This report of a survey collates member countries’ approaches to manage and mitigate the risk of pesticide use near residential areas.

The OECD Conference on Genome Editing: Applications in Agriculture – Implications for Health, Environment and Regulation will explore the regulatory considerations raised by genome edited products, with the aim to favour a coherent policy approach to facilitate innovation involving genome editing. More information on the programme and the speakers.

On Thursday 26 September 2019, the OECD discussed "Finding Alternatives to Per- and Polyfluoroalkyl Substances of Concern: A Difficult and Continuing Challenge" with the participation of W.L. Gore & Associates, Inc. Presenters shared efforts, successes and challenges in eliminating per and polyfluorinated chemicals of environmental concern from the life cycle of consumer products.

President Trump announced the $3billion food buy - part of April's $16billion farmer assistance program - would begin next week, as unemployment continues to soar in the US.

2. Naturally, filing of the writ application has been found to be defective being inconsistent with the filing procedure prescribed under the High Court Rules, on many counts.

3. The petitioner is a Primary Agriculture Cooperative Society (PACS) registered under the Bihar Cooperative Societies Act, 1935 and is, therefore, a body corporate. The PACS has been given licence to run a fair price shop. There is no averment in the writ application as to when such licence was granted to the PACS, though it is stated in paragraph-5 of the application that for last one decade various similar cooperative societies of the State are successfully conducting the business of fair price shops in addition to discharge of their other duties including procurement of food grains under the procurement schemes of the Government.

C.R.P. 57/2019 & CM APPL.9037/2019 (for interim relief), CM APPL.9038/2019 (for calling Trial Court record)

1. Petitioner impugns order dated 28.01.2019 whereby the Trial Court has allowed the application under Order 23 Rule 1(1) and 1(3) Code of Civil Procedure (CPC for short) filed by the Respondent and C.R.P. No. 57/2019 Page 1 of 9 permitted the Respondent to withdraw the Suit with liberty to file a fresh Suit for damages.

2. A License Agreement was entered into between the parties on 19.09.2015, whereby Petitioner had agreed to license part of its premises in commercial complex known as "Worldmark 1" located at Asset Area 11, situated at Hospitality District, Indira Gandhi International Airport, New Delhi. The license was entered into for a period of 15 years for the purposes of running of multi-tenanted Food & Beverage concepts under the brand and style of Epicuria.

Residents were baffled after the markings appeared at the end of Horseshoe Road in Spalding, Lincolnshire over the weekend.

The 'crap classics' list is made up of models that have seen a surge in demand - and value - as nostalgic previous owners look to regain some part of their youth with cars they drove years ago.

Happy Pinot Noir Day (yes, it really is a thing). I'm up for a bit of veneration - any excuse to celebrate the good things in life, and Pinot Noir is among the best

Memo to all writers of action thrillers, particularly ones who might just be putting the final touches to Bond 25 - I think we may already be at peak drone attack.

: Telangana Chief Minister K Chandrasekhar Rao has instructed officials to prepare a comprehensive agriculture policy for the state with an aim to make the agriculture sector profitable. Rao said he would be talking to farmers through clusters, farmers groups such as Rythu Bandhu Samithis and agriculture officers through a video conference very soon, an official release issued late on Saturday night said. Rao, who held a review on the agriculture department, instructed officials concerned to prepare the comprehensive agriculture policy and stressed the need for everything to happen in tune with it. "The government should decide on which crops the farmers should cultivate. Planning should be done in such a way that crops should be cultivated based on the food needs of people in the state and the crops, which are in demand in the markets in other regions," Rao said. Alternative crops should be identified and suggested to farmers and cultivation done on these lines, he said,

Schools are meant for making better citizens out of our children but in the Dewas district of Madhya Pradesh, they are forging and reinforcing caste-bondages instead. Inclusive education seems a far cry in the villages of Dewas, reports Shuriah Niazi.

