T-cell immunoglobulin and mucin domain–containing molecule 3 (TIM-3), a potential immunotherapeutic target for cancer, has been shown to display diverse characteristics in a context-dependent manner. Thus, it would be useful to delineate the precise functional features of TIM-3 in a given situation. Here, we report that glial TIM-3 shows distinctive properties in the brain tumor microenvironment. TIM-3 was expressed on both growing tumor cells and their surrounding cells including glia and T cells in an orthotopic mouse glioma model. The expression pattern of TIM-3 was distinct from those of other immune checkpoint molecules in tumor-exposed and tumor-infiltrating glia. Comparison of cells from tumor-bearing and contralateral hemispheres of a glioma model showed that TIM-3 expression was lower in tumor-infiltrating CD11b+CD45mid glial cells but higher in tumor-infiltrating CD8+ T cells. In TIM-3 mutant mice with intracellular signaling defects and Cre-inducible TIM-3 mice, TIM-3 affected the expression of several immune-associated molecules including iNOS and PD-L1 in primary glia-exposed conditioned media (CM) from brain tumors. Further, TIM-3 was cross-regulated by TLR2, but not by TLR4, in brain tumor CM- or Pam3CSK4-exposed glia. In addition, following exposure to tumor CM, IFNγ production was lower in T cells cocultured with TIM-3–defective glia than with normal glia. Collectively, these findings suggest that glial TIM-3 actively and distinctively responds to brain tumor, and plays specific intracellular and intercellular immunoregulatory roles that might be different from TIM-3 on T cells in the brain tumor microenvironment.Significance:TIM-3 is typically thought of as a T-cell checkpoint receptor. This study demonstrates a role for TIM-3 in mediating myeloid cell responses in glioblastoma.

Brain metastases are associated with poor prognosis irrespective of the primary tumor they originate from. Current treatments for brain metastases are palliative, and patients with symptomatic brain metastasis have a one-year survival of <20%. Lung cancer, breast cancer, and melanoma have higher incidences of brain metastases compared with other types of cancers. However, it is not very clear why some cancers metastasize to the brain more frequently than others. Studies thus far suggest that brain-specific tropism of certain types of cancers is defined by a winning combination of the following factors: unique genetic subtypes of primary tumors or its subclones enabling detachment, dissemination, blood–brain barrier penetration, plus proliferation and survival in hypoxic low-glucose microenvironment; specific transcriptomic and epigenetic changes of colony-forming metastatic cells, allowing their outgrowth; favorable metastasis-permissive microenvironment of the brain created by interactions of cancer cells and cells in the brain through triggering inflammation, recruiting myeloid-derived suppressor cells, and promoting metabolic adaptation; immunosuppression resulting in the failure of adaptive immune response to recognize or kill cancer cells in the brain. Here, we briefly review recent advances in understanding brain metastasis organotropism and outline directions for future research.

BACKGROUND AND PURPOSE:

The massa intermedia is a normal midline transventricular thalamic connection. Massa intermedia aberrations are common in schizophrenia, Chiari II malformation, X-linked hydrocephalus, Cornelia de Lange syndrome, and diencephalic-mesencephalic junction dysplasia, among others. We have noticed that massa intermedia abnormalities often accompany other midline malformations. The massa intermedia has never been formally evaluated in a group of exclusively pediatric patients, to our knowledge. We sought to compare and contrast the prevalence, size, and location of the massa intermedia in pediatric patients with and without congenital midline brain abnormalities.

MATERIALS AND METHODS:

Successive 3T brain MR imaging examinations from pediatric patients with and without midline malformations were procured from the imaging data base at a pediatric hospital. Massa intermedia presence, size, morphology, and position were determined using 3D-TIWI with 1-mm isotropic resolution. The brain commissures, septum pellucidum, hypothalamus, hippocampus, vermis, and brain stem were evaluated to determine whether alterations were related to or predictive of massa intermedia abnormalities.

RESULTS:

The massa intermedia was more frequently absent, dysmorphic, and/or displaced in patients with additional midline abnormalities than in those without. The massa intermedia was absent in 40% of patients with midline malformations versus 12% of patients with normal findings (P < .001). Massa intermedia absence, surface area, and morphology were predictable by various attributes and alterations of the commissures, hippocampus, hypothalamus, vermis, brain stem, and third ventricle.

CONCLUSIONS:

Most pediatric patients have a thalamic massa intermedia centered in the anterior/superior third ventricle. Massa intermedia abnormalities are commonly associated with other midline malformations. Normal-variant massa intermedia absence is a diagnosis of exclusion.

BACKGROUND AND PURPOSE:

Diffuse intrinsic pontine glioma is a lethal childhood brain cancer with dismal prognosis and MR imaging is the primary methodology used for diagnosis and monitoring. Our aim was to determine whether advanced diffusion, perfusion, and permeability MR imaging metrics predict survival and pseudoprogression in children with newly diagnosed diffuse intrinsic pontine glioma.

