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Integrating amino acids into Bcr-Abl inhibitors: design, synthesis, biological evaluation, and in silico studies

RSC Med. Chem., 2024, 15,3507-3528
DOI: 10.1039/D4MD00417E, Research Article
Yuying Liu, Zeyu Yang, Jie Zhang, Na Guo, Nanxin Liu, Qingqing Zhang, Xintao Dang, Yanchen Li, Jie Zhang, Xiaoyan Pan
In continuation of our previous research, a series of novel Bcr-AblT315I inhibitors with tert-leucine or serine as a flexible linker were developed and biological evaluation was performed in vitro.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design, synthesis, and structure–activity relationship studies of 6H-benzo[b]indeno[1,2-d]thiophen-6-one derivatives as DYRK1A/CLK1/CLK4/haspin inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00537F, Research Article
Open Access
Abdelfattah Faouzi, Alexandre Arnaud, François Hallé, Jean Roussel, Mandy Aymard, Vincent Denavit, Cong Viet Do, Angélique Mularoni, Mohamed Salah, Ahmed ElHady, Thanh-Nhat Pham, Alexandre Bancet, Marc Le Borgne, Raphaël Terreux, Roland Barret, Matthias Engel, Thierry Lomberget
A series of sulfur-containing tetracycles was designed and evaluated for their ability to inhibit protein kinase DYRK1A, a target known to have several potential therapeutic applications including cancers, Down syndrome or Alzheimer's disease.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis, in silico and bio-evaluation studies of new isothiocyanate derivatives with respect to COX inhibition and H2S release profiles

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00495G, Research Article
Yakup Berkay Yilmaz, Tuğba Güngör, Serhat Dönmez, Hazal Nazlıcan Atalay, Pınar Siyah, Serdar Durdağı, Mehmet Ay, Tugba Boyunegmez Tumer
New isothiocyanate derivatives (I1–3 and I1a–e) were synthesized and screened for their anti-inflammatory activities and H2S-releasing capacities. Compounds I1 and I1c demonstrated the most potent and selective COX-2 inhibition.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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‘Threat culture’ in Centre for West Asian Studies of JNU: former seminar coordinator

Sima Baidya also says she has lodged a complaint against the chairperson of the centre and has sought security from the university authorities as she has been intimidated




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Policy prescription for economic and political maladies

Bimal Jalan delves deep into issues that are critical to the country with suggestions on how to overcome challenges 




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Fertilizer subsidies to come down, Mandaviya says

The Minister said the Centre increased subsidy to protect farmers interest, and added that it is likely to come down




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Research paper warns against nationwide switch to natural farming without proper studies

It can hamper national food production, say authors, who cite contrasting results from two studies




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Polls to rural local bodies, due late December, may be delayed

This is because the process of re-organisation of local bodies in general and village panchayats in particular is not yet complete. An official, who handled the previous round of local bodies’ polls, says this may take three to four months




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Toddler dies after falling into water tank near Tirupattur




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Hindu Tamil Thisai journalist Kalyanasundaram dies at 50




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T.N. CM Stalin inaugurates new buildings for rural local bodies




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PN Rao plans to foray into power suits for the ladies

PN Rao, the century-old brand, known for its fine bespoke and ready-to-wear suits, is all set to launch its new women’s range




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Vizianagaram MLC election: A.P. High Court sets aside disqualification of Raghu Raju; election to local bodies hangs in balance

As per the earlier schedule, the election will take place on November 28 and counting is scheduled for December 1.




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Courses in Environmental and Sustainability Studies in the U.S.

With many students looking for courses on sustainability and environmental issues, here is a round up of some popular courses in American universities




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Visible-light heterogeneous photocatalysis with an ionic porous organic polymer (IPOP): synthesis of β-keto sulfoxides and benzothiophene diesters by tandem radical addition–oxidation reactions

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01382D, Research Article
Ajay Kumar Sahoo, Parag Tamuly, Jarugu Narasimha Moorthy
An IPOP, constructed constructed from cyanuric chloride and the readily accessible 2,5-di(pyridin-4-yl)thiazolo[5,4-d]thiazole (BpyTzTz), is shown to exhibit excellent visible light absorption and serve as a metal-free heterogeneous photocatalyst.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Livingstone rises to the occasion as England levels ODI series against West Indies

England finished its successful run chase on 329-5 in the second one-day international with 15 balls remaining




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Indian students can even work in UK after studies: UK minister




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Design, synthesis, biological evaluation, and in silico studies of novel N-substituted-2-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazole-6-carboxamides as promising anticancer agents

RSC Adv., 2024, 14,35323-35335
DOI: 10.1039/D4RA04492D, Paper
Open Access
Navid Dastyafteh, Manica Negahdaripour, Mohammad Hosein Sayahi, Mina Emami, Younes Ghasemi, Elham Safaei, Homa Azizian, Zahra Pakrouh Jahromi, Mehdi Asadi, Mohammad Reza Mohajeri-Tehrani, Fateme Zare, Minoo Shahidi, Zahra Pooraskari, Sayed Mahmoud Sajjadi-Jazi, Bagher Larijani, Mohammad Mahdavi, Sara Ranjbar
Synthesis and cytotoxicity evaluation of novel benzimidazoles were explained. The most potent derivative was subjected to cell cycle, apoptosis, and in silico investigations. Compound 5o proved to be a promising anticancer agent.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Surface science studies of the coverage dependent adsorption of methyl acetate and methyl propanoate on graphite