It appears that those at the bottom are getting richer - but sadly the maths just doesn't add up. George Monbiot doesn't buy the World Bank's arithmetic.

With the 2003-4 budget giving agriculture the go-by, Devinder Sharma outlines five criteria that nation's finance minister must keep in mind while crafting budgetary policy for agriculture.

Archives, Room Use Only - E608.P73 W38 1999

Here are some scenes from inside Italy's intensive care units, where medical staff are treating the most severe cases of COVID-19

The enzyme 4-hydroxy-tetrahydrodipicolinate synthase (DapA) is involved in the production of lysine and precursor molecules for peptidoglycan synthesis. In a multistep reaction, DapA converts pyruvate and l-aspartate-4-semialdehyde to 4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid. In many organisms, lysine binds allosterically to DapA, causing negative feedback, thus making the enzyme an important regulatory component of the pathway. Here, the 2.1 Å resolution crystal structure of DapA from the thermoacidophilic methanotroph Methylacidiphilum fumariolicum SolV is reported. The enzyme crystallized as a contaminant of a protein preparation from native biomass. Genome analysis reveals that M. fumariolicum SolV utilizes the recently discovered aminotransferase pathway for lysine biosynthesis. Phylogenetic analyses of the genes involved in this pathway shed new light on the distribution of this pathway across the three domains of life.

The interoperability of chemical and biological crystallographic data is a key challenge to research and its application to pharmaceutical design. Research attempting to combine data from the two disciplines, small-molecule or chemical crystallography (CX) and macromolecular crystallography (MX), will face unique challenges including variations in terminology, software development, file format and databases which differ significantly from CX to MX. This perspective overview spans the two disciplines and originated from the investigation of protein binding to model radiopharmaceuticals. The opportunities of interlinked research while utilizing the two databases of the CSD (Cambridge Structural Database) and the PDB (Protein Data Bank) will be highlighted. The advantages of software that can handle multiple file formats and the circuitous route to convert organometallic small-molecule structural data for use in protein refinement software will be discussed. In addition some pointers to avoid being shipwrecked will be shared, such as the care which must be taken when interpreting data precision involving small molecules versus proteins.

Mitochondrial calcium uptake proteins 1 and 2 (MICU1 and MICU2) mediate mitochondrial Ca2+ influx via the mitochondrial calcium uniporter (MCU). Its molecular action for Ca2+ uptake is tightly controlled by the MICU1–MICU2 heterodimer, which comprises Ca2+ sensing proteins which act as gatekeepers at low [Ca2+] or facilitators at high [Ca2+]. However, the mechanism underlying the regulation of the Ca2+ gatekeeping threshold for mitochondrial Ca2+ uptake through the MCU by the MICU1–MICU2 heterodimer remains unclear. In this study, we determined the crystal structure of the apo form of the human MICU1–MICU2 heterodimer that functions as the MCU gatekeeper. MICU1 and MICU2 assemble in the face-to-face heterodimer with salt bridges and me­thio­nine knobs stabilizing the heterodimer in an apo state. Structural analysis suggests how the heterodimer sets a higher Ca2+ threshold than the MICU1 homodimer. The structure of the heterodimer in the apo state provides a framework for understanding the gatekeeping role of the MICU1–MICU2 heterodimer.

Many biologists are now routinely seeking to determine the three-dimensional structures of their proteins of choice, illustrating the importance of this knowledge, but also of the simplification and streamlining of structure-determination processes. Despite the fact that most software packages offer simple pipelines, for the non-expert navigating the outputs and understanding the key aspects can be daunting. Here, the structure determination of the type IV pili (TFP) protein PilA1 from Clostridioides difficile is used to illustrate the different steps involved, the key decision criteria and important considerations when using the most common pipelines and software. Molecular-replacement pipelines within CCP4i2 are presented to illustrate the more commonly used processes. Previous knowledge of the biology and structure of TFP pilins, particularly the presence of a long, N-terminal α-helix required for pilus formation, allowed informed decisions to be made during the structure-determination strategy. The PilA1 structure was finally successfully determined using ARCIMBOLDO and the ab initio MR strategy used is described.

