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Generation of sulfones utilizing β-sulfinyl esters as masked aryl sulfinates under redox-neutral conditions

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00238E, Communication
Yixin Zhang, Zhu Yang, Hongjun Yang, Xuefeng Li, Lu Yang
A method for generation of SVI sulfones from β-sulfinyl esters (SIV) under transition-metal-free non-oxidative mild conditions is presented.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Not exclusively the activity, but the sweet spot: a dehydrogenase point mutation synergistically boosts activity, substrate tolerance, thermal stability and yield

Org. Biomol. Chem., 2024, 22,3009-3018
DOI: 10.1039/D4OB00211C, Paper
Yu-Ke Cen, Lin Zhang, Yue Jiang, Xiang-Fu Meng, Yuan Li, Chao Xiang, Ya-Ping Xue, Yu-Guo Zheng
A single-point mutation of 7α-HSDH achieved the highest activity and synergistically improved substrate tolerance, thermal stability, cofactor affinity, and conversion rate.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Photogenerated chlorine radicals activate C(sp3)–H bonds of alkylbenzenes to access quinazolinones

Org. Biomol. Chem., 2024, 22,2968-2973
DOI: 10.1039/D4OB00129J, Communication
Xin-Yao Pan, Gui-Xia Sun, Fang-Ping Huang, Wen-Jian Qin, Qing-Hu Teng, Kai Wang
An Fe-catalyzed visible-light induced condensation of alkylbenzenes with anthranilamides has been developed.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A phosphamide nucleotide analog: a substrate for polymerase synthesis of DNA

Org. Biomol. Chem., 2024, 22,2963-2967
DOI: 10.1039/D4OB00089G, Communication
Jiong Meng, Qiaqia Guo, Xiaona Zhai, Song Yang, Shuai Wang, Pengcheng Wang, Debin Ji
A phosphamide nucleotide analog (dNTPγNH2) exhibited higher stability than dNTPs and can be recognized by DNA polymerases in PCR.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Revisiting Biginelli-like Reactions: Solvent Effects, Mechanisms, Biological Applications and Correction of Several Literature Reports

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00272E, Paper
Brenno A. D. Neto, Pedro Beck, Arthur Leitão, Yasmin Santana, Jose R. Correa, Carime Vitória da Silva Rodrigues, Daniel Machado, Guilherme Matos, Luciana Machado Ramos, Claudia Cristina Gatto, Carlos Kleber Z. Andrade, Sarah Caldas
This study critically reevaluates reported Biginelli-like reactions using a Kamlet-Abboud-Taft-based solvent effect model. Surprisingly, structural misassignments were discovered in certain multicomponent reactions, leading to the identification of pseudo three-component derivatives...
The content of this RSS Feed (c) The Royal Society of Chemistry




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New Generation of Highly Reactive Allylborating Agents For Cu(I)-Catalyzed Allylation of Chiral Sulfinylimines

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00291A, Paper
Michael S. Alexeev, Tatyana V. Strelkova, Michail M. Ilyin, Jr., Yulia V. Nelyubina, Ivan A. Bespalov, Michael Medvedev, Victor N Khrustalev, Nikolai Kuznetsov
The implementation of selective catalytic processes with highly active reagents is an attractive strategy that meets modern principles of sustainable development of chemistry. In the current study, we for the...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Sustainable preparation of 2-acylbenzothiazoles under the cooperation of ionic liquids and microwave irradiation

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00315B, Paper
Shoushun Wang, Mengjie Liu, Yiyuan Yue, Xiude Hu, Yalin Zhang, Guodong Shen, Ruiguo Dong, Lilong Shi, Bing Yu, Xianqiang Huang
A series of 2-acylbenzothiazole derivatives were sustainably synthesized for the first time under the cooperation of ionic liquids and microwave irradiation, metal- and extra-additives-free conditions.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Deep tech is helping airlines sustain operations during Covid

Integrated biometric-enabled frameworks for real-time test results, travel details and vaccine status are key to making air travel safe




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Insolvency of aircraft operator: default remedies.

India should adopt Cape Town Convention as part of the domestic legal framework.




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Apple Intelligence launches the iPhone into the AI era

Apple has released a free software update that will inject its first dose of artificial intelligence into its iPhone 16 line-up as the trendsetting company tries to catch up with technology’s latest craze




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Out-of-pocket expenditure on health in Kerala is highest in country despite increased State investments

National Health Accounts figures show the per capita out-of-pocket expenditure on health in Kerala stands at ₹7,889. However, Kerala also tops the list when it comes to the per capita government spending on health, at ₹4,338




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Rapid assessment of pulse polio campaign shows high vaccine coverage, highlights gaps in Chennai

Chennai accounted for nearly 21% of the non-vaccinated children, highlighting the gaps in an urban area and the need for targeted community outreach




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Should men be allowed into operation theatres when their wives are having a baby? Doctors weigh in after YouTuber’s video sparks controversy

YouTuber Irfan recently posted a video on social media that showed him cutting the umbilical cord of his newborn, in the operation theatre of a private hospital in Chennai; consent of the medical personnel involved to being videoed was another aspect doctors say needs discussion




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What is stereotactic radiation therapy for prostate cancer? How does it compare to other treatments?

