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A Hybrid Insulin Epitope Maintains High 2D Affinity for Diabetogenic T Cells in the Periphery

β-Cell antigen recognition by autoreactive T cells is essential in type 1 diabetes (T1D) pathogenesis. Recently, insulin hybrid peptides (HIPs) were identified as strong agonists for CD4 diabetogenic T cells. Here, using BDC2.5 transgenic and NOD mice, we investigated T-cell recognition of the HIP2.5 epitope, which is a fusion of insulin C-peptide and chromogranin A (ChgA) fragments, and compared it with the WE14 and ChgA29–42 epitopes. We measured in situ two-dimensional affinity on individual live T cells from thymus, spleen, pancreatic lymph nodes, and islets before and after diabetes. Although preselection BDC2.5 thymocytes possess higher affinity than splenic BDC2.5 T cells for all three epitopes, peripheral splenic T cells maintained high affinity only to the HIP2.5 epitope. In polyclonal NOD mice, a high frequency (~40%) of HIP2.5-specific islet T cells were identified at both prediabetic and diabetic stages comprising two distinct high- and low-affinity populations that differed in affinity by 100-fold. This high frequency of high- and low-affinity HIP2.5 T cells in the islets potentially represents a major risk factor in diabetes pathogenesis.




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{beta}-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Posttranscriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1

The signal peptide of preproinsulin is a major source for HLA class I autoantigen epitopes implicated in CD8 T cell (CTL)–mediated β-cell destruction in type 1 diabetes (T1D). Among them, the 10-mer epitope located at the C-terminal end of the signal peptide was found to be the most prevalent in patients with recent-onset T1D. While the combined action of signal peptide peptidase and endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) is required for processing of the signal peptide, the mechanisms controlling signal peptide trimming and the contribution of the T1D inflammatory milieu on these mechanisms are unknown. Here, we show in human β-cells that ER stress regulates ERAP1 gene expression at posttranscriptional level via the IRE1α/miR-17-5p axis and demonstrate that inhibition of the IRE1α activity impairs processing of preproinsulin signal peptide antigen and its recognition by specific autoreactive CTLs during inflammation. These results underscore the impact of ER stress in the increased visibility of β-cells to the immune system and position the IRE1α/miR-17 pathway as a central component in β-cell destruction processes and as a potential target for the treatment of autoimmune T1D.




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Artificial intelligence versus clinicians: systematic review of design, reporting standards, and claims of deep learning studies




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Manual acupuncture versus sham acupuncture and usual care for prophylaxis of episodic migraine without aura: multicentre, randomised clinical trial




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Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study




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Global, regional, and national burden of neck pain in the general population, 1990-2017: systematic analysis of the Global Burden of Disease Study 2017




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Opioid agonist treatment and risk of mortality during opioid overdose public health emergency: population based retrospective cohort study




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Comparison of dietary macronutrient patterns of 14 popular named dietary programmes for weight and cardiovascular risk factor reduction in adults: systematic review and network meta-analysis of randomised trials




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Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal




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Use of electronic medical records in development and validation of risk prediction models of hospital readmission: systematic review




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Prospective registration and reporting of trial number in randomised clinical trials: global cross sectional study of the adoption of ICMJE and Declaration of Helsinki recommendations




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Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study




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Estimated population wide benefits and risks in China of lowering sodium through potassium enriched salt substitution: modelling study




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Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: national cross sectional study




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Term complications and subsequent risk of preterm birth: registry based study




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Occurrence, prevention, and management of the psychological effects of emerging virus outbreaks on healthcare workers: rapid review and meta-analysis




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Association between tax on sugar sweetened beverages and soft drink consumption in adults in Mexico: open cohort longitudinal analysis of Health Workers Cohort Study




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Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study




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Prognosis of unrecognised myocardial infarction determined by electrocardiography or cardiac magnetic resonance imaging: systematic review and meta-analysis




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Playa to cut Jamaican room count 40% with sale of two Jewels

The sale of two Jewel properties will inject US$60 million into loss-making Playa Resorts while reducing the hotel rooms it operates in Jamaica by more 40 per cent. Playa announced the sale of Jewel Runaway Bay Beach Resort...




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LNG complicates light bill savings

THE SWITCH towards liquefied natural gas, LNG, as fuel to produce power supplies for Jamaica has a downside for electricity customers, who are largely missing out on the big oil savings. The near two-thirds plunge in oil prices will have limited...




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To address AML oversight, BOJ creates sandbox for fintech applicants

FOUR MORE applicants are vying to provide mobile payment services in various formats, including one applicant seeking to use phone credit as a cash equivalent, but successful applicants will fall under a new framework the regulator calls its “...




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BCIC offers partial refund on April premiums

 British Caribbean Insurance Company Limited, BCIC, will refund a portion of April’s premium to holders of its public passenger vehicle, PPV, and Diamond Max private motor insurance next week. The move, which is expected to cost BCIC...




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Dwayne Devonish | Smart virus testing necessary for economic reboot

OP-ED CONTRIBUTION: COVID-19 AND THE ECONOMY FOR MOST countries in the Caribbean, the current testing for COVID-19 has not reached levels suitable for ascertaining an accurate picture of the state of outbreak and spread of the infection. This...




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Sagicor raises doubt about Scotia Life T&T deal

Sagicor Finance Company has raised doubt about whether the deal to acquire the assets of Scotia Life Trinidad...




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Digital Jamaica throws sales lifeline to furniture companies

DESPITE TUMBLING sales and challenges with hire-purchase accounts, two of the largest retailers of home furniture and appliances, Courts Jamaica and Singer Jamaica, have found glimmers of hope during the COVID-19 pandemic. That’s because work-from...




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Webinar: The UK's Unpredictable General Election?

Members Event Webinar

19 November 2019 - 11:30am to 12:00pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

Professor Matthew Goodwin, Visiting Senior Fellow, Europe Programme, Chatham House
Professor David Cutts, Associate Fellow, Europe Programme, Chatham House

On 12 December 2019, the United Kingdom will go to the polls in a fifth nationwide vote in only four years. This is expected to be one of the most unpredictable general elections in the nation’s post-war history with the anti-Brexit Liberal Democrats and Nigel Farage’s Eurosceptic Brexit Party both presenting a serious challenge to the UK’s established two-party system.

