Pletení, to přece není práce pro chlapa, řeknete si. Ovšem ve slovenských Čičmanech (a vůbec v celé oblasti Horního Pováží) by mnozí nesouhlasili. Tady bývalo pletení ponožek z ovčí vlny výsostnou činností tamních bačů. V dnešní době je ovšem takový pletač nadmíru vzácný.

A new study released by researchers from the United Kingdom found that for every extra hour a teen spent inactive, there was an eight percent to 11 percent increase in depression later in life. However, there was some good news in the report as well. If a teen increased their physical activity, even just by one hour, it cut their risk of depression by about ten percent. A teen that increased their physical activity by two hours cut the risk by 20 percent.

The researchers also found that just light to moderate physical activity could do the trick. Everyday things like walking at school or home, running errands, and even standing to talk to someone can make a difference. If you feel you should increase your physical activity for your own mental health, try having stretch breaks, always take the stairs, do a few chores, play an instrument, or even just stand at a desk while doing your homework.

The EARN IT Act is dangerous. It threatens speech on the internet and tech companies' ability to provide secure communications for their users. There may not be anything about encryption in the dry text of the bill, but the threat is there all the same. No one knows what "best practices" the law will demand from online services, but the bill's focus on child porn strongly suggests any platform that "allows" this information to be transmitted using encrypted communications will be targeted by the government.

Bill Barr and Chris Wray have made it clear encryption is the enemy. Both have advocated for encryption backdoors, even if they're both too cowardly to use that term. No one thinks the government and service providers shouldn't do all they can to prevent the sharing of child porn, but undermining encryption isn't the solution. It may shield some child porn producers and consumers from detection, but the government's efforts in this area show encryption hasn't posed much of a problem to investigators and prosecutors.

Encryption protects people who aren't criminals. As Runa Sundvik explains for TechCrunch, targeting encryption via the EARN IT Act also threatens some of the foremost beneficiaries of the First Amendment: journalists.

[T]echnology experts warn the bill not only fails to meet the challenge, it creates new problems of its own. My job is to enable journalists to do their work securely — to communicate with others, research sensitive stories and publish hard-hitting news. This bill introduces significant harm to journalists’ ability to protect their sources.

Strip communications platforms of their encryption and you make it that much easier to expose journalists' sources and snoop on their communications. This isn't an existential threat. It's an actual threat. The FBI has spied on journalists and several successive presidential administrations have made rooting out leakers a priority.

But it does more than harm journalists. It also harms the people they're trying to reach: readers. Encryption protects readers who visit news sites utilizing HTTPS. That's almost all of them at this point. This ensures their connection is shielded from people trying to snoop on their web activity. More importantly, it ensures the sites they reach are legit and the content originating from the journalists the site says it is.

If EARN IT becomes law, whistleblowers and other sources will see their secure options disappear. Tor, Signal, etc. will be considered nothing more than aiders and abettors of criminal activity. Anything secured by encryption will be treated as a virtual dead drop for criminal content.

Protecting children from exploitation is important. But the tradeoff legislators are demanding isn't actually a tradeoff. The American public will receive no net benefit from this tangential attack on encryption. Very often we're first informed about serious government misconduct by journalists. Destroying this outlet works out well for the government so often exposed as untrustworthy, but it does nothing for the governed.

'Seriously sometimes seems Google's moderators are only optimized to respond to social media outrage'

Three weeks after Google removed 49 Chrome extensions from its browser's software store for stealing crypto-wallet credentials, 11 more password-swiping add-ons have been spotted – and some are still available to download.…

And now to avoid container sprawl costing you plenty

Microsoft has slipped out licensing details for SQL Server running in containers and it will likely encourage developers to be pretty diligent in their use of Redmond’s database.…

A review by Medio DeCritici (165). A 2020 Review - Aliens Versus Predator (PC, 1999)

A review by Medio DeCritici (165). A 2020 Review - Aliens vs. Predator (PC, 2010)

Компания MediaTek анонсировала свой новый флагманский процессор, который должен составить конкуренцию чипам Qualcomm.

Компания Google выпустила новую версию приложения Google Lens с несколькими полезными изменениями.

Nitrozac had to undergo an emergency endodontic procedure, *ouch*, so she is off for a few days to let her recover. We'll be back with a new smile soon, in the meantime, here's one of our fave retros...