MATERIALS AND METHODS:

A clinical trial using the poly (adenosine diphosphate ribose) polymerase (PARP) inhibitor veliparib concurrently with radiation therapy, followed by maintenance therapy with veliparib + temozolomide, in children with diffuse intrinsic pontine glioma was conducted by the Pediatric Brain Tumor Consortium. Standard MR imaging, DWI, dynamic contrast-enhanced perfusion, and DSC perfusion were performed at baseline and approximately every 2 months throughout treatment. ADC histogram metrics of T2-weighted FLAIR and enhancing tumor volume, dynamic contrast-enhanced permeability metrics for enhancing tumors, and tumor relative CBV from DSC perfusion MR imaging were calculated. Baseline values, post-radiation therapy changes, and longitudinal trends for all metrics were evaluated for associations with survival and pseudoprogression.

RESULTS:

Fifty children were evaluable for survival analyses. Higher baseline relative CBV was associated with shorter progression-free survival (P = .02, Q = 0.089) and overall survival (P = .006, Q = 0.055). Associations of higher baseline mean transfer constant from the blood plasma into the extravascular extracellular space with shorter progression-free survival (P = .03, Q = 0.105) and overall survival (P = .03, Q = 0.102) trended toward significance. An increase in relative CBV with time was associated with shorter progression-free survival (P < .001, Q < 0.001) and overall survival (P = .004, Q = 0.043). Associations of longitudinal mean extravascular extracellular volume fraction with progression-free survival (P = .03, Q = 0.104) and overall survival (P = .03, Q = 0.105) and maximum transfer constant from the blood plasma into the extravascular extracellular space with progression-free survival (P = .03, Q = 0.102) trended toward significance. Greater increases with time were associated with worse outcomes. True radiologic progression showed greater post-radiation therapy decreases in mode_ADC_FLAIR compared with pseudoprogression (means, –268.15 versus –26.11, P = .01.)

CONCLUSIONS:

ADC histogram, perfusion, and permeability MR imaging metrics in diffuse intrinsic pontine glioma are useful in predicting survival and pseudoprogression.

BACKGROUND AND PURPOSE:

Endovascular embolization only has been advocated for treatment of brain arteriovenous malformations in recent trials. Our aim was to evaluate the results of embolization only in a cohort of patients who were enrolled in the A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA) study at 39 clinical sites in 9 countries.

MATERIALS AND METHODS:

We analyzed the rates and severity of stroke and death in patients who underwent embolization only. Events were identified through in-person neurologic follow-up visits performed at 6-month intervals during the first 2 years and annually, with telephone contact every 6 months thereafter. All event-related data were reviewed by independent adjudicators.

RESULTS:

Among 30 patients who had embolization planned, 26 underwent embolization only. A total of 13 stroke events were reported in the follow-up period among 26 subjects (ischemic, hemorrhagic, or both in 4, 7, and 2 subjects, respectively). The adverse event occurred after the first embolization in 11 of 13 patients. One patient had a major motor deficit, and 2 patients developed major visual field deficits. One event was fatal. The modified Rankin Scale score was 0–2 at last follow-up in 11 of the 12 stroke survivors. Estimated stroke-free survival was 46% at 12 months.

CONCLUSIONS:

Although the rates of stroke and/or death were high in patients treated with embolization only in ARUBA, the rates of favorable outcomes following stroke were high during follow-up.

BACKGROUND AND PURPOSE:

Embolization is widely performed to treat brain arteriovenous malformations, but little has been reported on factors contributing to complications. We retrospectively reviewed a nationwide surveillance to identify risk factors contributing to complications and short-term clinical outcomes in the endovascular treatment of brain arteriovenous malformations.

MATERIALS AND METHODS:

Data for endovascular treatment of brain arteriovenous malformations were extracted from the Japanese nationwide surveillance. Patient characteristics, brain arteriovenous malformation features, procedures, angiographic results, complications, and clinical outcomes at 30 days postprocedure were analyzed.

RESULTS:

A total of 1042 endovascular procedures (788 patients; mean, 1.43 ± 0.85 procedures per patient) performed in 111 institutions from 2010 to 2014 were reviewed. Liquid materials were used in 976 procedures (93.7%): to perform presurgical embolization in 638 procedures (61.2%), preradiosurgical embolization in 160 (15.4%), and as sole endovascular treatment in 231 (22.2%). Complete or near-complete obliteration of brain arteriovenous malformations was obtained in 386 procedures (37.0%). Procedure-related complications occurred in 136 procedures (13.1%), including hemorrhagic complications in 59 (5.7%) and ischemic complications in 57 (5.5%). Univariate analysis identified deep venous drainage, associated aneurysms, infratentorial location, and preradiosurgical embolization as statistically significant risk factors for complications. Multivariate analysis showed that embolization of brain arteriovenous malformations in the infratentorial location was significantly associated with complications. Patients with complications due to endovascular procedures had worse clinical outcomes 30 days after the procedures than those without complications.

CONCLUSIONS:

Complications arising after endovascular treatment of brain arteriovenous malformations are not negligible even though they may play a role in adjunctive therapy, especially in the management of infratentorial brain arteriovenous malformations.

BACKGROUND AND PURPOSE:

Anoxic brain injury is a result of prolonged hypoxia. We sought to describe the nonquantitative arterial spin-labeling perfusion imaging patterns of anoxic brain injury, characterize the relationship of arterial spin-labeling and DWI, and evaluate the normalized diffusion-to-perfusion ratio to differentiate patients with anoxic brain injury from healthy controls.

