The contestants bring the heat onstage.

It’s been six days without the NBA

The Olympic gymnast showed off her amazing skills.

Both players were diagnosed with the deadly virus.

A newspaper analysis shows the disparity between communities

Coronavirus can’t stop, won’t stop a Motor City tradition.

The line reached all the way outside the mall.

The enforcement was meant to protect from coronavirus spread

Trump Administration not sticking to its own order.

Walker & Company introduces product with help of rap legend.

Just when you thought it couldn't get any worse.

Most general aviation (GA) airports are minimally staffed and rarely employ environmental specialists, and the National Environmental Policy Act (NEPA) can be overwhelming to work through for those not familiar with the requirements. The TRB Airport Cooperative Research Program's ACRP Research Report 211: Guidance for Using the Interactive Tool for Understanding NEPA at General Aviation Airports , and the accompanying interactive tool that was developed, will help airport staff from GA airports understan...

The Genetics Society of America (GSA) is pleased to announce the 2020 recipients of its annual awards for distinguished service in the field of genetics. The awardees were nominated and selected by their colleagues and will be recognized with presentations at The Allied Genetics Conference (TAGC), held April 22-26, 2020, in the metro Washington, DC area.

Yesterday I lost my best friend. Nine years ago you saved my life and brought me happiness every day since. Selfishly I wanted to keep you around forever

2 days ago I lost my best friend. Nine years ago you saved my life and stole my heart. You brought me happiness at my lowest point and gave me reason to

It’s time to try these homemade Tandoori Garlic Rotis. These delicious flatbreads are extremely easy to make and can easily be customized to suit everyone’s tastes.

craving more? check out TasteSpotting

Instant Pot Cranberry Cornbread Bites shaped like Christmas Jingle Bells, pair up for the perfect bite of sweet and tart spiced cranberries.

craving more? check out TasteSpotting

One-year-old company NovaMed has inked a deal with Hong Kong-based DHB Global that will see the start-up medical consultancy transitioning to a producer of healthcare personal protective equipment, or PPE. Under the deal finalised earlier this...

-Album Details- Title: Distant Worlds: music from FINAL FANTASY JIRITSU Publisher: Square Enix Music Catalog Number: SQEX-10659~60 Release Date: September 20th, 2018 Ripped by: dancey -Info- Nothing new or revelatory here other than it was only available at TGS2018, enjoy nonetheless.

Drive more reaction when you fabricate your image story at the purpose of decision. A point of decision is where a possibility or purchaser will make a move activity to move to the subsequent stage in the purchasing procedure. Research,… Continue Reading →

Limit your exposure!

The post What’s Cooking: Why Bleeding your Fish is Important? appeared first on Ocean Blue Fishing Adventures.

The post Unpacking After a Fishing Trip: Why is it so Important? appeared first on Ocean Blue Fishing Adventures.

An in-depth understanding of immune escape mechanisms in cancer is likely to lead to innovative advances in immunotherapeutic strategies. However, much remains unknown regarding these mechanisms and how they impact immunotherapy resistance. Using several preclinical tumor models as well as clinical specimens, we identified a mechanism whereby CD8+ T cell activation in response to programmed cell death 1 (PD-1) blockade induced a programmed death ligand 1/NOD-, LRR-, and pyrin domain–containing protein 3 (PD-L1/NLRP3) inflammasome signaling cascade that ultimately led to the recruitment of granulocytic myeloid-derived suppressor cells (PMN-MDSCs) into tumor tissues, thereby dampening the resulting antitumor immune response. The genetic and pharmacologic inhibition of NLRP3 suppressed PMN-MDSC tumor infiltration and significantly augmented the efficacy of anti–PD-1 antibody immunotherapy. This pathway therefore represents a tumor-intrinsic mechanism of adaptive resistance to anti–PD-1 checkpoint inhibitor immunotherapy and is a promising target for future translational research.

Curing HIV infection will require the elimination of a reservoir of infected CD4+ T cells that persists despite HIV-specific cytotoxic T cell (CTL) responses. Although viral latency is a critical factor in this persistence, recent evidence also suggests a role for intrinsic resistance of reservoir-harboring cells to CTL killing. This resistance may have contributed to negative outcomes of clinical trials, where pharmacologic latency reversal has thus far failed to drive reductions in HIV reservoirs. Through transcriptional profiling, we herein identified overexpression of the prosurvival factor B cell lymphoma 2 (BCL-2) as a distinguishing feature of CD4+ T cells that survived CTL killing. We show that the inducible HIV reservoir was disproportionately present in BCL-2hi subsets in ex vivo CD4+ T cells. Treatment with the BCL-2 antagonist ABT-199 was not sufficient to drive reductions in ex vivo viral reservoirs when tested either alone or with a latency-reversing agent (LRA). However, the triple combination of strong LRAs, HIV-specific T cells, and a BCL-2 antagonist uniquely enabled the depletion of ex vivo viral reservoirs. Our results provide rationale for novel therapeutic approaches targeting HIV cure and, more generally, suggest consideration of BCL-2 antagonism as a means of enhancing CTL immunotherapy in other settings, such as cancer.