For decades, car owners looking for the latest technology features have had to wait for the arrival of a new model year. Now, their daily ride can always be state of the art. The Xpeng P7 is an all-electric sports sedan developed from the ground up for an intelligent driving future. Introduced this week in Read article >

The post Beyond Horsepower: Xpeng P7 Shows What’s Next for Intelligent Transportation appeared first on The Official NVIDIA Blog.

Eversheds Sutherland were delighted to partner with Women in ETFs for a one hour webinar 'Navigating Lockdown and Beyond - Practical steps to support ourselves and others through a unique time' on 30 April. The presentation was delivered by Á...

Lady Gaga, Stevie Wonder, Lizzo, Shawn Mendes and others sang classic songs brimmed with messages of hope and change during a TV special aimed at fighting the coronavirus, while Beyoncé and Alicia Keys spoke passionately about how the virus has disproportionately affected black Americans.

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Title: Dental Anxiety Has Consequences Beyond Tooth Decay
Category: Health News
Created: 5/3/2017 12:00:00 AM
Last Editorial Review: 5/4/2017 12:00:00 AM

Ubiquitin (UB) transfer cascades consisting of E1, E2, and E3 enzymes constitute a complex network that regulates a myriad of biologic processes by modifying protein substrates. Deubiquitinating enzymes (DUBs) reverse UB modifications or trim UB chains of diverse linkages. Additionally, many cellular proteins carry UB-binding domains (UBDs) that translate the signals encoded in UB chains to target proteins for degradation by proteasomes or in autophagosomes, as well as affect nonproteolytic outcomes such as kinase activation, DNA repair, and transcriptional regulation. Dysregulation of the UB transfer pathways and malfunctions of DUBs and UBDs play causative roles in the development of many diseases. A greater understanding of the mechanism of UB chain assembly and the signals encoded in UB chains should aid in our understanding of disease pathogenesis and guide the development of novel therapeutics. The recent flourish of protein-engineering approaches such as unnatural amino acid incorporation, protein semisynthesis by expressed protein ligation, and high throughput selection by phage and yeast cell surface display has generated designer proteins as powerful tools to interrogate cell signaling mediated by protein ubiquitination. In this study, we highlight recent achievements of protein engineering on mapping, probing, and manipulating UB transfer in the cell.

Mineral exploration under relatively young, exotic cover still presents a major challenge to discovery. Advances and future developments can be categorized in four key areas, (1) understanding metal mobility and mechanisms, (2) rapid geochemical analyses, (3) data access, integration and interoperability and (4) innovation in laboratory-based methods.

Application of ‘regolith-style' surface mapping in covered terrains outside of conventional lateritic terrains is achieving success in terms of reducing background noise and improving geochemical contrasts. However, process models for anomaly generation are still uncertain and require further research. The interaction between the surface environment, microbes, hydrocarbons and chemistry is receiving greater attention. While significant progress has been achieved in understanding the role of vegetation, interaction with the water table and cycling of metals in the near surface environment in Australia, other regions of the world, for example, the till-covered terrains in the northern hemisphere and arid colluvium-covered areas of South America, have seen less progress. In addition to vegetation, the influence of bacteria, fungi and invertebrates is not as well studied with respect to metal mobilization in cover. Field portable XRF has become a standard field technique, though more often used in a camp setting. Apart from a tweaking of analytical quality, instruments have probably reached their peak of analytical development with add-ons, such as cameras, beam-limiters, wireless transmission and GPS as the main differences between instrument suppliers. Their future rests in automated application in unconventional configurations, for example, core scanning and better integration of analytical data with other information such as spectral analyses. Pattern drilling that persists in industry, however, has benefited from innovative application of field-portable tools along with rock and mineral chemistry to provide near real-time results and assist in a shift toward more flexible and targeted drilling in greenfields settings.

Innovation in the laboratory continues to progress. More selective geochemical analysis, imaging of fine particle size fractions and resistate mineral phases and isotope analysis are faster and more accessible than ever before. The application of genomics (and data analysis) as mineral exploration tools is on the horizon. A continuing problem in geoscience, the supply to industry of suitably trained geochemists, persists although some needs, particularly at junior level, will be met by recent initiatives at various universities at graduate level. Unfortunately, the current economic climate has had a significant impact on R&D and retention of geochemistry skills by the industry. Whilst the future is positive, significant investment is required to develop the next generation of geochemical exploration tools and concepts.

