Full Article
isa In conversation with HRH Prince Turki AlFaisal By www.chathamhouse.org Published On :: Fri, 16 Aug 2024 09:27:14 +0000 In conversation with HRH Prince Turki AlFaisal 13 September 2024 — 11:00AM TO 12:00PM Anonymous (not verified) 16 August 2024 Chatham House and Online This event will discuss how the ongoing Gaza war is impacting the region and the role external actors can play to support de-escalation. The Gaza war, now in its tenth month, continues with ever-worsening consequences for Palestinians and no end in sight. The Israeli-Palestinian conflict has also heightened tensions across the Middle East with fears of a broader regional war that would include Iran and aligned groups from the ‘axis of resistance’.Against this backdrop, ceasefire negotiations supported by regional and international mediators, have not amounted to an agreement nor have there been any concrete proposals for a way forward out of the crisis by key actors such as the United States, Gulf countries or other key stakeholders.In this event, His Royal Highness Prince Turki AlFaisal will discuss how the Gaza war and related developments are impacting the Middle East, and will share his views on the role of regional and external actors in supporting de-escalation efforts.The addresses:How are Middle Eastern countries managing regional security and heightened tensions with Iran and aligned groups in Iraq, Lebanon and Yemen?What role are Gulf countries playing in efforts to de-escalate tensions?How can they support short- and long-term planning for a way forward in the Israeli-Palestinian conflict?How are relationships between Middle East countries and external powers such as the United States changing as a result of the Gaza war?In person places for this event are balloted. Confirmations will be sent by email on Monday 9 September at 3pm or a placed on the waiting list. Virtual registrations are confirmed immediately.Individual membership provides you with the complete Chatham House experience, connecting you with a unique global policy community. Find out more about membership. Full Article
isa Islamic radicalisation in Central Asia By www.chathamhouse.org Published On :: Tue, 20 Aug 2024 15:47:13 +0000 Islamic radicalisation in Central Asia 18 September 2024 — 10:00AM TO 11:30AM Anonymous (not verified) 20 August 2024 Chatham House and Online Experts analyse rising foreign recruitment, current counter-radicalisation efforts and challenge past Chatham House predictions made of the Central Asia region. In 2014, Chatham House released a report titled The Myth of Post-Soviet Muslim Radicalisation in the Central Asian Republics. At that time, a significant, Western-funded counter-radicalisation industry was addressing what was believed to be a major issue of Islamic violent extremism in the region.Over the past decade, two key developments have occurred. First, Western interest in the region has declined in favour of traditional geopolitical concerns. Second, while violent extremism incidents within Central Asia remain rare, there has been a notable recruitment of Central Asians by foreign groups, with several attacks carried out by Central Asians overseas.In this event, the original report’s authors, John Heathershaw and David Montgomery, will discuss whether the report’s arguments are still valid and how we might answer these questions today.This raises several questions:What did the report accurately predict, and where did it fall short?How can we explain the lack of violent extremist organisations (VEOs) within Central Asia but the presence of Central Asians in VEOs abroad?Could repression by Central Asian states both domestically and transnationally have contributed to this issue?What, if anything, can the counter-radicalisation industry do today to address this problem more effectively?Please note that in-person places are limited. Please wait for confirmation before participating. Full Article
isa Independent Thinking: Humanitarian disaster in Syria and Turkey By www.chathamhouse.org Published On :: Thu, 16 Feb 2023 18:29:56 +0000 Independent Thinking: Humanitarian disaster in Syria and Turkey Audio NCapeling 16 February 2023 Episode 15 of our weekly podcast examines the far-reaching consequences of the earthquakes which struck Turkey and Syria on the region’s fragile geopolitics. With thousands killed and international aid flooding in, what hope is there for the many thousands of people in Syria and Turkey caught between the groups and governments involved in conflict for more than a decade. The panel aslo discusses the political impact within Turkey, as fears grow that President Recep Tyap Erdogan may postpone the upcoming election amid outcries over corruption and the devastating loss of life. Joining Bronwen this week is Lina Sinjab, Syrian filmmaker and BBC journalist covering the Middle East, Charles Lister, senior fellow and director of the Syria programme at the Middle East Institute, and Ziya Meral, senior associate fellow on Turkey at the Royal United Services Institute (RUSI). About Independent Thinking A weekly podcast hosted by Chatham House director Bronwen Maddox, in conversation with leading policymakers, journalists, and Chatham House experts providing insight on the latest international issues. Full Article