MATERIALS AND METHODS:

We identified all patients diagnosed with anoxic brain injuries from 2002 to 2019. Twelve ROIs were drawn on arterial spin-labeling with coordinate-matched ROIs identified on DWI. Linear regression analysis was performed to examine the relationship between arterial spin-labeling perfusion and diffusion signal. Normalized diffusion-to-perfusion maps were generated using a custom-built algorithm.

RESULTS:

Thirty-five patients with anoxic brain injuries and 34 healthy controls were identified. Linear regression analysis demonstrated a significant positive correlation between arterial spin-labeling and DWI signal. By means of a combinatory cutoff of slope of >0 and R² of > 0.78, linear regression using arterial spin-labeling and DWI showed a sensitivity of 0.86 (95% CI, 0.71–0.94) and specificity of 0.82 (95% CI, 0.66–0.92) for anoxic brain injuries. A normalized diffusion-to-perfusion color map demonstrated heterogeneous ratios throughout the brain in healthy controls and homogeneous ratios in patients with anoxic brain injuries.

CONCLUSIONS:

In anoxic brain injuries, a homogeneously positive correlation between qualitative perfusion and DWI signal was identified so that areas of increased diffusion signal showed increased ASL signal. By exploiting this relationship, the normalized diffusion-to-perfusion ratio color map may be a valuable imaging biomarker for diagnosing anoxic brain injury and potentially assessing BBB integrity.

BACKGROUND AND PURPOSE:

Accurate differentiation between glioblastoma and solitary brain metastasis is of vital importance clinically. This study aimed to investigate the potential value of the inflow-based vascular-space-occupancy MR imaging technique, which has no need for an exogenous contrast agent, in differentiating glioblastoma and solitary brain metastasis and to compare it with DSC MR imaging.

MATERIALS AND METHODS:

Twenty patients with glioblastoma and 22 patients with solitary brain metastasis underwent inflow-based vascular-space-occupancy and DSC MR imaging with a 3T clinical scanner. Two neuroradiologists independently measured the maximum inflow-based vascular-space-occupancy–derived arteriolar CBV and DSC-derived CBV values in intratumoral regions and peritumoral T2-hyperintense regions, which were normalized to the contralateral white matter (relative arteriolar CBV and relative CBV, inflow-based vascular-space-occupancy relative arteriolar CBV, and DSC-relative CBV). The intraclass correlation coefficient, Student t test, or Mann-Whitney U test and receiver operating characteristic analysis were performed.

RESULTS:

All parameters of both regions had good or excellent interobserver reliability (0.74~0.89). In peritumoral T2-hyperintese regions, DSC-relative CBV (P < .001), inflow-based vascular-space-occupancy arteriolar CBV (P = .001), and relative arteriolar CBV (P = .005) were significantly higher in glioblastoma than in solitary brain metastasis, with areas under the curve of 0.94, 0.83, and 0.72 for discrimination, respectively. In the intratumoral region, both inflow-based vascular-space-occupancy arteriolar CBV and relative arteriolar CBV were significantly higher in glioblastoma than in solitary brain metastasis (both P < .001), with areas under the curve of 0.91 and 0.90, respectively. Intratumoral DSC-relative CBV showed no significant difference (P = .616) between the 2 groups.

CONCLUSIONS:

Inflow-based vascular-space-occupancy has the potential to discriminate glioblastoma from solitary brain metastasis, especially in the intratumoral region.

BACKGROUND AND PURPOSE:

Brain metastases are a common finding on brain MRI. However, the factors that dictate their size and distribution are incompletely understood. Our aim was to discover a statistical model that can account for the size distribution of parenchymal metastases in the brain as measured on contrast-enhanced MR imaging.

MATERIALS AND METHODS:

Tumor volumes were calculated on the basis of measured tumor diameters from contrast-enhanced T1-weighted spoiled gradient-echo images in 68 patients with untreated parenchymal metastatic disease. Tumor volumes were then placed in rank-order distributions and compared with 11 different statistical curve types. The resultant R² values to assess goodness of fit were calculated. The top 2 distributions were then compared using the likelihood ratio test, with resultant R values demonstrating the relative likelihood of these distributions accounting for the observed data.

RESULTS:

Thirty-nine of 68 cases best fit a power distribution (mean R² = 0.938 ± 0.050), 20 cases best fit an exponential distribution (mean R² = 0.957 ± 0.050), and the remaining cases were scattered among the remaining distributions. Likelihood ratio analysis revealed that 66 of 68 cases had a positive mean R value (1.596 ± 1.316), skewing toward a power law distribution.

CONCLUSIONS:

The size distributions of untreated brain metastases favor a power law distribution. This finding suggests that metastases do not exist in isolation, but rather as part of a complex system. Furthermore, these results suggest that there may be a relatively small number of underlying variables that substantially influence the behavior of these systems. The identification of these variables could have a profound effect on our understanding of these lesions and our ability to treat them.

