engineer

Scientific Consensus Shows Covid-19 'Not Genetically Engineered', India Funding Vaccine Development: DBT Secretary

Ministry of Science and Technology's Department of Biotechnology (DBT) Dr Renu Swarup says that based on the latest WHO consensus, Covid-19 as a 'lab release' theory is likely to be false.




engineer

SSC CHSL, Junior Engineer And Stenographer Exams Postponed Due to Coronavirus

The country is going through a national emergency due to the outbreak of Novel Coronavirus pandemic and hence is currently observing the lockdown till May 3, 2020. Most of the entrance exams along with board exams deferred due to COVID. There




engineer

SSC Results Postponed For Junior Engineer, MTS And CGL Due To Coronavirus

The Staff Selection Commission (SSC) has announced that the results of various exams have been postponed due to the outbreak of Novel Coronavirus (COVID 19). The Commission has postponed the results of dates of Junior Engineer (Civil, Mechanical, Electrical and Quantity




engineer

A textbook on telegraph engineering / International Correspondence Schools, Scranton, Pa

Archives, Room Use Only - TK5261.I58 1901




engineer

Submarine telegraphy: instruction paper / presented by the engineers of the Western Union Telegraph Company

Archives, Room Use Only - TK5621.A44 1920




engineer

McNeill's code: arranged to meet the requirements of mining, metallurgical and civil engineers; directors of mining, smelting and other companies; bankers; stock and share brokers; solicitors, accountants, financiers and general merchants: safety and

Archives, Room Use Only - HE7677.M6 M36 1895




engineer

Sir William Preece, F.R.S.: Victorian engineer extraordinary / E. C. Baker

Archives, Room Use Only - TK140.P73 B34 1976




engineer

Electricity in theory and practice, or, The elements of electrical engineering / by Bradley A. Fiske

Archives, Room Use Only - TK145.F57 1884




engineer

Text book on telegraph cable engineering / [Eastern Associated Telegraph Companies] ; edited by J.H. Stephens

Archives, Room Use Only - TK5481.E27 1925




engineer

Catalogue of the Wheeler gift of books, pamphlets and periodicals in the library of the American Institute of Electrical Engineers / edited by William D. Weaver ; with introduction, descriptive and critical notes by Brother Potamian

Archives, Room Use Only - ZTK143.N532




engineer

The life story of Sir Charles Tilston Bright, civil engineer: with which is incorporated the story of the Atlantic cable, and the first telegraph to India and the colonies / by Charles Bright

Archives, Room Use Only - TK5611.B85 1910




engineer

The history of the Institution of Electrical Engineers (1871-1931) / by Rollo Appleyard

Archives, Room Use Only - TK1.I42 1939




engineer

Submarine telegraphy / prepared by the Engineers of The Western Union Telegraph Company

Archives, Room Use Only - TK5626.W47 1920




engineer

McNeill's code: arranged to meet the requirements of mining, metallurgical and civil engineers; directors of mining, smelting and other companies; bankers; stock and share brokers; solicitors, accountants, financiers and general merchants: safety and

Archives, Room Use Only - HE7677.M6 M36 1905




engineer

Duplex and quadruplex telegraphy: instruction paper / prepared by the engineers of the Western Union Telegraph Company

Archives, Room Use Only - TK5521.A44 1917




engineer

The new general and mining telegraph code ...: alphabetically arranged for the use of mining companies, mining engineers, stockbrokers, financial agents, and trust and finance companies / by C. Algernon Moreing and Thomas Neal

Archives, Room Use Only - HE7677.M6 M67 1907




engineer

Modern electrical engineering / prepared under the editorship of Magnus Maclean

Archives, Room Use Only - TK145.M334 1919




engineer

Telegraphy and telephony with railroad applications / by Charles Stanley Rhoads ; a description of the fundamentals of telegraphy and telephony and of the organization, outside and inside plant, apparatus, circuits and methods of operation, engineering a

Archives, Room Use Only - TK5262.R46 1924




engineer

Telegraph repeaters: instruction paper / prepared by the Engineers of the Western Union Telegraph Company

Archives, Room Use Only - TK5571.W47 1918




engineer

District telegraph and time service: instruction paper / prepared by the Engineers of the Western Union Telegraph Company

Archives, Room Use Only - TK5263.W468 1917




engineer

History of the Engineering department / by E.C. Baker

Archives, Room Use Only - HE6935.B35 1939




engineer

London international telephone exchange: reproduced from the Post Office Electrical Engineers' Journal of July, 1934 / by S. Birch and C.H. Hartwell

Archives, Room Use Only - TK6211.B57 1934




engineer

Pioneer inventions and pioneer patents: a lecture on patent law delivered to the senior engineering students of Purdue University of the classes of '22, '23, and '24 and previous classes / by Frank Keiper