Thematic collection: This article is part of the Exploration 17 collection available at: https://www.lyellcollection.org/cc/exploration-17

In a gaming era rife with flashy, bombastic AAA software, there’s definitely still a place for classic button-mashing brawlers. Ditching the cinematic bells and whistles, these are games that get straight to the point, pummelling you with pure gameplay and near-constant action. Developer Emilie Coyo and Blowfish Studios superbly tap into that late-80s gaming feel with their thrilling action romp, Infinite: Beyond the Mind. 

Along with the recent renaissance of Streets of Rage, games like this remind one just how appealing this forgotten genre once was. Comparisons to the old TMNT games, Final Fight, and Double Dragon tend to be dredged up soon after being dropped into the action. At the same time, the game adds a bit of depth with some platforming level design to keep you on your toes. A few imperfections and simplicities hold it back from reaching the lofty heights of those gems, to be sure. Regardless, Infinite mostly succeeds in emulating retro beat ‘em ups at their peak.

As you might expect with a 3 hour, pixelated button-mashing sprint, the story is marginal and cliche at best. You play as one of two women who have discovered the ability to use special powers. This has made them the target of a tyrannical Kingdom and its sorcerer queen, Evangelyn. The queen sends forth her brigades of pesky, heat-packing troops, bots, and artillery, which you must dash and slash your way through. 

These enemies range in terms of behaviors, as well as offensive and defensive prowess. Most, however, take the form of fairly stock military men wielding various weapons running the gamut from pistols to machine guns to grenades. There’s also a boss fight waiting for you after each multi-level biome, which proves exciting without being ridiculously tough.

Playing as either Tanya or Olga, you’ll be given mostly the same palette of moves - and it's a limited one, to be sure. Your basic jump can be extended into a double jump, which you’ll sometimes need in order to hop across some tough-to-reach platforms. Additionally, you can perform a dash move, which drains a meter displayed beneath your health bar. Dashing is fun, satisfying, and also quite useful. You can use it to dodge mid-air projectiles, evade tough spots, leap across vast gaps, and flash through deadly lasers. You’re also able to roll, which is akin to a ground-level version of this dash. 

Your offensive abilities are a bit more limited, as they basically amount to frequent close-range slashing. However, with a full meter, you’ll eventually unlock more powerful, bullet-deflecting slashes while airborne. You can bust out an explosive, screen-wiping special move a couple of times per stage, too. Given the rarity of upgrades, the speed of your character, and lack of offensive moves, Infinite: Beyond the Mind tends to stress speed and survival over sheer firepower. Wailing on tons of foes in a short time will occasionally net you extra lives, and you’re rewarded with higher scores when knocking out a stage quickly.

The majority of baddies can be slain with your close-range slash move in just a couple of hits. Still, you’ll usually want to measure their behaviors, rather than marching in while mindlessly button mashing. These anticipatory moves will help you dodge their projectiles and live to fight another day. Though you’ll stumble upon health and extra life pickups at times, these are scarce - as are the checkpoints, which only kick in at the conclusion of each “area.” 

The game further adheres to this unforgivable NES style by allowing you to save only at the end of each multi-area stage, granting you only a few lives and a short health bar in the process. This grind-it-out showdown is even tougher with the “expert” difficulty setting, as your health bar is even shorter and the ability to save is stripped away. Basically, you’ll want to be sharp, especially on the highest difficulty.

As you power through the 16 stages (each of which contains 2 or 3 bite-sized areas plus a boss), more competent and dangerous foes start showing up. You’ll come upon certain enemies covering in trenches, popping out of trucks, or posted up on high platforms. You’ll even run into tough vehicles and machinery like helicopters and robots. It certainly adds to the difficulty, while keeping feelings of repetition at bay.

One neat little inclusion is the ability to occasionally match this firepower by way of saddling up in a stationary tank. While inside, you can mow down waves of incoming troops all around you for a short time. Similarly, you’ll also be forced into static survival portions sans the tank, which can amp up the intensity quite a bit. There are even a couple of flying and scrolling areas to mix things up.