SUMMARY:

The remarkable temperature sensitivity of the brain is widely recognized and has been studied for its role in the potentiation of ischemic and other neurologic injuries. Pyrexia frequently complicates large-vessel acute ischemic stroke and develops commonly in critically ill neurologic patients; the profound sensitivity of the brain even to minor intraischemic temperature changes, together with the discovery of brain-to-systemic as well as intracerebral temperature gradients, has thus compelled the exploration of cerebral thermoregulation and uncovered its immutable dependence on cerebral blood flow. A lack of pragmatic and noninvasive tools for spatially and temporally resolved brain thermometry has historically restricted empiric study of cerebral temperature homeostasis; however, MR thermometry (MRT) leveraging temperature-sensitive nuclear magnetic resonance phenomena is well-suited to bridging this long-standing gap. This review aims to introduce the reader to the following: 1) fundamental aspects of cerebral thermoregulation, 2) the physical basis of noninvasive MRT, and 3) the physiologic interdependence of cerebral temperature, perfusion, metabolism, and viability.

Sau 5 năm đi làm, chàng trai 9X ở Hà Tĩnh đã mua được một căn hộ chung cư rộng rãi tại Hà Nội với giá gần 2 tỷ đồng từ tiền tiết kiệm.

Gia đình có việc cần muốn bán lô đất trang trại nhà vườn tại xã Cố Nghĩa, huyện Lạc Thủy, tỉnh Hòa Bình, diện tích 2050m2, có 400m2 đất ở thổ cư, còn lại đất vườn, nằm ở vị trí đắc địa đất cao thoáng mát, trước mặt bám hồ nước bao quanh trên đất đã trồng 300 gốc bưởi diễn 4 năm t...

Hiện tại đang có mảnh vườn gần khu du lịch Bà Nà cần bán với diện tích khá lớn 50.000m2 sổ đỏ đất trồng cây lâu năm. Vị trí cách khu du lịch Bà Nà tầm 3km - cách đường vành đai Nguyễn Tất Thành nối dài tầm 1km. Lô đất có vị trí hai mặt tiền đường nhìn khá là đẹp. Anh chị dưới thà...

Trang trại trang bị đầy đủ các thiết bị theo quy cách của nhà máy CP. Chia 2 chuồng. Kích thước mỗi chuồng là rộng là 15.60m dài 78m nuôi tổng 2 trại được gần 20 vạn gà trắng. Có đầy đủ nhà ăn khu vực sinh hoạt cho công nhân. Vị trí cách quốc lộ 6A và trung tâm huyện Lương Sơn 5k...

Cần bán đất vườn, khu du lịch sinh thái, đất làm kho công ty. 1. Bảo Quang. A/1.1ha Bảo Quang trồng bưởi và ít lúa giá 3.8 tỷ, mặt tiền đường bê tông. B/8 sào, đất đang trồng ủ hoa rừng. Hiện là đất lúa còn lại, quy hoạch đất trồng cây lâu năm, đất cao ráo. Cách trung tâm 4km, đư...

Cần tiền nên gia đình muốn bán miếng đất trang trại rộng hơn 5.900 m2, có 100m2 thổ cư và 1 ngôi nhà nhỏ, sổ đỏ giấy tờ đầy đủ. Đất ở mặt tiền đường hẻm dân cư ở BL, yên tĩnh, xinh đẹp. Đất nở hậu nên mang may mắn, tài lộc cho chủ nhân, hiện trồng dâu tằm, xen kẽ bơ, cafe, sầu ri...

Chính chủ cho thuê trang trại (1,2ha) mặt tiền 88m đường nhựa lộ 20m xe ô tô vào tận nhà, cách chợ 312 chỉ 800 mét, khu dân cư hiện hữu đông đúc, Đăk Mil, Đắk Nông.Tự do chăn nuôi vd: - Nuôi gà, bồ câu, chim cảnh... - Nuôi dúi, thỏ hoặc heo rừng, chó cảnh...Tự do trồng trọt: - Đã...

Cho thuê trại heo tại xã An Phú, Củ Chi (Đường Nguyễn Thị Rành vào 1km; cách Ngã tư An Sương, Tp. HCM 45km). Trại nuôi khép kín, đang hoạt động, xe tải vào tận nơi: - Công suất chuồng heo nái: 500. - Công suất chuồng heo thịt: 1,000. - Diện tích khuôn viên chuồng trại: 1 hecta. -...

Chơi thuê trại heo tổng khuôn viên 10.000m2 đã xây bao quanh khép kín có chuồng, ao, thoát nước, công suất nuôi khoảng 1000 con còn đất trống làm thêm chuồng, điện nước đầy đủ, khu xa dân cư không sợ ô nhiễm đường sá thuận tiện. LH 0907 223 277 0963 000 298....

Chính chủ cho thuê trang trại tại xã Tiến Bộ, tổng 9ha đã trồng keo 5 ha, cách Quốc Lộ 37 400m đường bê tông xe tải 6 tấn chạy hàng ngày, đường sá, điện đóm đầy đủ, đường độc đạo vào trang trại, suối chảy vòng quanh; - Có 700m chuồng lợn xây kiên cố theo tiêu chuẩn Vietgap. - Có ...

Rất nhiều khách hàng bất ngờ với trải nghiệm độc đáo và tiện lợi khi sử dụng sản phẩm cho vay mua nhà của Techcombank từ đầu tháng 9 vừa qua.