Insights were obtained into the structure of the 4-hydroxy-tetrahydrodipicolinate synthase from the thermoacidophilic methanotroph Methylacidiphilum fumariolicum SolV and the phylogeny of the aminotransferase pathway for the biosynthesis of lysine.

Aerobic thermoacidophilic archaea belonging to the genus Sulfolobus harbor peroxiredoxins, thiol-dependent peroxidases that assist in protecting the cells from oxidative damage. Here, the crystal structure of the 1-Cys peroxiredoxin from Sulfolobus islandicus, named 1-Cys SiPrx, is presented. A 2.75 Å resolution data set was collected from a crystal belonging to space group P212121, with unit-cell parameters a = 86.8, b = 159.1, c = 189.3 Å, α = β = γ = 90°. The structure was solved by molecular replacement using the homologous Aeropyrum pernix peroxiredoxin (ApPrx) structure as a search model. In the crystal structure, 1-Cys SiPrx assembles into a ring-shaped decamer composed of five homodimers. This quaternary structure corresponds to the oligomeric state of the protein in solution, as observed by size-exclusion chromatography. 1-Cys SiPrx harbors only a single cysteine, which is the peroxidatic cysteine, and lacks both of the cysteines that are highly conserved in the C-terminal arm domain in other archaeal Prx6-subfamily proteins such as ApPrx and that are involved in the association of dimers into higher-molecular-weight decamers and dodecamers. It is thus concluded that the Sulfolobus Prx6-subfamily protein undergoes decamerization independently of arm-domain cysteines.

A study published in the journal Global Change Biology finds that while fertilizer has been the dominant source of nitrogen pollution in Caribbean coastal ecosystems for the past 50 years, such pollution is on the decline, thanks in part to the introduction of more advanced, environmentally responsible agricultural practices during the last decade.

The post National Museum of Natural History’s coral collection used in Caribbean agricultural and sewage pollution study appeared first on Smithsonian Insider.

Since researchers began surveys in the 1980s, coral reefs in the Caribbean have undergone widespread change following bleaching and disease epidemics that have reduced the […]

The post Study reveals Agriculture and Fishing Cause Coral Reef Decline appeared first on Smithsonian Insider.

Leafcutter Ants—an amazing species that has been employing agriculture and antibiotics for some 50 million years.

The post Leafcutter ants—first in agiculture and antibiotics appeared first on Smithsonian Insider.

Flowers are usually associated with butterflies, but not the Dutchman’s Pipe (Aristolochia grandiflora). This deciduous vine, native to Brazil, has large flowers that emit an odor of decaying flesh, which attracts flies and beetles.

The post Video: Smithsonian horticulturalist Janet Draper discusses the pollination of the pelican flower appeared first on Smithsonian Insider.

Educational and business leaders want todays students both to master school subjects and to excel in areas such as problem solving, critical thinking, and communication

Producing more precise county-level estimates of crops and farmland cash rents will require integrating multiple data sources using model-based predictions that are more transparent and reproducible, says a new report from the National Academies of Sciences, Engineering, and Medicine.

A new report from the National Academies of Sciences, Engineering, and Medicine identifies the most promising scientific breakthroughs that are possible to achieve in the next decade to increase the U.S. food and agriculture system’s sustainability, competitiveness, and resilience.

To ensure that U.S. agricultural policies are well-informed, data collection programs must be periodically revisited to reflect current realities of the agricultural sector, says a new report from the National Academies of Sciences, Engineering, and Medicine.

A new study has investigated the effects of set-aside management —when fields are taken out of agricultural production — on common invertebrate decomposers in soil. The diversity of woodlice species was higher in set-aside fields compared to neighbouring wheat fields and this effect increased in older set-asides. This study highlights the importance of set-aside areas as habitats for soil invertebrates, which are important for soil health.

