ann AT#211 - Travel to Johannesburg, South Africa By africa.amateurtraveler.com Published On :: Sat, 12 Dec 2009 15:00:00 +0000 The Amateur Traveler talks to Ilana Fayerman from Project Explorer about Johannesburg, South Africa. Project Explorer creates educational videos for kids and Ilana is one of the video hosts. She traveled to Johannesburg to meet its people, experience its culture and eat something very weird (see picture). She will take us on a virtual tour of neighborhoods like Newtown where she will introduce us to the New Market Theatre. She will take us into the township of Soweto. Out of the poverty of Soweto has come some of the hope of South Africa. It boasts the only street in the world (Vilakazi Street) to have produced two winners of the Nobel Peace prize. Ilana will also tell us which game animal is the tastiest and what happens when you put too much Chakalaka on your pap. We will dance in gum boots, take a safari to KwaZulu-Natal, learn when you can join a drum circle, lunch with art and visit the cradle of Human Kind. Full Article
ann AT#329 - Travel to Savannah, Georgia By usa.amateurtraveler.com Published On :: Sat, 09 Jun 2012 18:57:59 +0000 The Amateur Traveler talks to Neil Kristianson about one of his favorite travel destinations Savannah, Georgia. Neil and his wife were drawn to Savannah originally because of the movie and the book “Midnight In the Garden of Good and Evil”. They fell in love with the Antebellum architecture, the many public squares, the Southern hospitality and pace, and, strangely enough, with the cemeteries. Savannah is rich in history and has been a destination for travelers even before Sherman’s March to the sea. Learn where to eat and what restaurant is overrated. Stay in a local historic inn one one of the city squares in the walkable historic downtown. Full Article
ann AT#492 - Trekking the Annapurna Circuit in Nepal By asia.amateurtraveler.com Published On :: Sat, 28 Nov 2015 15:30:00 +0000 Hear about Trekking the Annapurna Circuit in Nepal as the Amateur Traveler talks to the Su Family from sufamilyadventures.com about tackling this well known route. Full Article
ann AT#670 - Africa Overland - Johannesburg to Victoria Falls By AmateurTraveler.com Published On :: Sat, 24 Aug 2019 14:00:00 +0000 In this special episode of Amateur Traveler, I get to introduce to you some of the wonderful people who joined me in Africa last May. We drove overland from Johannesburg, South Africa to Victoria Falls, Zimbabwe. Full Article
ann Huge Group of California Churches Announces Plan To Defy Governor Newsom’s Order By www.westernjournal.com Published On :: Sat, 09 May 2020 02:21:33 +0000 An evangelical church network in California will ignore Democratic Gov. Gavin Newsom’s executive prohibitions this month, opening sanctuary doors for communal worship despite the ongoing coronavirus pandemic. According to Fox News, California Church United, representing roughly 3,000 churches and 2.5 million congregants statewide, announced Thursday that it will return to conducting in-person services by Pentecost… The post Huge Group of California Churches Announces Plan To Defy Governor Newsom’s Order appeared first on The Western Journal. Full Article News California Christianity Coronavirus Culture Faith Politics US News
ann This TikTok perfectly captures how annoying coworkers are over Zoom By feedproxy.google.com Published On :: Sat, 09 May 2020 17:27:20 +0000 Zoom has become a way of life for some people as of late (despite, uh, some safety concerns), especially when it comes to work meetings. Whether it's a company-wide all hands or a team check-in, it's likely that if you're working from home due to the coronavirus pandemic, you've had to see your coworkers' shining faces in a video call. Actor, writer, and Groundlings comedian Caitlin Reilly perfectly encapsulated that one co-worker you just can't stand during these video meetings: It's so relevant it hurts. Who hasn't heard the phrase "to piggyback off of" during one of these calls? The inspiration behind the 'tok was experiences Reilly had sitting in Zoom meetings on behalf of her boss. "I had actually never been in a zoom meeting before, so it was funny for me to see all the different 'personality' types in a situation like that," Reilly told Mashable. "And so it popped in my head one day and I just made the video." Read more...More about Viral Video, Zoom, Tiktok, Culture, and Web Culture Full Article Viral Video Zoom Tiktok Culture Web Culture
ann Sport24.co.za | AC Milan announce no first team coronavirus cases By www.sport24.co.za Published On :: Sat, 09 May 2020 18:53:35 +0200 AC Milan have revealed that none of their first-team footballers or staff were positive for coronavirus. Full Article
ann Photo Gallery: 75th Anniversary of VE Day By barrie.ctvnews.ca Published On :: Fri, 8 May 2020 12:33:56 -0400 Friday, May 8, 2020, marks the 75 anniversary of VE Day. Full Article
ann Bells sound across Barrie to mark the 75th anniversary of VE Day By barrie.ctvnews.ca Published On :: Fri, 8 May 2020 17:29:51 -0400 Church bells rang out across the city of Barrie on Friday morning to commemorate the anniversary of the Victory in Europe Day on Friday. Full Article
ann Council votes against proposed cannabis store location in Lakeshore By windsor.ctvnews.ca Published On :: Fri, 8 May 2020 16:54:00 -0400 In Lakeshore, it may be a little while longer before a retail cannabis store opens. Full Article
ann Owners of new retail cannabis store hoping to open soon in Pillette Village By windsor.ctvnews.ca Published On :: Fri, 8 May 2020 16:51:00 -0400 At a time when store front vacancies are growing thanks to COVID-19, a new retail cannabis store in Pillette Village is hoping to open soon. Full Article