isa Nato Leaders’ Summit 2019: Treaty organisation faces deep divisions at 70 By www.chathamhouse.org Published On :: Tue, 21 Jan 2020 14:33:46 +0000 Source The National URL https://www.thenational.ae/world/nato-leaders-summit-2019-treaty-organisation-fa... Release date 02 December 2019 Expert Dr Lindsay Newman In the news type Op-ed Hide date on homepage Full Article
isa Centralisation is hobbling China’s response to the coronavirus By www.chathamhouse.org Published On :: Mon, 10 Feb 2020 16:26:40 +0000 URL https://www.ft.com/content/1a76cf0a-4695-11ea-aee2-9ddbdc86190d Release date 05 February 2020 Expert Dr Yu Jie In the news type Op-ed Hide date on homepage Full Article
isa On Lamperti transformation and AR(1) type characterisations of discrete random fields By www.ams.org Published On :: Tue, 05 Nov 2024 14:10 EST Marko Voutilainen, Lauri Viitasaari and Pauliina Ilmonen Theor. Probability and Math. Statist. 111 (), 181-197. Abstract, references and article information Full Article
isa The heptameric structure of the flagellar regulatory protein FlrC is indispensable for ATPase activity and disassembled by cyclic-di-GMP [Protein Structure and Folding] By www.jbc.org Published On :: 2020-12-11T00:06:20-08:00 The bacterial enhancer-binding protein (bEBP) FlrC, controls motility and colonization of Vibrio cholerae by regulating the transcription of class-III flagellar genes in σ54-dependent manner. However, the mechanism by which FlrC regulates transcription is not fully elucidated. Although, most bEBPs require nucleotides to stimulate the oligomerization necessary for function, our previous study showed that the central domain of FlrC (FlrCC) forms heptamer in a nucleotide-independent manner. Furthermore, heptameric FlrCC binds ATP in “cis-mediated” style without any contribution from sensor I motif 285REDXXYR291 of the trans protomer. This atypical ATP binding raises the question of whether heptamerization of FlrC is solely required for transcription regulation, or if it is also critical for ATPase activity. ATPase assays and size exclusion chromatography of the trans-variants FlrCC-Y290A and FlrCC-R291A showed destabilization of heptameric assembly with concomitant abrogation of ATPase activity. Crystal structures showed that in the cis-variant FlrCC-R349A drastic shift of Walker A encroached ATP-binding site, whereas the site remained occupied by ADP in FlrCC-Y290A. We postulated that FlrCC heptamerizes through concentration-dependent cooperativity for maximal ATPase activity and upon heptamerization, packing of trans-acting Tyr290 against cis-acting Arg349 compels Arg349 to maintain proper conformation of Walker A. Finally, a Trp quenching study revealed binding of cyclic-di-GMP with FlrCC. Excess cyclic-di-GMP repressed ATPase activity of FlrCC through destabilization of heptameric assembly, especially at low concentration of protein. Systematic phylogenetic analysis allowed us to propose similar regulatory mechanisms for FlrCs of several Vibrio species and a set of monotrichous Gram-negative bacteria. Full Article
isa The Capture of a Disabled Proteasome Identifies Erg25 as a Substrate for Endoplasmic Reticulum Associated Degradation [Research] By www.mcponline.org Published On :: 2020-11-01T00:05:37-07:00 Studies in the yeast Saccharomyces cerevisiae have helped define mechanisms underlying the activity of the ubiquitin–proteasome system (UPS), uncover the proteasome assembly pathway, and link the UPS to the maintenance of cellular homeostasis. However, the spectrum of UPS substrates is incompletely defined, even though multiple techniques—including MS—have been used. Therefore, we developed a substrate trapping proteomics workflow to identify previously unknown UPS substrates. We first generated a yeast strain with an epitope tagged proteasome subunit to which a proteasome inhibitor could be applied. Parallel experiments utilized inhibitor insensitive strains or strains lacking the tagged subunit. After affinity isolation, enriched proteins were resolved, in-gel digested, and analyzed by high resolution liquid chromatography-tandem MS. A total of 149 proteasome partners were identified, including all 33 proteasome subunits. When we