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Advances, opportunities, and challenges in methods for interrogating the structure activity relationships of natural products

Nat. Prod. Rep., 2024, 41,1543-1578
DOI: 10.1039/D4NP00009A, Review Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Christine Mae F. Ancajas, Abiodun S. Oyedele, Caitlin M. Butt, Allison S. Walker
This review highlights methods for studying structure activity relationships of natural products and proposes that these methods are complementary and could be used to build an iterative computational-experimental workflow.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Estimating the extent of adulteration of the popular herbs black cohosh, echinacea, elder berry, ginkgo, and turmeric – its challenges and limitations

Nat. Prod. Rep., 2024, 41,1604-1621
DOI: 10.1039/D4NP00014E, Review Article
Open Access
Nilüfer Orhan, Stefan Gafner, Mark Blumenthal
This review article focuses on the challenges and limitations of estimating the prevalence of adulteration in preparations made from black cohosh, echinacea, elder berry, ginkgo, and turmeric.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Key challenges faced by farmer producer companies in the agricultural ecosystem

Building genuine connections and understanding the intrinsic motivations of farmers can create a vibrant ecosystem




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Proper road infrastructure, skilled workforce among key challenges for logistics industry: experts

These challenges are pushing logistics firms to balance cost management, workforce, and technology investment to maintain competitiveness




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Adani Kattupalli port continues to face operational challenges

Only one container ship to be berthed between November 11 and 14




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Dilute nanocomposites for capacitive energy storage: progress, challenges and prospects

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05437G, Perspective
Open Access
Li Li, Wenhan Xu, Guanchun Rui, Shixian Zhang, Qiming Zhang, Qing Wang
Electrostatic capacitors (ECs) are critical components in advanced electronics and electric power systems due to their rapid charge-discharge rate and high power density. While polymers are ideal for ECs due...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Chinmaya Mission takes up growing challenges of mental health




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India steps up critical mineral acquisition plans in Africa, challenging China’s dominance

Race for critical minerals primarily focuses on cobalt and copper – key EV battery making metals, apart from lithium.




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Denmark Open badminton: Indian challenge ends in women’s and mixed doubles

Both the Indian pairs is action — Treesa Jolly and Gayatri Gopichand (women’s doubles) and B Summeth Reddy and N Sikki Reddy (mixed doubles) — suffered heartbreak three-game defeats in their opening contests




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Sri Lanka’s multi-ethnic east reflects challenges facing Anura Kumara Dissanayake

Voters in Ampara district voice hope, skepticism ahead of November 14 parliamentary polls 




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​Last mile woes: On inflation data and the challenges

Inflation should not be allowed to undermine the economic momentum 




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Challenges on the water front

Weather anomalies, pollution, mindless exploitation… the problems are many but solutions are available.




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Delhi excise policy case: HC asks ED to respond to Kejriwal’s plea challenging summons

Justice Manoj Kumar Ohri refused to stay the trial in the criminal case and said the trial court’s order, which has been challenged by Kejriwal, is two months old and not a fresh order




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S. Korea woos startups in India with ‘grand challenge’

Wants them to look at Korea as a testing bed for their ventures




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Udhayanidhi Stalin responds to Palaniswami’s challenge




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The summer shape-up challenge

Experts share cool tips for a hot weather workout.




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Editorial. Agri Stack can be transformative, but implementation will be a challenge

Land records remain contested, despite over 90 per cent digitisation. Concerns over data theft and cyber fraud cannot be disregarded




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For new players, existing expense of management regulations are a challenge: Zuno General Insurance CEO

Zuno General Insurance continued to grow faster than the industry in the second quarter of this fiscal, says Shanai Ghosh, MD & CEO of the company



  • Money & Banking

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JC Flowers ARC seeks bids to sell ₹2,613 crore of bad loans via Swiss challenge mode

The NPAs on block were part of YES Bank’s legacy bad loan portfolio.



  • Money & Banking

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A strike, and Tamil Nadu’s challenge

The State government cannot afford to neglect the interests of workers




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Delhi’s challenges in school education

Absenteeism, discriminatory policies, and poor infrastructure are major issues




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Kishan Reddy slams Revanth government for failing farmers, challenges Rahul Gandhi to tour villages in Telangana




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NewGen stars have a chance to shine as Proteas challenge awaits 

It is imperative for them to shed the tag of sidekicks and establish themselves as the first-choice players in this format.




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The UPSC challenge

Several myths surround the UPSC examination, but here is what you need to do to succeed.




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The challenge of Economics

How prepared are you to face the CBSE exam on this application-oriented subject?




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Role of Rajasthan’s tribal communities in meeting global challenges highlighted at U.N. event

The best practices of tribal communities highlighted at the forum included the production of local seeds, water conservation at source, use of animals in agriculture, checking soil erosion through mixed cropping, and the use of uncultivated food for nutritional security




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Federation cup: Neeraj beats the heat and Manu’s challenge




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Diamond League season finale: Neeraj Chopra, Avinash Sable spearhead Indian challenge

The showpiece is spread over two days for the first time and the field features top athletes from all continents, including an unprecedented number of Olympic medal winners, who will be vying for the top honours in 32 disciplines.