Chiếc giường êm ái, chăn gối thơm tho, sạch sẽ cùng thiết kế phòng đẹp mắt… luôn là những trải nghiệm khó quên với những ai từng lưu trú tại các khách sạn hạng sang. Chỉ cần chú ý tới những chi tiết đắt giá, bạn đã sở hữu ngay một phòng ngủ sang trọng, tinh tế không thua kém phòng khách sạn 5 sao trị giá hàng trăm triệu đồng mỗi đêm.

In addition to price and legality, location with weather condition is also a very important factor to consider when buying real estate. The rainy season is beginning in Vietnam’s Southern region, especially in Ho Chi Minh City. Expert says this is an appropriate time for home buyers to learn about the location of the homes they are interested in.

Chồng tôi sinh năm 1983, tôi sinh năm 1985, con trai tôi sinh năm 2012 và 2015. Vợ chồng tôi muốn xây nhà trong năm 2018 mà tuổi chồng tôi không hợp. Vậy chúng tôi lấy tuổi con trai có được không?

छत्तीसगढ़ में एक टैंक की सफाई करते समय कथित तौर पर गैस रिसाव होने के बाद पेपर मिल के सात श्रमिकों को अस्पताल में भर्ती कराया गया है।

We might pride ourselves on our top-notch LMS and training content, and how it can help learners develop as professionals and as people. But let […]

The post Learning from Our Mothers: 8 Lessons from the World's Greatest Trainers appeared first on e-Learning Feeds.

Sony Interactive Entertainment announced Rainbow Six Siege, The Evil Within 2 and Get Even are now available for PlayStation Now subscribers. 

Rainbow Six Siege will only be available to download and stream until Monday, November 2. Downloads for the game are limited to the PlayStation 4 only. 

PlayStation Now features over 800 games on the PlayStation 4, PlayStation 3 and PlayStation 2 available to stream and play on the PlayStation 4 and Windows PC. PS4 subscribers can download and install over 300 games to play locally. 

Here is an overview of the three games:

Rainbow Six Siege

It’s the perfect time to try out the deeply tactical, always tense multiplayer shooter that has become an esports phenomenon in the years since its 2015 debut. Strained matches are built around two competing teams of players using a variety of weapons, gadgets and sound strategies to triumph over the other. While you’ll need to adapt to its uncompromising gameplay, it only makes every well-earned victory all the sweeter. Please note: this is the base edition.

The Evil Within 2

Genre aficionados will have plenty to savour with this horror sequel as you enter the alternate reality town of Union in search of your long thought dead daughter. Sickeningly brilliant creature designs and jump scares await as you explore the town’s expansive areas filled with dangers and secrets. But armed as you are with an arsenal of monster-shredding weaponry, as well as having the option to keep things low-key with a more stealthy approach, you’re ready to take on every abomination that stands between you and your family reunion.

Get Even

Puzzler, shooter, psychological thriller. Developer The Farm 51’s mashup of genres makes for an intriguing first-person adventure. Finding yourself trapped inside an insane asylum with a virtual reality device surgically grafted to your head, you’re forced to track down and ‘enter’ memories to gradually unravel the mystery behind your incarceration. As gripping as any murder mystery and with events shaped by your decisions, Get Even is a must play for those who love stories with plenty of twists.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443391/playstation-now-adds-rainbow-six-siege-the-evil-within-ii-and-get-even/

Developer Naughty Dog announced via Twitter a new trailer for the upcoming PlayStation 4 exclusive, The Last of Us Part II, will be released tomorrow, May 6 at 7am PT / 10am ET.

Here is an overview of the game:

Five years after their dangerous journey across the post-pandemic United States, Ellie and Joel have settled down in Jackson, Wyoming. Living amongst a thriving community of survivors has allowed them peace and stability, despite the constant threat of the infected and other, more desperate survivors. When a violent event disrupts that peace, Ellie embarks on a relentless journey to carry out justice and find closure. As she hunts those responsible one by one, she is confronted with the devastating physical and emotional repercussions of her actions.

Key Features:

• A Complex and Emotional Story – Experience the escalating moral conflicts created by Ellie’s relentless pursuit of vengeance. The cycle of violence left in her wake will challenge your notions of right versus wrong, good versus evil, and hero versus villain.

  A Beautiful Yet Dangerous World – Set out on Ellie’s journey, taking her from the peaceful mountains and forests of Jackson to the lush, overgrown ruins of greater Seattle. Encounter new survivor groups, unfamiliar and treacherous environments, and terrifying evolutions of the infected. Brought to life by the latest iteration of the Naughty Dog engine, the deadly characters and world are more realistic and meticulously detailed than ever before.

• Tense and Desperate Action-Survival Gameplay – New and evolved gameplay systems deliver upon the life-or-death stakes of Ellie’s journey through the hostile world. Feel her desperate struggle for survival through improved features such as high-intensity melee combat, fluid movement, and dynamic stealth. A broad variety 

The Last of Us Part II will launch for the PlayStation 4 on June 19.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443393/the-last-of-us-part-ii-new-trailer-drops-tomorrow-may-6/

Publisher Sony Interactive Entertainment and developer Naughty Dog have released the story trailer for The Last of Us Part II ahead of the game's release next month.