Hair cells, the mechanosensory receptors of the inner ear, are responsible for hearing and balance. Hair cell death and consequent hearing loss are common results of treatment with ototoxic drugs, including the widely used aminoglycoside antibiotics. Induction of heat shock proteins (HSPs) confers protection against aminoglycoside-induced hair cell death via paracrine signaling that requires extracellular heat shock 70-kDa protein (HSP70). We investigated the mechanisms underlying this non–cell-autonomous protective signaling in the inner ear. In response to heat stress, inner ear tissue releases exosomes that carry HSP70 in addition to canonical exosome markers and other proteins. Isolated exosomes from heat-shocked utricles were sufficient to improve survival of hair cells exposed to the aminoglycoside antibiotic neomycin, whereas inhibition or depletion of exosomes from the extracellular environment abolished the protective effect of heat shock. Hair cell–specific expression of the known HSP70 receptor TLR4 was required for the protective effect of exosomes, and exosomal HSP70 interacted with TLR4 on hair cells. Our results indicate that exosomes are a previously undescribed mechanism of intercellular communication in the inner ear that can mediate nonautonomous hair cell survival. Exosomes may hold potential as nanocarriers for delivery of therapeutics against hearing loss.

Curing HIV infection will require the elimination of a reservoir of infected CD4+ T cells that persists despite HIV-specific cytotoxic T cell (CTL) responses. Although viral latency is a critical factor in this persistence, recent evidence also suggests a role for intrinsic resistance of reservoir-harboring cells to CTL killing. This resistance may have contributed to negative outcomes of clinical trials, where pharmacologic latency reversal has thus far failed to drive reductions in HIV reservoirs. Through transcriptional profiling, we herein identified overexpression of the prosurvival factor B cell lymphoma 2 (BCL-2) as a distinguishing feature of CD4+ T cells that survived CTL killing. We show that the inducible HIV reservoir was disproportionately present in BCL-2hi subsets in ex vivo CD4+ T cells. Treatment with the BCL-2 antagonist ABT-199 was not sufficient to drive reductions in ex vivo viral reservoirs when tested either alone or with a latency-reversing agent (LRA). However, the triple combination of strong LRAs, HIV-specific T cells, and a BCL-2 antagonist uniquely enabled the depletion of ex vivo viral reservoirs. Our results provide rationale for novel therapeutic approaches targeting HIV cure and, more generally, suggest consideration of BCL-2 antagonism as a means of enhancing CTL immunotherapy in other settings, such as cancer.

BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR agonists could also improve obesity-related metabolic disease by increasing brown adipose tissue (BAT) thermogenesis, white adipose tissue (WAT) lipolysis, and insulin sensitivity.METHODS We treated 14 healthy women of diverse ethnicities (27.5 ± 1.1 years of age, BMI of 25.4 ± 1.2 kg/m2) with 100 mg mirabegron (Myrbetriq extended-release tablet, Astellas Pharma) for 4 weeks in an open-label study. The primary endpoint was the change in BAT metabolic activity as measured by [18F]-2-fluoro-d-2-deoxy-d-glucose (18F-FDG) PET/CT. Secondary endpoints included resting energy expenditure (REE), plasma metabolites, and glucose and insulin metabolism as assessed by a frequently sampled intravenous glucose tolerance test.RESULTS Chronic mirabegron therapy increased BAT metabolic activity. Whole-body REE was higher, without changes in body weight or composition. Additionally, there were elevations in plasma levels of the beneficial lipoprotein biomarkers HDL and ApoA1, as well as total bile acids. Adiponectin, a WAT-derived hormone that has antidiabetic and antiinflammatory capabilities, increased with acute treatment and was 35% higher upon completion of the study. Finally, an intravenous glucose tolerance test revealed higher insulin sensitivity, glucose effectiveness, and insulin secretion.CONCLUSION These findings indicate that human BAT metabolic activity can be increased after chronic pharmacological stimulation with mirabegron and support the investigation of β3-AR agonists as a treatment for metabolic disease.TRIAL REGISTRATION Clinicaltrials.gov NCT03049462.FUNDING This work was supported by grants from the Intramural Research Program of the NIDDK, NIH (DK075112, DK075116, DK071013, and DK071014).

While the pandemic has been chipping away at the furry convention scene, other furs have stepped forward to try and give those in the community events to look forward to over the now dormant weekends. This had started with a group of Furnal Equinox members creating a digital replacement for their late March convention called Keep Calm and Carry Con - Furnal Isolation. More have started to spring up this spring.