ann The EU Cannot Build a Foreign Policy on Regulatory Power Alone By feedproxy.google.com Published On :: Tue, 11 Feb 2020 16:33:26 +0000 11 February 2020 Alan Beattie Associate Fellow, Global Economy and Finance Programme and Europe Programme @alanbeattie LinkedIn Brussels will find its much-vaunted heft in setting standards cannot help it advance its geopolitical interests. 2020-02-11-Leyen.jpg EU Commission President Ursula von der Leyen speaks at the European Parliament in Strasbourg in February. Photo: Getty Images. There are two well-established ideas in trade. Individually, they are correct. Combined, they can lead to a conclusion that is unfortunately wrong.The first idea is that, across a range of economic sectors, the EU and the US have been engaged in a battle to have their model of regulation accepted as the global one, and that the EU is generally winning.The second is that governments can use their regulatory power to extend strategic and foreign policy influence.The conclusion would seem to be that the EU, which has for decades tried to develop a foreign policy, should be able to use its superpower status in regulation and trade to project its interests and its values abroad.That’s the theory. It’s a proposition much welcomed by EU policymakers, who know they are highly unlikely any time soon to acquire any of the tools usually required to run an effective foreign policy.The EU doesn’t have an army it can send into a shooting war, enough military or political aid to prop up or dispense of governments abroad, or a centralized intelligence service. Commission President Ursula von der Leyen has declared her outfit to be a ‘geopolitical commission’, and is casting about for any means of making that real.Through the ‘Brussels effect’ whereby European rules and standards are exported via both companies and governments, the EU has indeed won many regulatory battles with the US.Its cars, chemicals and product safety regulations are more widely adopted round the world than their American counterparts. In the absence of any coherent US offering, bar some varied state-level systems, the General Data Protection Regulation (GDPR) is the closest thing the world has to a single model for data privacy, and variants of it are being adopted by dozens of countries.The problem is this. Those parts of global economic governance where the US is dominant – particularly the dollar payments system – are highly conducive to projecting US power abroad. The extraterritorial reach of secondary sanctions, plus the widespread reliance of banks and companies worldwide on dollar funding – and hence the American financial system – means that the US can precisely target its influence.The EU can enforce trade sanctions, but not in such a powerful and discriminatory way, and it will always be outgunned by the US. Donald Trump could in effect force European companies to join in his sanctions on Iran when he pulled out of the nuclear deal, despite EU legislation designed to prevent their businesses being bullied. He can go after the chief financial officer of Huawei for allegedly breaching those sanctions.By contrast, the widespread adoption of GDPR or data protection regimes inspired by it may give the EU a warm glow of satisfaction, but it cannot be turned into a geopolitical tool in the same way.Nor, necessarily, does it particularly benefit the EU economy. Europe’s undersized tech sector seems unlikely to unduly benefit from the fact that data protection rules were written in the EU. Indeed, one common criticism of the regulations is that they entrench the power of incumbent tech giants like Google.There is a similar pattern at work in the adoption of new technologies such as artificial intelligence and the Internet of Things. In that field, the EU and its member states are also facing determined competition from China, which has been pushing its technologies and standards through forums such as the International Telecommunication Union.The EU has been attempting to write international rules for the use of AI which it hopes to be widely adopted. But again, these are a constraint on the use of new technologies largely developed by others, not the control of innovation.By contrast, China has created a vast domestic market in technologies like facial recognition and unleashed its own companies on it. The resulting surveillance kit can then be marketed to emerging market governments as part of China’s enduring foreign policy campaign to build up supporters in the developing world.If it genuinely wants to turn its economic power into geopolitical influence – and it’s not entirely clear what it would do with it if it did – the EU needs to recognize that not all forms of regulatory and trading dominance are the same.Providing public goods to the world economy is all very well. But unless they are so particular in nature that they project uniquely European values and interests, that makes the EU a supplier of useful plumbing but not a global architect of power.On the other hand, it could content itself with its position for the moment. It could recognize that not until enough hard power – guns, intelligence, money – is transferred from the member states to the centre, or until the member states start acting collectively, will the EU genuinely become a geopolitical force. Speaking loudly and carrying a stick of foam rubber is rarely a way to gain credibility in international relations.This article is part of a series of publications and roundtable discussions in the Chatham House Global Trade Policy Forum. Full Article
ann Chatham House Prize 2015 Nominees Announced By feedproxy.google.com Published On :: Wed, 15 Apr 2015 15:03:27 +0000 20 March 2015 Chatham House is pleased to announce the nominees for the 2015 Chatham House Prize. The nominees are: Mahamadou Issoufou, President of the Republic of NigerMédecins Sans FrontièresAngela Merkel, Chancellor of the Federal Republic of GermanyJuan Manuel Santos, President of the Republic of Colombia The Chatham House Prize is awarded to the person or organization deemed to have made the most significant contribution to the improvement of international relations in the previous year. The winner will be announced later this year and an award ceremony will take place in the autumn. More about the 2015 nominees About the Chatham House Prize The selection proceed for the nominees draws on the expertise of Chatham House's research teams and three presidents - Lord Ashdown, Sir John Major and Baroness Scotland. Our members are then invited to vote for the winner in a ballot. The winner will be announced later this year. The winner will receive a crystal award and a scroll signed by our Patron, Her Majesty the Queen. An award ceremony will take place in London with keynote speeches by leading figures in international affairs. Previous winners include: Melinda Gates (2014); Hillary Rodham Clinton, former US Secretary of State (2013); Sheikh Rached Ghannouchi, Head of the Ennahdha movement, Tunisia and Dr Moncef Marzouki, President of Tunisia (2012); Aung San Suu Kyi, Burmese democracy campaigner (2011); HE Abdullah Gül, President of Turkey (2010), HE President Luiz Inácio Lula da Silva of Brazil (2009), President John Kufuor of Ghana (2008), HH Sheikha Mozah, Chairperson, Qatar Foundation (2007), HE Joaquim Chissano, former President of Mozambique (2006) and HE President Victor Yushchenko of Ukraine (2005). More about the Prize and previous winners Full Article