Physical and occupational therapists carry bags of personal protective equipment on their way to the room of a COVID-19 patient in a Stamford Hospital intensive care unit in Stamford, Conn., on April 24. This "prone team" turns over COVID-19 to help them breathe.; Credit: John Moore/Getty Images

Intensive care teams inside hospitals are rapidly altering the way they care for patients with COVID-19.

The changes range from new protective gear to new treatment protocols aimed at preventing deadly blood clots.

"Things are moving so fast within this pandemic, it's hard to keep up" says Dr. Angela Hewlett, an infectious diseases physician at University of Nebraska Medical Center in Omaha and medical director of the Nebraska Biocontainment Unit. To stay current, she says, ICUs are updating their practices "on an hourly basis."

"We are learning at light speed about the disease," says Dr. Craig Coopersmith , interim director of the critical care center at Emory University. "Things that previously might have taken us years to learn, we're learning in a week or two. Things that might have taken us a month to learn beforehand, we're learning in a day or two."

The most obvious changes involve measures to protect ICU doctors, nurses and staff from the virus.

"There is a true and real probability of infection," says Dr. Tiffany Osborn a critical care specialist at Washington University School of Medicine and Barnes-Jewish Hospital in St. Louis. "You have to think about everything you touch as if it burned."

So ICUs are adapting measures used at special biocontainment units like the one at the University of Nebraska. These units were designed to care for patients affected by bioterrorism or infected with particularly hazardous communicable diseases like SARS and Ebola.

The Nebraska biocontainment unit "received several patients early on in the pandemic who were medically evacuated from the Diamond Princess cruise ship," Hewlett says. But it didn't have enough beds for the large numbers of local patients who began arriving at the University of Nebraska Medical Center.

So the nurses, respiratory therapists and physicians from the biocontainment team have "fanned out and are now working within those COVID units to make sure that all of our principles and protocols are followed there as well," Hewlett says.

Those protocols involve measures like monitoring ICU staff when they remove their protective gear to make sure the virus isn't transmitted, and placing infected patients in negative pressure rooms, which draw air inward, when possible to prevent the virus from escaping.

One of the riskiest ICU procedures is inserting a breathing tube in a COVID-19 patient's airway, which creates a direct path for virus to escape from a patient's lungs. "If you're intubating a patient, that's a much higher risk than, say, going in and doing routine patient care," Hewlett says.

So ICU teams are being advised to add several layers of protection beyond a surgical mask.

Extra personal protective equipment may include an N95 respirator, goggles, a full face shield, a head hood, an impermeable isolation gown and double gloves.

In many ICUs, teams are also placing a clear plastic box or sheet over the patient's head and upper body before inserting the tube. And as a final safety measure, the doctor may guide the tube using a video camera rather than looking directly down a patient's airway.

"It usually takes 30 minutes or so in order to get all of that equipment together, to get all of the right people there," says Dr. Kira Newman, a senior resident physician at UW Medical Center in Seattle. "and that would be a particularly fast intubation."

But most changes in the ICU are in response to an ongoing flood of new information about how COVID-19 affects the body.

There's a growing understanding, for example, that the infection can cause dangerous blood clots to form in many severely ill patients. These clots can kill if they block arteries supplying the lungs or brain. But they also can prevent blood from reaching the kidneys or even a patient's arms and legs.

Clots are a known risk for all ICU patients, Cooperman says, but the frequency and severity appears much greater with COVID-19. "So we're starting them on a higher level of medicine to prevent blood clots and if somebody actually develops blood clots, we have a plan B and a plan C and a plan D," he says.

ICU teams are also recalibrating their approach to ensuring that patients are getting enough oxygen. Early in the pandemic, the idea was to put patients on mechanical ventilator quickly to make sure their oxygen levels didn't fall too far.

But with experience, doctors have found that mechanical ventilators don't seem to work as well for COVID patients as they do for patients with other lung problems. They've also learned that that many COVID-19 patients remain lucid and relatively comfortable even when the oxygen levels in their blood are extremely low.