They can have internet dealers dens, streaming dance competitions, and other staples that conventions are known for. Accessible from the safety of your own home.

Below is a comprehensive list of conventions. Last updated May 2nd, 2020 12:18 ET.

Please feel free to place any not listed here in the comments below and we will look into adding it if it appears legitimate.

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Eyewitness News has learned that the Berlin High School football recruiting scandal may have cost Berlin taxpayers tens of thousands of dollars. Continue reading →

Гитарист QUEENSRŸCHE Michael Wilton опубликовал фотографию в одной из социальных сетей, на которой он играет на гитаре и снабдил ее подписью:

«Напряженно тружусь в домашней студии над новым альбомом!» #Queensrÿche #GrungeRock #Grunge_Rock #ProgressiveMetal #Progressive_Metal

IBM Research today opened its second research location on the African continent and announced several new project collaborations in the areas of data driven healthcare, digital urban ecosystems and astronomy.

ENGIE, a global leader in energy transition, today announced a new initiative with IBM. This nonexclusive, technological and commercial alliance is designed to improve the management of cities by looking at patterns, event correlation, anomaly detection and real-time data across all parts of cities.

The Weather Company, an IBM Business, and PRISA Noticias, one of the world’s leading Spanish-language media groups and owner of EL PAÍS newspaper, announced today a collaboration to combine the most accurate forecasts with one of the Spanish-speaking world’s largest media groups. The Weather Company will provide in-depth weather data and forecasts, as well as tailored content across PRISA properties. In turn, PRISA Noticias will provide locally relevant articles, photos and video content within the Spanish versions of The Weather Channel app and website (weather.com). The collaboration will also enable local marketers to access advanced data-driven advertising solutions from IBM Watson Advertising (formerly The Weather Company’s ad sales business) across both companies’ properties.

IBM today announced that Vissensa, a UK-based managed service provider (MSP), has taken delivery of the IBM Enterprise Cloud System, which will help the company offer new and improved cloud services to its customers.

[Image: An example of gravitational lens effects, via Wikipedia.] Over at WIRED, Daniel Oberhaus, author of the recent book Extraterrestrial Languages, takes a look at some proposals from NASA’s Innovative Advanced Concept (NIAC) program. “Among this year’s NIAC grants,” Oberhaus writes, “are proposals to turn a lunar crater into a giant radio dish, to develop … Continue reading "Gravitational Lensing, Interstellar Cinematography, and the Future of Magical Warfare in Space"

IBM today announced a new agreement with Walgreens, one of the country’s largest drugstore chains, to deploy IBM retail analytics at more than 8,100 locations nationwide to help improve the efficiency of field service support for these locations.

La enfermedad de Parkinson es un trastorno neurológico degenerativo crónico que afecta a una de cada 100 personas mayores de 60 años. Se estima que más de 5 millones de personas en el mundo tienen Parkinson y el número está aumentando con la población actual que envejece.

La inteligencia artificial (IA) promete transformar tanto el futuro del trabajo como la función de Recursos Humanos (RRHH). Alineado con esta premisa, IBM (NYSE: IBM) anunció hoy IBM Talent & Transformation, una nueva unidad destinada a ayudar a las organizaciones y a sus empleados a tener éxito en la era de la inteligencia artificial y la automatización.

Cette semaine, des chercheurs d’IBM Research et de l’Université de Yamagata au Japon ont annoncé leur collaboration pour utiliser l’IA d’IBM, couplée à des algorithmes de machine learning et des données géospatiales, afin d’en découvrir davantage à propos de ces mystérieux anciens géoglyphes. Grâce à IBM Power Systems, ce partenariat a déjà abouti à la découverte d’un nouveau géoglyphe à figure humaine avec trois éléments décoratifs sur la tête, le premier grâce à l’IA.

IBM (NYSE: IBM) today announced that Queensland Sugar Limited (QSL), a global leader in raw sugar marketing that manages over 90 percent of Australia’s raw sugar exports, has selected IBM advanced storage systems to support rapidly growing data demands.

Queensland Motorways has awarded IBM a technology and services contract to introduce automated free-flow tolling across south east Queensland’s toll roads.

IBM (NYSE: IBM) and the Australian Bureau of Statistics (ABS) today announced that more than 2.6 million households across Australia submitting Census forms via the web-based eCensus solution. This represents a significant jump from the 2006 Census, when 778,000 (9.1 per cent) of Australian households completed their forms online.

rickowensonline:

LAS PALMAS AVE, HOLLYWOOD, 2002

peterboyden:

americanapparel:

Source: idea.ltd

BOYDENS Magazine

20aliens:

Home of Architect Colin St. John Wilson, Cambridge, England 1972. 