ann Eliza Manningham-Buller Appointed as Co-President of Chatham House By feedproxy.google.com Published On :: Tue, 21 Jul 2015 13:10:28 +0000 22 July 2015 Manningham-BullerElizahz1.jpg Eliza Manningham-Buller is confirmed as a president of Chatham House replacing Paddy Ashdown who steps down after 10 years.The appointment of Baroness Manningham-Buller as a president of Chatham House was confirmed at the institute’s annual general meeting on Tuesday 21 July. Baroness Manningham-Buller joins Sir John Major and Baroness Scotland of Asthal as a co-president and succeeds Lord Ashdown of Norton-sub-Hamdon who has stepped down from the role after two terms.Eliza Manningham-Buller was director-general of the UK Security Service (MI5) between 2002 and 2007 and became an independent life peer in 2008. She served as Chairman of Imperial College London from 2011 to 2015. She brings to Chatham House an extensive knowledge of and experience in international security as well as a deep interest in medical research and global health, having served as a member of the Board of Governors of the Wellcome Trust since 2008. In October 2015, Baroness Mannigham-Buller will become Chairman of the Trust’s Board of Governors.Paddy Ashdown steps down after serving as a president for 10 years alongside Sir John Major, Patricia Scotland and their predecessors Lord Hurd of Westwell and Lord Robertson of Port Ellen, respectively. Over that period, the institute benefitted enormously from his extensive experience in international politics and conflict resolution, including as High Representative for Bosnia and Herzegovina from 2002 to 2006.Dr Robin Niblett, director of Chatham House, said:'I am delighted to welcome Elizabeth Manningham-Buller as a president of Chatham House. Throughout her career, she has brought deep knowledge, careful analysis and sound judgement to bear upon some of the most difficult dimensions of public policy. The institute will benefit greatly from these qualities as it draws on her engagement with Chatham House over the coming years.I would like to pay tribute to Paddy Ashdown for his long-standing support of Chatham House. His contributions to our substantive debates, both internally and externally, have been invaluable on numerous occasions, and we look forward to his continued involvement with the institute as a member of our Panel of Senior Advisers.'Baroness Manningham-Buller said:“I am delighted to be elected as a Chatham House president at this important time in the institute’s history, as it grapples with a complex and inter-connected agenda of policy challenges. I look forward to working with John Major and Patricia Scotland in supporting Chatham House and its valuable and necessary work. Editor's notes A president’s term at Chatham House is for five years, renewable once. There are no governance responsibilities, which reside solely with the institute’s Council.Chatham House’s three presidents underpin the institute’s independent, non-partisan voice on international affairs. The presidents confirm, through their experiences at the highest levels of government and diplomacy, the connection between Chatham House and policy-makers. Full Article
ann Chatham House Prize 2016 Nominees Announced By feedproxy.google.com Published On :: Tue, 05 Apr 2016 15:36:14 +0000 5 April 2016 Chatham House is pleased to announce the nominees for the 2016 Chatham House Prize. CHP13-0644.jpg The nominees are:Laurent Fabius & Christiana Figueres: nominated for their pivotal role in delivering a global climate agreement at the COP 21 meeting in Paris in December 2015.Attahiru Muhammadu Jega: nominated for his professionalism, determination and integrity as chairman of Nigeria’s electoral commission, which, in 2015, ensured the conduct of Nigeria’s most credible election since the country’s return to civilian rule in 1999.John Kerry & Mohammad Javad Zarif: nominated for their crucial roles, throughout 2015, in successfully negotiating the historic nuclear deal between Iran and the P5+1.The Chatham House Prize is awarded to the person, persons or organization deemed to have made the most significant contribution to the improvement of international relations in the previous year.The winner will be announced later this year and an award ceremony will take place in the autumn.More about the 2016 nomineesMore about the Prize and previous winners Full Article
ann Chatham House is pleased to announce Koc Holding’s support for the Turkey Project By feedproxy.google.com Published On :: Wed, 22 Feb 2017 09:35:10 +0000 22 February 2017 Chatham House is delighted to announce Koc Holding’s support for the Turkey Project, based in the Europe Programme. The project aims to analyze and highlight important issues emanating from Turkey’s geostrategic position and bring a Turkish perspective to important regional developments. Areas of research include Turkey’s evolving relationship with Europe and its contribution to the new ‘silk road’ known as the Belt and Road initiative, aimed at strengthening trade and infrastructure links between Asia and Europe.Mr Ali Y Koc, vice chairman of Koc Holding, has also joined the Chatham House Panel of Senior Advisers, to which he will bring his experience and perspectives on Turkey and on wider global political, economic and social issues.Koc Holding is the leading business group in Turkey with extensive activities in the manufacturing, energy, defence and finance sectors. Mr Ali Y Koc is a board member and executive committee member of Koc Holding and chairman of the 1907 Fenerbahce Association and the National Competitiveness Research Association. He is a board member of the Foreign Economic Relations Board (DEIK), Endeavor Turkey and vice president of the Turkish Industrialists' and Business Association (TUSIAD). He is also a member of the Bank of America Global Advisory Council.Robin Niblett, director of Chatham House, said: 'We are grateful to Mr Ali Y Koc and Koc Holding for supporting this initiative, which builds on our established track record of work on Turkey. Turkey plays an increasingly important strategic role, and through this project, Chatham House will be able to expand its analysis and activities in this area. I am also delighted that Chatham House will benefit from the input and expertise of Mr Koc as a member of the institute’s Panel of Senior Advisers.'Mr Ali Y Koc said: 'Koc Holding is pleased to establish a long-term partnership with Chatham House and support a distinctive research project on Turkey at a world-leading think-tank. We look forward to sharing our insights on Turkey and other significant issues in international affairs among such a distinguished globally-renowned group of individuals in foreign policy, business and civil society on the Panel of Senior Advisers.' Full Article
