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The UN High Commission for Refugees estimates that nearly 50,000 migrants are in Greece, awaiting asylum interviews in which they will make their cases for staying in Europe. While many migrants remain without jobs, some have found work in camps, or have even started their own businesses.

LILLE, FRANCE — More than 360 migrants were rescued Sunday while attempting the perilous crossing between the north coast of France and the south coast of England, in small boats, French officials said.    Regional maritime boats and a French Navy patrol ship made multiple trips to rescue groups of people in difficulty in the Channel, the French coastal authority Premar said.   In all, they rescued 367 people, taking them to the French ports of Calais, Boulogne and Dunkirk.  Increasing numbers of migrants seeking to reach England are trying to cross the Channel in makeshift boats now that officials have increased security at Calais and the cross-Channel tunnel.  The waterway is one of the busiest sea routes in the world, with more than 400 vessels crossing it every day and the weather conditions are often difficult.  Since the beginning of the year, a record 33,500 people have crossed the Channel in small boats.  According to figures from Britain's interior ministry, 94% of the migrants who reached the U.K. in the past four years went on to apply for asylum. Of those who had received a response, most had been successful.  As the law currently stands, a migrant must be physically in the U.K. to start the asylum process. 

The majority of U.S. airlines don't pay their flight attendants until the airplane door closes, even though plane boarding is one of the most stressful parts of their job.

[VOA] At least 11 Somali regional and federal government forces were killed in fierce fighting on Wednesday in the south of the country, officials said.

[Radio Dalsan] Two soldiers from Somalia's Southwest State were ambushed and killed by al-Shabab militants on Tuesday while travelling by motorcycle between Wanlaweyn and Afgoye districts in the Lower Shabelle region, residents reported.

[Shabelle] Mogadishu -- Somalia's National Intelligence and Security Agency (NISA) conducted a targeted operation in the Dharaarweyn area near Galcad city, within the Galgaduud region.

Judges block Albania model again and order return of 7 migrants to Italy

Over the past few months, the escalation of gang violence and mass displacement in Haiti have been of great concern for humanitarian organizations. Severe levels of armed violence have resulted in significant instability, with food insecurity, sexual violence, civilian casualities, and restricted freedom of movement plaguing the nation. Displacement cases have risen sharply, to the […]

Endangered succulents in the Richtersveld have been given a lifeline from poaching, mining, overgrazing, and climate change

Denzel Washington made his debut in 1981 film 'Carbon Copy'Danzel Washington has spilled beans about his retirement, but before that there are a few films lined up ahead that he wishes to first. The Equalizer actor even confirmed the making of Black Panther 3, however, Marvel has not yet said...

South Asia study of foreign direct investments impact in India, Pakistan, Bangladesh, Sri Lanka and Nepal on economic growth, domestic investment, and export; special emphasis on the role of infrastructure.

India’s federal power minister on Tuesday asked the states that are away from coal resources to consider setting up nuclear-based power plants, besides identifying and listing the power utilities to meet investments to support growing power demand.

The Indian government in its federal budget this year had proposed to partner with private players to develop small nuclear reactors to increase the amount of electricity from sources that do not produce carbon dioxide emissions.

States should consider setting up nuclear power plants at the sites where coal-based thermal power plants have completed their life, Manohar Lal, the country’s power minister, told states as per a government statement.

India’s stringent nuclear compensation laws have hampered talks with foreign power plant builders such as General Electric GE.N and Westinghouse.

The country, which currently has about 8 gigawatts of nuclear capacity, aims to increase it to 20 GW by 2032.

The minister also asked the states to identify and list their power utilities in the country’s stock exchange to meet increasing investment demand in the power sector as well as improve the transmission system to add more renewable capacity.

India has pledged to achieve a net zero carbon emission target by 2070 and has a target of 500 GW of renewable energy by 2030.