This webinar will discuss the UK general election and will unpack some of the reasons behind its supposed unpredictability. To what extent will this be a Brexit election and what are the other issues at the forefront of voters’ minds? And will the outcome of the election give us a clear indication of the UK’s domestic, European and wider international political trajectory?

Please note, this event is online only. Members can watch webinars from a computer or another internet-ready device and do not need to come to Chatham House to attend.




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UK General Election 2019: BBC-Chatham House Foreign Policy Debate

Members Event

28 November 2019 - 10:30am to 11:30am

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

Stephen Gethins, Candidate for Fife North East and Shadow Spokesperson for Foreign and Commonwealth Office (2018-19), Scottish National Party (remote)
Dominic Raab, Candidate for Esher & Walton, Foreign Secretary and First Secretary of State (2019), Conservative Party
Emily Thornberry, Candidate for Islington South & Finsbury and Shadow Foreign Secretary (2016-19), Labour Party
Chuka Umunna, Candidate for Cities of London & Westminster and Spokesperson for Foreign and Commonwealth Affairs (2019), Liberal Democrat Party
Chair: Ritula Shah, The World Tonight, BBC Radio 4
 

As the United Kingdom prepares to go to the polls on 12 December 2019, this event, organized in conjunction with the BBC's show, The World Tonight, will give a Chatham House audience the opportunity to put their foreign policy questions to a panel of senior UK politicians.
 
Important Information About the Event
This event is hosted in collaboration with the BBC. It will be recorded and broadcast on BBC Radio 4The World Tonight. Given the BBC’s commitment to due impartiality during the election period, questions will be asked to be pre-submitted via email by audience members the day before the event. The BBC will then select a balanced and diverse range of questions from those submitted. The panellists will not receive the questions in advance of the event.
 
About the Ballot
Due to the expected popularity of this event, this event will be balloted. Please register your interest for the event by 11:59pm on Monday 25 November. Successful registrants – selected at random – will be notified on Tuesday 26 November and then invited to submit their questions. The BBC will contact directly those audience members whose questions they select.
 
As priority will be given to members, we are unable to register members’ guests for this event.

Event attributes

E-ticket event

Members Events Team




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Iceland and the Wellbeing Economy

Members Event

3 December 2019 - 1:30pm to 2:30pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

Katrín Jakobsdóttir, Prime Minister, Iceland
Chair: Professor Tim Benton, Director, Energy Environment and Resources Department, Chatham House
 

In 2018, Iceland joined the Wellbeing Economy Alliance, a network of countries developing frameworks to measure social, economic and environmental factors in an attempt to move beyond GDP being the sole measurement of economic success. Other governments and organizations supporting this approach include New Zealand, Scotland and the Organisation for Economic Co-operation and Development (OECD).
 
Against this backdrop, the prime minister of Iceland and 2019 Chatham House Prize nominee, Katrín Jakobsdóttir, shares insights into her government’s approach and her personal and political motivations for embarking on the wellbeing economy project.

Event attributes

Livestream

Members Events Team




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UK General Election 2019: Foreign Policy Implications

Members Event

11 December 2019 - 5:30pm to 6:30pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

John Casson, Associate Fellow, Europe Programme, Chatham House
Tom Raines, Head, Europe Programme, Chatham House
Dr Yu Jie, Senior Research Fellow, Asia-Pacific Programme, Chatham House
Antony Froggatt, Senior Research Fellow, Energy, Environment and Resource Governance, Chatham House

On the eve of the UK general election, a group of senior Chatham House experts analyse a range of key foreign policy issues that will hinge on the election’s outcome.

Members Events Team




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Can the New European Commission Deliver on Its Promises to Africa?

4 December 2019

Fergus Kell

Projects Assistant, Africa Programme

Damir Kurtagic

Former Academy Robert Bosch Fellow, Africa Programme
Familiar promises of equal partnership must be backed by bolder action, including an expanded budget, internal reform and a rethink of its approach to trade negotiations.

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Jutta Urpilainen, new EU commissioner for international partnerships, at the European Parliament in Brussels in October. Photo: Getty Images.

The new European Commission, headed by Ursula von der Leyen, assumed office on 1 December, and there are early signs that Africa will begin near the top of their foreign policy priorities. Policy towards Africa under the new EU administration is yet to be fully defined, but its contours are already visible in the selection of commissioners and assignment of portfolios.  

Although rumours of a dedicated commissioner for Africa were unfounded, the appointment of Jutta Urpilainen to the new role of commissioner for international partnerships – replacing the former post of development commissioner – is a strong signal of ongoing change in EU development thinking, away from bilateral aid towards trade and investment, including by the private sector. 

This may have significant consequences for the EU’s relationship with Africa. In her mission letter to Urpilainen in September, von der Leyen listed the first objective as a new ‘comprehensive strategy for Africa’. Urpilainen, Finland’s finance minister before being posted to Ethiopia as special representative on mediation, has also described her appointment as an opportunity to move on from traditional measures of aid delivery. 

Ambition or incoherence? 

However, this ambition may be at odds with other EU priorities and practices, notably managing migration and institutions and instruments for governing EU–Africa relations that remain rooted in a ‘traditional’ model of North–South development cooperation rather than equitable partnership.

Another newly created post will see Margaritis Schinas assume the role of vice-president for promoting the European way of life – formerly ‘protecting our European way of life’ before a backlash saw it changed – a reminder that migration will remain high on the EU’s foreign policy agenda. The new high representative for foreign and security policy and chief EU diplomat, Josep Borrell, has highlighted the need for bilateral partnership with countries of origin and transit, mainly in Africa. 

Negotiations also continue to stall on a replacement to the Cotonou Agreement, the 20-year partnership framework between the EU and the African, Caribbean and Pacific (ACP) group of states, which now looks certain to be extended for at least 12 months beyond its expiry in February 2020.