RSC Adv., 2024, 14,35373-35385
DOI: 10.1039/D4RA04466E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Jack E. Fulker, Wendy A. Brown
The adsorption of methyl acetate and methyl propanoate has been studied on a graphite surface at 28 K. TPD data show that the desorption energy of both molecules is highly coverage dependent with repulsive interactions being seen at low coverages.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Harnessing the UiO-67 metal–organic framework for advanced detection of cadmium ions in water bodies

RSC Adv., 2024, 14,35618-35627
DOI: 10.1039/D4RA06811D, Paper
Open Access
Bhuvaneswari Selvaraj, Lakshmi Priya G., Selva Balasubramanian
Heavy metal ions are hazardous pollutants that pose serious threats to ecosystems and human health, making it imperative to detect and monitor their presence in water for environmental protection.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Advancements in green diesel production for energy sustainability: a comprehensive bibliometric analysis

RSC Adv., 2024, 14,36040-36062
DOI: 10.1039/D4RA06262K, Paper
Open Access
Jeesica Hermayanti Pratama, Zeni Rahmawati, Alvin Rahmad Widyanto, Triyanda Gunawan, Wan Nazwanie Wan Abdullah, Nor Laili Azua Jamari, Afan Hamzah, Hamzah Fansuri
This bibliometric analysis explores recent advancements in green diesel production, emphasizing its potential for enhancing energy sustainability and contributing to the 2050 net-zero emissions goal.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Olympic silver medallist gymnast Poujade dies at 51




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Ugandan Olympic runner Cheptegei dies after being set on fire by boyfriend

The 2024 Paris Olympian was doused in petrol and set on fire by her boyfriend, making her the third female athlete to be killed in the country since 2021




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PIX: West Indies breeze past minnows Scotland

Riding on their excellent show with the ball, West Indies got the better of Scotland by six wickets in their Women's T20 World Cup match in Dubai on Sunday.




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Leopard, rescued in MP’s Bandhavgarh after attack on four persons, dies

The elephant deaths had put the Reserve into national limelight with multiple agencies of the State and Central governments launching separate probes into them




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Gold steadies after slide below key $2,300 level

Spot gold was up 0.2% at $2,396.69 per ounce, as of 0146 GMT. U.S. gold futures fell 0.5% to $2,313.60



  • Gold & Silver

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Gold steadies after Iran strikes spark surge of haven buying

Gold has rallied nearly 30 per cent this year, hitting a series of record highs.



  • Gold & Silver

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Three organic–inorganic polyoxoniobate-based compounds modified with Cu(II) amine complexes: synthesis, characterization, and catalytic studies for oxidation of styrene

Dalton Trans., 2024, 53,17880-17892
DOI: 10.1039/D4DT02544J, Paper
Zhi-Cheng Duan, Guanghua Li, Ke-Chang Li, Xiao-Bing Cui
Three novel organic–inorganic polyoxoniobate-based compounds modified with Cu(II) amine complexes were synthesized under hydrothermal conditions. Additionally, the catalytic efficacy of these compounds in the oxidation of styrene was investigated.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Mechanistic studies of NOx reduction reactions involving copper complexes: encouragement of DFT calculations

Dalton Trans., 2024, Advance Article
DOI: 10.1039/D4DT02420F, Frontier
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Yohei Kametani, Yoshihito Shiota
Mechanistic analysis of nitrite (NO2) and nitric oxide (NO) reduction reactions promoted by copper complexes provides a reliable view of electron transfer and atom movement.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Cationic first-row transition metal saccharinate complexes with tris(2-pyridylmethyl)amine: synthesis, structures and anticancer studies

Dalton Trans., 2024, Advance Article
DOI: 10.1039/D4DT02258K, Paper
Ceyda Icsel, Seyma Aydinlik, Muhittin Aygun, Veysel T. Yilmaz
Highly cytotoxic dinuclear oxo-bridged Fe(III) saccharinate complex with tris(2-pyridylmethyl)amine induces excessive ROS generation, mitochondrial and DNA damage in HT29 colon cancer cells.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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BJP made money from heaps of dead bodies during COVID-19, claims Dinesh Gundu Rao




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Applicability of β-lactamase entrapped agarose discs for removal of doripenem antibiotic: reusability and scale-up studies

Environ. Sci.: Water Res. Technol., 2024, Advance Article
DOI: 10.1039/D4EW00572D, Paper
Huma Fatima, Amrik Bhattacharya, Sunil Kumar Khare
Schematic diagram illustrating antibiotic removal via β-lactamase-entrapped agarose discs in a fixed-bed column bioreactor, highlighting the potential for scale-up.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Centre for Development Studies: Looking to the future, evolving strategies to meet present-day challenges

CDS is evolving strategies for research and financial self-sufficiency while maintaining original mandate, exploring new programmes and training opportunities.