ann Chatham House Prize 2017 Nominees Announced By feedproxy.google.com Published On :: Fri, 31 Mar 2017 10:35:44 +0000 3 April 2017 Chatham House is pleased to announce the nominees for the 2017 Chatham House Prize. CHP2017Nominees.jpg The Chatham House Prize is awarded to the person, persons or organization deemed to have made the most significant contribution to the improvement of international relations in the previous year.The nominees are:Charlotte Osei, Chairperson of the Electoral Commission of Ghana: nominated for ensuring a peaceful and transparent electoral process in Ghana in December 2016, further consolidating Ghana’s 24-year long democratic journey.Juan Manuel Santos, President of Colombia: nominated for formally ratifying a peace agreement with the FARC rebel group and bringing an end to the war in Colombia.Jens Stoltenberg, Secretary-General of NATO: nominated for steering NATO through one of the most complicated periods in its recent history.The winner will be announced later this year, and an award ceremony will take place in the autumn.More about the 2017 nomineesMore about the Prize and previous winners Full Article
ann Queen Elizabeth II Academy for Leadership Announces 2018/19 Fellows By feedproxy.google.com Published On :: Mon, 24 Sep 2018 08:16:49 +0000 1 October 2018 The Queen Elizabeth II Academy for Leadership in International Affairs, based at Chatham House, is delighted to announce the arrival of its new cohort of Academy fellows. 2018-10-01-CH.jpg The Academy was launched by Her Majesty the Queen in November 2014 to offer potential and established leaders from around the world the opportunity to spend ten months as Academy fellows and develop the tools needed to address the major policy challenges and critical issues facing the world today.Academy fellows are drawn from government and the broader policy community, the private sector, media and civil society. During their time at the Academy, fellows deepen their understanding of critical issues, learn new skills, develop their networks and propose new ideas and solutions to complex policy challenges and opportunities.Dr Leslie Vinjamuri, Dean, QEII Academy for Leadership in International Affairs says:'Chatham House recognizes the need for inspirational and effective leadership in today’s complex and rapidly changing global environment. We remain absolutely committed to the mission of developing leadership skills and feel privileged to welcome the 2018-19 Academy Fellows. The Queen Elizabeth II Academy is uniquely well-positioned, drawing on the historical depth of expertise at Chatham House, our international and national networks, and the dynamism of London to develop skills, knowledge, and global insights that benefit emerging and accomplished leaders across diverse sectors in Europe, Africa, the Middle East, Asia and the Americas.'Academy Fellows 2018/19Rustam AnshbaRustam’s research will explore the prospects for transforming the Georgian-Abkhaz conflict. He will be hosted by the Russia and Eurasia Programme. His fellowship is supported by the Robert Bosch Stiftung.Rita DayoubRita will analyse attacks against healthcare systems during conflicts in Syria and South Sudan. She will be hosted by the Centre on Global Health Security. Her fellowship is supported by the Asfari Foundation.Isabel DunstanIsabel’s research will focus on digital literacy among women as a means to counter radicalization and intolerance in Indonesia. She will be hosted by the Asia-Pacific Programme. Her fellowship is supported by Mr Richard Hayden.Sophia IgnatidouSophia will examine the political and security implications of Artificial Intelligence. She will be hosted by the International Security Department. Her fellowship is supported by the Stavros Niarchos Foundation.Anna KorbutAnna’s research will examine the current media landscape in Ukraine and its transformative potential. She will be hosted by the Russia and Eurasia Programme. Her fellowship is supported by the Robert Bosch Stiftung.Damir KurtagicDamir will research the challenges and possibilities of private sector engagement in Sub-Saharan Africa. He will be hosted by the Africa Programme. His fellowship is supported by the Robert Bosch Stiftung.Zaki MehchyZaki will research the role and dynamics of non-state actors in Syria and their relationship with state institutions. He will be hosted by the Middle East and North Africa Programme. His fellowship is supported by the Asfari Foundation.Anne NyambaneAnne will examine the synergies and trade-offs involved in the implementation of the Sustainable Development Goals (SDGs). She will be hosted by the Energy, Environment and Resources Department. Her fellowship is supported by the Mo Ibrahim Foundation.MasterclassThe Academy is also pleased to welcome three Masterclass participants from the European Bank for Reconstruction and Development. Full Article
ann Lara Hollmann By feedproxy.google.com Published On :: Wed, 15 Jan 2020 13:54:14 +0000 Research Assistant, Global Health Programme Biography Lara works on health security issues with a focus on threats that arise at the human-animal-environment interface (One Health). Her research explores governance and accountability challenges in health security and preparedness and response to health emergencies of international concern.Prior to joining Chatham House, Lara gained work experience at the Directorate General for European Civil Protection and Humanitarian Aid Operations (DG ECHO) at the European Commission where she worked on humanitarian and global health policy.She holds an MSc in Global Health from the University of Copenhagen, with time spent at Kilimanjaro Christian Medical College in Moshi, and a BSc in Development Studies with a major in Human Geography from Lund University. Areas of expertise Global health governanceOne/Planetary HealthSocial determinants of healthPandemic preparedness and responseHealth security 020 7314 3656 Email @lara_hollmann LinkedIn Full Article