next compared data between inhibitor sensitive and resistant cells, 27 proteasome partners were significantly enriched. Among these proteins were known UPS substrates and proteins that escort ubiquitinated substrates to the proteasome. We also detected Erg25 as a high-confidence partner. Erg25 is a methyl oxidase that converts dimethylzymosterol to zymosterol, a precursor of the plasma membrane sterol, ergosterol. Because Erg25 is a resident of the endoplasmic reticulum (ER) and had not previously been directly characterized as a UPS substrate, we asked whether Erg25 is a target of the ER associated degradation (ERAD) pathway, which most commonly mediates proteasome-dependent destruction of aberrant proteins. As anticipated, Erg25 was ubiquitinated and associated with stalled proteasomes. Further, Erg25 degradation depended on ERAD-associated ubiquitin ligases and was regulated by sterol synthesis. These data expand the cohort of lipid biosynthetic enzymes targeted for ERAD, highlight the role of the UPS in maintaining ER function, and provide a novel tool to uncover other UPS substrates via manipulations of our engineered strain. Full Article
isa Nuclear Disarmament and the Protection of Cultural Heritage By www.chathamhouse.org Published On :: Fri, 06 Oct 2017 13:24:22 +0000 Nuclear Disarmament and the Protection of Cultural Heritage Research paper sysadmin 6 October 2017 States possessing nuclear weapons should be called upon to consider and publish the risks posed to cultural heritage, and their mitigation strategies, in their nuclear-weapons doctrines and policies. — A woman walks on the roof of the Great Mosque of Djenné, a World Heritage Site, after praying. Photo: United Nations. Summary Renewed risk assessments for nuclear weapons and policies are taking place around the world in light of nuclear modernization and the changing geostrategic environment that is making the use of nuclear weapons more likely. As such the humanitarian impacts of nuclear weapons and tests have received increased attention. However, the effect on cultural heritage has so far been neglected. The potential for armed conflict to destroy cultural heritage has been recognized in international law since 1954. There is significant evidence on the impact of nuclear weapons on cultural heritage including the consequences of their use in Hiroshima and Nagasaki and the effect of nuclear-testing programmes in places of cultural significance since 1945. States that possess nuclear weapons have increased liabilities and responsibilities to protect cultural heritage and cultural rights. The need to protect cultural heritage should strengthen the case for reducing and eliminating nuclear weapons. Failure to take into account the protection of heritage in the development of nuclear weapons policies – including disarmament, non-proliferation and arms-control negotiations – significantly undermines states’ existing commitments to protecting heritage threatened by conflict. Risk assessments of the impact of nuclear weapons on cultural heritage and important cultural artefacts – and methods of preventing such catastrophic damage – should be part of protecting cultural heritage in every country and the subject of informed public debate. A new body of knowledge on the full range of nuclear weapons impacts would introduce a fresh perspective to inform decision-makers, international organizations and the public in thinking about nuclear weapons policies and practices. Risk and resilience frameworks, which provide sets of solutions for risk assessments, would allow assessments of nuclear weapons threats to heritage and highlight vulnerabilities that need to be addressed. Such frameworks would provide a basis for policymakers to identify the world’s cultural heritage most at risk and help develop mitigation strategies to ensure that it is protected. In particular, states possessing nuclear weapons should be called upon to consider and publish the risks posed to cultural heritage, and their mitigation strategies, in their nuclear weapons doctrines and policies, as a contribution to transparency and confidence-building, and as a responsibility to the world’s shared heritage. International organizations, such as the UN Educational, Scientific, and Cultural Organization (UNESCO), have a role to play in bridging security perspectives with protecting cultural heritage. 2017-10-10-nuclear disarmament-cultural-heritage-aghlani-lewis-unal-final (PDF) Full Article
isa Lords recommend “passive immunisation” if bird flu reaches UK By www.bmj.com Published On :: Thursday, January 5, 2006 - 22:52 Full Article
isa An adolescent with disabling abdominal pain By www.bmj.com Published On :: Wednesday, December 7, 2016 - 09:46 Full Article