ann Cells and Molecules Underpinning Cannabis-Related Variations in Cortical Thickness during Adolescence By www.jneurosci.org Published On :: 2024-10-09T09:30:20-07:00 During adolescence, cannabis experimentation is common, and its association with interindividual variations in brain maturation well studied. Cellular and molecular underpinnings of these system-level relationships are, however, unclear. We thus conducted a three-step study. First, we exposed adolescent male mice to -9-tetrahydrocannabinol (THC) or a synthetic cannabinoid WIN 55,212-2 (WIN) and assessed differentially expressed genes (DEGs), spine numbers, and dendritic complexity in their frontal cortex. Second, in human (male) adolescents, we examined group differences in cortical thickness in 34 brain regions, using magnetic resonance imaging, between those who experimented with cannabis before age 16 (n = 140) and those who did not (n = 327). Finally, we correlated spatially these group differences with gene expression of human homologs of mouse-identified DEGs. The spatial expression of 13 THC-related human homologs of DEGs correlated with cannabis-related variations in cortical thickness, and virtual histology revealed coexpression patterns of these 13 genes with cell-specific markers of astrocytes, microglia, and a type of pyramidal cells enriched in dendrite-regulating genes. Similarly, the spatial expression of 18 WIN-related human homologs of DEGs correlated with group differences in cortical thickness and showed coexpression patterns with the same three cell types. Gene ontology analysis indicated that 37 THC-related human homologs are enriched in neuron projection development, while 33 WIN-related homologs are enriched in processes associated with learning and memory. In mice, we observed spine loss and lower dendritic complexity in pyramidal cells of THC-exposed animals (vs controls). Experimentation with cannabis during adolescence may influence cortical thickness by impacting glutamatergic synapses and dendritic arborization. Full Article
ann Glucocorticoids Rapidly Modulate CaV1.2-Mediated Calcium Signals through Kv2.1 Channel Clusters in Hippocampal Neurons By www.jneurosci.org Published On :: 2024-11-06T09:30:07-08:00 The precise regulation of Ca2+ signals plays a crucial role in the physiological functions of neurons. Here, we investigated the rapid effect of glucocorticoids on Ca2+ signals in cultured hippocampal neurons from both female and male rats. In cultured hippocampal neurons, glucocorticoids inhibited the spontaneous somatic Ca2+ spikes generated by Kv2.1-organized Ca2+ microdomains. Furthermore, glucocorticoids rapidly reduced the cell surface expressions of Kv2.1 and CaV1.2 channels in hippocampal neurons. In HEK293 cells transfected with Kv2.1 alone, glucocorticoids significantly reduced the surface expression of Kv2.1 with little effect on K+ currents. In HEK293 cells transfected with CaV1.2 alone, glucocorticoids inhibited CaV1.2 currents but had no effect on the cell surface expression of CaV1.2. Notably, in the presence of wild-type Kv2.1, glucocorticoids caused a decrease in the surface expression of CaV1.2 channels in HEK293 cells. However, this effect was not observed in the presence of nonclustering Kv2.1S586A mutant channels. Live-cell imaging showed that glucocorticoids rapidly decreased Kv2.1 clusters on the plasma membrane. Correspondingly, Western blot results indicated a significant increase in the cytoplasmic level of Kv2.1, suggesting the endocytosis of Kv2.1 clusters. Glucocorticoids rapidly decreased the intracellular cAMP concentration and the phosphorylation level of PKA in hippocampal neurons. The PKA inhibitor H89 mimicked the effect of glucocorticoids on Kv2.1, while the PKA agonist forskolin abrogated the effect. In conclusion, glucocorticoids rapidly suppress CaV1.2-mediated Ca2+ signals in hippocampal neurons by promoting the endocytosis of Kv2.1 channel clusters through reducing PKA activity. Full Article
ann High-level event commemorating the Fifth Anniversary of the Paris Agreement By www.fao.org Published On :: Wed, 09 Dec 2020 00:00:00 GMT On the occasion of the fifth anniversary of the Paris Agreement, the event will highlight the key role of the agricultural sectors in supporting the Paris Agreement. The Paris Agreement, [...] Full Article
ann Annual Report on Private Sector Engagement, 2021 By www.fao.org Published On :: Tue, 31 May 2022 00:00:00 GMT This newly-released report highlights the progress made since FAO’s Strategy for Private Sector Engagement 2021-2025 was approved during the 165th session of the Council in December 2020. It discusses important [...] Full Article