Archives, Room Use Only - T223.Z1 K45 1924




engineer

Chemical crystallography and crystal engineering

Today, there is very little doubt that chemistry owes as much to crystallography as crystallography does to chemistry. This mutual synergy defines modern chemical crystallography.






engineer

Engineering a surrogate human heteromeric α/β glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein

Protein-engineering methods have been exploited to produce a surrogate system for the extracellular neurotransmitter-binding site of a heteromeric human ligand-gated ion channel, the glycine receptor. This approach circumvents two major issues: the inherent experimental difficulties in working with a membrane-bound ion channel and the complication that a heteromeric assembly is necessary to create a key, physiologically relevant binding site. Residues that form the orthosteric site in a highly stable ortholog, acetylcholine-binding protein, were selected for substitution. Recombinant proteins were prepared and characterized in stepwise fashion exploiting a range of biophysical techniques, including X-ray crystallography, married to the use of selected chemical probes. The decision making and development of the surrogate, which is termed a glycine-binding protein, are described, and comparisons are provided with wild-type and homomeric systems that establish features of molecular recognition in the binding site and the confidence that the system is suited for use in early-stage drug discovery targeting a heteromeric α/β glycine receptor.




engineer

Crystal engineering of exemestane to obtain a co-crystal with enhanced urease inhibition activity

Co-crystallization is a phenomenon widely employed to enhance the physio-chemical and biological properties of active pharmaceutical ingredients (APIs). Exemestane, or 6-methyl­ideneandrosta-1,4-diene-3,17-dione, is an anabolic steroid used as an irreversible steroidal aromatase inhibitor, which is in clinical use to treat breast cancer. The present study deals with the synthesis of co-crystals of exemestane with thio­urea by liquid-assisted grinding. The purity and homogeneity of the exemestane–thio­urea (1:1) co-crystal were confirmed by single-crystal X-ray diffraction followed by thermal stability analysis on the basis of differential scanning calorimetry and thermogravimetric analysis. Detailed geometric analysis of the co-crystal demonstrated that a 1:1 co-crystal stoichiometry is sustained by N—H⋯O hydrogen bonding between the amine (NH2) groups of thio­urea and the carbonyl group of exemestane. The synthesized co-crystal exhibited potent urease inhibition activity in vitro (IC50 = 3.86 ± 0.31 µg ml−1) compared with the API (exemestane), which was found to be inactive, and the co-former (thio­urea) (IC50 = 21.0 ± 1.25 µg ml−1), which is also an established tested standard for urease inhibition assays in vitro. The promising results of the present study highlight the significance of co-crystallization as a crystal engineering tool to improve the efficacy of pharmaceutical ingredients. Furthermore, the role of various hydrogen bonds in the crystal stability is successfully analysed quantitatively using Hirshfeld surface analysis.




engineer

Forthcoming article in Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials




engineer

Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization

Immunoglobulin E (IgE) plays a central role in the allergic response, in which cross-linking of allergen by Fc∊RI-bound IgE triggers mast cell and basophil degranulation and the release of inflammatory mediators. The high-affinity interaction between IgE and Fc∊RI is a long-standing target for therapeutic intervention in allergic disease. Omalizumab is a clinically approved anti-IgE monoclonal antibody that binds to free IgE, also with high affinity, preventing its interaction with Fc∊RI. All attempts to crystallize the pre-formed complex between the omalizumab Fab and the Fc region of IgE (IgE-Fc), to understand the structural basis for its mechanism of action, surprisingly failed. Instead, the Fab alone selectively crystallized in different crystal forms, but their structures revealed intermolecular Fab/Fab interactions that were clearly strong enough to disrupt the Fab/IgE-Fc complexes. Some of these interactions were common to other Fab crystal structures. Mutations were therefore designed to disrupt two recurring packing interactions observed in the omalizumab Fab crystal structures without interfering with the ability of the omalizumab Fab to recognize IgE-Fc; this led to the successful crystallization and subsequent structure determination of the Fab/IgE-Fc complex. The mutagenesis strategy adopted to achieve this result is applicable to other intractable Fab/antigen complexes or systems in which Fabs are used as crystallization chaperones.




engineer

Wanted to do software engineering.





engineer

Next Engineering Revolution Is Hiding in Museum Collections

Engineers shouldn’t have to reinvent the wheel—or wings, or sonar systems—when mother nature has already done much of the heavy design work. In fact, finding […]

The post Next Engineering Revolution Is Hiding in Museum Collections appeared first on Smithsonian Insider.




engineer

21 Centurys Grand Engineering Challenges Unveiled

The U.S. National Academy of Engineering (NAE) today announced the grand challenges for engineering in the 21st century. A diverse committee of experts from around the world, convened at the request of the U.S. National Science Foundation, revealed 14 challenges that, if met, would improve how we live.




