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Revisiting Biginelli-like Reactions: Solvent Effects, Mechanisms, Biological Applications and Correction of Several Literature Reports

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00272E, Paper
Brenno A. D. Neto, Pedro Beck, Arthur Leitão, Yasmin Santana, Jose R. Correa, Carime Vitória da Silva Rodrigues, Daniel Machado, Guilherme Matos, Luciana Machado Ramos, Claudia Cristina Gatto, Carlos Kleber Z. Andrade, Sarah Caldas
This study critically reevaluates reported Biginelli-like reactions using a Kamlet-Abboud-Taft-based solvent effect model. Surprisingly, structural misassignments were discovered in certain multicomponent reactions, leading to the identification of pseudo three-component derivatives...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Recent developments in the enzymatic modifications of steroid scaffolds

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00327F, Review Article
Open Access
Huibin Wang, Ikuro Abe
This review highlights the recent advancements in the enzymatic modifications of steroid scaffolds, emphasizing enzymatic hydroxylation, ketoreduction, dehydrogenation, enzymatic cascade reactions, and other modifications.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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DevTools Digest - Chrome 35: Updates to the Developer Tools in Chrome 35

Updates to the Chrome Developer Tools: CSS property quick search, memory stats for heap snapshots, CodeMirror upgrade and more.




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Why Mount Everest is a no-fly zone

Hurricane-force winds and frequent snowstorms are obstacles




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Corporate travel is unlikely to reach pre-Covid levels

However, with offices opening up, many airlines are seeing increased demand with an uptick for premium cabins




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First-ever gravity-defying plane swap set for April 24

Two pilots will swap planes mid-air




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Thrust reversal in aircraft

It functions by directing the thrust produced by the plane’s jet engines forward, rather than backwards




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Hope you never get into a ‘coffin corner’ while flying

This situation occurs when the aircraft’s low-speed stall and high-speed buffet meet




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Google to develop AI that takes over computers: Report

Google is developing AI technology that takes over a web browser to complete tasks such as research and shopping, The Information reported




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GitHub unveils multi-model Copilot, Spark for AI developers

Anthropic’s Claude 3.5 Sonnet will be available via GitHub Copilot starting today and Google’s Gemini 1.5 Pro will be available in the coming weeks




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Chinese researchers develop AI model for military use on back of Meta's Llama

ChatBIT was fine-tuned and "optimised for dialogue and question-answering tasks in the military field", the paper said




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Amazon's improving retail sales boost third-quarter profit, revenue beats estimates

Like its tech peers, Amazon said it expected higher capital expenditures for the foreseeable future to help develop artificial intelligence software




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OpenAI’s Whisper transcription tool used in hospitals invents things no one ever said, researchers claim

Whisper is a popular transcription tool powered by artificial intelligence, but it has a major flaw




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Doctors stress healthy lifestyle, regular check-up to prevent strokes in young adults

The webinar was held as part of The Hindu’s Wellness Series




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Tuberculosis infected 8 million people last year, the most WHO has ever tracked

The World Health Organization says more than 8 million people were diagnosed with tuberculosis last year




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Following WHO guidelines for sodium content in packaged food could prevent 3 lakh deaths in India in 10 years: study

Additionally, about 1.7 million new cardiovascular disease cases and 7,00,000 new chronic kidney disease cases could be prevented compared to current practices, the study said




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Lassa fever: Understanding the risk, response and global threat

The Lassa virus causes Lassa fever, a zoonotic disease; humans usually contract the virus through contact with food or items contaminated by the the Mastomys rat’s urine or faeces.




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Osteoporosis can shorten your life − here’s how to prevent fractures and keep bones healthy

The key to having healthy bones for a lifetime is to take some simple preventive measures – and the earlier, the better




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Can mid-level healthcare providers compensate for physician shortages in rural India?

To make up for doctor shortages, several countries around the world have introduced a cadre of MLHPs into their health systems; however, in India, mainstreaming of MLHPs has time and again been met with resistance from organised medicine 




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Severe staff shortage leaves Tamil Nadu’s obstetricians and gynaecologists overworked

Doctors are forced to take turns doing frequent 24-hour shifts — in some cases two to three 24-hour shifts a week. Inquiries with government OB-GYNs reveal that several health facilities have been short-staffed for years, and vacant posts remain unfilled




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Revealed: YouTube's India Plans

'Two in three creators in India who earn money from YouTube agree that YouTube is their primary source of revenue.'




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'Men, women, everybody, we want love'

'When something like this happens, it's just like all the weight and all the time that there was no work and the auditions were not cracking, you feel it's just worth it.'




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'I have never called him Dad'

'I have two sisters. One is 13 and the other is 17.' 'For them, their father is the director of Shahid, Omerta, Simran, Scam 1992 and Scoop.' 'For me, my father is the director of Jayate, Dil Pe Mat Le Yaar, Chhal, Yeh Kya Ho Raha Hai, three unreleased films and Woodstock Villa.''No one has seen these films.'