ann Candidates for the post of FAO Director-General announced By www.fao.org Published On :: Fri, 03 Mar 2023 00:00:00 GMT FAO member nations to choose head of the UN specialized agency in July during the 43rd session of the FAO Conference Full Article
ann Annual Report on Private Sector Engagement 2022 out now By www.fao.org Published On :: Mon, 13 Mar 2023 00:00:00 GMT This newly-released annual report charts progress in FAO's work with the private sector in 2022. It highlights developments across FAO's portfolio of private sector engagements, documents major achievements and lessons learned [...] Full Article
ann The Food and Agriculture Organization of the United Nations (FAO) launches its new Annual and Monthly Funding Overview websites By www.fao.org Published On :: Wed, 22 Mar 2023 00:00:00 GMT Rome – The newly released Annual Report for 2020, 2021 and 2022 raises the visibility of the Organization's Resource Partners, including FAO Members, international financial institutions (IFIs), United Nations entities, [...] Full Article
ann Annual Report on Private Sector Engagement 2022 By www.fao.org Published On :: Fri, 28 Apr 2023 00:00:00 GMT This annual report charts progress in FAO's work with the private sector in 2022. It highlights developments across FAO's portfolio of private sector engagements, documents major achievements and lessons [...] Full Article
ann In his International Youth Day 2023 message, QU Dongyu announces the establishment of FAO's new Office for Youth and Women By www.fao.org Published On :: Sat, 12 Aug 2023 00:00:00 GMT The FAO Director-General today issued the following message on the occasion of International Youth Day 2023: Full Article
ann Pioneering Video Artist Peter Campus Presents His Version of the Star-Spangled Banner By www.smithsonianmag.com Published On :: Sat, 28 Sep 2024 00:00:00 -0000 Full Article
ann The Smithsonian Channel Commemorates the 50th Anniversary of the Wilderness Act By www.smithsonianmag.com Published On :: Mon, 07 Oct 2024 00:00:00 -0000 Aerial America: Wilderness premieres Sunday, Sept. 7 at 9PM ET/PT Full Article
ann Matt Mahurin's Vision of the Star-Spangled Banner By www.smithsonianmag.com Published On :: Mon, 21 Oct 2024 00:00:00 -0000 Full Article
ann Scanning the Worlds Greatest Violins By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 In between trips to archaeology digs around the world, scientist Bruno Frohlich uses 3-D imaging to uncover what makes a great stringed instrument. Read more at: https://www.smithsonianmag.com/smithsonian-institution/scanning-a-stradivarius-13807009/ Full Article
ann To the Moon and Back: Apollo 11 Celebrates its 40th Anniversary By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 Sending a man to the moon required an overhaul of the entire space program, involving more powerful rockets and new spacecraft (Video: Lauren Hogan, Beth Py-Lieberman, Brian Wolly) Full Article
ann The Descendants: Deanna Stanford Walz as Harriet Tubman By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 Smithsonian magazine commissioned Drew Gardner for a project that connects Black Americans today to their lost ancestry. Read about Gardner’s project and process, as well as more details about the subjects of this incredible series here: https://www.smithsonianmag.com/history/descendants-black-civil-war-heroes-wear-heritage-pride-180983397/ Video produced by Sierra Theobald. Special thanks to Drew Gardner Additional credits: Emma MacBeath, WikiTree US Black Heritage project; Ottawa Goodman, research and coordinator; Sam Dole, Penumbra Foundation; Elizabeth Zuck, set design; Calvin Osbourne, props and costume; Angela Huff, hair and make up; Diego Huerta, Lexia Krebs, behind-the-scenes filming; background prints by Fujifilm USA Full Article
ann Announcing the Winners of the 21st Annual Smithsonian Magazine Photo Contest By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 After reviewing more than 30,000 photos, the editors of Smithsonian magazine are proud to announce the winning submissions. Learn more about the finalists and winners of 2024 here: https://www.smithsonianmag.com/arts-culture/see-winners-21st-annual-smithsonian-magazine-photo-contest-180984001/. --- For more videos from Smithsonian Magazine: https://www.smithsonianmag.com/videos/ Digital Editorial Director: Brian Wolly Supervising Producer & Scriptwriter: Michelle Mehrtens Video Editor: Sierra Theobald Full Article