View the trailer below:

Here is an overview of the game:

Five years after their dangerous journey across the post-pandemic United States, Ellie and Joel have settled down in Jackson, Wyoming. Living amongst a thriving community of survivors has allowed them peace and stability, despite the constant threat of the infected and other, more desperate survivors. When a violent event disrupts that peace, Ellie embarks on a relentless journey to carry out justice and find closure. As she hunts those responsible one by one, she is confronted with the devastating physical and emotional repercussions of her actions.

Key Features:

• A Complex and Emotional Story – Experience the escalating moral conflicts created by Ellie’s relentless pursuit of vengeance. The cycle of violence left in her wake will challenge your notions of right versus wrong, good versus evil, and hero versus villain.

  A Beautiful Yet Dangerous World – Set out on Ellie’s journey, taking her from the peaceful mountains and forests of Jackson to the lush, overgrown ruins of greater Seattle. Encounter new survivor groups, unfamiliar and treacherous environments, and terrifying evolutions of the infected. Brought to life by the latest iteration of the Naughty Dog engine, the deadly characters and world are more realistic and meticulously detailed than ever before.

• Tense and Desperate Action-Survival Gameplay – New and evolved gameplay systems deliver upon the life-or-death stakes of Ellie’s journey through the hostile world. Feel her desperate struggle for survival through improved features such as high-intensity melee combat, fluid movement, and dynamic stealth. A broad variety of weapons, crafting items, skills, and upgrades allows you to personalize Ellie’s capabilities to your play style.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443406/the-last-of-us-part-ii-story-trailer-released/

ebb software has released a new trailer for the Xbox Series X version of the atmospheric first-person horror adventure, Scorn. The game is in development for the Xbox Series X and Windows PC via Steam and Windows Store.

View the Xbox Series X trailer below:

Here is an overview of the game:

Scorn is set in a nightmarish universe of odd forms and somber tapestry. It is designed around the idea of "being thrown into the world". Isolated and lost inside this dream-like world, you will explore different interconnected regions in a non-linear fashion. Every location contains its own theme, puzzles and characters that are integral in creating a cohesive world.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443422/horror-adventure-game-scorn-xbox-series-x-trailer-released/

Ubisoft has released the first look gameplay trailer for Assassin’s Creed Valhalla. The gameplay is "representative of Xbox Series X gameplay."

"As developers, we’re always excited to work with new hardware because it gives us a greater ability to express our creative vision," said Assassin’s Creed Valhalla creative director Ashraf Ismail. "Assassin’s Creed has always been committed to exploring new technologies and leveraging new consoles’ abilities to deliver the most immersive experience possible. We are excited to be collaborating closely with Microsoft to bring Assassin’s Creed Valhalla to the Xbox Series X."

View the Assassin’s Creed Valhalla gameplay trailer below:

Here is an overview of the game:

In Assassin’s Creed Valhalla, you are Eivor, a fierce Viking warrior raised on tales of battle and glory. Explore a dynamic and beautiful open world set against the brutal backdrop of England’s Dark Ages. Raid your enemies, grow your settlement, and build your political power in your quest to earn your place among the gods in Valhalla.

Key Features:

• Write Your Viking Saga – Advanced RPG mechanics allow you to shape the growth of your character and influence the world around you. With every choice you make, from political alliances and combat strategy to dialogue and gear progression, you will carve your own path to glory.
• Visceral Combat System – Dual-wield powerful weapons such as axes, swords, and even shields to relive the ruthless fighting style of the Viking warriors. Brutally decapitate your foes, vanquish them from afar, or stealthily assassinate targets with your hidden blade. Challenge yourself with the most varied collection of deadly enemies ever found in an Assassin’s Creed game.
• A Dark Age Open World – Sail from the harsh and mysterious shores of Norway to the beautiful but forbidding kingdoms of England and beyond. Immerse yourself in the Viking way of life through fishing, hunting, drinking games, and more.
• Lead Epic Raids – Launch massive assaults against Saxon troops and fortresses throughout England. Lead your clan in surprise attacks from your longship and pillage enemy territories to bring riches and resources back to your people.
• Grow Your Settlement – Construct and upgrade buildings that allow for deep customization, including a barracks, blacksmith, tattoo parlor, and more. Recruit new members to your clan and personalize your Viking experience.
• Mercenary Vikings – Create and customize a unique Viking raider within your clan and share it online with friends to use during their own raids.

Assassin’s Creed Valhalla will launch for Xbox Series X, PlayStation 5, PlayStation 4, Xbox One, Windows PC, and Google Stadia in Holiday 2020. The game will support Smart Delivery on the Xbox. This means if you purchase the game on the Xbox One or Xbox Series X, you will automatically gain access to the other version of the game. 

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443428/assassins-creed-valhalla-gets-xbox-series-x-first-look-gameplay-trailer/

Originally published by The Vinyl Factory. “It is a living instrument producing a living sound.” Soulwax, aka David & Stephen Dewaele, explore their love of the EMS Synthi 100 in a new album and book that pay tribute to the bulky hybrid synth. Both will be released via The Vinyl Factory and DEEWEE this May, and […]

The post Soulwax celebrate the EMS Synthi 100 in new trailer appeared first on FACT Magazine.

Big Tech is coming for your transaction data.