When worker ants are exposed to a pathogenic fungus, they build nests that are more compartmentalised to reduce the risk of an epidemic

A traditional yogurt-making practice from south-eastern Europe uses live ants as a starter, with the insects providing the bacteria and acid needed to initiate fermentation

Asian elephants at Berlin Zoo show impressive skill when using a hose as a tool, and even appear to sabotage each other by stopping the flow of water

Alex Lupsasca plans to extend Earth's largest telescope network beyond the atmosphere with a space-based dish. It could spot part of a black hole we've never seen before – and perhaps discover new physics

Devices that let people with paralysis walk and talk are rapidly improving. Some see a future in which we alter memories and download skills – but major challenges remain

Our ancestors probably used a wide range of plant-based tools that have since been lost to history. Now we're finally getting a glimpse of this Botanic Age

Asian elephants at Berlin Zoo show impressive skill when using a hose as a tool, and even appear to sabotage each other by stopping the flow of water

Our ancestors probably used a wide range of plant-based tools that have since been lost to history. Now we're finally getting a glimpse of this Botanic Age

Our ancestors probably used a wide range of plant-based tools that have since been lost to history. Now we're finally getting a glimpse of this Botanic Age

Title: Scientists Shock Spuds in Bid to Boost Antioxidants
Category: Health News
Created: 8/23/2010 2:10:00 PM
Last Editorial Review: 8/24/2010 12:00:00 AM

Title: Bottled Teas May Not Deliver on Antioxidants
Category: Health News
Created: 8/23/2010 12:10:00 PM
Last Editorial Review: 8/24/2010 12:00:00 AM

Title: Black Rice Is Cheap Way to Get Antioxidants
Category: Health News
Created: 8/27/2010 10:06:00 AM
Last Editorial Review: 8/27/2010 10:06:13 AM

Title: Stomach Bug Vaccine for Infants Protects Entire Community: CDC
Category: Health News
Created: 8/27/2013 4:36:00 PM
Last Editorial Review: 8/28/2013 12:00:00 AM

Title: Do Antidepressants in Pregnancy Raise Risks for Mental Woes in Kids?
Category: Health News
Created: 8/27/2014 12:35:00 PM
Last Editorial Review: 8/28/2014 12:00:00 AM

Title: Medical Groups Endorse Early Exposure to Peanut Products for High-Risk Infants
Category: Health News
Created: 8/26/2015 12:00:00 AM
Last Editorial Review: 8/27/2015 12:00:00 AM

Title: Cheap Face Masks Little Help Against Air Pollutants
Category: Health News
Created: 8/24/2016 12:00:00 AM
Last Editorial Review: 8/25/2016 12:00:00 AM

Title: Survey Says: Hair Transplants Make Men Look Younger
Category: Health News
Created: 8/25/2016 12:00:00 AM
Last Editorial Review: 8/26/2016 12:00:00 AM

Title: 'Dream Vaccine' for All COVID Variants
Category: Health News
Created: 8/23/2021 12:00:00 AM
Last Editorial Review: 8/24/2021 12:00:00 AM

Title: For Better Breastfeeding, 'Lactation Consultants' Can Help
Category: Health News
Created: 8/25/2021 12:00:00 AM
Last Editorial Review: 8/25/2021 12:00:00 AM

Title: COVID Boosters Targeted to Latest Variants Could Be Ready After Labor Day
Category: Health News
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/24/2022 12:00:00 AM

Title: GERD (Acid Reflux) in Infants and Children
Category: Diseases and Conditions
Created: 1/31/2005 12:00:00 AM
Last Editorial Review: 8/18/2022 12:00:00 AM

The transcription factor (TF) cone-rod homeobox (CRX) is essential for the differentiation and maintenance of photoreceptor cell identity. Several human CRX variants cause degenerative retinopathies, but most are variants of uncertain significance. We performed a deep mutational scan (DMS) of nearly all possible single amino acid substitutions in CRX using a cell-based transcriptional reporter assay, curating a high-confidence list of nearly 2000 variants with altered transcriptional activity. In the structured homeodomain, activity scores closely aligned to a predicted structure and demonstrated position-specific constraints on amino acid substitution. In contrast, the intrinsically disordered transcriptional effector domain displayed a qualitatively different pattern of substitution effects, following compositional constraints without specific residue position requirements in the peptide chain. These compositional constraints were consistent with the acidic exposure model of transcriptional activation. We evaluated the performance of the DMS assay as a clinical variant classification tool using gold-standard classified human variants from ClinVar, identifying pathogenic variants with high specificity and moderate sensitivity. That this performance could be achieved using a synthetic reporter assay in a foreign cell type, even for a highly cell type-specific TF like CRX, suggests that this approach shows promise for DMS of other TFs that function in cell types that are not easily accessible. Together, the results of the CRX DMS identify molecular features of the CRX effector domain and demonstrate utility for integration into the clinical variant classification pipeline.

