Back in the 1980s and 1990s, the twin forces of privatization and deregulation of public infrastructure services ascended to a global paradigm of progress and development. Government management of services such as telecommunications, transportation, water, and energy was deemed inefficient, underperforming, and monopolistic. Private industry – accountable to the profits and losses of an open market and, thus, believed more efficient than government – was proclaimed the better way for consumer choice and a more efficient use of taxpayers’ expenses.

Back in the 1980s and 1990s, the twin forces of privatization and deregulation of public infrastructure services ascended to a global paradigm of progress and development. Government management of services such as telecommunications, transportation, water, and energy was deemed inefficient, underperforming, and monopolistic. Private industry – accountable to the profits and losses of an open market and, thus, believed more efficient than government – was proclaimed the better way for consumer choice and a more efficient use of taxpayers’ expenses.

The offshore wind market in the is lagging behind other areas of the energy sector when it comes to embracing – and understanding – the potential of digital technologies.

Back in the 1980s and 1990s, the twin forces of privatization and deregulation of public infrastructure services ascended to a global paradigm of progress and development. Government management of services such as telecommunications, transportation, water, and energy was deemed inefficient, underperforming, and monopolistic. Private industry – accountable to the profits and losses of an open market and, thus, believed more efficient than government – was proclaimed the better way for consumer choice and a more efficient use of taxpayers’ expenses.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Venezuela will try two Americans captured during a failed bid by mercenaries to invade the country, President Nicolas Maduro said on Wednesday, as the United States vowed to “use every tool available”

In late 2008, the Financial Services Authority (FSA) reviewed how firms had implemented key aspects of the Markets in Financial Instruments Directive (MiFID). It has now published the results of that review. Generally the FSA has been encouraged by ...

 Amy Sadro, Principal Associate in Eversheds Sutherland’s Environment, Health and Safety Team and Dr Chris Nelson, a Principal Consultant and specialist in noise and vibration at Finch Consulting give their views on recent HAVS prosecutio...

As Bruce Dear writes, “COVID-19 poses a threat of unparalleled potency to our real estate markets and economy. So our industry and government must unite behind a grand, generous and visionary response to match the scale of this once in a cent...

MLS (Overseas) Limited v The Secretary of State for Defence [2017] EWHC 3389 (TCC) Summary In a recent judgment following a challenge to a competitive procurement process run by the Ministry of Defence (“MoD”) (MLS (Overseas) Limited v T...

South Africa has been praised by the World Health Organization for acting swiftly and delaying the spread of the virus. However, we must guard against being complacent as we begin the gradual easing of the lockdown.

Background The Government’s latest proposal in reforming the English schooling system was laid before Parliament last week in the form of the Education and Adoption Bill 2015-16 (“the Bill”). The Bill sets out provisions to conver...

The security of personal information, including customer payment card data and related details, is integral to the functioning of retailers with an online offering, and there are serious consequences in the event of security breaches. Penalties...

Suez Fortune Investments Ltd and another v Talbot Underwriting Ltd [2016] EWHC 1085 (Comm) Introduction On the 15 January 2015, the English Commercial Court handed down a decision that highlights the importance of compliance with disclosure obligati...

On Sunday, the Venezuelan army frustrated an...

The Venezuelan military defector...

Venezuela's Chief Prosecutor Tarek William Saab said his office has requested arrest warrants against U.S. military veteran Jordan Goudreau as well as Jose Rendon and Sergio Vergara, two Venezuelans accused of involvement in a failed armed incursion earlier this week aimed at overthrowing the government of President Nicolas Maduro.

The market for wearable tech is huge and growing, driven by new wellness applications and improved connectivity. Add to that the increasing number of new IoT devices and applications in the home, workplace and industry, and the opportunities both fo...

President Donald Trump laid into some of his close Senate allies for siding with Democrats on an Iran war powers bill even as Congress failed to override his veto.

As many as 44 million people in Africa could be infected with Covid-19 in the first year of the pandemic if containment measures fail – causing 83,000 to 190,000 deaths – according to modelling by the World Health Organisation, reflecting fears of a potential widening crisis on the continent.The study, released on Thursday by WHO Africa, looked at 47 countries with a combined population of 1 billion people and suggested smaller countries alongside Algeria, South Africa and Cameroon were at a…

Social and cultural myths around sex may also become prominent.