Ambiguities in the EU’s negotiating approach have certainly contributed to the delay: having pushed initially for a separate regional pillar for Africa that would be opened to the North African countries (who are not ACP members) and include a loosely defined role for the African Union, this would later be abandoned in favour of a dual-track process on separate new agreements with the AU and ACP respectively.

The EU also continues to pursue controversial economic partnership agreements under the aegis of Cotonou, despite their increasing appearance of incompatibility with the pathbreaking African Continental Free Trade Area (AfCFTA) – one of the clearest expressions to date of African agency.

The EU has so far attempted to gloss over this incoherence, claiming that EPAs can somehow act as the ‘building blocks’ for Africa-wide economic integration. But tensions are appearing between EU departments and within the commission, with the European External Action Service inclined to prioritize a more strategic continental relationship with the AU, while the Directorate-General for International Cooperation and Development remains committed to the ACP as the conduit for financial support and aid delivery.

And it is unlikely to get away with such incoherence for much longer. Change is now urgent, as numerous countries in sub-Saharan Africa continue to attract the strategic and commercial interests of the EU’s competitors: from established players such as China and potentially in future the UK, which is intent on remodelling its Africa ties post-Brexit, to emerging actors such as Turkey or Russia, which held its first Africa summit in October. 

The need for delivery

If the EU is serious about its rhetoric on equal partnership, it must therefore move beyond convoluted hybrid proposals. Delivering on the Juncker administration’s proposal to increase funding for external action by 30 per cent for 2021–27 would mark an important first step, particularly as this involves streamlining that would see the European Development Fund – the financial instrument for EU-ACP relations – incorporated into the main EU budget.

The new commission should therefore continue to exert pressure on the European Council and European Parliament to adopt this proposal, as negotiations on this financial framework have been repeatedly subject to delay and may not be resolved before the end of the year. 

Beyond this, proactive support for the AfCFTA and for structural transformation more broadly must be prioritized ahead of vague promises for a continent-to-continent free trade agreement, as held out by Juncker in his final State of the Union address in 2018. 

The significance of internal EU reforms for Africa should also not be discounted. The EU’s Common Agricultural Policy, for instance, has placed the African sector at a particular disadvantage and has made it harder to compete even in domestic markets, let alone in the distant EU export markets. EU efforts to stimulate inflows of private investments into the African agricultural sector, abolish import tariffs and offer technical support for African producers to satisfy EU health and safety regulations will be of little use if they are undermined by heavy subsidies across Europe.

Ultimately, changes to job titles alone will be insufficient. The new commission’s rhetoric, while ambitious, differs little from that of the previous decade – Africa has heard the promise of a ‘partnership of equals’ and of ‘shared ownership’ since before the advent of the Joint Africa–EU Strategy in 2007. Now is the time for truly bold steps to implement this vision.




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Don’t Be Afraid of Political Fragmentation

16 December 2019

Pepijn Bergsen

Research Fellow, Europe Programme
If managed correctly, splintering and more volatile political systems – so-called ‘Dutchification’ – need not be a ticket to political and policy paralysis.

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Voters cast their vote as part of the Dutch general elections on March 15, 2017 at a polling station in a mill in Oisterwijk. Photo by ROB ENGELAAR/AFP via Getty Images.

In recent decades, political party systems across Europe have fragmented and electoral volatility has increased. The number of parties represented in parliaments across the continent has grown and the formerly dominant mainstream parties have seen their support base collapse, forcing parties into often uncomfortable and unstable coalitions.

From the United Kingdom to Germany, politicians and commentators talk of such scenarios in often apocalyptic terms and associate it with political instability and policy paralysis.

They shouldn’t. Instead they should focus their energy on making these increasingly competitive political markets work.

The Netherlands is frequently held up as a prime example of this process, which is therefore sometimes referred to as ‘Dutchification’. Its highly proportional political system has created the opportunity for new parties and specific interest groups to win parliamentary representation, ranging from an animal rights party and a party catering specifically to the interests of the elderly.

This has been accompanied by increased electoral volatility. In the 1970s, less than 15% of seats in the Dutch parliament would change party at any election, but in the last election in 2017, this was just over a quarter. The system also created space for the relatively early rise of populist far-right parties, though it was not the cause of their rise.

Nevertheless, despite the regularly difficult coalition politics, it remains one of the most well-governed countries in the world.

A short history of fragmentation

Looking at the effective number of parties represented in parliaments, the number of parties, corrected for their size, provides a good measure of the extent of fragmentation. In the Netherlands this steadily increased from around four in the 1980s to over eight following the election in 2017. Even the populist far-right vote has fragmented, with two parties partly competing for the same electorate. In other countries it has been a more recent phenomenon. Spain remained a de facto two-party system until the financial crisis. Dissatisfaction with both mainstream parties has seen challenger parties on both the left and the right attract significant support, making it harder to form stable coalitions. Political fragmentation decreased slightly in Italy in recent years, but that was from a high base as it shot up in the early 1990s when the post-war political settlement crumbled.

German politics, long a hallmark of stability, is struggling with the decrease in support for the parties that dominated its political scene in the post-war period. The Christian Democrats and Social Democrats only barely managed to win a majority together in the election in 2017, at 53.4% of the vote compared with the 81.3% achieved 30 years earlier. The latest polls suggest they would only get to 40% together if an election were held today.

A similar trend is visible within the European Parliament. Whereas the two largest groups in the European Parliament, the Christian Democrats and the Social Democrats, together won 66% of the vote in the election in 1999, they did not even manage to win a majority together in 2019, taking just 39.5% of the vote.

No crisis of democracy

If electoral volatility and political fragmentation does indeed constitute some sort of crisis of democracy, we should expect to see voters become unhappy about how their national democracy functions. Largely, the opposite seems to be the case.

In the Netherlands, satisfaction with its democracy went up at the same time as Dutchification did its work. Similar trends are visible in other highly fragmented European political systems, often those with very proportional systems. Despite regular minority governments, satisfaction with democracy is above 90% in Denmark and at 80% in Sweden, according to the latest Eurobarometer data.

In comparison, it stood at 52% in the United Kingdom and 53% in France, where the electoral system has, at least on the surface, prevented the kind of fragmentation supposedly plaguing proportional systems.

