Time has been extremely kind to Checketts' Knicks tenure.

Leitrim's historic 1994 Connacht championship success was the culmination of a building process initiated five years earlier

Between 83,000 and 190,000 people could die of COVID-19 in Africa, with 29 million to 44 million infected, in the coronavirus pandemic’s first year if containment measures do not work, the African regional office of the World Health Organization (WHO) said Thursday.

Lin-Manuel Miranda, Neil Patrick Harris, Josh Groban and Meryl Streep are just a few of the artists featured in Take Me to the World, a tribute to the iconic Broadway composer and lyricist.

Lin-Manuel Miranda, Neil Patrick Harris, Josh Groban and Meryl Streep are just a few of the artists featured in Take Me to the World, a tribute to the iconic Broadway composer and lyricist.

The conservative radio host spent an extraordinary six decades in the broadcasting business.

The conservative radio host spent an extraordinary six decades in the broadcasting business.

Between 83,000 and 190,000 people could die of COVID-19 in Africa, with 29 million to 44 million infected, in the coronavirus pandemic’s first year if containment measures do not work, the African regional office of the World Health Organization (WHO) said Thursday.

Time has been extremely kind to Checketts' Knicks tenure.

Owen Bieber, who shepherded the UAW through a recession, the Reagan era, industry downsizing and rapidly expanding global competition, dies at 90.

After he retired, Tidwell pleaded guilty to taking hundreds of guns from evidence lockers

Swedish actor Max von Sydow, the stately import whose theater roots laid the groundwork for a vast onscreen career in nearly a dozen Ingmar Bergman productions, has died.

We drove the 2020 Genesis G90, the latest flagship from Hyundai's luxury arm: It's rich on details and sophisticated systems and discounted on price.

Valentino's Le Blanc program takes the crisp white shirt from runway to reality.

The best performances in "Take Me to the World: A Sondheim 90th Birthday Celebration" showed how the composer doesn't traffic in formulas.

Jules Haimovitz, who's served as president of MGM Networks and Viacom, is asking $21.32 million for his estate in the Beverly Hills Post Office area.

Boss of Britain's busiest air hub calls for 'a common international standard for healthcare screening in airports'

Lin-Manuel Miranda, Neil Patrick Harris, Sutton Foster, Bernadette Peters, Audra McDonald, Christine Baranski, Katrina Lenk and Michael Cerveris salute composer Stephen Sondheim.

In this video taken by a Vintage Tabernacle Apartments resident, Dmytro Luke is seen being taken into custody by police after firing a gun inside a student housing complex.

A look at Indianapolis after the turn of the 20th century

Como crise atingiu primeiro americanos, na opinião de analistas e operadores de empresas de remessas migrantes devem se recuperar financeiramente a tempo de socorrer familiares em suas cidades originais.

James "Jim" Cummings Jr., who was the last living founder of Indiana Black Expo., died late Thursday at age 90 of a heart attack.

战争的血腥，没有让90后却步。参军，仍然是一个人生选择……

'Last Dance' brings back memories of tough 90's NBA for Pacers coach Nate McMillan

'Last Dance' brings back memories of tough 90's NBA for Pacers coach Nate McMillan

The transport secretary warns social distancing will mean severely-reduced passenger capacity.

'Last Dance' brings back memories of tough 90's NBA for Pacers coach Nate McMillan

Covid-19 could linger for years and "smoulder in transmission hot spots", the WHO warns.

As COVID-19 continues to shut down sporting events across the globe, a former Roughriders’ CEO says it could be the greatest threat the CFL has ever faced.

"Final Fantasy VII Remake" is a beautiful-looking game with a juvenile mindset that’s fun to pass through but hard for non-teenagers to be riveted by.

velocityconf: RT @OReillyAnimals Advice, please! Elephant Listening Project asks for ideas/solutions/help with 3 practical problems http://t.co/Y90YP3maoz

Brazil

The Amateur Traveler talks to Carole Terwilliger Meyers the author of Weekend Adventures in San Francisco and Northern California. Carole comes on the show to talk about California’s traditional wine country of Napa and Sonoma Valleys. This episode focuses primarily on the Napa Valley and the many wineries that can be found there. We explore recreated castles, wine tasting , tours as well as other none wine related sites like mud baths, petrified forests, and the CIA (The Culinary Institute). We talk about restaurants and hotels, picnics and the wine train. Whether you are a connoisseur, a foodie or just a tourist, the Napa Valley has much to offer.