Railway Recruitment 2020 – रेलवे युवाओं को नौकरी का मौका दे रहा है। इस बार पश्चिमी रेलवे में भर्तियों होने जा रही हैं।

Exoplanet WASP-76b, which is about 390 light years from the solar system, has a strange iron signature in its atmosphere, suggesting the metal is raining down on the planet's night side

Spending at least six months in microgravity can cause astronauts’ brain volumes to increase, causing pressure to build up in their heads and creating vision problems

The leading hypothesis for how the moon formed involves a collision between a Mars-sized object and Earth that would have boiled away elements like carbon, making its discovery on the moon a mystery

Your weekly selection of awesome robot videos

Because we don't have enough on our plates as it is, now we've got 'murder hornets' flying around the United States. Murder hornets (actually Asian Giant Hornets, but that name didn't strike enough fear into the masses) have a sting powerful enough that China recommends medical treatment if stunk more than ten times, and emergency treatment if stung more than 30. *pours out a little liquor for Macaulay Culkin in My Girl*. And where is his glasses?! He can't see without his glasses! Put his glasses on! Here's a video of Coyote Peterson getting stung by one (the Japanese Giant Hornet was previously believed to be a subspecies of the Asian Giant Hornet, but has since been recategorized as a color morph). This is a video of a praying mantis eating a Giant Asian hornet until it's just a pile of limbs. So yeah, praying mantises -- start breeding them. And make sure to selectively breed them too so we can produce them bigger and bigger until they're preying on us because the way things are going how is that not how this ends? Keep going for the video while I surround my Animal Crossings town with preying mantises to protect my villagers and keep my five-star rating (okay, three).

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Focused ultrasound, the researchers hope, could revolutionize treatment for conditions from Alzheimer's to epilepsy to brain tumors -- and even help repair the devastating damage caused by stroke.

Adding yoga to your regularly prescribed migraine treatment may be better than medication alone, according to a new study. The new research suggests yoga may help people with migraines have headaches that happen less often, don't last as long and are less painful.

New research finds that sleep problems in a baby's first 12 months may not only precede an autism diagnosis, but also may be associated with altered growth trajectory in a key part of the brain, the hippocampus.

