Prospective performers and their families are invited to learn about Pacific Crest, our 2025 season, and auditions. A brief presentation will be followed by an AUA (ask us anything) session. All […]

Rows of armed agents were deployed around the protests in Washington, D.C. this past week, but it was not obvious who they were: They had no name tags, no badge numbers and no emblems to identify which agencies they worked for. Their arrival sparked shock and alarm. Now, Democratic lawmakers are calling for legislation that would make it illegal for these officers to not identify themselves. In the Senate, Minority Leader Chuck Schumer (D-N.Y.) and Chris Murphy (D-Conn.) are cosponsoring a bill that would require officers to identify themselves while "engaged in crowd control or arresting individuals involved in civil disobedience or protests in the United States." In the House, Virginia Democrat Don Beyer, whose district is just across the Potomac River from Washington, D.C., is working on similar legislation. "How do we tell these alleged federal police officers from white supremacist militia groups?" Beyer said in an interview Sunday with NPR's Weekend Edition . "How do you ever

Hidden changes are warping the already broken ecosystem that determines how many citizens—particularly in America—construct their sense of reality. (slSubstack)

Y'all, I know there are folks who don't like Substack/NYT links but here we are and I thought this was worth posting in the aftermath of a disastrous election.

Vallejo habla sobre el informe de la ONU

Claudia habla sobre el informe anual de la ONU

Juan Carlos Flórez habla sobre el informe de la ONU respecto a la situación de los líderes sociales

Panelistas analizaron los casos de hackeo y seguridad informática tras filtración de datos en diferentes plataformas y redes sociales; también sobre desinformación en tiempos de vacunación.

Panelistas consideran que informe es preciso en plantear los distintos ángulos de la protesta; para otros, hace falta mayor énfasis en el papel de bandas criminales.

Panelistas señalaron que el gobierno pierde la oportunidad de acoger las recomendaciones y abrir diálogo; otros creen que gobierno reconocen aspectos positivos del informe.

Panelistas consideran que no hay sistematicidad, creen que se desconocen elementos como los efectos de los bloqueos y critican la reacción del gobierno ante el contenido de los documentos.

Analistas plantearon los desafíos que tendrá la prensa y las redes sociales ante la llegada de un nuevo gobierno; también un balance de la relación entre medios y candidatos durante la campaña.

Panelistas analizaron la importancia del informe para avanzar hacia la reconciliación; creen que su difusión y comprensión será clave en los próximos años.

Panelistas analizaron quién decide qué debe estar en internet, la manipulación con Inteligencia Artificial a campañas políticas y el uso de la tecnología en niños

Panelistas consideran que algunos de los informes pueden ser tibios, consideran que es urgente hacer cambios a la política en seguridad.

Panelistas consideran que la discusión se sigue politizando, pero consideran que la reforma no resolvería los problemas de financiación del sistema.

Panelistas analizaron lo que significa la permanencia de Ricardo Roa en la presidencia de Ecopetrol y lo que viene con los cambios de la junta directiva.

Panelistas analizaron el informe del PNUD que plantea el grado de satisfacción de los habitantes de los municipios PDET sobre la implementación del Acuerdo de Paz con las Farc.

Luigi Echeverri, exintegrante de la Junta Directiva de Ecopetrol, reveló que hace un tiempo se envió una información a la Fiscalía sobre presuntas irregularidades que involucran a Edwin Palma, el primer sindicalista en la Junta de la entidad, pero que esta quedó “engavetada”

Yahir Acuña, mandatario de la capital del Cesar, defendió en 10AM la medida que adoptaron en la ciudad de fundar un “frente de seguridad”

General, Herbert Benavidez, comandante de la Policía de Barranquilla, se refiere a las alertas por presunta presencia de las disidencias de las FARC en la capital del Atlántico.

El director Nilson Antonio Liz, estuvo invitado en el programa 6AM de Caracol radio, para hablar sobre cuáles son los incumplimientos de este y los otros gobiernos con los campesinos del país

Qué información tienen sobre los perpetradores del asesinato del ganadero, Esteban Urueta, y de dos de los trabajadores de una de las fincas del comerciante.

Armando Novoa, jefe del equipo negociador del Gobierno nacional con la Segunda Marquetalia de ‘Iván Márquez’, estuvo en 6AM para abordar las especulaciones sobre la muerte del guerrillero disidente.

What Danielle Smith posted on her subscribers-only social media; how litter boxes in schools became a Republican talking point; Yankee scented candle reviews as COVID indicator; a surgeon struggles to care for patients through Ethiopia's civil war; Brent Bambury returns and more.