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'Everybody rejected me'

'I have been trying to make a movie for seven years. I got a chance only now.''I have taken my script to every office from Dharma to Tips to Eros.''I have narrated my script to every actor possible. Nobody believed me.''Because of OTT, people like me are finally getting a chance to make something.'




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'Manthan Never Looked As Good'

'The problems that the film explores still remain. It was a different time when we made the film. We were young and we thought we could change the world.'




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Revealed! Shatru To Attend Sona Wedding

'He can't remain upset for long, not with Sonakshi.'




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'Social Media Has Complicated Everything'

'I would have become a big star 11 years ago if things had worked as per my plans.'




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'Everyday Is A Struggle'

'It's a struggle for everybody, even established people are struggling.'




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60fps scrolling using pointer-events: none

Paul Lewis did an interesting article a while back about avoiding unnecessary paints through disabling hover effects as the user scrolls, which is a great approach. The down side being managing all your hover states through a parent class. UPDATE: I’ve done a follow up article which demonstrates a more robust technique. .hover .element:hover { … Continue reading "60fps scrolling using pointer-events: none"




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Rajesh Munirathnam's Journey: From Senior Developer to Leading AI-Powered Data Initiatives in Data, Analytics, and AI

Rajesh Munirathnam's journey includes his pursuit of advanced education, such as enrolling in MIT Professional Education's Applied Data Science Program, which emphasizes leveraging AI for effective decision-making




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Shaping the Future of Web Apps: Full Stack Developer's Expertise in API Design and Cloud Deployment

Naga Lalitha has become visible as someone who is changing the face of technology for industry verticals like supply chain and manufacturing.




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Revel in her verses

‘Meera’ to be staged on July 30.




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Journey up the seven hills

‘Srinivasam Prapadhye’ wove history, puranas and folklore to present Lord Venkateswara’s story.




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The never ending voyage

Sharmila Biswas seamlessly blended three dance forms in the performance.




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Skill Development - Bharat U: the ultimate B-school?

Top management talent from across the world heading to India




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Leadership: Seven myths about workplace culture

These urban legends prevent firms from getting sustainable advantage




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Pulses a worry even as kharif grain output may rise 1.5-4%

Production of pulses, some coarse cereals and groundnut seen likely hitting a 3-year low as per initial independent crop estimates; rice, cereals seen buoying overall output this season




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‘Dirty Fashion’ report reveals pollution in big brands’ supply chains

How H&M, Zara and Marks & Spencer are buying viscose from highly polluting factories in Asia. By Natasha Hurley.




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Masaba Gupta: Not your everyday wedding designer

Up, close and personal with Masaba Gupta on wedding outfits and life choices




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Developing inclusive schools [electronic resource] : pathways to success / Mel Ainscow.

Abingdon, Oxon ; New York, NY : Routledge , 2024.




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Everyday artfulness [electronic resource] : a posthuman perspective on young children's play with materials / Lucy Hill.

Oxford ; New York : Peter Lang, [2024]




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How successful schools are more than effective [electronic resource] : principals who build and sustain teacher and student wellbeing and achievement / Christopher Day, David Gurr, editors

Cham : Springer, [2024]




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Neurodevelopment in the post-pandemic world [electronic resource] : the altered trajectory of children's education, mental health, and brain development / Molly Colvin, Jennifer Linton Reesman, Tannahill Glen.

New York, NY : Oxford University Press, [2024]




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Poornima Indrajith is a revelation in the Malayalam film ‘Thuramukham’

Poornima Indrajith effortlessly transforms for the role of a lifetime in Rajeev Ravi’s opus Thuramukham




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Sathyan Sooryan on ‘Dasara’: We wanted everything to look natural

Cinematographer Sathyan Sooryan gets into the details of filming the Telugu film ‘Dasara’, from the metaphorical lighting for characters played by Nani, Keerthy Suresh and Deekshith Shetty to the extensive night portions




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Director Venu Yeldandi on ‘Balagam’: Every character stems from real-life observations

As the Telugu film ‘Balagam’ wins hearts and international awards, director Venu Yeldandi talks about how he wanted the film to reflect native culture and relationships in Sircilla, Telangana




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Vijay Deverakonda, Mrunal Thakur team up for a Telugu film

Mrunal Thakur signs her third Telugu film, which also brings together the hit trio Vijay Deverakonda, Parasuram Petla and Gopi Sunder once again




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Director Neelakanta: I worked with a bound script even 20 years ago

Discussing his new Telugu movie ‘Circle’, director Neelakanta says his style of filmmaking has changed to connect with the present generation  




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Anand Deverakonda: Vaishnavi Chaitanya’s character is the soul of ‘Baby’

‘Baby’ is the most emotional film he has done so far, says actor Anand Deverakonda, while asserting that it’s a gender-sensitive film with Vaishnavi Chaitanya’s character as its backbone




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Lenovo India registers 26.9% revenue growth in Q2

Tech major’s total revenue for all businesses was USD 621 million.



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