Satisfaction with democracy seems to be affected by a number of factors. This includes the state of the economy, particularly in countries that were hit the hardest by the global financial and euro zone crises. Nevertheless, the data suggests that, even if we can’t say that Dutchification by definition leads to more satisfaction with democracy, it is clearly not associated with falling faith in the system.

A competitive political market

Dutchification should be seen as accompanying a more competitive political marketplace. A more emancipated, demanding and politically engaged electorate than in the post-war decades is willing to shop around instead of merely vote according to socioeconomic class or other dividing lines, such as religious ones. The fragmented parliaments that emerge as a result provide better representation of different groups within European societies.

This makes life harder for Europe’s political parties and politicians, as they juggle large coalitions, or changing coalitions under minority governments, but provides voters with more choice and democratic renewal. If handled correctly this would also allow more responsiveness to shifts in public opinion.

Such democratic creative destruction in competitive political markets is to be celebrated in a well-functioning democracy. Just as companies prefer to operate in an oligopoly, political parties prefer the stability of limited political competition. But wishing for this kind of stability comes perilously close to preferring stability over proper representation.

Worrying about Dutchification risks confusing a crisis of the traditional mainstream parties with a crisis of democracy. For some countries, particularly those like the Netherlands and Denmark which have longer histories of consensus-based politics and coalition building, this is an easier adjustment. But this should not be an excuse to not attempt to make politics work better as they were forced to go through, arguably still ongoing, adjustment processes too.

Instead of investing in futile attempts to get back to how things were in the old days, or hoping this will somehow magically happen, political leaders and parties across Europe need to reassess how they deal with the new reality of Dutchification.




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Transatlantic Dialogue on China

A joint Chatham House-RUSI project that focuses on strengthening common understanding across the Atlantic and develop new ideas for how the US and Europe can better engage with and respond to China’s rise.

This will be done through examining transatlantic approaches and responses to China through the lens for four key themes (digital technology; trade and investment; governance of global commons; and climate change and the environment) that have been identified as crucial to developing effective policy responses and fostering collaboration.

The project will strengthen national, regional and international responses to the risks and opportunities posed by China’s changing role within the global economy and international rules-based order.

Department contact

Pepijn Bergsen

Research Fellow, Europe Programme
020 795 75748

More on Transatlantic Dialogue on China




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Britain Must Balance a Transatlantic Heart With a European Head

19 December 2019

Robin Niblett

Director and Chief Executive, Chatham House
Returning from an EU-rooted foreign and economic policy to one which is more international in outlook will be difficult, take time, and be more costly than the new UK government currently envisages.

GettyImages-1189074470.jpg

Boris Johnson chairs the first cabinet meeting after winning a majority of 80 seats in the 2019 UK general election. Photo by Matt Dunham – WPA Pool/Getty Images.

The convincing general election win for the Conservative Party and Boris Johnson opens a new chapter in British history. On 31 January 2020, Britain will withdraw from the EU and return to its historical position as a separate European power.

Recognising the strategic significance of this change, the Queen’s speech opening the new parliament stated that 'the government will undertake the deepest review of Britain's security, defence, and foreign policy since the end of the Cold War'. But in what context?

Prime Minister Boris Johnson and other Brexit supporters have yearned for Britain to return to its exceptional trajectory. In their view, Britain can once again become a trading nation - more global in outlook and ambition than its European neighbours, freed from the shackles of an ageing and fractured European continent and its deadening regulatory hand.

This imagery makes good copy. But the 21st century does not offer Britain the same opportunities as did the 18th, 19th or early 20th centuries. This is a different world, and Britain’s position in it needs to be crafted with a sharp eye to what is possible.

Geopolitics undergoing wrenching change

This is not declinism. The UK remains an economically strong and politically influential country by relative global standards – it is currently the fifth or sixth largest economy in the world, and the second largest donor of official development assistance. It has ubiquitous cultural brands from fashion and music to the royal family, and an eminent diplomatic and security position at the heart of all of the world’s major international institutions and alliances, from NATO and the UN security council to the IMF, G7, G20 and Commonwealth. 

But Britain leaves the EU just as the geopolitical landscape is undergoing wrenching change. The United States has turned inwards, closer to its own historic norm, and is undermining the international institutions which it created alongside Britain in the 1940s. China’s international influence is on the rise alongside its vast and still growing economy, challenging traditional norms of individual freedom and public transparency.

Russia is navigating the cracks and crevices of the fracturing rules-based international order with ruthless efficiency. Sensing the change in the wind, many governments are now back-tracking on their post-Cold War transitions to more open and democratic societies.

The implications of this new context have yet to be fully internalised by those who look forward to Britain’s future outside the EU. Britain will be negotiating new trade deals in an increasingly transactional, fragmented and protectionist international economic environment. It will be trying to sell its world-class services into markets where national control over finance, law, technology and media is increasingly prized.

Making new diplomatic inroads will be no easier. The government will face strong internal and external criticism if it lends security assistance to states that are simultaneously clamping down on their citizens’ rights. With the number of military personnel in decline and investment in new equipment stretched across multiple expensive platforms, the UK could struggle to project meaningful defence cooperation to new security partners in Asia at the same time as upholding its NATO commitments and its deployments in conflict zones around the world.

Britain also opens its new global chapter at a time when it is changing domestically. There is no over-riding reason for a missionary British foreign policy – neither the economic returns or image of national glory that drove Empire, nor the existential defence of its land, interests and freedom that drove it during the Cold War.

Stretching liberal interventionism to Iraq, as Tony Blair did when he was prime minister, and to Libya as David Cameron did in 2011, has injected a deep dose of popular scepticism to the idea that Britain - with or without allies - can or should help make the world in its own image.

This more defensive mindset – epitomised by parliament’s refusal to use military force to punish President Bashar al Assad’s regime for using chemical weapons against its citizens in 2013 – will not abate soon. Especially when the new government’s political bandwidth will be stretched by fiendishly complex trade-offs between its financial promises to support domestic renewal, the imperatives of striking and implementing a new free trade agreement with the EU, and the economic consequences of leaving the single market.