The SARS-CoV-2 frameshifting element (FSE) has been intensely studied and explored as a therapeutic target for coronavirus diseases, including COVID-19. Besides the intriguing virology, this small RNA is known to adopt many length-dependent conformations, as verified by multiple experimental and computational approaches. However, the role these alternative conformations play in the frameshifting mechanism and how to quantify this structural abundance has been an ongoing challenge. Here, we show by DMS and dual-luciferase functional assays that previously predicted FSE mutants (using the RAG graph theory approach) suppress structural transitions and abolish frameshifting. Furthermore, correlated mutation analysis of DMS data by three programs (DREEM, DRACO, and DANCE-MaP) reveals important differences in their estimation of specific RNA conformations, suggesting caution in the interpretation of such complex conformational landscapes. Overall, the abolished frameshifting in three different mutants confirms that all alternative conformations play a role in the pathways of ribosomal transition.

Extract

With a disproportionate burden of tuberculosis (TB) amongst migrants in Europe [1], Burman et al. [2] have highlighted the pressing need for alternative approaches to make TB infection (TBI) screening comprehensive and accessible. Across high-income Organisation for Economic Co-operation and development countries, a median of 52% of TB cases occur in foreign-born individuals, who are at their highest risk of developing TB disease within the first 5 years of migration [3]. Molecular epidemiological studies indicate that the majority of these cases occur as a result of TBI reactivation, often acquired overseas [4]. Within the UK, overseas-born migrants have a 14-fold higher TB incidence than UK-born individuals [5]. The World Health Organization therefore recommends that migrants from countries with a high TB burden may be prioritised for TBI screening [6, 7].

Background

Control of latent tuberculosis infection (LTBI) is a priority in the World Health Organization strategy to eliminate TB. Many high-income, low TB incidence countries have prioritised LTBI screening and treatment in recent migrants. We tested whether a novel model of care, based entirely within primary care, was effective and safe compared to secondary care.

Exogenous substances, including drugs and chemicals, can transfer into human seminal fluid and influence male fertility and reproduction. In addition, substances relevant in the context of sports drug testing programs, can be transferred into the urine of a female athlete (after unprotected sexual intercourse) and trigger a so-called adverse analytical finding. Here, the question arises as to whether it is possible to distinguish analytically between intentional doping offenses and unintentional contamination of urine by seminal fluid. To this end, 480 seminal fluids from nonathletes were analyzed to identify concentration ranges and metabolite profiles of therapeutic drugs that are also classified as doping agents. Therefore, a screening procedure was developed using liquid chromatography connected to a triple quadrupole mass spectrometer, and suspect samples (i.e., samples indicating the presence of relevant compounds) were further subjected to liquid chromatography-high-resolution accurate mass (tandem) mass spectrometry. The screening method yielded 90 findings (including aromatase inhibitors, selective estrogen receptor modulators, diuretics, stimulants, glucocorticoids, beta-blockers, antidepressants, and the nonapproved proliferator-activated receptor delta agonist GW1516) in a total of 81 samples, with 91% of these suspected cases being verified by the confirmation method. In addition to the intact drug, phase-I and -II metabolites were also occasionally observed in the seminal fluid. This study demonstrated that various drugs including those categorized as doping agents partition into seminal fluid. Monitoring substances and metabolites may contribute to a better understanding of the distribution and metabolism of exogenous substances in seminal fluid that may be responsible for the impairment of male fertility.