ann Fannie Lou Hamer Risked Her Life for the Right to Vote By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 Fannie Lou Hamer, a voting rights activist, suffered unspeakable violence and intimidation at the hands of white supremacists and police. Her response: to elevate her cause by launching a long-shot campaign for the U.S. Senate Full Article
ann A Brief History of Book Banning in America By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 Book-banning might seem like a relic of less enlightened times, but the practice is back in a big way. The American Library Association reports (https://www.smithsonianmag.com/smart-news/american-library-association-names-2022s-most-banned-books-180982048/) that 2022 saw more attempts to have books removed from public libraries than in any prior year this century — indeed, it documented more than twice as many attempted bans in 2022 than in 2021. In schools, attempts to keep certain books out of the hands of students have been even more aggressive and draconian. What’s new about these efforts is the subject that binds the most-challenged titles: Most of them address themes of LGBT+ identity or gender expression. In this episode, we talk with journalist Colleen Connolly about Thomas Morton’s New English Canaan, the first book ever to be suppressed in North America. What did the Puritans find so threatening about it, and how has this book echoed through subsequent centuries? Then we’re joined by Dr. Carla Hayden, Librarian of Congress, for a wide-ranging conversation about the history of book bans in the United States, how a resurgent wave of book bans in many states differs from those of prior eras, and why organized attempts to prevent specific people from reading specific books usually fail. A transcript of this episode can be found here (http://smithsonianmag.com/history/a-brief-history-of-banned-books-in-america-180983011) . Read Colleen’s Smithsonian story about New English Canaan here (https://www.smithsonianmag.com/history/how-americas-first-banned-book-survived-and-became-an-anti-authoritarian-icon-180982971/) . Find prior episodes of our show here (https://www.smithsonianmag.com/podcast/) . There’s More to That is a production of Smithsonian magazine and PRX Productions. From the magazine, our team is Chris Klimek, Debra Rosenberg and Brian Wolly. From PRX, our team is Jessica Miller, Adriana Rosas Rivera, Genevieve Sponsler, Terence Bernardo, and Edwin Ochoa. The Executive Producer of PRX Productions is Jocelyn Gonzales. Fact-checking by Stephanie Abramson. Episode artwork by Emily Lankiewicz. Music by APM Music. Full Article
ann Ask Smithsonian: Do Cannibals Still Exist? By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 Hungry for an answer? Host, Eric Schulze, dishes one up in less than a minute. Full Article
ann Meet the Grand Prize Winner of the 21st Annual Smithsonian Magazine Photo Contest By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 After reviewing more than 30,000 photos, the editors of Smithsonian Magazine are proud to announce the Grand Prize Winner. #shorts Full Article
ann 3-D Scanning: Bringing History Back to Life By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 More on 3D scanning: http://j.mp/JM43KD Specialists are using new technology to unravel a mystery in the Smithsonian collections. Full Article
ann Anne Kelly Knowles Uses GIS Tools to Re-Write History By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 The American Ingenuity Award winner is using geographic information systems to map history's most iconic landscapes Full Article
ann Erin Brockovich Congratulates Marc Edwards & LeeAnne Walters | Smithsonian American Ingenuity Awards By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 “Superman isn’t coming. It is a moment in our time when we must look to ourselves, and not take for granted or wait for something from the top to come down, but rather…pick up the torch, carry the torch, to find information and the truth…” – Erin Brockovich applauds Marc Edwards and LeeAnne Walters for their work exposing the Flint water crisis | Smithsonian Magazine American #IngenuityAwards Read more about Edwards and Walters’ work: http://smithmag.co/D4dIHy The Smithsonian has been celebrating innovation in American culture for more than 150 years, and following in this tradition, Smithsonian magazine presents the American Ingenuity Awards, honoring revolutionary breakthroughs in the arts and sciences, education and social progress. http://smithmag.co/R7hyRO Full Article