All this points to the fact that the most important step for Britain at the beginning of this new national chapter will be to establish an effective partnership with the EU and its member states. They face the same international risks as Britain and have as much to gain from the preservation of rules-based international behaviour. Recognising the continued interdependence between Britain and the EU will offer both sides greater leverage in a more competitive and hostile world.

A new transatlantic relationship

Once it has agreed its new relationship with the EU, Britain can turn to crafting its new relationship with the mighty United States. US-UK economic interdependence and close security ties should help discipline the bilateral economic relationship. The more difficult challenge will be for the UK to avoid falling into fissures between the US and the EU over how to manage bilateral relations with China and Russia, particularly if President Trump wins a second term.

Britain will have to get used to this difficult balancing act between its transatlantic heart and European head after Brexit. This makes it all the more important for the UK to develop new diplomatic and commercial initiatives with countries that are also struggling to cope with the current uncertain, transactional international environment.

Canada, Japan, South Korea, Australia and New Zealand can grow as bilateral economic partners and as allies in international institutions, such as the G7, OECD and WTO. They may even open a door to British engagement in regional trade arrangements such as the Comprehensive and Progressive Agreement for Trans-Pacific Partnership (CP-TPP), which do not require the same political commitments as EU membership.

Turning from an EU-rooted foreign and economic policy to one that is once again more international in outlook will be difficult, take time and be more costly than the government currently envisages. The irony is that for this to be successful requires sustained political investment by the Johnson government to build a strong relationship with the EU that it is focused on leaving.




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The Indo-Pacific: Geostrategic Outlook to 2024 - Workshop 4

Invitation Only Research Event

26 November 2019 - 9:30am to 12:00pm

Gateway House, Stevens Street, Colaba

This closed-door roundtable explores possible strategic shifts in the Indo-Pacific between now and 2024.

Focusing on trade security, climate change disruptions and security cooperation, it aims to enhance the understanding of the regional goals of, and strategic relationships between, the key countries active in the region.

The workshop is part of a larger project funded by the Strategic Policy Division of the Australian Department of Defence.

The project includes workshops in the United States, the United Kingdom, France, Japan, India and the Pacific Islands (Tonga).

Anna Aberg

Research Analyst, Energy, Environment and Resources Programme
020 7314 3629




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The UK, US and Mauritius: Decolonization, Security, Chagos and the ICJ

Invitation Only Research Event

30 January 2020 - 8:15am to 9:15am

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

Professor Philippe Sands QC, Professor of Law, UCL 
Richard Burt, Managing Partner, McLarty Associates
Chair: Dr Leslie Vinjamuri, Director, US and Americas Programme; Dean, Queen Elizabeth II Academy, Chatham House

The Chagos archipelago in the Indian Ocean has garnered media attention recently after the UK failed to abide by a UN deadline to return the islands to Mauritius. The US has landed in the middle of the dispute as a 1965 agreement with the UK has allowed the US to establish a military base on one of the islands, Diego Garcia, which has since become instrumental in US missions in the Asia-Pacific and the Middle East. 

In February 2019, an Advisory Opinion of the International Court of Justice (ICJ) found that the Chagos archipelago was unlawfully dismembered from Mauritius, in violation of the right to self-determination and that the United Kingdom is under an obligation to end its administration of the Chagos archipelago ‘as rapidly as possible’. The UN General Assembly subsequently voted overwhelmingly in favour of the UK leaving the islands by the end of November 2019 and the right of the former residents who were removed by the UK to return. The UK does not accept the ICJ and UN rulings and argues that the islands are needed to protect Britain from security threats while Mauritius has made clear the base can remain.

Professor Philippe Sands QC, professor of law at University College London and lead counsel for Mauritius on the ICJ case on Legal Consequences of the Separation of the Chagos archipelago from Mauritius in 1965, will be joining Ambassador Richard Burt, US chief negotiator in the Strategic Arms Reduction Talks with the former Soviet Union for a discussion on the fate of the archipelago including the future of the military base and the right of return of former residents.  

Attendance at this event is by invitation only. 

Event attributes

Chatham House Rule

Department/project

US and Americas Programme




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Deepening Economic Ties? The Future of Africa-UK Trade and Investment

Corporate Members Event

25 February 2020 - 6:00pm to 7:00pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

Raj Kulasingam, Senior Counsel, Dentons

Megan McDonald, Head of Investment Banking (International), Standard Bank Group

Chair: Dr Alex Vines OBE, Managing Director, Ethics, Risk & Resilience; Director, Africa Programme, Chatham House

Theresa May’s announcement in 2018 on the UK’s ambition to become the G7’s largest investor in Africa by 2022 has been followed by similar stated ambitions at the recent UK-Africa Investment Summit, which saw the attendance of 16 African heads of states. Such ambitions mirror overtures from various international players including a call for a ‘comprehensive strategy for Africa’ by the EU in 2019. While the UK’s recent expansion of its diplomatic networks in Africa and the signing of the Economic Partnership Agreement with the Southern African Customs Union and Mozambique appear promising, there are significant challenges to deepening partnerships including visa restrictions and complex business environments.
 
At this event, the panellists will assess the future of trade and investment relations between the UK and Africa. Amid a proliferation of new trading partners including Asia’s emerging economies, Russia and the Gulf states, what are the points of change and continuity in the long-standing relationship between Africa and the UK? And what are the challenges and opportunities facing governments and businesses in Africa and the UK in efforts to build long-lasting economic ties?
 
This event will be followed by a drinks reception.

This event is open to Chatham House Corporate Members and corporate contacts of Chatham House's Africa Programme only.

Not a member? Find out moreFor further information on the different types of Chatham House events, visit Our Events Explained.

 

 

Members Events Team




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The EU Cannot Build a Foreign Policy on Regulatory Power Alone

11 February 2020

Alan Beattie

Associate Fellow, Global Economy and Finance Programme and Europe Programme
Brussels will find its much-vaunted heft in setting standards cannot help it advance its geopolitical interests.

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EU Commission President Ursula von der Leyen speaks at the European Parliament in Strasbourg in February. Photo: Getty Images.

There are two well-established ideas in trade. Individually, they are correct. Combined, they can lead to a conclusion that is unfortunately wrong.