He claims bank accounts were opened unprocedurally with signatories not known

Investors and lawmakers in Hong Kong are urging regulators to seek compensation for people who lose money when listed companies collapse shortly after their initial public offerings.Under the current system, when banks sponsoring IPOs are found to have fallen short in their due diligence duties, the proceeds of any fine imposed by the watchdog goes to the government, not investors. Those fines amount to almost HK$1 billion (US$130 million) over the last 20 years, according to calculations by…

Russell Crowe reveals his Hollywood friend told him 'Gladiator' was going to fail at box office

WASHINGTON: The US Senate on Thursday failed to override President Donald Trump’s veto of a bipartisan measure that would have limited his power to attack Iran. Lawmakers voted 49-44 to support the resolution that passed Congress earlier this year, short of the two-thirds majority necessary...

ISLAMABAD: The State Bank of Pakistan’s Refinance Scheme for Small Businesses has so far failed to take off due to multiple reasons as the commercial banks are not designed and fully equipped to provide credit line to Small and Medium Enterprises .“The SBP’s Refinance Scheme for...

ISLAMABAD: The State Bank of Pakistan’s Refinance Scheme for Small Businesses has so far failed to take off due to multiple reasons as the commercial banks are not designed and fully equipped to provide credit line to Small and Medium Enterprises .“The SBP’s Refinance Scheme for...

ISLAMABAD: The State Bank of Pakistan’s Refinance Scheme for Small Businesses has so far failed to take off due to multiple reasons as the commercial banks are not designed and fully equipped to provide credit line to Small and Medium Enterprises .“The SBP’s RefinanceScheme for...

Islamabad : It has been rather unfortunate that despite a huge relief package of Rs50 billion for Utility Stores Corporation and a cut in POL products by almost 31 rupees in a month by the federal government, its impact has not trickled down to the grassroots level, as the general public is still...

Title: Implantable Defibrillator Wires Prone to Failure
Category: Health News
Created: 5/1/2007 2:00:00 AM
Last Editorial Review: 5/1/2007 12:00:00 AM

Title: New Drug Fails to Improve Odds for Heart Failure Patients
Category: Health News
Created: 5/2/2007 2:00:00 AM
Last Editorial Review: 5/2/2007 12:00:00 AM

Title: Fish Oil Doesn't Cut Failure Rate of Hemodialysis Grafts
Category: Health News
Created: 5/1/2012 6:05:00 PM
Last Editorial Review: 5/2/2012 12:00:00 AM

Title: Aspirin as Effective as Warfarin for Heart Failure: Study
Category: Health News
Created: 5/2/2012 6:05:00 PM
Last Editorial Review: 5/3/2012 12:00:00 AM

Title: Knowledge Is Power for Patients With Heart Failure
Category: Health News
Created: 4/29/2015 12:00:00 AM
Last Editorial Review: 4/30/2015 12:00:00 AM

Title: Heart Failure Implant Tied to Weakening of Thinking, Memory
Category: Health News
Created: 4/30/2015 12:00:00 AM
Last Editorial Review: 5/1/2015 12:00:00 AM

Title: Contraception Safety Program for Acne Drug Failing in Canada
Category: Health News
Created: 4/25/2016 12:00:00 AM
Last Editorial Review: 4/26/2016 12:00:00 AM

Title: Heart Failure, Job Loss May Be Deadly Combo
Category: Health News
Created: 5/2/2017 12:00:00 AM
Last Editorial Review: 5/3/2017 12:00:00 AM

Title: Have Heart Failure? Take Precautions During Pandemic
Category: Health News
Created: 4/28/2020 12:00:00 AM
Last Editorial Review: 4/28/2020 12:00:00 AM

Title: FDA OKs Farxiga for Heart Failure With Reduced Ejection Fraction
Category: Health News
Created: 5/6/2020 12:00:00 AM
Last Editorial Review: 5/7/2020 12:00:00 AM

The FDA today approved a new use for the diabetes drug, dapagliflozin (Farxiga), to reduce the risk of a hospital stay or death in people who have a type of heart failure.

Title: Male Fertility Supplements Fail to Deliver
Category: Health News
Created: 1/7/2020 12:00:00 AM
Last Editorial Review: 1/8/2020 12:00:00 AM