The voice of Ahsoka Tano tells StarWars.com about writing the new Little Golden Book and rewatching Star Wars: The Clone Wars for inspiration.

Because I love a good story and groove on rich immersive themes, legacy games really appeal to me. The chance to be part of an unfolding narrative is wonderful. It provides a structure for friends to commit to an investment of their time together on a regular basis. It holds everyone's interest over time (when the story is well written and executed). Especially valuable for me is that it lessens the bitter taste of a loss; I get so interested in the plot that I don't care as much about winning. I'm trying to tamp down my competitiveness and narrative driven games help. Finally, I’m a huge fan of Inka and Markus Brand (we have a number of their games in our library already, including all of the Exit  games, Encore, and Raja of Ganges). For all of these reasons, I was really excited when Ravensburger sent me a copy of Inka and Markus’s newest legacy game, Rise of Queensdale, to review.

I actually received my review copy early in 2019, but our RoQ group consists of parents with busy schedules so we can only get together about once a month to play. We've made our way through 13 games so far, and with only 2 or 3 more to go before we finish the legacy series of games, I thought it was a good time to sit down and share my thoughts on the game (Especially in light of Christmas approaching).

Rise of Queensdale  is a legacy worker placement game set in Medieval times. Players take on the role of subjects to King Nepomuk II and Queen Margaret and are tasked with building a new city, Queensdale, on behalf of the royal family. Each player is given jurisdiction over one quarter of the city and is competing against the other players to build the best borough.

As the legacy series of games progresses, players continue to build different types of structures to earn favor with the royal family (fame points) in the midst of dealing with political drama, disease, and other Medieval happenings. Each game in the series sees players attempting to reach their next epoch goal (a target number of fame points). If they are successful, they will have a new, higher epoch goal during the subsequent game.  Note that multiple players can reach their epoch goals during the same game as gameplay continues through the end of the current round once one player reaches their goal. The winner of each game is the person who surpassed their epoch goal by the most points.

The artwork in the game is illustrated by Michael Menzel with graphic design provided by the Fiore GMBH studio in Germany. Michael is probably most familiar to the US based board game community as the illustrator for the Legends of Andor series of games. He brings the same fantasy style drawings he used in that game, with their romantic fonts and soft palettes of color to his work here and it’s lovely. There are a lot of components included in Rise of Queensdale   and Michael does a good job of tying them all to the theme as a cohesive set with the artwork.

Components include dozens of different types of wooden tokens (huts, meeples, player score markers, etc.); the city building board,  scoreboard (epoch tracker, fame counter, and more), action board, player boards, building tiles, and other pieces made out of cardboard; and wooden dice. Everything has held up wonderfully as the months and games have gone by. The rulebook is flipped through frequently and while it’s showing signs of wear, it’s still holding together, staples in place. The rulebook is straightforward and we haven’t had any issues understanding the nuances of the rules.

The narrative in Rise of Queensdale is well written.  It’s memorable and everything that happens makes sense in the framework of the fictional universe laid down by the designers. We’ve played a lot of narrative driven games (Pandemic Legacy, Betrayal Legacy, Middara, Aeon’s End Legacy, Legacy of Dragonholt, Charterstone,  and Seafall, just to name a few) and Rise of Queensdale ranks near the top for narrative driven games that do a good job of incorporating the game play into the storyline. Some legacy games feel more like a story was loosely slapped on top of the game mechanisms, but that isn’t the case here. At the same time, this isn’t an RPG with some board game elements thrown in. The mechanics of the board game have been adeptly planned and implemented; they’re challenging and provide a compelling experience. As the legacy series unfolds, more actions are added to the action board; no one gets complacent or bored because new options keep coming available. Our game group has agreed that there seems to be enough components and actions to allow for replayability as a standard board game even after we’ve reached the very end of our last game in the legacy series.