The first idea is that, across a range of economic sectors, the EU and the US have been engaged in a battle to have their model of regulation accepted as the global one, and that the EU is generally winning.

The second is that governments can use their regulatory power to extend strategic and foreign policy influence.

The conclusion would seem to be that the EU, which has for decades tried to develop a foreign policy, should be able to use its superpower status in regulation and trade to project its interests and its values abroad.

That’s the theory. It’s a proposition much welcomed by EU policymakers, who know they are highly unlikely any time soon to acquire any of the tools usually required to run an effective foreign policy.

The EU doesn’t have an army it can send into a shooting war, enough military or political aid to prop up or dispense of governments abroad, or a centralized intelligence service. Commission President Ursula von der Leyen has declared her outfit to be a ‘geopolitical commission’, and is casting about for any means of making that real.

Through the ‘Brussels effect’ whereby European rules and standards are exported via both companies and governments, the EU has indeed won many regulatory battles with the US.

Its cars, chemicals and product safety regulations are more widely adopted round the world than their American counterparts. In the absence of any coherent US offering, bar some varied state-level systems, the General Data Protection Regulation (GDPR) is the closest thing the world has to a single model for data privacy, and variants of it are being adopted by dozens of countries.

The problem is this. Those parts of global economic governance where the US is dominant – particularly the dollar payments system – are highly conducive to projecting US power abroad. The extraterritorial reach of secondary sanctions, plus the widespread reliance of banks and companies worldwide on dollar funding – and hence the American financial system – means that the US can precisely target its influence.

The EU can enforce trade sanctions, but not in such a powerful and discriminatory way, and it will always be outgunned by the US. Donald Trump could in effect force European companies to join in his sanctions on Iran when he pulled out of the nuclear deal, despite EU legislation designed to prevent their businesses being bullied. He can go after the chief financial officer of Huawei for allegedly breaching those sanctions.

By contrast, the widespread adoption of GDPR or data protection regimes inspired by it may give the EU a warm glow of satisfaction, but it cannot be turned into a geopolitical tool in the same way.

Nor, necessarily, does it particularly benefit the EU economy. Europe’s undersized tech sector seems unlikely to unduly benefit from the fact that data protection rules were written in the EU. Indeed, one common criticism of the regulations is that they entrench the power of incumbent tech giants like Google.

There is a similar pattern at work in the adoption of new technologies such as artificial intelligence and the Internet of Things. In that field, the EU and its member states are also facing determined competition from China, which has been pushing its technologies and standards through forums such as the International Telecommunication Union.

The EU has been attempting to write international rules for the use of AI which it hopes to be widely adopted. But again, these are a constraint on the use of new technologies largely developed by others, not the control of innovation.

By contrast, China has created a vast domestic market in technologies like facial recognition and unleashed its own companies on it. The resulting surveillance kit can then be marketed to emerging market governments as part of China’s enduring foreign policy campaign to build up supporters in the developing world.

If it genuinely wants to turn its economic power into geopolitical influence – and it’s not entirely clear what it would do with it if it did – the EU needs to recognize that not all forms of regulatory and trading dominance are the same.

Providing public goods to the world economy is all very well. But unless they are so particular in nature that they project uniquely European values and interests, that makes the EU a supplier of useful plumbing but not a global architect of power.

On the other hand, it could content itself with its position for the moment. It could recognize that not until enough hard power – guns, intelligence, money – is transferred from the member states to the centre, or until the member states start acting collectively, will the EU genuinely become a geopolitical force. Speaking loudly and carrying a stick of foam rubber is rarely a way to gain credibility in international relations.

This article is part of a series of publications and roundtable discussions in the Chatham House Global Trade Policy Forum.




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Iran Workshop Series: Domestic, Regional and International Outlook

Invitation Only Research Event

17 December 2019 - 10:00am to 3:30pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

After a summer of regional tensions and continued uncertainty regarding the future of the JCPOA, the Chatham House MENA Programme held a closed workshop to examine the impact of the Trump administration’s maximum pressure campaign.

Discussions focused on the domestic developments and challenges inside Iran, prospects for new negotiations with Iran, and the regional issues facing the country. Participants also considered the differences between American and European approaches towards Iran.

 

Event attributes

Chatham House Rule

Reni Zhelyazkova

Programme Coordinator, Middle East and North Africa Programme
+44 (0)20 7314 3624




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POSTPONED: Is a 'Geopolitical' Europe Possible?

Invitation Only Research Event

25 March 2020 - 8:30am to 9:30am

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

Michael Karnitschnig, Director for External Relations, Secretariat-General, European Commission

What role does the EU want to play in a world characterised increasingly by power politics? The new European Commission has explicitly stated its ambition for the EU to become a stronger geopolitical actor. Is it capable of becoming a third pole in an enduring US-China stand-off?

From climate change to trade policy and security, the next 5 years may prove decisive in proving the EU can be a strong player both in its neighbourhood and globally. Given what is at stake, what are the Commission’s strategic and policymaking priorities for the next five years? With the discussions on the future EU budget ongoing, what areas will be prioritized when member states come to make decisions between competing objectives? Does the way the EU is perceived externally depend on its member states’ ability to put on a united front when it comes to the most pressing global challenges?

Finally, is this ambitious geopolitical vision deliverable within the EU’s existing structures? If not, are member states ready to give up more control for a stronger Europe at the EU level?

PLEASE NOTE THIS EVENT IS POSTPONED UNTIL FURTHER NOTICE.

Event attributes

Chatham House Rule

Alina Lyadova

Europe Programme Coordinator




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Webinar: Labour, Foreign Policy and Internationalism

Members Event Webinar Online Event

25 March 2020 - 6:00pm to 6:45pm

Event participants

Lisa Nandy MP, Member of Parliament for Wigan

Chair: Thomas Raines, Director, Europe Programme, Chatham House

Labour leadership candidate, Lisa Nandy, reflects on the party's foreign policy priorities and makes the case for a foreign policy underpinned by internationalism.