ann ABC transporters control ATP release through cholesterol-dependent volume-regulated anion channel activity [Signal Transduction] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 Purinergic signaling by extracellular ATP regulates a variety of cellular events and is implicated in both normal physiology and pathophysiology. Several molecules have been associated with the release of ATP and other small molecules, but their precise contributions have been difficult to assess because of their complexity and heterogeneity. Here, we report on the results of a gain-of-function screen for modulators of hypotonicity-induced ATP release using HEK-293 cells and murine cerebellar granule neurons, along with bioluminescence, calcium FLIPR, and short hairpin RNA–based gene-silencing assays. This screen utilized the most extensive genome-wide ORF collection to date, covering 90% of human, nonredundant, protein-encoding genes. We identified two ABCG1 (ABC subfamily G member 1) variants, which regulate cellular cholesterol, as modulators of hypotonicity-induced ATP release. We found that cholesterol levels control volume-regulated anion channel–dependent ATP release. These findings reveal novel mechanisms for the regulation of ATP release and volume-regulated anion channel activity and provide critical links among cellular status, cholesterol, and purinergic signaling. Full Article
ann DHHC7-mediated palmitoylation of the accessory protein barttin critically regulates the functions of ClC-K chloride channels [Cell Biology] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 Barttin is the accessory subunit of the human ClC-K chloride channels, which are expressed in both the kidney and inner ear. Barttin promotes trafficking of the complex it forms with ClC-K to the plasma membrane and is involved in activating this channel. Barttin undergoes post-translational palmitoylation that is essential for its functions, but the enzyme(s) catalyzing this post-translational modification is unknown. Here, we identified zinc finger DHHC-type containing 7 (DHHC7) protein as an important barttin palmitoyl acyltransferase, whose depletion affected barttin palmitoylation and ClC-K-barttin channel activation. We investigated the functional role of barttin palmitoylation in vivo in Zdhhc7−/− mice. Although palmitoylation of barttin in kidneys of Zdhhc7−/− animals was significantly decreased, it did not pathologically alter kidney structure and functions under physiological conditions. However, when Zdhhc7−/− mice were fed a low-salt diet, they developed hyponatremia and mild metabolic alkalosis, symptoms characteristic of human Bartter syndrome (BS) type IV. Of note, we also observed decreased palmitoylation of the disease-causing R8L barttin variant associated with human BS type IV. Our results indicate that dysregulated DHHC7-mediated barttin palmitoylation appears to play an important role in chloride channel dysfunction in certain BS variants, suggesting that targeting DHHC7 activity may offer a potential therapeutic strategy for reducing hypertension. Full Article
ann The EU Cannot Build a Foreign Policy on Regulatory Power Alone By feedproxy.google.com Published On :: Tue, 11 Feb 2020 16:33:26 +0000 11 February 2020 Alan Beattie Associate Fellow, Global Economy and Finance Programme and Europe Programme @alanbeattie LinkedIn Brussels will find its much-vaunted heft in setting standards cannot help it advance its geopolitical interests. 2020-02-11-Leyen.jpg EU Commission President Ursula von der Leyen speaks at the European Parliament in Strasbourg in February. Photo: Getty Images. There are two well-established ideas in trade. Individually, they are correct. Combined, they can lead to a conclusion that is unfortunately wrong.The first idea is that, across a range of economic sectors, the EU and the US have been engaged in a battle to have their model of regulation accepted as the global one, and that the EU is generally winning.The second is that governments can use their regulatory power to extend strategic and foreign policy influence.The conclusion would seem to be that the EU, which has for decades tried to develop a foreign policy, should be able to use its superpower status in regulation and trade to project its interests and its values abroad.That’s the theory. It’s a proposition much welcomed by EU policymakers, who know they are highly unlikely any time soon to acquire any of the tools usually required to run an effective foreign policy.The EU doesn’t have an army it can send into a shooting war, enough military or political aid to prop up or dispense of governments abroad, or a centralized intelligence service. Commission President Ursula von der Leyen has declared her outfit to be a ‘geopolitical commission’, and is casting about for any means of making that real.Through the ‘Brussels effect’ whereby European rules and standards are exported via both companies and governments, the EU has indeed won many regulatory battles with the US.Its cars, chemicals and product safety regulations are more widely adopted round the world than their American counterparts. In the absence of any coherent US offering, bar some varied state-level systems, the General Data Protection Regulation (GDPR) is the closest thing the world has to a single model for data privacy, and variants of it are being adopted by dozens of countries.The problem is this. Those parts of global economic governance where the US is dominant – particularly the dollar payments system – are highly conducive to projecting US power abroad. The extraterritorial reach of secondary sanctions, plus the widespread reliance of banks and companies worldwide on dollar funding – and hence the American financial system – means that the US can precisely target its influence.The EU can enforce trade sanctions, but not in such a powerful and discriminatory way, and it will always be outgunned by the US. Donald Trump could in effect force European companies to join in his sanctions on Iran when he pulled out of the nuclear deal, despite EU legislation designed to prevent their businesses being bullied. He can go after the chief financial officer of Huawei for allegedly breaching those sanctions.By contrast, the widespread adoption of GDPR or data protection regimes inspired by it may give the EU a warm glow of satisfaction, but it cannot be turned into a geopolitical tool in the same way.Nor, necessarily, does it particularly benefit the EU economy. Europe’s undersized tech sector seems unlikely to unduly benefit from the fact that data protection rules were written in the EU. Indeed, one common criticism of the regulations is that they entrench the power of incumbent tech giants like Google.There is a similar pattern at work in the adoption of new technologies such as artificial intelligence and the Internet of Things. In that field, the EU and