The Amateur Traveler talks to New York travel writer Jeanine Barone about the Azores. The Azores are a chain of islands belonging to Portugal. Your travel agent will extol the beauty of the beaches but Jeanine says that the best of the Azores can be seen through hiking its craggy islands.

    If you want to be in a place that feels very unspoiled, but is so close actually to fly there, a place where you feel like you stepped back to another era, then that’s why you should go to the Azores.

    These are just gorgeous islands. Each island has its own personality and character. I just adore them.

Hear about travel to Ireland as Chris, the Amateur Traveler himself, talks about a recent trip to the Emerald Isle. Chris did a driving tour with 7 family members and friends from Dublin to the west point of Ireland and of Europe.

Hear about travel to Moscow as the Amateur Traveler talks to Alex Block of alexblocktravels.com about his home town and Russia's capital.

Hear about travel to India as the Amateur Traveler talks to participants from the Amateur Traveler trip to India in November of 2017. 

Hear about what to do in Tainan, Taiwan as the Amateur Traveler talks to Katy Liang from photospired.com about her native Taiwan.

We performed post-hoc analyses on the utility of pre-therapeutic and early interim ⁶⁸Ga-DOTA-Tyr3-octreotide (⁶⁸Ga-DOTATOC) positron emission tomography (PET) tumor uptake and volumetric parameters and a recently proposed biomarker, the inflammation-based index (IBI), for peptide receptor radionuclide therapy (PRRT) in neuroendocrine tumor (NET) patients treated with ⁹⁰Y-DOTATOC in the setting of a prospective phase II trial. Methods: Forty-three NET patients received up to four cycles of 1.85 GBq/m²/cycle ⁹⁰Y-DOTATOC with a maximal kidney biologic effective dose of 37 Gy. All patients underwent a ⁶⁸Ga-DOTATOC PET/computed tomography (CT) at baseline and seven weeks after the first PRRT cycle. ⁶⁸Ga-DOTATOC-avid tumor lesions were semi-automatically delineated using a customized standardized uptake value (SUV) threshold-based approach. PRRT response was assessed on CT using RECIST 1.1. Results: Median progression-free survival (PFS) and overall survival (OS) were 13.9 and 22.3 months, respectively. An SUVmean higher than 13.7 (75th percentile (P75)) was associated with better survival (hazard ratio (HR) 0.45; P = 0.024), whereas a ⁶⁸Ga-DOTATOC-avid tumor volume higher than 578 ml (P75) was associated with worse OS (HR 2.18; P = 0.037). Elevated baseline IBI was associated with worse OS (HR 3.90; P = 0.001). Multivariate analysis corroborated independent associations between OS and SUVmean (P = 0.016) and IBI (P = 0.015). No significant correlations with PFS were found. A composite score based on SUVmean and IBI allowed to further stratify patients in three categories with significantly different survival. On early interim PET, a decrease in SUVmean of more than 17% (P75) was associated with worse survival (HR 2.29; P = 0.024). Conclusion: Normal baseline IBI and high ⁶⁸Ga-DOTATOC tumor uptake predict better outcome in NET patients treated with ⁹⁰Y-DOTATOC. This can be used for treatment personalization. Interim ⁶⁸Ga-DOTATOC PET does not provide information for treatment personalization.