Rise of Queensdale is a great board game for bringing friends and family together. It’s competitive, so those who turn up their noses at cooperative games and like to win against others will find it enjoyable. Everyone is working toward their own epoch goal and multiple players can reach their goal during a game, so everyone can feel accomplished even when they don’t win. This also creates a brilliant built-in catch up mechanism as the player in last place has the nearest epoch goal to reach. The further a player gets ahead of others in the series of games, the farther their epoch goal becomes and the greater the chance that the players behind them will reach their goals before the leader does. In our games, no one has been able to run away with the scoreboard so far. That helps the game stay family friendly. The narrative turns the game into a shared adventure where everyone is an active participant. Better than going to a movie is feeling like you’re starring in one. And as I mentioned at the beginning of this review, because Rise of Queensdale  is a series of games,  right from the beginning, it fosters a commitment for players to spend time together on a regular basis. That’s the best gift to share with friends and family – our time – and anything like Rise of Queensdale that can make that happen is a wonderful Christmas present to place or find under the tree.

-------------------------------------------------
Publisher: Ravensburger
Players: 2-4 (We played with 4)
Actual Playing Time (vs the guideline on the box): About 1 hour per game
Game type: narrative driven, legacy, dice rolling, worker placement
Rating:

Jenni’s rating scale:
OUI: I would play this game again; this game is ok. I probably would not buy this game myself but I would play it with those who own it and if someone gave it to me I would keep it.
OUI OUI: I would play this game again; this game is good. I would buy this game.
OUI OUI OUI: I LOVE THIS GAME. I MUST HAVE THIS GAME.
NON: I would not play this game again. I would return this game or give it away if it was given to me.

Na jednorázový příspěvek 500 korun denně budou mít nově nárok i malé společnosti s ručením omezeným postižené šířením koronaviru. „Čekáme na schválení Senátem a prezidentem, žádosti budou moci podávat zřejmě do týdne,“ uvedla ve čtvrtek ministryně financí Alena Schillerová.

Mezinárodní ratingová agentura Fitch Ratings snížila hodnocení úvěrové spolehlivosti Slovenska o jeden stupeň na úroveň A se stabilním výhledem. Důvodem jsou hlavně dopady koronaviru na slovenskou ekonomiku. Jde o první změnu ratingu země v době pandemie.

Tensor Considered Harmful, by Alexander Rush

TL;DR: Despite its ubiquity in deep learning, Tensor is broken. It forces bad habits such as exposing private dimensions, broadcasting based on absolute position, and keeping type information in documentation. This post presents a proof-of-concept of an alternative approach, named tensors, with named dimensions. This change eliminates the need for indexing, dim arguments, einsum- style unpacking, and documentation-based coding. The prototype PyTorch library accompanying this blog post is available as namedtensor.

Thanks to Edward Z. Yang for pointing me to this "Considered Harmful" position paper.

When Queens Becomes Kings (Tiger King)

The hysteria around the Netflix show "Tiger King" has been very eyeopening. What is it about this low-rent animal abuser has Jared Leto, Cardi B, and the many other celebrities peacocking their obsessions with his unforgivable shenanigans?

I Mean…What?!?

1. 76 nieuwe overlijdens in de afgelopen 24 uur, evenveel ziekenhuisopnames  Het Belang van Limburg
2. OVERZICHT. Dalende curve zet zich voort. 76 overlijdens, 210 patiënten naar huis en 76 nieuwe opnames  Het Laatste Nieuws
3. Coronavirus: 76 overlijdens, 210 patiënten ontslagen uit het ziekenhuis  newsmonkey
4. Minder patiënten in onze ziekenhuizen  Het Nieuwsblad
5. OVERZICHT. 76 nieuwe ziekenhuisopnames en overlijdens, 585 nieuwe besmettingen | Binnenland | Nieuws  Het Laatste Nieuws
6. Hele verhaal bekijken via Google Nieuws

Noodnummer 1722 geactiveerd wegens slecht weer op zondag  Het NieuwsbladHele verhaal bekijken via Google Nieuws

LIVE. De Wever over eventuele tweede piek: “Normale quarantaine is er een van zieken, niet van gezonde mensen”  Het Laatste Nieuws

A new play by Nick Dear, based on the novel by Mary Shelley. Watch Danny Boyle’s monster hit Frankenstein with Benedict Cumberbatch as the creature and Jonny Lee Miller as Victor Frankenstein. Frankenstein with Benedict Cumberbatch as the creature is streaming for free from 7pm UK time on Thursday 30 April. Available on demand until […]

Readers of Language Log will certainly be aware of Tocharian, but when I began my international research project on the Tarim Basin mummies in 1991, very few people — only a tiny handful of esoteric researchers — had ever heard of the Tocharians and their language since they went extinct more than a millennium ago, […]