ann DNA Reveals Identity of Officer on the Lost Franklin Expedition—and His Remains Show Signs of Cannibalism By www.smithsonianmag.com Published On :: Thu, 26 Sep 2024 20:08:48 +0000 Researchers recently identified James Fitzjames, a captain on the ill-fated HMS Erebus that went looking for the Northwest Passage in 1845 Full Article
ann Minnesota Teacher's 2,471-Pound Gourd Triumphs in Annual Pumpkin-Weighing Competition By www.smithsonianmag.com Published On :: Thu, 17 Oct 2024 17:07:50 +0000 Travis Gienger, who nicknamed his prize-winning pumpkin "Rudy," has been growing gourds for nearly 30 years Full Article
ann Walk Through a Full-Scale Replica of the Secret Annex Where Anne Frank's Family Took Shelter During the Holocaust By www.smithsonianmag.com Published On :: Tue, 22 Oct 2024 19:19:15 +0000 Featuring more than 100 original artifacts, a new immersive exhibition in New York City will explore the young Jewish diarist's life and legacy Full Article
ann Images of the Star-Spangled Banner from Across the Country By www.smithsonianmag.com Published On :: Sat, 01 Mar 2014 21:16:54 +0000 See images of the American flag captured by our readers. Full Article
ann Announcing the Finalists of the 12th Annual Smithsonian.com Photo Contest By www.smithsonianmag.com Published On :: Wed, 04 Mar 2015 18:26:12 +0000 See the finalists of our 2014 photo contest and vote for the Readers' Choice winner Full Article
ann This veteran started a workshop in his garage to help others channel PTSD into art By www.cbc.ca Published On :: Mon, 11 Nov 2024 13:42:51 EST Dominic April fell in love with forging after his career in the military came to an end in 2015. Now operating a blacksmith studio near Quebec City, he hopes to help other veterans dealing with PTSD find creativity and purpose. Full Article News/Canada/Montreal
ann How Spam Went from Canned Necessity to American Icon By www.smithsonianmag.com Published On :: Wed, 05 Jul 2017 14:41:51 +0000 Out-of-the-can branding helped transform World War II's rations into a beloved household staple Full Article
ann New schools planned for P.E.I. are an investment in youth, says head of Public Schools Branch By www.cbc.ca Published On :: Tue, 12 Nov 2024 17:53:19 EST Public Schools Branch director Tracy Beaulieu speaks with CBC News: Compass host Steve Bruce about the money for schools in the new capital budget the province presented last week, and about the work that lies ahead. Full Article
ann Hamilton council defers vote on banning encampments in parks to next year By www.cbc.ca Published On :: Wed, 06 Nov 2024 17:45:37 EST City will wait for legal advice, staff report before voting early next year to avoid potential rights violations. While some people in the community argue Hamilton doesn't have enough shelter beds to justifiably remove encampments, others say they feel unsafe in their homes and unable to access parks. Full Article News/Canada/Hamilton
ann In The Key Of C: Hear Danny Michel, Chastity, Fred Penner, Laila and more By www.cbc.ca Published On :: Sat, 09 Nov 2024 13:01:00 EST Host Craig Norris plays a whole bunch of music in this week's show. Hear tunes from Danny Michel, Chastity, Fred Penner, Tragically Hip, Angela Saini, Laila and a lot more. Full Article News/Canada/Kitchener-Waterloo
ann Banners put veterans front and centre in small town Ontario By www.cbc.ca Published On :: Mon, 11 Nov 2024 04:00:00 EST A heartfelt initiative is taking root in some small towns across eastern Ontario where light and hydro poles are being adorned with banners that pay tribute to local veterans. Full Article News/Canada/Ottawa
ann Planning Commission on 2019-09-23 7:00 PM - Sep 23, 2019 By oregon-city.granicus.com Published On :: Mon, 23 Sep 2019 07:15:00 -0800 The agenda for Planning Commission on 2019-09-23 7:00 PM dated Monday, 23 September 2019 has been archived. Access it here: https://oregon-city.granicus.com/MediaPlayer.php?view_id=4&clip_id=2318 Download File Full Article
ann Planning Commission on 2019-10-14 7:00 PM - Oct 14, 2019 By oregon-city.granicus.com Published On :: Mon, 14 Oct 2019 07:15:00 -0800 The agenda for Planning Commission on 2019-10-14 7:00 PM dated Monday, 14 October 2019 has been archived. Access it here: https://oregon-city.granicus.com/MediaPlayer.php?view_id=4&clip_id=2329 Download File Full Article
ann Planning Commission on 2019-10-28 7:00 PM - Oct 28, 2019 By oregon-city.granicus.com Published On :: Mon, 28 Oct 2019 07:30:00 -0800 The agenda for Planning Commission on 2019-10-28 7:00 PM dated Monday, 28 October 2019 has been archived. Access it here: https://oregon-city.granicus.com/MediaPlayer.php?view_id=4&clip_id=2337 Download File Full Article