BRUNSWICK, Ga. -- When the Glynn County Police Department arrived at the scene of a fatal shooting in February in southeastern Georgia, officers encountered a former colleague with the victim's blood on his hands.They took down his version of events and let him and his adult son, who had fired the shots, go home.Later that day, Wanda Cooper, the mother of the 25-year-old victim, Ahmaud Arbery, received a call from a police investigator. She recounted later that the investigator said her son had been involved in a burglary and was killed by "the homeowner," an inaccurate version of what had happened.More than two months after that fatal confrontation, the Georgia Bureau of Investigation, which took over the case this week, arrested the former officer, Gregory McMichael, and his son, Travis McMichael, on charges of murder and aggravated assault.The charges -- which came after the release of a graphic video showing the killing as the two white men confront Arbery, who was African American -- made clear the depths of the local department's bungling of the case, which was just the latest in a series of troubling episodes involving its officers.And it was one element of the broader potential breakdown of the justice system in South Georgia. Attorney General Chris Carr, through a spokeswoman, said Friday that he planned to start a review of all of the relevant players in that system.Carr's office has already determined that George E. Barnhill, a district attorney who was assigned the case in February but recused himself late last month, should have never taken it on. Among his many conflicts: His son once worked alongside one of the suspects at the local prosecutor's office.S. Lee Merritt, a lawyer representing Arbery's family, has called for a federal civil rights investigation focused not only on the men who pursued Arbery but also the broader justice system."It's small-town America," Merritt said in an interview Thursday. "Those counties, the law enforcement community there, they know each other well; they recycle officers in between themselves -- it's a very tight-knit community."Over the years, Glynn County police officers have been accused of covering up allegations of misconduct, tampering with a crime scene, interfering in an investigation of a police shooting and retaliating against fellow officers who cooperated with outside investigators.The police chief was indicted days after Arbery's killing on charges related to an alleged cover-up of an officer's sexual relationship with an informant. The chief, John Powell, had been hired to clean up the department, which the Glynn County manager described last fall as suffering from poor training, outdated policies and "a culture of cronyism."The Glynn County force was the sort of department where disciplinary records went missing and where evidence room standards were not maintained, leading the state to strip it of its accreditation.Arbery was killed after the McMichaels confronted him while he was running in the Satilla Shores neighborhood just outside of Brunswick, the Glynn County seat. But neither of the McMichaels was arrested immediately after the slaying, which occurred Feb. 23 about 1 p.m.According to a police report, Gregory McMichael said that he saw Arbery running through his neighborhood and thought that he looked like the suspect in a rash of recent break-ins. McMichael, 64, told authorities that he and his son, Travis McMichael, 34, armed themselves and began chasing him in a truck.Gregory McMichael had been a Glynn County police officer from 1982 to 1989 and later worked as an investigator in the local prosecutor's office, before retiring last year.Darren W. Penn, a lawyer and a department critic, said the Ahmaud Arbery case was "another symptom or sign of a police department that appears willing to protect those that they know."Penn is representing a woman who is suing the department over claims that it failed to intervene with her estranged son-in-law, a Glynn County officer, who killed her daughter, a friend and himself in 2018.County officials and a police spokesman could not be reached Friday for comment.From the start, McMichael's connections to the police department and the prosecutor's office presented other challenges.The first district attorney assigned to the case, Jackie Johnson, recused herself because she had worked with McMichael. The second prosecutor, Barnhill, advised Glynn County police that there was "insufficient probable cause" to issue arrest warrants, according to an internal document.Finally, the case moved to Tom Durden, the district attorney in Georgia's Atlantic Judicial Circuit in Hinesville, who this week formally asked the state bureau of investigation to get involved, according to a GBI statement. A Justice Department spokesperson said this week that the FBI was assisting in the investigation.Bob Coleman, a county commissioner at large, was critical of Johnson, saying she should have given the case to the state attorney general, not Barnhill. After the Georgia Bureau of Investigation made arrests this week, Coleman said, "That's what should have happened a long time ago before the sun went down. They killed a person in the bright sunlight."Glynn County is a marshy coastal corner of Georgia about 300 miles southeast of Atlanta with about 85,000 residents, and is known mostly for its mellow barrier islands and its rich African American coastal culture.Like many Southern communities, its history is studded with racial violence, including three late 19th-century lynchings. Today, the county is about 70% white and 27% black, according to census figures.On Friday, hundreds gathered under the moss-draped trees outside the Glynn County courthouse to protest, arguing that the handling of the case had been botched as months went by without charges."I will never call the Glynn County police to my house!" one of Arbery's aunts said.Mario Baggs, a lifelong resident of Brunswick, said he believed that race was a factor in Arbery's killing, given the unfair treatment black men have long received."The black man is an endangered species," Baggs, 46, said. "We need justice; we need relief; we need the world to pay attention."Yet he also believed that Arbery's case fit into a larger pattern of dysfunction.Over the last decade, the Glynn County Police Department, which has 122 officers, has faced at least 17 lawsuits, including allegations of illegal search and seizure.One suit accused the department of wrongfully killing an unarmed white woman after officers fired through her car windshield. An investigation into that shooting found that Glynn County officers had tried to interfere with the inquiry to protect the officers involved.One of the officers in that shooting later killed his estranged wife and a friend. The wife's mother accused police of ignoring several alarming encounters in the months before the killings.Powell, the police chief, was arrested this year along with three other department officials after an investigation into a disbanded narcotics task force. The inquiry found that Powell had actively tried to shield wrongdoing by the task force. That led to his indictment on charges including violating the oath of office, criminal attempt to commit a felony and influencing a witness.As details of Arbery's death slowly emerged and were reported in The Brunswick News, Arbery's mother, increasingly distraught, called the department. She said that she had been told one thing but that the newspaper had reported something else entirely.Cooper's faith was shaken. "It's hard when you can't really believe what authority tells you, you know?" she said. "When you just cannot believe the people that's supposed to look out for all people. And when you question that, it's not a good feeling."Attempts to reach Gregory McMichael late last month were unsuccessful. In a brief phone conversation late last month, Travis McMichael, who runs a company that gives custom boat tours, declined to comment, citing the continuing investigation.The two men made a brief appearance in Glynn County Magistrate Court on Friday afternoon, but court officials said they did not enter a plea. No information about their lawyers was immediately available.Questions about the handling of Arbery's case extend beyond the police department and to Barnhill, the prosecutor who told police that there was insufficient probable cause to arrest the McMichaels.In an email Barnhill wrote to the state attorney general's office April 7, he asked to be taken off the case, stating that his son, an assistant district attorney in the Brunswick prosecutor's office, had handled a felony probation revocation case involving Arbery. He also said Gregory McMichael had helped with "a previous prosecution of Arbery."Court records show that Arbery was convicted of shoplifting and of violating probation in 2018; according to local news reports, he was indicted five years earlier for taking a handgun to a basketball game.Barnhill's office most recently drew attention beyond south Georgia for its prosecution of a black woman in rural Coffee County who had helped a first-time voter use a voting machine in the 2012 election. In 2018, a jury found the woman not guilty of multiple felonies. Her lawyers called the case "a racially motivated targeted prosecution."J. Peter Murphy, a Glynn County commissioner, on Friday defended the Police Department's decision to make no arrests in the shooting of Arbery. Murphy said the agency had been advised not to make arrests by both Barnhill and officials at the office of Johnson, the district attorney in Brunswick who formally asked to be taken off the case four days after the shooting. Neither prosecutor could be reached for comment."Tell me what the agency did wrong when its men and women were told several times not to arrest anyone?" Murphy said, referring to police. "What were they supposed to do? Cuff these guys and walk them into the jail and have no one prosecute them?"This article originally appeared in The New York Times.(C) 2020 The New York Times Company

This heartwarming documentary traces the lives of a baseball star and her partner, now in their 90s, who pretended to be ‘just good friends’ for decades

This documentary from Netflix is a real heart-soother. Directed with tremendous sensitivity and intimacy by Chris Bolan, it’s a love story about two women now in their 90s – Terry Donahue and Pat Henschel, who have been together since the 1940s.

For decades they kept up the pretence of being “just good friends” to their families before finally coming out a few years ago. Talking to outsiders, they still describe each other as “cousins”. The legacy of shame and fear among older people in the gay community is explored in the film, but the overwhelming mood here is love.

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