So many specialists are now recommending alternatives to mechanical ventilation, even for some of the sickest patients. "We're really trying now to not intubate," Osborn says.

Instead, ICU teams are relying on devices that deliver oxygen through the nasal passages, or through a mask that fits tightly over the face. And there's renewed interest in an old technique to help patients breathe. It's called proning.

"Instead of them being on their back, we're turning them on their front," Osborn says. The reason, she says is to open up a part of the lung that is collapsed when a patient is on their back.

This content is from Southern California Public Radio. View the original story at SCPR.org.

The long-lasting and negative effects of intensive farming on soils persist even where complex animal communities have been reintroduced to the soil in attempt to restore the natural balance, according to a recent study. The findings highlight the possible effects of historical land use on soils' ability to deliver ecosystem services.

There is a need to broaden the debate on sustainable food security from a straight comparison between organic and conventional farming to a consideration of a variety of farming techniques. This is the conclusion of a new review of research that indicates, for some crop types, organic yields can nearly match conventional yields under good management practices and growing conditions.

Alien plant invasions can have significant environmental, ecosystem and economic implications. Since ornamental horticulture is the primary pathway for invasive alien plant introductions, it is a suitable focus for prevention policies. A recent review of published evidence has examined the effectiveness of four major instruments: pre-border import restrictions, post-border sales bans, industry codes of conduct, and consumer education. The study highlights that, while each instrument has the potential to contribute to a reduction in plant invasion risk, none is sufficient to achieve this goal alone. The researchers, therefore, describe how the four instruments can be integrated along the ornamental horticulture industry supply chain to reduce risk more effectively, and outlines the role that government, industry and other stakeholders must play to achieve this goal.

For more than 120 years the Venus Table of the Dresden Codex -- an ancient Mayan book containing astronomical data -- has been of great interest to scholars around the world. The accuracy of its observations, especially the calculation of a kind of 'leap year' in the Mayan Calendar, was deemed an impressive curiosity used primarily for astrology.

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Acute exacerbations of chronic obstructive pulmonary disease, or COPD, are associated with significant long-term lung function loss, according to research published online, ahead of print in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

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Agriculture plays a large role in the management of water in the EU. However, there is little consistent information on water use in irrigation. New EU supported research has estimated how much water is used for irrigation in European countries, providing a framework to analyse agricultural pressures on water quantity.

Estonian research has identified land use practices and agrochemical use as the main pressures that are causing a decline in pollinating insects in Europe, such as bees and butterflies. It calls for increased funds for agri-environment measures from the Common Agricultural Policy (CAP) to help tackle pollinator loss.

Researchers have calculated how much phosphorus is taken from the land by major crops around the world and how much is applied as fertiliser, to help estimate agriculture's phosphorus footprint. Among their conclusions, they argue that phosphorus fertiliser needs to be used more sustainably to address global imbalances in its use.

Indonesia’s plans to double palm oil production by 2020 have obvious financial benefits, but implications for food, biodiversity and carbon stocks are not so clear. A new model predicts the impacts of five possible palm oil production strategies and indicates the best approach is to target degraded and agricultural land that is most productive for palm oil.

The long-lasting and negative effects of intensive farming on soils persist even where complex animal communities have been reintroduced to the soil in attempt to restore the natural balance, according to a recent study. The findings highlight the possible effects of historical land use on soils' ability to deliver ecosystem services.

There is a need to broaden the debate on sustainable food security from a straight comparison between organic and conventional farming to a consideration of a variety of farming techniques. This is the conclusion of a new review of research that indicates, for some crop types, organic yields can nearly match conventional yields under good management practices and growing conditions.

New research has investigated the long-term effects of applying sewage sludge to Spanish soils. The results indicate that sludge enhances soil properties, but recommends a maximum dose of 40 tons per hectare, applied biannually. Above this level, it appears the soil properties will not improve and may even worsen.