In recent years, the Labour party has struggled to reach cross-party consensus on its foreign policy agenda. While the current leadership election offers the party an opportunity to debate and redefine its position on issues such as immigration, security and Brexit, the extent to which Labour can reconcile its factionalism remains unclear. As Labour undergoes a process of reflection, what kind of foreign policy agenda should the party rally behind that will also appeal to voters outside of its traditional base?

Can the Labour party be unified on its approach to international issues? Is an internationalist foreign policy an attractive choice for voters? And as Brexit tensions persist, what might the party's framework be to ensure new trade deals and partnerships align with fundamental Labour priorities such as workers' rights?




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Webinar: European Union – The Economic and Political Implications of COVID-19

Corporate Members Event Webinar

26 March 2020 - 5:00pm to 5:45pm

Online

Event participants

Colin Ellis, Chief Credit Officer, Head of UK, Moody’s Investors Service
Susi Dennison, Director, Europe Power Programme, European Council of Foreign Relations
Shahin Vallée, Senior Fellow, German Council of Foreign Relations (DGAP)
Pepijn Bergsen, Research Fellow, Europe Programme, Chatham House

Chair: Hans Kundnani, Senior Research Fellow, Europe Programme, Chatham House


 

In the past few weeks, European Union member states have implemented measures such as social distancing, school and border closures and the cancellation of major cultural and sporting events in an effort to curb the spread of COVID-19. Such measures are expected to have significant economic and political consequences, threatening near or total collapse of certain sectors. Moreover, the management of the health and economic crises within the EU architecture has exposed tensions and impasses in the extent to which the EU is willing to collaborate to mitigate pressures on fellow member states.

The panellists will examine the European Union's response to a series of cascading crises and the likely impact of the pandemic on individual member states. Can the EU prevent an economic hit from developing into a financial crisis? Are the steps taken by the European Central Bank to protect the euro enough? And are member states expected to manage the crisis as best they can or will there be a united effort to mitigate some of the damage caused?  

This event is part of a fortnightly series of 'Business in Focus' webinars reflecting on the impact of COVID-19 on areas of particular professional interest for our corporate members.

Not a corporate member? Find out more.

 




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Webinar: European Democracy in the Last 100 Years: Economic Crises and Political Upheaval

Members Event Webinar

6 May 2020 - 1:00pm to 2:00pm

Event participants

Pepijn Bergsen, Research Fellow, Europe Programme, Chatham House

Dr Sheri Berman, Professor of Political Science, Barnard College

Chair: Hans Kundnani, Senior Research Fellow, Europe Programme, Chatham House

 

In the last 100 years, global economic crises from the Great Depression of the 1930s to the 2008 financial crash have contributed to significant political changes in Europe, often leading to a rise in popularity for extremist parties and politics. As Europe contends with a perceived crisis of democracy - now compounded by the varied responses to the coronavirus outbreak - how should we understand the relationship between externally-driven economic crises, political upheaval and democracy?

The panellists will consider the parallels between the political responses to some of the greatest economic crises Europe has experienced in the last century. Given that economic crises often transcend borders, why does political disruption vary between democracies? What can history tell us about the potential political impact of the unfolding COVID-19-related economic crisis? And will the unprecedented financial interventions by governments across Europe fundamentally change the expectations citizens have of the role government should play in their lives?

This event is based on a recent article in The World Today by Hans Kundnani and Pepijn Bergsen who are both researchers in Chatham House's Europe Programme. 'Crawling from the Wreckage' is the first in a series of articles that look at key themes in European political discourse from the last century. You can read the article here

This event is open to Chatham House Members. Not a member? Find out more.




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The multilevel identity politics of the 2019 Eurovision Song Contest

7 May 2020 , Volume 96, Number 3

Galia Press-Barnathan and Naama Lutz

This article uses the 2019 Eurovision Song Contest (ESC) that took place in Tel Aviv to explore how cultural mega-events serve both as political arenas and as tools for identity construction, negotiation and contestation. These processes of identity politics are all conducted across national–subnational–international–transnational levels. The hosting of mega-events fleshes out these multiple processes in a very strong manner. We first discuss the politics of hosting mega-events in general. We then examine the identity politics associated more specifically with the Eurovision Song Contest, before examining in depth the complex forms of identity politics emerging around the competition following the 2018 Israeli victory. We suggest that it is important to study together the multiple processes—domestic, international and transnational—of identity politics that take place around the competition, as they interact with each other. Consequently, we follow the various stakeholders involved at these different levels and their interactions. We examine the internal identity negotiation process in Israel surrounding the event, the critical actors debating how to use the stage to challenge the liberal, western, ‘normal’ identity Israel hoped to project in the contest and how other stakeholders (participating states, national broadcasting agencies, participating artists) reacted to them, and finally we examine the behaviour of the institution in charge, the European Broadcasting Union, and national governments. We contribute to the study of mega-events as fields of contestation, to the understanding of the complex, multilevel nature of national identity construction, negotiation and contestation in the current era, and more broadly to the role that popular culture plays in this context.




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Geostrategic Outlook for the Indo-Pacific 2019-2024

The project aims to broaden and deepen understanding of the geostrategic realities in, and outlook for, the Indo-Pacific region.

Focusing on trade security, climate change disruptions and security cooperation, the project will develop scenarios exploring possible shifts in regional economic and security priorities from 2019-2024.

Research staff from Chatham House will, in cooperation with local partners, convene expert roundtables in the United Kingdom, France, Japan, India, the United States and Tonga to enhance the discourse and understanding of the strategic relationships in the region, as well as the shared – or disparate – goals of the various countries.

A podcast will be recorded and released in conjunction with each event. The project will culminate with a research paper, amalgamating the roundtable discussions with analyses and policy recommendations developed by the Chatham House team.

Department contact

Anna Aberg

Research Analyst, Energy, Environment and Resources Programme
020 7314 3629




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The EU’s Un-Common Agricultural Policy

Invitation Only Research Event

21 October 2019 - 8:30am to 10:00am

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

Ian Mitchell, Co-Director, Development Cooperation in Europe; Senior Policy Fellow and Associate Fellow, Energy, Environment and Resources Department, Chatham House
Chair: Ana Yang, Head of Land Use and Food Systems, Hoffmann Centre for Sustainable Resource Economy, Chatham House

Despite its name, the EU’s Common Agricultural Policy (CAP) provides support to the agricultural sector that varies widely between the 27 member states. The OECD calculates the extent of this support at the EU level but members have blocked the organization calculating support levels for individual EU members. Overall, the EU’s producer support is equivalent to 20 per cent of farm income which is well-above the levels seen in the US at 12.2 per cent and China at 14.3 per cent.
 