engineer

Genetically Engineered Crops Benefit Many Farmers, but the Technology Needs Proper Management to Remain Effective

Many U.S. farmers who grow genetically engineered (GE) crops are realizing substantial economic and environmental benefits -- such as lower production costs, fewer pest problems, reduced use of pesticides, and better yields -- compared with conventional crops, says a new report from the National Research Council.




engineer

National Academy of Engineering Elects 67 Members and 11 Foreign Associates

The National Academy of Engineering (NAE) has elected 67 new members and 11 foreign associates, announced NAE President C.D. (Dan) Mote Jr. today. This brings the total U.S. membership to 2,250 and the number of foreign associates to 214.




engineer

Genetically Engineered Crops - Experiences and Prospects

An extensive study by the National Academies of Sciences, Engineering, and Medicine has found that new technologies in genetic engineering and conventional breeding are blurring the once clear distinctions between these two crop-improvement approaches.




engineer

New Report Examines Role of Engineering Technology, Calls for Increased Awareness of Field of Study and Employment

While workers in the engineering technology (ET) field play an important role in supporting U.S. technical infrastructure and the country’s capacity for innovation, there is little awareness of ET as a field of study or category of employment in the U.S., says a new report from the National Academy of Engineering.




engineer

Statement by the National Academies of Sciences, Engineering, and Medicine regarding PLOS ONE article on our study of genetically engineered crops

The National Academies Committee on Genetically Engineered Crops - Past Experiences and Future Prospects authored an almost 600-page landmark report, released in May 2016. It was perhaps the most comprehensive analysis of genetically engineered crops to date.




engineer

U.S. National Academies of Sciences, Engineering, and Medicine to Host InterAcademy Partnership for Research (IAP-R) Secretariat

The U.S. National Academies of Sciences, Engineering, and Medicine are now serving as the host for the InterAcademy Partnership for Research (IAP-R) secretariat.




engineer

Computer Science Pioneer to Receive the 2018 Charles Stark Draper Prize for Engineering

The National Academy of Engineering announced today that the 2018 Charles Stark Draper Prize for Engineering will be awarded to Bjarne Stroustrup.




engineer

EngineerGirl Announces 2018 Community Infrastructure Essay Contest Winners

The National Academy of Engineering today announced the winners of its 2018 EngineerGirl essay competition.




engineer

Statement by the Presidents of the National Academy of Sciences, National Academy of Engineering, and National Academy of Medicine on Preventing Sexual Harassment

Sexual harassment in science, engineering, and medicine diminishes the integrity of the U.S. research enterprise.




engineer

National Academies Launch “New Voices” Project to Engage Next-Generation Leaders in Science, Engineering, and Medicine

The National Academies of Sciences, Engineering, and Medicine are launching the “New Voices in Sciences, Engineering, and Medicine” initiative to identify outstanding early-career science, engineering, and medicine (SEM) leaders.




engineer

John L. Anderson Nominated to be Next National Academy of Engineering President

The National Academy of Engineering (NAE) 2019 nominating committee1 has recommended John L. Anderson, President Emeritus and distinguished professor of chemical engineering at the Illinois Institute of Technology (Illinois Tech), to stand as the sole candidate2 for the NAE presidency.




engineer

National Academy of Engineering Announces Winners of 2018 Ramo Founders and Bueche Awards

On Sunday, Sept. 30, during its 2018 annual meeting, the National Academy of Engineering (NAE) will present two awards for extraordinary impact on the engineering profession.




engineer

Investigation and Design Can Improve Student Learning in Science and Engineering - Changes to Instructional Approaches Will Require Significant Effort

Centering science instruction around investigation and design can improve learning in middle and high schools and help students make sense of phenomena in the world around them.




engineer

Curbing Climate Change and Sustainably Supplying Food, Water, and Energy Among Top Challenges Environmental Engineering Can Help Address, New Report Says

Over the next several decades as the global population grows, society will be faced with pressing challenges such as providing reliable supplies of food and water, diminishing climate change and adapting to its impacts, and building healthy, resilient cities.




engineer

Interview - John L. Anderson Discusses His New Role as the National Academy of Engineerings President

When John L. Anderson, president emeritus and distinguished professor of chemical engineering at the Illinois Institute of Technology, was first elected to the National Academy of Engineering almost 30 years ago, he remembers being deeply honored and excited about how the recognition would help his career.




engineer

Global Grand Challenges Summit 2019 Will Bring Over 900 Engineers to London to Address Engineering in an Unpredictable World

International thought leaders will join the next generation of engineers in London from Sept. 16 to 18 for the Global Grand Challenges Summit 2019. The summit aims to help inspire and equip future engineering leaders to address the rapidly evolving challenges of an unpredictable world.