its member states are also facing determined competition from China, which has been pushing its technologies and standards through forums such as the International Telecommunication Union.The EU has been attempting to write international rules for the use of AI which it hopes to be widely adopted. But again, these are a constraint on the use of new technologies largely developed by others, not the control of innovation.By contrast, China has created a vast domestic market in technologies like facial recognition and unleashed its own companies on it. The resulting surveillance kit can then be marketed to emerging market governments as part of China’s enduring foreign policy campaign to build up supporters in the developing world.If it genuinely wants to turn its economic power into geopolitical influence – and it’s not entirely clear what it would do with it if it did – the EU needs to recognize that not all forms of regulatory and trading dominance are the same.Providing public goods to the world economy is all very well. But unless they are so particular in nature that they project uniquely European values and interests, that makes the EU a supplier of useful plumbing but not a global architect of power.On the other hand, it could content itself with its position for the moment. It could recognize that not until enough hard power – guns, intelligence, money – is transferred from the member states to the centre, or until the member states start acting collectively, will the EU genuinely become a geopolitical force. Speaking loudly and carrying a stick of foam rubber is rarely a way to gain credibility in international relations.This article is part of a series of publications and roundtable discussions in the Chatham House Global Trade Policy Forum. Full Article
ann Labour Cannot Be Complacent About UKIP’s Advance By feedproxy.google.com Published On :: Tue, 02 Sep 2014 08:38:31 +0000 2 September 2014 Professor Matthew Goodwin Visiting Senior Fellow, Europe Programme @GoodwinMJ LinkedIn Google Scholar Support for UKIP is growing among the groups in which Labour is struggling. 20140902Farage.jpg Nigel Farage speaks to voters in Clacton-on-Sea the day after Douglas Carswell MP announced he is switching allegiance from the Conservative party to UKIP. Photo by Oli Scarff/Getty Images. The UK Independence Party (UKIP) turns 21 years old this month and has cause to celebrate. The insurgent party won a national election in May and last week enjoyed the most significant coup in its history when Conservative MP Douglas Carswell defected to UKIP and announced a forthcoming by-election. Given that his coastal seat of Clacton is UKIP’s most demographically favourable seat in the country, Carswell has almost certainly handed the party its first elected member of parliament.The events in Clacton will be seen by many as validating one of the oldest myths about UKIP; that it is nothing more than a second home for disgruntled Conservatives. Carswell’s defection will be especially welcomed on the left, where many argue UKIP is dividing the right and clearing the path for Labour’s return to power in 2015. This is dangerously misguided.To understand why, we can start with Clacton. The seat has the largest concentration of the 'left behind' demographic; older, white, blue-collar voters who lack qualifications, felt excluded from Britain’s economic transformation long before the crisis, are cut adrift from politics, and are intensely anxious over the cultural as well as economic effects of migration.But as a Conservative-held seat, Clacton is also an outlier. For our book, Revolt on the Right, Robert Ford and I ranked all seats according to their demographic receptiveness to UKIP. Contrary to the prevailing wisdom, most are in Labour territory where MPs are battling with the same cocktail as Carswell: economic stagnation, unease over migration, an entrenched anti-politics consensus and anxieties over rapid social change. Of the 20 seats most demographically receptive to UKIP, 18 have Labour incumbents. Of the top 50, Labour holds 42. Of course, demography alone is not necessarily destiny. Aside from a receptive local population, UKIP also needs a favourable political context. Unlike Conservative-held seats that are at genuine risk from UKIP, Labour’s heartland seats are currently protected by large majorities.But a cursory glance at the recent European parliament results reveals the direction of travel. UKIP comfortably won the popular vote in a swath of Labour territory, and talks ambitiously of becoming the main rival to Labour in northern England. It appears to be succeeding. Across 39 local authorities in the northwest, UKIP won more votes than Labour in 13 and finished as its main rival in 23. It is similarly bleak in the northeast; across 12 authorities UKIP won the popular vote in five and finished second to Labour in seven.Since 2010, UKIP has grown fastest among the groups in which Labour is struggling most: the over-65s, the working-class and those who left education early. UKIP is tearing off this section of the electorate, creating a fundamental divide in British politics between those with the skills, education and resources to adapt, and those who have little and feel intensely angry. This is why some Ukippers talk of a '2020 strategy' and plot further advances under an Ed Miliband-led post-2015 government.Those who compare the party to earlier attempts to redraw the political map, such as the Social Democratic Party in the 1980s, or populist crusaders like the French Poujadists in the 1950s, miss a crucial point. UKIP is anchored in modern Britain’s most socially distinctive support base; it is the most working-class movement since Michael Foot’s Labour Party. Labelling UKIP as 'populist' implies that it appeals across society. It does not. Its strength is concentrated in the 'left behind', who cluster in specific geographical areas. Crucially, this is essential for success under first-past-the-post.Labour should be under no illusion. UKIP is attracting the Carswells of this world but it is also emerging as the main opposition in many northern heartlands, where it benefits from the toxicity of the Tories, moribund Labour machines that have not had to compete for decades, and the short-sightedness of some close to Ed Miliband who think only of the impact UKIP might have in 2015, and not beyond. Should UKIP’s insurgency continue, not only will it cause a rupture on the centre right, but also bring back into play Labour constituencies that have not been competitive for generations.This article was originally published in the Financial TimesTo comment on this article, please contact Chatham House Feedback Full Article