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High-flying Unnathi and her progression into a new challenge

Having won many medals in the 200m sprint and 100m hurdles, Unnathi’s move to the 400m hurdles — considered the toughest in track and field — has been encouraged by her father and coach Aiyappa




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Diagnostic protocols, more research needed to combat H. pylori challenge in India: experts

The bacterial infection, which often begins in childhood, is almost 10 times more prevalent than diabetes in the country and is a major cause of chronic gastritis, peptic ulcers and even stomach cancer, according to doctors




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Blinken says India-US working to address regional and global challenges after meeting Jaishankar

Jaishankar met Blinken on Tuesday at the Foggy Bottom headquarters of the US State Department.




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Border-Gavaskar Trophy: Australian opener McSweeney braces for "unique" Bumrah challenge

McSweeney was drafted into the Australia squad after a slew of impressive performances in the Sheffield Shield tournament and in the recent ‘A’ series against India




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Centre for Development Studies: Looking to the future, evolving strategies to meet present-day challenges

CDS is evolving strategies for research and financial self-sufficiency while maintaining original mandate, exploring new programmes and training opportunities.




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Leadership void at DUK and KTU: Administrative challenges persist amid Vice-Chancellor vacancies




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How are tyre-makers gearing up for challenges?

Dumping of Chinese tyres, new axle norms, switch to BS VI norms and move to electric vehicles are issues of concern




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Facing the camera is more challenging than playing the game: Tendulkar




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Ahead Of Uttar Pradesh Bypolls, Yogi Adityanath Faces A 'Youth' Challenge

UPPCS Protest: Amid the bypolls contest, the Yogi Adityanath government is facing a challenge which the BJP was not anticipating at this time.




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Edtech giant Byju’s challenges insolvency proceedings in NCLAT

Byju’s remains solvent with plans to settle ₹158 crore dispute




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Youngsters will learn if you challenge them: Ashok Jhunjhunwala

Prof. Ashok Jhunjhunwala receives businessline Iconic Changemaker Award




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Ready for bigger challenges

With several medal-winning performances in recent inter-state and Open National events, the top athletes from Tamil Nadu exude an air of confidence these days




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‘The violence, to me, seemed scripted against Dalits,’ says Ajaz Ashraf, author of Bhima Koregaon — Challenging Caste

Different castes remember the incident at Bhima Koregaon on January 1, 2018, and the reasons for it differently




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Deep ion mass transfer addressing the capacity shrink challenge of aqueous Zn‖MnO2 batteries during the cathode scaleup

Energy Environ. Sci., 2024, 17,8904-8914
DOI: 10.1039/D4EE02871F, Paper
Na Jiang, You Zeng, Qi Yang, Puda Lu, Keqi Qu, Lihang Ye, Xuejun Lu, Ziqiang Liu, Xixian Li, Yongchao Tang, Jinchao Cao, Shimou Chen, Chunyi Zhi, Jieshan Qiu
This work shows that the introduction of interstitial carbon into the MnO2 lattice could reduce the affinity toward SO42− and OH, thus suppressing the surface coverage of ZHS and improving the Zn||MnO2 battery performance under large loading mass.
The content of this RSS Feed (c) The Royal Society of Chemistry




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The future challenges in J&K

The interlocutors from PM Gandhi’s side were insistent that Sheikh Abdullah’s pre-condition that he should be given the pre-1953 status should not be met while Sheikh’s aides were in no mood to compromise




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Biological effects and mechanisms of dietary chalcones: latest research progress, future research strategies, and challenges

Food Funct., 2024, 15,10582-10599
DOI: 10.1039/D4FO03618B, Review Article
Yun Liang Zhang, Shuang Jiao Sun, Li Zeng
Chalcones are widely distributed in food and have multiple biological activities; there are limitations and drawbacks in the application of dietary chalcones in food; future research strategies and key issues for dietary chalcones.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Delhi HC asks ED to respond to Kejriwal’s plea challenging summons

AAP leader has challenged a trial court’s September 17 order rejecting his plea challenging the summons issued to him on ED’s complaint in a money laundering case related to the alleged Delhi excise scam




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Microgels for bioprinting: recent advancements and challenges

Biomater. Sci., 2024, 12,1950-1964
DOI: 10.1039/D3BM01733H, Review Article
Mingjun Xie, Ji Wang, Sufan Wu, Sheng Yan, Yong He
This review introduces different methods used to generate microgels and the microgel-based bioink for bioprinting. Besides, the further tendency of microgel development in future is predicted.
The content of this RSS Feed (c) The Royal Society of Chemistry




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In Maharashtra Polls, Gavit Family Holds Key To All Four Nandurbar Seat - A Stiff Challenge For BJP, Congress

In Nandurbar district, 70 per cent of the population is tribal and the region has consistently ranked among the lowest in Maharashtra's Human Development Index.




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Ahead Of Uttar Pradesh Bypolls, Yogi Adityanath Faces A `Youth` Challenge

UPPCS Protest: Amid the bypolls contest, the Yogi Adityanath government is facing a challenge which the BJP was not anticipating at this time.




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Today’s top tech news: Apple’s labour challenges; Russian trolls target U.S. elections; Microsoft’s AI users in India




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Committee on Science: Exploring emerging scientific challenges and opportunities