The major obstacle to a cure for HIV infection is the persistence of replication-competent viral reservoirs during antiretroviral therapy. HIV-specific chimeric antigen receptor (CAR) T cells have been developed to target latently infected CD4⁺ T cells that express virus either spontaneously or after intentional latency reversal. Whether HIV-specific CAR-T cells can recognize and eliminate the follicular dendritic cell (FDC) reservoir of HIV-bound immune complexes (ICs) is unknown. We created HIV-specific CAR-T cells using human peripheral blood mononuclear cells (PBMCs) and a CAR construct that enables the expression of CD4 (domains 1 and 2) and the carbohydrate recognition domain of mannose binding lectin (MBL) to target native HIV Env (CD4-MBL CAR). We assessed CAR-T cell cytotoxicity using a carboxyfluorescein succinimidyl ester (CFSE) release assay and evaluated CAR-T cell activation through interferon gamma (IFN-) production and CD107a membrane accumulation by flow cytometry. CD4-MBL CAR-T cells displayed potent lytic and functional responses to Env-expressing cell lines and HIV-infected CD4⁺ T cells but were ineffective at targeting FDC bearing HIV-ICs. CD4-MBL CAR-T cells were unresponsive to cell-free HIV or concentrated, immobilized HIV-ICs in cell-free experiments. Blocking intercellular adhesion molecule-1 (ICAM-1) inhibited the cytolytic response of CD4-MBL CAR-T cells to Env-expressing cell lines and HIV-infected CD4⁺ T cells, suggesting that factors such as adhesion molecules are necessary for the stabilization of the CAR-Env interaction to elicit a cytotoxic response. Thus, CD4-MBL CAR-T cells are unable to eliminate the FDC-associated HIV reservoir, and alternative strategies to eradicate this reservoir must be sought.

IMPORTANCE Efforts to cure HIV infection have focused primarily on the elimination of latently infected CD4⁺ T cells. Few studies have addressed the unique reservoir of infectious HIV that exists on follicular dendritic cells (FDCs), persists in vivo during antiretroviral therapy, and likely contributes to viral rebound upon cessation of antiretroviral therapy. We assessed the efficacy of a novel HIV-specific chimeric antigen receptor (CAR) T cell to target both HIV-infected CD4⁺ T cells and the FDC reservoir in vitro. Although CAR-T cells eliminated CD4⁺ T cells that express HIV, they did not respond to or eliminate FDC bound to HIV. These findings reveal a fundamental limitation to CAR-T cell therapy to eradicate HIV.

Upper Lutetian–Bartonian sedimentary mélanges, corresponding to ancient mud-rich submarine mass transport deposits, are widely distributed over an area c. 300 km long and tens of kilometres wide along the exhumed outer part of the External Ligurian accretionary wedge in the Northern Apennines. The occurrence of methane-derived carbonate concretions (septarians) in a specific tectonostratigraphic position below these sedimentary mélanges allows us to document the relationships among a significant period of regional-scale slope failure, climate change (the Early and Mid-Eocene Optimum stages), the dissociation of gas hydrates and accretionary tectonics during the Ligurian Tectonic Phase (early–mid-Lutetian). The distribution of septarians at the core of thrust-related anticlines suggests that the dissociation of gas hydrates was triggered by accretionary tectonics rather than climate change. The different ages of slope failure emplacement and the formation of the septarians support the view that the dissociation of gas hydrates was not the most important trigger for slope failure. The latter occurred during a tectonic quiescence stage associated with a regressive depositional trend, and probably minor residual tectonic pulses, which followed the Ligurian Tectonic Phase, favouring the dynamic re-equilibrium of the External Ligurian accretionary wedge. Our findings provide useful information for a better understanding of the factors controlling giant slope failure events in modern accretionary settings, where they may cause tsunamis.

Inadequate insulin secretion in response to glucose is an important factor for β-cell failure in type 2 diabetes (T2D). Although HMG-CoA reductase degradation 1 (HRD1), a subunit of the endoplasmic reticulum–associated degradation complex, plays a pivotal role in β-cell function, HRD1 elevation in a diabetic setting contributes to β-cell dysfunction. We report in this study the excessive HRD1 expression in islets from humans with T2D and T2D mice. Functional studies reveal that β-cell–specific HRD1 overexpression triggers impaired insulin secretion that will ultimately lead to severe hyperglycemia; by contrast, HRD1 knockdown improves glucose control and response in diabetic models. Proteomic analysis results reveal a large HRD1 interactome, which includes v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA), a master regulator of genes implicated in the maintenance of β-cell function. Furthermore, mechanistic assay results indicate that HRD1 is a novel E3 ubiquitin ligase that targets MafA for ubiquitination and degradation in diabetic β-cells, resulting in cytoplasmic accumulation of MafA and in the reduction of its biological function in the nucleus. Our results not only reveal the pathological importance of excessive HRD1 in β-cell dysfunction but also establish the therapeutic importance of targeting HRD1 in order to prevent MafA loss and suppress the development of T2D.

PURPOSE

Operational failures are system-level errors in the supply of information, equipment, and materials to health care personnel. We aimed to review and synthesize the research literature to determine how operational failures in primary care affect the work of primary care physicians.