ann ABC transporters control ATP release through cholesterol-dependent volume-regulated anion channel activity [Signal Transduction] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 Purinergic signaling by extracellular ATP regulates a variety of cellular events and is implicated in both normal physiology and pathophysiology. Several molecules have been associated with the release of ATP and other small molecules, but their precise contributions have been difficult to assess because of their complexity and heterogeneity. Here, we report on the results of a gain-of-function screen for modulators of hypotonicity-induced ATP release using HEK-293 cells and murine cerebellar granule neurons, along with bioluminescence, calcium FLIPR, and short hairpin RNA–based gene-silencing assays. This screen utilized the most extensive genome-wide ORF collection to date, covering 90% of human, nonredundant, protein-encoding genes. We identified two ABCG1 (ABC subfamily G member 1) variants, which regulate cellular cholesterol, as modulators of hypotonicity-induced ATP release. We found that cholesterol levels control volume-regulated anion channel–dependent ATP release. These findings reveal novel mechanisms for the regulation of ATP release and volume-regulated anion channel activity and provide critical links among cellular status, cholesterol, and purinergic signaling. Full Article
ann S-Palmitoylation of the sodium channel Nav1.6 regulates its activity and neuronal excitability [Cell Biology] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 S-Palmitoylation is a reversible post-translational lipid modification that dynamically regulates protein functions. Voltage-gated sodium channels are subjected to S-palmitoylation and exhibit altered functions in different S-palmitoylation states. Our aim was to investigate whether and how S-palmitoylation regulates Nav1.6 channel function and to identify S-palmitoylation sites that can potentially be pharmacologically targeted. Acyl-biotin exchange assay showed that Nav1.6 is modified by S-palmitoylation in the mouse brain and in a Nav1.6 stable HEK 293 cell line. Using whole-cell voltage clamp, we discovered that enhancing S-palmitoylation with palmitic acid increases Nav1.6 current, whereas blocking S-palmitoylation with 2-bromopalmitate reduces Nav1.6 current and shifts the steady-state inactivation in the hyperpolarizing direction. Three S-palmitoylation sites (Cys1169, Cys1170, and Cys1978) were identified. These sites differentially modulate distinct Nav1.6 properties. Interestingly, Cys1978 is exclusive to Nav1.6 among all Nav isoforms and is evolutionally conserved in Nav1.6 among most species. Cys1978 S-palmitoylation regulates current amplitude uniquely in Nav1.6. Furthermore, we showed that eliminating S-palmitoylation at specific sites alters Nav1.6-mediated excitability in dorsal root ganglion neurons. Therefore, our study reveals S-palmitoylation as a potential isoform-specific mechanism to modulate Nav activity and neuronal excitability in physiological and diseased conditions. Full Article
ann Crimean Reality Check: Four Years of Annexation By feedproxy.google.com Published On :: Wed, 14 Mar 2018 00:00:00 +0000 Full Article
ann Planning for Africa's Future: Youth Perspectives from Kenya and South Africa By feedproxy.google.com Published On :: Wed, 25 Apr 2018 00:00:00 +0100 Full Article
ann The Militarization of the Black Sea After the Annexation of Crimea By feedproxy.google.com Published On :: Wed, 13 Mar 2019 00:00:00 +0000 Full Article
ann Delineating an extracellular redox-sensitive module in T-type Ca2+ channels [Membrane Biology] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 T-type (Cav3) Ca2+ channels are important regulators of excitability and rhythmic activity of excitable cells. Among other voltage-gated Ca2+ channels, Cav3 channels are uniquely sensitive to oxidation and zinc. Using recombinant protein expression in HEK293 cells, patch clamp electrophysiology, site-directed mutagenesis, and homology modeling, we report here that modulation of Cav3.2 by redox agents and zinc is mediated by a unique extracellular module containing a high-affinity metal-binding site formed by the extracellular IS1–IS2 and IS3–IS4 loops of domain I and a cluster of extracellular cysteines in the IS1–IS2 loop. Patch clamp recording of recombinant Cav3.2 currents revealed that two cysteine-modifying agents, sodium (2-sulfonatoethyl) methanethiosulfonate (MTSES) and N-ethylmaleimide, as well as a reactive oxygen species–producing neuropeptide, substance P (SP), inhibit Cav3.2 current to similar degrees and that this inhibition is reversed by a reducing agent and a zinc chelator. Pre-application of MTSES prevented further SP-mediated current inhibition. Substitution of the zinc-binding residue His191 in Cav3.2 reduced the channel's sensitivity to MTSES, and introduction of the corresponding histidine into Cav3.1 sensitized it to MTSES. Removal of extracellular cysteines from the IS1–IS2 loop of Cav3.2 reduced its sensitivity to MTSES and SP. We hypothesize that oxidative modification of IS1–IS2 loop cysteines induces allosteric changes in the zinc-binding site of Cav3.2 so that it becomes sensitive to ambient zinc. Full Article
ann Christophe Bellmann By feedproxy.google.com Published On :: Thu, 23 Apr 2020 14:27:27 +0000 Associate Fellow, Hoffmann Centre for Sustainable Resource Economy Biography Christophe is a senior resident research associate at ICTSD with decades of experience working on international trade negotiations and policymaking from a sustainable development perspective.He joined ICTSD in 1998 as programme officer for outreach and partnership, then became director of policy dialogues. Since 2002, he has been programmes director.He previously worked for the Swiss Coalition of Development Organisations (SCDO) where he was responsible for activities on multilateral trade and sustainable development issues, and has also worked as a research associate at the Economic Commission for Latin America and the Caribbean (ECLAC) in Santiago, Chile on the relationship between trade and the environment.Christophe has edited and published a wide range of books, articles and opinion pieces in English, French and Spanish on trade and sustainable development. His work focuses on international trade negotiations, development policies and environmental governance in areas such as agriculture and food security, fisheries, tariffs and non-tariff barriers, rules, regional trade, services and intellectual property rights.He holds an MA in international relations from the Graduate Institute for International Studies in Geneva. Email LinkedIn Full Article