Electron transport chain (ETC) disorders are a group of rare, multisystem diseases caused by impaired oxidative phosphorylation and energy production. Deficiencies in complex III (CIII), also known as ubiquinol–cytochrome c reductase, are particularly rare in humans. Ubiquinol–cytochrome c reductase core protein 2 (UQCRC2) encodes a subunit of CIII that plays a crucial role in dimerization. Several pathogenic UQCRC2 variants have been identified in patients presenting with metabolic abnormalities that include lactic acidosis, hyperammonemia, hypoglycemia, and organic aciduria. Almost all previously reported UQCRC2-deficient patients exhibited neurodevelopmental involvement, including developmental delays and structural brain anomalies. Here, we describe a girl who presented at 3 yr of age with lactic acidosis, hyperammonemia, and hypoglycemia but has not shown any evidence of neurodevelopmental dysfunction by age 15. Whole-exome sequencing revealed compound heterozygosity for two novel variants in UQCRC2: c.1189G>A; p.Gly397Arg and c.437T>C; p.Phe146Ser. Here, we discuss the patient's clinical presentation and the likely pathogenicity of these two missense variants.

T-lymphoblastic lymphoma (T-LLy) is the most common lymphoblastic lymphoma in children and often presents with a mediastinal mass. Lymphomatous suprarenal masses are possible but rare. Here, we discuss the case of a previously healthy 3-yr-old male who presented with mediastinal T-LLy with bilateral suprarenal masses. Following initial treatment, surgical biopsy of persisting adrenal masses revealed bilateral neuroblastoma (NBL). A clinical genetics panel for germline cancer predisposition did not identify any pathogenic variants. Combination large panel (864 genes) profiling analysis in the context of a precision oncology study revealed two novel likely pathogenic heterozygous variants: SMARCA4 c.1420-1G > T p.? and EZH2 c.1943G > C p.(Ile631Phefs*44). Somatic analysis revealed potential second hits/somatic variants in EZH2 (in the T-LLy) and a segmental loss in Chromosome 19p encompassing SMARCA4 (in the NBL). Synchronous cancers, especially at a young age, warrant genetic evaluation for cancer predisposition; enrollment in a precision oncology program assessing germline and tumor DNA can fulfill that purpose, particularly when standard first-line genetic testing is negative and in the setting of tumors that are not classic for common cancer predisposition syndromes.

Anna Marie briefly stops by to tell us about what she's been playing while recovering. The Series X has a price now, will the PS5 get one this week? Also, PAX is happening!

The post RPG Cast – Episode 555: “Kelley Just Wants to Fight You” appeared first on RPGamer.

Pascal falls asleep while playing every game except one. Chris knows nothing about pretty much every game. Matt needs to put some clothes on. And Josh gets a salt lick. Man this chafing sucks.

The post RPG Cast – Episode 583: “Tight Pants” appeared first on RPGamer.

One of my lesser quality tests for an RPG is whether the shopkeepers complain at you for not buying anything. Grumpy shopkeepers, good RPG. This most specific of litmus tests has served me well, although I must admit that I’d happily upgrade it to ‘shopkeepers you can attack’, would that not disqualify 99% of games. But not turn based dungeon crawler Thysiastery, it turns out. This “dungeon crawler RPG featuring traditional roguelike and turn-based gameplay” apparently trusts you enough to let you recklessly batter its friendly wandering lizard merchants. You’d be a monster for it, of course, but it’s nice to have options.

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Much the same as anyone with a soul, I find ants deeply fascinating and, much the same as anyone who occasionally drops small pieces of sandwich on the floor, I will continue to uphold my respect for them as long as they come nowhere near my feet. Yes. I admit it: I am a bug hypocrite, loudly extolling their virtue and beauty at a distance then getting irritated if they decide to come sit on me.

Fortunately, real time strategy Empire Of The Ants understands that the best place for insects to be is inside a screen, where they can be appreciated but cannot under any circumstances touch you. It’s out this week, as it happens, and here’s a new launch trailer to celebrate. Follow your pheromone trail to the video below.

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Devices that let people with paralysis walk and talk are rapidly improving. Some see a future in which we alter memories and download skills – but major challenges remain