The purpose of this study was to establish the dose-response relationship of selective internal radiation therapy (SIRT) in patients with metastatic colorectal cancer (mCRC), when informed by radiobiological sensitivity parameters derived from mCRC cell lines exposed to yttrium-90 (⁹⁰Y). Methods: 23 mCRC patients with liver metastases refractory to chemotherapy were included. ⁹⁰Y bremsstrahlung SPECT images were transformed into dose maps assuming the local dose deposition method. Baseline and follow-up CT scans were segmented to derive liver and tumor volumes. Mean, median, and D₇₀ (minimum dose to 70% of tumor volume) values determined from dose maps were correlated with change in tumor volume and vRECIST response using linear and logistic regression, respectively. Radiosensitivity parameters determined by clonogenic assays of mCRC cell lines HT-29 and DLD-1 after exposure to ⁹⁰Y or external beam radiotherapy (EBRT; 6MV photons) were used in biological effective dose (BED) calculations. Results: Mean administered radioactivity was 1469±428 MBq (847-2185 MBq), achieving a mean radiation absorbed tumor dose of 35.5±9.4 Gy and mean normal liver dose of 26.4±6.8 Gy. A 1.0 Gy increase in mean, median, and D₇₀ absorbed dose was associated with reduction in tumor volume of 1.8%, 1.8%, and 1.5%, respectively, and increased probability of vRECIST response (odds ratio: 1.09, 1.09, and 1.10 respectively). Threshold mean, median and D₇₀ doses for response were 48.3, 48.8, and 41.8 Gy respectively. EBRT-equivalent BEDs for ⁹⁰Y are up to 50% smaller than those calculated by applying protraction-corrected radiobiological parameters derived from EBRT alone. Conclusion: Dosimetric studies have assumed equivalence between ⁹⁰Y SIRT and EBRT, leading to inflation of BED for SIRT and possible under-treatment. Radiobiological parameters for ⁹⁰Y were applied to a BED model, providing a calculation method that has the potential to improve assessment of tumor control.

In randomized clinical trials (RCTs), no survival benefit has been observed for selective internal radiotherapy (SIRT) over sorafenib in patients with advanced hepatocellular carcinoma (aHCC). This study aimed to assess by means of a meta-analysis whether overall survival (OS) with SIRT, as monotherapy or followed by sorafenib, is non-inferior to sorafenib, and compare safety profiles for patients with aHCC. Methods: We searched MEDLINE, EMBASE, and the Cochrane Library up to February 2019 to identify RCTs comparing SIRT as monotherapy, or followed by sorafenib, to sorafenib monotherapy among patients with aHCC. The main outcomes were OS and frequency of treatment-related severe adverse events (AEs grade ≥3). The per-protocol population was the primary analysis population. A non-inferiority margin of 1.08 in terms of hazard ratio (HR) was pre-specified for the upper boundary of 95% confidence interval (CI) for OS. Pre-specified subgroup analyses were performed. Results: Three RCTs, involving 1,243 patients, comparing sorafenib with SIRT (SIRveNIB and SARAH) or SIRT followed by sorafenib (SORAMIC), were included. After randomization, 411/635 (64.7%) patients allocated to SIRT and 522/608 (85.8%) allocated to sorafenib completed the studies without major protocol deviations. Median OS with SIRT, whether or not followed by sorafenib, was non-inferior to sorafenib (10.2 and 9.2 months, [HR 0.91, 95% CI 0.78–1.05]). Treatment-related severe adverse events were reported in 149/515 patients (28.9%) who received SIRT and 249/575 (43.3%) who received sorafenib only (p<0.01). Conclusion: SIRT as initial therapy for aHCC is non-inferior to sorafenib in terms of OS, and offers a better safety profile.

Oh boy what a meaty session we have for you as Christina Mercer, Somrata Sarkar, David Price and Henry Burrell tackle three whopics (whopping topics) head on.

Somrata takes us into the sometimes scary thoughts of our own digital afterlives. Should we be worried that we'll end up as misrepresentative chat bots one day? Who will have the authority to police the companies that harvest our data?

Then Christina explains the knife edge America is on when it comes to net neutrality. Despite recent hope, there's still a chance the web across the pond will be ruthlessly metered and segmented.

Finally David asks us if we've checked our unused email accounts recently, as there might be a lot of desperate noodle companies in there begging you to stay on their mailing lists.

See acast.com/privacy for privacy and opt-out information.

When you register an Oracle table to the metadata, it might fail and generate an error similar to the following: "ERROR: An exception has been encountered...ERROR: Read Access Violation METALIB..."

Severity: Medium Description: PROC IMPORT contains a stack-corruption vulnerability. Potential Impact: Under certain circumstances (with use of the DBM

Severity: Medium Description: PROC EXPORT contains a stack-corruption vulnerability. Potential Impact: Under certain circumstances, the use of PROC EXP

The problem occurs on a content release on the SAS Risk Governance Framework.

The select * from "SYSCAT"."SYSCAT"."X_EFFECTIVE_OBJECT_PRIVILEGES" query runs for hours. In this scenario, SAS Federation Server stops responding, making it unavailable for use. Restarting SAS Federation Server solves t