ann Planning Commission on 2019-11-18 7:00 PM - Special Date - Nov 18, 2019 By oregon-city.granicus.com Published On :: Mon, 18 Nov 2019 07:15:00 -0800 The agenda for Planning Commission on 2019-11-18 7:00 PM - Special Date dated Monday, 18 November 2019 has been archived. Access it here: https://oregon-city.granicus.com/MediaPlayer.php?view_id=4&clip_id=2344 Download File Full Article
ann Planning Commission on 2019-11-25 7:00 PM - Nov 25, 2019 By oregon-city.granicus.com Published On :: Mon, 25 Nov 2019 07:00:00 -0800 The agenda for Planning Commission on 2019-11-25 7:00 PM dated Monday, 25 November 2019 has been archived. Access it here: https://oregon-city.granicus.com/MediaPlayer.php?view_id=4&clip_id=2349 Download File Full Article
ann Planning Commission on 2019-12-16 7:00 PM - Special Meeting - Dec 16, 2019 By oregon-city.granicus.com Published On :: Mon, 16 Dec 2019 07:15:00 -0800 The agenda for Planning Commission on 2019-12-16 7:00 PM - Special Meeting dated Monday, 16 December 2019 has been archived. Access it here: https://oregon-city.granicus.com/MediaPlayer.php?view_id=4&clip_id=2360 Download File Full Article
ann Planning Commission on 2020-01-27 7:00 PM - Jan 27, 2020 By oregon-city.granicus.com Published On :: Mon, 27 Jan 2020 07:15:00 -0800 The agenda for Planning Commission on 2020-01-27 7:00 PM dated Monday, 27 January 2020 has been archived. Access it here: https://oregon-city.granicus.com/MediaPlayer.php?view_id=4&clip_id=2380 Download File Full Article
ann Planning Commission on 2020-02-10 7:00 PM - Feb 10, 2020 By oregon-city.granicus.com Published On :: Mon, 10 Feb 2020 07:15:00 -0800 The agenda for Planning Commission on 2020-02-10 7:00 PM dated Monday, 10 February 2020 has been archived. Access it here: https://oregon-city.granicus.com/MediaPlayer.php?view_id=4&clip_id=2386 Download File Full Article
ann Planning Commission on 2020-02-24 7:00 PM - Feb 24, 2020 By oregon-city.granicus.com Published On :: Mon, 24 Feb 2020 07:15:00 -0800 The agenda for Planning Commission on 2020-02-24 7:00 PM dated Monday, 24 February 2020 has been archived. Access it here: https://oregon-city.granicus.com/MediaPlayer.php?view_id=4&clip_id=2393 Download File Full Article
ann Planning Commission on 2020-03-09 7:00 PM - Mar 09, 2020 By oregon-city.granicus.com Published On :: Mon, 09 Mar 2020 07:15:00 -0800 The agenda for Planning Commission on 2020-03-09 7:00 PM dated Monday, 09 March 2020 has been archived. Access it here: https://oregon-city.granicus.com/MediaPlayer.php?view_id=4&clip_id=2400 Download File Full Article
ann Planning Commission on 2020-06-08 7:00 PM - Jun 08, 2020 By oregon-city.granicus.com Published On :: Mon, 08 Jun 2020 07:15:00 -0800 The agenda for Planning Commission on 2020-06-08 7:00 PM dated Monday, 08 June 2020 has been archived. Access it here: https://oregon-city.granicus.com/MediaPlayer.php?view_id=4&clip_id=2431 Download File Full Article
ann Planning Commission on 2020-06-22 7:00 PM - Jun 22, 2020 By oregon-city.granicus.com Published On :: Mon, 22 Jun 2020 07:15:00 -0800 The agenda for Planning Commission on 2020-06-22 7:00 PM dated Monday, 22 June 2020 has been archived. Access it here: https://oregon-city.granicus.com/MediaPlayer.php?view_id=4&clip_id=2435 Download File Full Article
ann Change to E-mini S&P Options User Defined Spreads Market Data Channel By www.cmegroup.com Published On :: Sun, 22 Sep 2024 17:13:00 -0500 Full Article Product Launch Electronic Trading (CME Globex)
ann Amsterdam police detain pro-Palestinian protesters at banned demonstration By www.cbc.ca Published On :: Sun, 10 Nov 2024 13:29:43 EST Full Article News/World
ann Ontario Liberals announce tax cuts for middle class families as part of election platform By www.cbc.ca Published On :: Tue, 12 Nov 2024 14:49:17 EST The Ontario Liberal Party is pledging to reduce the income tax rate for middle class families and eliminate provincial sales tax on hydro bills, if they win in the 2026 election. Full Article News/Canada/Toronto
ann CME Group Announces First Trades of CBL Australian Carbon Credit Unit (ACCU) Futures By www.cmegroup.com Published On :: Thu, 17 Oct 2024 20:00:00 -0500 CME Group, the world's leading derivatives marketplace, today announced its new CBL Australian Carbon Credit Unit (ACCU) futures have launched and are available for trading. A total of five... Full Article Press Release CME Group