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Economics Nobel Winners 2024 and their studies on ‘how institutions are formed and affect prosperity’

Daron Acemoglu and Simon Johnson are professors at the Massachusetts Institute of Technology while James Robinson is based at the Harris School of Public Policy and Department of Political Science at the University of Chicago.




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IIMA proves it is gold standard for management studies, bags top spot in NIRF list for 5th consecutive time

Institute has been topping NIRF’s list of best management colleges since 2020




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‘Ozempic seemed to change more than the patients’ bodies,’ says Johann Hari, author of Magic Pill

Writer-journalist Johann Hari brings himself into the Ozempic conversation, taking readers through the risks of obesity, its causes and effects, and what the drug does




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Selective hydrogenation of 5-hydroxymethylfurfural to 2,5-bis(hydroxymethyl)furan over Ni–Ga intermetallic catalysts and its kinetic studies

React. Chem. Eng., 2024, Advance Article
DOI: 10.1039/D4RE00129J, Paper
Weixiao Sun, Fuzeyu Zhong, Xiaohu Ge, Wenyao Chen, Gang Qian, Yueqiang Cao, Xuezhi Duan, Xinggui Zhou, Jing Zhang
5-Hydroxymethylfurfural (HMF) has been listed as the “TOP 14” most important biomass-derived platform molecules, which can be converted into 2,5-bis(hydroxymethyl)furan (BHF) via selective hydrogenation of the carbonyl group on HMF.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Laapataa Ladies Review

Laapataa Ladies is gentle yet firm in calling out the hypocrisies colouring everyday mindsets and prejudices without acquiring the high-handedness of a crusader, observes Sukanya Verma.




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Journal of Qur'anic studies [electronic resource] = Majallat al-dirāsāt al-Qurʹānīyah / Centre of Islamic Studies, School of Oriental and African Studies, University of London

London : Centre of Islamic Studies, 1999-




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Journal of ritual studies [electronic resource]

Pittsburgh, Pa. : Dept. of Religious Studies, University of Pittsburgh, ©1987-




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Fundamental studies of ruthenium species supported on boron nitride nanotubes: metal loading and pretreatment effects on CO oxidation

Catal. Sci. Technol., 2024, 14,6198-6206
DOI: 10.1039/D4CY00945B, Paper
Jinwon Choi, Amol Pophali, Byeongseok Kim, Kwangsuk Yoon, Thomas You-Seok Kim, Hocheol Song, Sang Eun Shim, Jaewoo Kim, Taejin Kim
RuOx/BNNT catalysts were prepared with varying metal loadings and under oxidation and reduction conditions. RuOx/BNNT showed superior catalytic activity than Ru/BNNT. The catalyst will be favorable to the ER mechanism over the LH mechanism.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Combining computational and experimental studies to gain mechanistic insights for n-butane isomerisation with a model microporous catalyst

Catal. Sci. Technol., 2024, Advance Article
DOI: 10.1039/D4CY01035C, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Matthew E. Potter, Lucas Spiske, Philipp N. Plessow, Evangeline B. McShane, Marina Carravetta, Alice E. Oakley, Takudzwa Bere, James H. Carter, Bart D. Vandegehuchte, Kamila M. Kaźmierczak, Felix Studt, Robert Raja
Using a model microporous catalyst, the influence of acid site density and partial pressure is explored in alkane isomerisation. Combining with DFT calculations shows the role of olefins in this industrially important catalytic process.
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Wake up babe, new iCandies just dropped!

Latest launches include the new iMac, Mac mini, plus Apple Intelligence finally on devices




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The blue collar ‘fades away’ fast, say studies

These personnel have to be won over in the first three months; and organisations are increasingly alive to the need to chalk out strategies to retain them




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Busting the myth that Liberal Studies programmes do not lead to careers

Students acquire critical thinking, communication, flexibility, and lifelong learning skills that prepare them for the workforce




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Former Minister, five-time MLA Reddy Satyanarayana dies at 99

He had won from Madugula Assembly constituency in 1983 and served as Animal Husbandry Minister in NTR’s Cabinet




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10 Tamil Comedies You Must Watch On OTT

Comedies are a difficult genre to pull off in today's day and age, thanks to the audiences' increasing exposure to diverse content and dwindling attention spans. Still, there are quite a few Tamil movies that can bring on the laughs. Arjun Menon lists the recent releases you can watch at home.




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Rohit Bal, czar of high fashion, dies at 63

The celebrated designer, Gudda to his friends, stitched together flamboyance, elegance and talent in his work and in his persona too.




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Test cricket | West Indies give us a peep into the past, England into the future

If fortune favours the brave, it also tends to desert the timid, which is what India were in the Hyderabad Test




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Finance Commission Conclave to map effective devolution of fiscal powers to local bodies

Organised by Panchayati Raj Ministry, the Conclave attempts to bring together key stakeholders like the Central & State Finance Commission for the development of ‘grameen bharat’