ann Lara Hollmann By feedproxy.google.com Published On :: Wed, 15 Jan 2020 13:54:14 +0000 Research Assistant, Global Health Programme Biography Lara works on health security issues with a focus on threats that arise at the human-animal-environment interface (One Health). Her research explores governance and accountability challenges in health security and preparedness and response to health emergencies of international concern.Prior to joining Chatham House, Lara gained work experience at the Directorate General for European Civil Protection and Humanitarian Aid Operations (DG ECHO) at the European Commission where she worked on humanitarian and global health policy.She holds an MSc in Global Health from the University of Copenhagen, with time spent at Kilimanjaro Christian Medical College in Moshi, and a BSc in Development Studies with a major in Human Geography from Lund University. Areas of expertise Global health governanceOne/Planetary HealthSocial determinants of healthPandemic preparedness and responseHealth security 020 7314 3656 Email @lara_hollmann LinkedIn Full Article
ann Scanning Ancient Sites By www.ams.org Published On :: Mon, 5 Oct 2015 10:47:45 -0400 Researcher: Jackson Cothren, University of Arkansas Moment Title: Scanning Ancient Sites Description: Jackson Cothren talks about creating three-dimensional scans of ancient sites. Full Article
ann euromicron AG’s Annual General Meeting adopts all agenda items and elects new Supervisory Board By www.euromicron.de Published On :: Fri, 30 Aug 2019 14:46:00 +0200 euromicron AG, a medium-sized technology group and expert on digital networking of business and production processes, held its Annual General Meeting 2019 in Frankfurt/Main on August 29, 2019. 42 percent of the share capital was represented. At the Annual General Meeting, the Executive Board reported on the operating performance in fiscal year 2018 and in the first half of 2019 and gave an outlook on the current fiscal year. One focus was on the implementation of the measures initiated to focus on and further develop the business model. Full Article
ann 11 September 2013 marks the 10th anniversary of the entry into force of the Cartagena Protocol on Biosafety. The theme for the anniversary is: "10 Years of Promoting Safety in the Use of Biotechnology. By bch.cbd.int Published On :: Wed, 11 Sep 2013 00:00:00 GMT Full Article
ann The Biannual Report on the Administration of the Convention on Biological Diversity for January to June 2013 is now available (page 27). By www.cbd.int Published On :: Wed, 23 Oct 2013 00:00:00 GMT Full Article
ann The Biannual Report on the Administration of the Convention on Biological Diversity for July to December 2013 is now available (page 36). By www.cbd.int Published On :: Thu, 08 May 2014 00:00:00 GMT Full Article
ann A webinar entitled "Integrating Biosafety into NBSAPs and Other Conservation Planning Tools" took place on 25 October 2016 at 9:00 EDT By nbsapforum.net Published On :: Mon, 31 Oct 2016 00:00:00 GMT Full Article
ann The 15th anniversary of the entry into force of the Cartagena Protocol on Biosafety, 11 September 2018, webpage is now available By bch.cbd.int Published On :: Fri, 07 Sep 2018 00:00:00 GMT Full Article
ann A webinar for the 15th anniversary of the entry into force of the Cartagena Protocol on Biosafety was held on 11 September 2018. The recording is now available. By www.youtube.com Published On :: Thu, 11 Oct 2018 00:00:00 GMT Full Article
ann Housing minister announces plans to boost UK proptech sector with data By www.techworld.com Published On :: Tue, 22 Oct 2019 07:12:00 GMT Esther McVey said the government will release local data on properties and land to help the proptech sector thrive Full Article
ann CBD Press release: Germany and the United Nations Biodiversity Secretariat announce a "Green COP". By www.cbd.int Published On :: Thu, 22 May 2008 00:00:00 GMT Full Article
ann CBD News: Statement from Dr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the Twelfth Regular Session of the African Ministerial Conference on the Environment, Johannesburg, South Africa, 7-12 June 2008 By www.cbd.int Published On :: Wed, 11 Jun 2008 00:00:00 GMT Full Article
ann CBD News: Statement by the Executive Secretary, Ahmed Djoghlaf, at the Annual Ministerial Review of the High-level Segment of the 2008 Substantive Session of the Economic and Social Council, United Nations, New York, 1 July 2008 By www.cbd.int Published On :: Tue, 01 Jul 2008 00:00:00 GMT Full Article
ann CBD News: International Treaty on Biosafety marks its Fifth Anniversary. By www.cbd.int Published On :: Mon, 08 Sep 2008 00:00:00 GMT Full Article
ann CBD News: Message from the UN Secretary-General Ban Ki-moon on the fifth anniversary of the entry into force of the Cartagena Protocol on Biosafety By www.cbd.int Published On :: Thu, 11 Sep 2008 00:00:00 GMT Full Article
ann CBD News: Disaster Reduction and Climate Change Adaptation, statement by the Executive Secretary, Ahmed Djoghlaf, on the occasion of the 5th Annual United Nations Day for South-South Cooperation and the Launch of the Global South-South Development Expo or By www.cbd.int Published On :: Wed, 17 Dec 2008 00:00:00 GMT Full Article
ann CBD News: Statement by Mr. Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of the 32nd Annual General Assembly of the Canadian Environmental Network (RCEN), 12 June 2009, Edmonton, Canada. By www.cbd.int Published On :: Fri, 12 Jun 2009 00:00:00 GMT Full Article
ann CBD News: Statement by Mr Ahmed Djoghlaf, Executive Secretary of the Convention on Biological Diversity, on the occasion of Diversity for Life - Planning Workshop, 17 July 2009, Bellagio, Italy. By www.cbd.int Published On :: Fri, 17 Jul 2009 00:00:00 GMT Full Article
ann CBD News: Announcement of the International University of Andalusia (Spain): The 9th Master's Degree in Management, Access and Conservation of Species in Trade: The International Framework (April-June 2010). By www.cbd.int Published On :: Tue, 29 Sep 2009 00:00:00 GMT Full Article
ann CBD News: Déclaration de M. Ahmed Djoghlaf, Secrétaire exécutif de la Convention sur la diversite biologique, à l'occasion du devoilement du logotype de l'Annee internationale de la biodiversite, 5 Octobre 2009, Nairobi, Kenya. By www.cbd.int Published On :: Mon, 05 Oct 2009 00:00:00 GMT Full Article