In general, the game walks that tightrope nicely in terms of difficulty - at least on its default setting. It can seem a bit chaotic at first with the breadth of projectiles from multiple areas, especially since you can only answer with close-range hits. Still, Infinite becomes far simpler once you’ve taken your lumps a couple of times and get a feel for the baddies and the stage layout. It’s easier when you’re prepared to handle that incoming tank or chopper, or can anticipate that electric wall or falling platform. Rarely did I feel like my deaths were anything but my own fault. With that said, the Double Dragon-esque push backs that sometimes knocked me into pits didn’t exactly feel just.

The control method makes a difference in tightening things up and offering a smoother experience. I wouldn’t typically stress opting for a D-pad-laced Joy-con, but in this case the improvement is vast. Seriously, if you’re inclined to make the most out of the game, consider shelling out for the HORI D-Pad left Joy-con. Infinite is still suitable when mashing the standard directional buttons, for the record, but there’s a level of swiftness and precision with the D-pad controller that meshes perfectly with the fast-paced, NES-style experience. Tanya/Olga seem to genuinely move around quicker and more sharply.

Another addition that’s both helpful and enjoyable is simultaneous co-op. In true Final Fight fashion, two players can kick some butt at once, doubling both the fun and efficiency in combat. Playing with separate Joy-cons isn’t always the most comfortable or intuitive, but the added offense makes up for some of that.

Any real blemishes of this game mostly boil down to nitpicks, and major flaws are few and far between. There’s the aforementioned prominence of push-backs while getting hit, but only rarely do these coax catastrophic death plummets. Also, while the environmental detail and layering is nice, it can sometimes be tough to make out just where you can jump and where you can’t. Jumping onto ladders to climb can also be a somewhat spotty, finicky endeavor, though these aren’t abundant at least.

Infinite: Beyond the Mind won’t blow any minds with its (literal) straightforward gameplay and brevity. Nonetheless, it makes for a fun, delightful throwback to the side-scrolling brawlers of decades past. This tight, undiluted action gameplay is complemented by a charming pixel-art-meets-anime style and appealing synthetic tunes. The 16-bit sprites add some retro character, though they’re really put to good use with the multi-layered backgrounds and colorful, vibrant biomes. These range from military bases to industrial furnaces to ice tundras. 

Overall, Infinite is a captivating action sidescroller that early 90s brawler fans, in particular, should get a kick out of. It’s a short and fairly basic experience, but worth checking out at just 10USD. Play with a friend or use a D-pad attachment to really get the most out of this already enjoyable romp.

Full Article - https://www.vgchartz.com/article/443401/infinite-beyond-the-mind-ns/

China just tested its biggest rocket yet, along with a new capsule designed to carry humans to its planned space station, the moon and beyond

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The post The Beyonce Effect: OnlyFans Sees Massive Traffic Surge After Diva Drops Name appeared first on Man's World India.

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Anne Elkins from The Felix Project shares her story You can donate here virginmoneygiving.com/fund/FoodforLondonNOW

Boris Johnson has paid his respects to fallen soldiers ahead of the 75th anniversary of Victory in Europe (VE) Day on a visit to Westminster Abbey.

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Ugly makeup is imperfect, sloppy, chaotic – and only worn to please the wearer, against social expectations

In 2018, Rosanna Meikle felt like a failure. She was toiling through beauty school, and she hadn’t been able to find much work nor garner much attention for her creations online. She was exhausted from the sameness she saw around her, “a sea of beautiful girls, smoky eyes and plumped lips”, she remembers. “My school was in an expensive area of Auckland, which made me feel so out of place. I couldn’t afford the products or the clothes, my kit wasn’t ‘professional’ enough and neither was my look.”

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Like most football fans, Jurgen Klopp has found himself with a lot of time on his hands since Premier League action was suspended.

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It's a common phenomenon we know from cracked sneakers and burst tyres: worn-out materials can cause anything from mild annoyance to fatal accidents. But while fatigue is well understood in synthetic materials, we know much less about such processes in mammalian tissue. An international team led by HITS researchers has shown that mechanical stress can similarly deteriorate collagen tissue. The findings might help to advance material research and biomedicine.

The Prime Minister was welcomed to the abbey by the Dean of Westminster, and lit a candle on the eve on the 75th anniversary of the Allied v

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