A response from Fang Wengen, the lawyer of Mrs Yang Huiyan

Ascot announced today the appointment of Ian Grayson as Chief Information Officer for UK/ Bermuda. A spokesperson said, “In this newly created role, Ian is responsible for developing and executing a technology transformation strategy and driving technology-based innovation and growth to support the company’s robust UK and Bermuda platforms. He will report to Owen Williams, […]

Three years after the shooting at Robin Hood Restaurant, the police are urging anyone with information on this case to come forward. A police spokesperson said, “Around 6pm on Tuesday 26th October 2021, Police operations received several 911 calls from persons reporting gunshots from inside the Robin Hood Restaurant, located at #25 Richmond Road, Pembroke. “The […]

The CIA from the very first days of the Trump administration, even before he was inaugurated, devoted themselves to sabotaging the administration because Donald Trump questioned just a few of their pieties. And that can't be done in Washington. Whoever does that must be destroyed. And so the CIA and the Deep State operatives became heroes of the liberal left, the people who support the Democratic party. They're now in a full union with the neocons, the Bush Cheney operatives, the CIA, Silicon Valley, and Wall Street. That is the union of power along with mainstream media outlets that are fully behind the Democratic party, which is likely to at least take over one branch of government, if not all of them, with the coming election, and that is a very alarming proposition because they're authoritarian, they believe in censorship, and they believe in suppression of information that exposes them in any kind of a critical light. Continue reading →

The government is instructing social media companies what should and shouldn't be allowed to be on the internet, these are the people least competent to judge what is misinformation. Continue reading →

1. Amerikaanse militair Jack Teixeira (22), die geheime informatie over oorlog lekte, krijgt 15 jaar cel  Het Nieuwsblad
2. Jonge Amerikaanse militair die Pentagon-documenten lekte veroordeeld tot 15 jaar cel  VRT.be
3. Live - Oorlog in Oekraïne. Jack Teixeira, die geheime documenten over oorlog lekte, veroordeeld tot 15 jaar cel • Noord-Koreaanse soldaten betrokken bij gevechten, zeggen VS  De Morgen
4. 15 jaar cel voor Amerikaanse militair die geheime documenten lekte  NOS
5. 15 jaar cel voor Amerikaanse militair die geheime informatie op internet deelde  NU.nl

This is a paper produced as part of the PROP2 (Practitioner Research: Outcomes and Partnership) programme, a partnership between the Centre for Research on Families and Relationships (CRFR) at the University of Edinburgh and Iriss that was about health and social care in Scotland. This paper was written by Alan Gilmour from Glasgow City Community Health Partnership who participated in the PROP2 programme. This research aimed to gain an understanding of how training and information support contributes to positive outcomes for carers. It provided a range of information to answer specific questions such as: • Do carers feel that their needs are identified appropriately at different stages of their journey? • Does training contribute to the carer’s outcomes? • What are the barriers to carers engaging in training?

Informational text — resources whose purpose is to inform — is essential to daily life and fundamental to literacy. Unfortunately, young children typically have limited exposure to informational text. Two 9-week randomized controlled trials with 263 first-grade children from low-income communities examined whether free educational videos and digital games from the PBS KIDS show “Molly of Denali” supported children’s ability to use informational text to answer real-world questions. Study 1 found significant positive intervention impacts on child outcomes; Study 2 replicated these findings.

An important mechanism of resistance to β-lactam antibiotics is via their β-lactamase–catalyzed hydrolysis. Recent work has shown that, in addition to the established hydrolysis products, the reaction of the class D nucleophilic serine β-lactamases (SBLs) with carbapenems also produces β-lactones. We report studies on the factors determining β-lactone formation by class D SBLs. We show that variations in hydrophobic residues at the active site of class D SBLs (i.e. Trp105, Val120, and Leu158, using OXA-48 numbering) impact on the relative levels of β-lactones and hydrolysis products formed. Some variants, i.e. the OXA-48 V120L and OXA-23 V128L variants, catalyze increased β-lactone formation compared with the WT enzymes. The results of kinetic and product studies reveal that variations of residues other than those directly involved in catalysis, including those arising from clinically observed mutations, can alter the reaction outcome of class D SBL catalysis. NMR studies show that some class D SBL variants catalyze formation of β-lactones from all clinically relevant carbapenems regardless of the presence or absence of a 1β-methyl substituent. Analysis of reported crystal structures for carbapenem-derived acyl-enzyme complexes reveals preferred conformations for hydrolysis and β-lactone formation. The observation of increased β-lactone formation by class D SBL variants, including the clinically observed carbapenemase OXA-48 V120L, supports the proposal that class D SBL-catalyzed rearrangement of β-lactams to β-lactones is important as a resistance mechanism.

JL Dixon
Feb 1, 1993; 34:167-179
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