This roundtable will discuss the first estimates of support levels by EU countries produced by Ian Mitchell from the Center for Global Development. It will look at both direct subsidies under the CAP and those that inflate market prices. The discussion will consider the implications for EU finance, for the potential role of EU subsidy reform and for the UK’s options after Brexit.
 
Attendance at this event is by invitation only. 

Event attributes

Chatham House Rule

Chloé Prendleloup




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The Indo-Pacific: Geostrategic Perspectives to 2024 - Workshop 3

Invitation Only Research Event

17 October 2019 - 9:30am to 2:00pm

Institut Francais des Relations Internationales, 27 rue de la Procession, 75740 Paris Cedex 15, France

This closed-door roundtable explores possible strategic shifts in the Indo-Pacific between now and 2024. Focusing on trade security, climate change disruptions and security cooperation, it aims to enhance the understanding of the regional goals of, and strategic relationships between, the key countries active in the region.

The workshop is part of a larger project funded by the Strategic Policy Division of the Australian Department of Defence. The project includes workshops in the United States, the United Kingdom, France, Japan, India and the Pacific Islands (Tonga).

Attendance at this event is by invitation only.

Anna Aberg

Research Analyst, Energy, Environment and Resources Programme
020 7314 3629




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Energy and Displacement in Eight Objects: Insights from Sub-Saharan Africa

5 November 2019

This ethnographic study is the first of its kind to analyse energy access and resilience strategies deployed in two refugee camps in Kenya and Burkina Faso. It highlights the need for new methodological approaches to expand the evidence base for humanitarian energy interventions and policies.

Owen Grafham

Manager, Energy, Environment and Resources Programme

Glada Lahn

Senior Research Fellow, Energy, Environment and Resources Programme

Jamie Cross

Senior Lecturer in Social Anthropology, University of Edinburgh

Megan Douglas

PhD Candidate in International Development, University of Edinburgh

Craig Martin

Reader in Design, University of Edinburgh.

Charlotte Ray

Research Associate, University of Loughborough

Arno Verhoeven

Lecturer in Design, University of Edinburgh

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Portable battery connected to a solar PV and used to recharge mobile phones and power a radio in Goudoubo Refugee camp (Burkina Faso). Photo: Edoardo Santangelo

In recent years, clean energy access for refugees and internally displaced people has emerged as a potential method of improving humanitarian outcomes and enabling self-reliance. While recent research emphasizes the need for more quantitative data to inform energy access interventions, better qualitative understanding would also improve innovation in this area.

This ethnographic study is the first of its kind to analyse energy access and resilience strategies deployed in two refugee camps, Kakuma in Kenya and Goudoubo in Burkina Faso. The stories of residents in these camps demonstrate the importance of considering everyday experiences of displaced people in developing sustainable humanitarian energy interventions.

This paper highlights the need for new methodological approaches to expand the evidence base for humanitarian energy interventions and policies. Future research could usefully inform humanitarian energy projects by examining the technical knowledge and existing practices of refugees in the design of energy technologies, systems and business models. Uptake and sustained use of new systems may be more likely where interventions build on or work in harmony with these factors.




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Sino-Russian Gas Cooperation: Power of Siberia I and II and Implications for Global LNG Supplies

Invitation Only Research Event

27 November 2019 - 8:30am to 9:30am

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

Professor Keun-Wook Paik, Associate Fellow, Energy, Environment and Resources Department, Chatham House
Chair: John Lough, Associate Fellow, Russia and Eurasia Programme, Chatham House

In a new event in the Sustainable Transitions series, the speaker will present an update of Sino-Russian gas cooperation.

To give a comprehensive account of their impact on global liquefied natural gas (LNG) supplies, he will discuss the following points:

  • Gas is scheduled to start flowing from the Power of Siberia I (POS) on 2 December 2019. But what is the background of development of POS 1 and what is its current status and prospects? 
  • What are the chances of exporting gas through the proposed Altai pipeline? Why is the Mongolia export route so significant? And how will it affect the Central Asian Republics and in particular Turkmenistan’s gas export to China? 
  • What are the implications of both POS I and Altai gas via Mongolia route in the context of global LNG supply?
  • What are the prospects for multilateral pipeline gas cooperation in northeast Asia?
  • What are the implications for other Arctic onshore LNG supply, in particular, for Novatek's Yamal LNG and Arctic LNG 1 and 2 to China on top of POS 1 and Altai gas?

Attendance at this event is by invitation only.

Event attributes

Chatham House Rule

Chloé Prendleloup




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COP26 Diplomatic Briefing Series: Outcomes of COP25 and What It Means for 2020

Invitation Only Research Event

22 January 2020 - 4:30pm to 6:00pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

HE Raffaele Trombetta, Italian Ambassador to the UK, Co-Host, COP 26
Archie Young, UK Lead Climate Negotiator, Cabinet Office 
Peter Betts, Associate Fellow, Energy, Environment and Resources Department, Chatham House
Chair: Professor Tim Benton, Research Director, Energy, Environment and Resources, Chatham House  

The UK will host the 26th Conference of the Parties (COP26) in November 2020 in Glasgow. In the run up, Chatham House is organizing a monthly briefing series targeted to:

  • The diplomatic service based in London, in particular, staff of the London embassies who are reporting on climate change issues.
  • Senior UK government civil servants, officials and politicians engaged in climate change.
  • Academics, experts, business representatives and NGOs.

The first briefing in the series focuses on the results from COP25 held in Madrid in December 2019 and what this means for 2020.

This briefings series offer an opportunity to discuss, in an informal setting, the most pressing and complex climate issues of the day with UK and international government officials and experts.

Johanna Tilkanen

Project Manager, Energy, Environment and Resources Department

Event attributes

Chatham House Rule