Stereotactic radiotherapy uses high doses of radiation to target and kill cancer cells; it uses newer machines that can deliver very focused radiation beams




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Bridging the gap in mental healthcare services: NGOs launch dementia clinics in Hyderabad’s slums

India continues to grapple with a dearth of mental healthcare services, even as the number of persons with dementia is expected to rise over the next two decades




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Ayushman Bharat: All seniors above 70 can avail health coverage except those in Delhi, West Bengal

Senior citizens eligible for PM-JAY regardless of income; Ayushman Vaya Vandana card will help cut out-of-pocket health spends; on Ayurveda Day, PM launches initiatives to validate traditional herbal medicine, promote Indian medical systems




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Glioblastoma: why immunotherapy may offer hope for brain cancer patients

Recent trials have shown that immunotherapy can safely be delivered through injections into the cerebrospinal fluid; scientists are now exploring how to adapt these methods to penetrate the tumour more effectively




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'Scale at which this scam operates is shocking'

'There is an eminently fertile ground that perpetrators must be finding in our society.'




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The Girl From Laapataa Ladies, Heeramandi

'I joined Heeramandi's shoot right after completing Laapataa Ladies.''When I landed on the Heeramandi sets, I was like "Oh my God!" because this was for the first time I was seeing such a huge set in my life.'




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'Heeramandi wasn't another sex scene'

'While I was performing it, I had a weird feeling that people would love it because it's so bizarre.'




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Role of soft skills in industrial and product design career success: Preparing next generation of designers

Kushal Karwa, a thought leader in design education, emphasizes the need for integrating soft skills training into career preparation programs to help young designers thrive in real-world environments.




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Expert clinic director successfully implements half-hour scheduling system, boosting therapist productivity

As word spread about the success of the half-hour schedule, some early adopters became curious after the clinic director and the team showcased the benefits.




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Empowering Pharma with AI, Analytics: Accelerating Drug Discovery, Optimizing Healthcare Outcomes By Rajesh Munirathnam

While AI is making significant strides in healthcare, it is also transforming other industries, such as insurance.




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Kanak Rele was a doyenne of Mohiniyattam who redefined and reinterpreted the traditional dance form of Kerala

In her passing, Mohiniyattam has lost a crusader who widened its repertoire and gave it a new aesthetics rooted in Kerala




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Risk Management: Learning to tackle operational surprises

Knowing what can go wrong is key to getting things done right




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Hierarchy of desire in organisations




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Realigning HR in the post-Covid era

Handling the organisation’s ‘resources’ in a ‘humane’ manner is the way forward for HR




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Cooperatives are the solution for hunger, farmers’ woes: Brazil Agriculture Minister

Minister Carlos Fávaro offers transfer of technology to India to boost cooperative production




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Centre increases Fair and Remunerative Price of sugarcane; will be in force from October 1

Minister Anurag Thakur says the decision will benefit 5 crore farmers, including family members, and lakhs of other persons involved in the sugar sector




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PM Modi lauds role of cooperatives in farmers’ welfare

PM Modi made his comments while inaugurating the pilot project of “world’s largest grain storage plan”, which is being done across 11 States




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Guaranteed MSP is an ethical imperative

Farmers hardly get 30% of the price paid by the consumers. This will increase if MSP is guaranteed




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Ask LukeW: Text Generation Differences

As the number of highly capable large language models (LLMs) released continues to quickly increase, I added the ability to test new models when they become available in the Ask Luke conversational interface on this site.

For context there's a number of places in the Ask Luke pipeline that make use of AI models to transform, clean, embed, retrieve, generate content and more. I put together a short video that explains how this pipeline is constructed and why if you're interested.

Specifically for the content generation step, once the right content is found, ranked, and assembled into a set of instructions, I can select which large language model to send these instructions to. Every model gets the same instructions unless they can support a larger context window. In which case they might get more ranked results than a model with a smaller context size.

Despite the consistent instructions, switching LLMs can have a very big impact on answer generation. I'll leave you to guess which of these two answers is powered by OpenAI's GPT-4 and which one comes from Antrhopic's new (this week) Claude 3.5 Sonnet.

Some of you might astutely point out that the instruction set could be altered in specific ways when changing models. Recently, we've found the most advanced LLMs to be more interchangeable than before. But there's still differences in how they generate content as you can clearly see in the example above. Which one is best though... could soon be a matter of personal preference.

Thanks to Yangguang Li and Sam for the dev help on this feature.




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A Proliferation of Terms

When working through the early stages of a product design, it's common that labels for objects and actions emerge organically. No one is overly concerned about making these labels consistent (yet). But if this proliferation of terms doesn't get reined in early, both product design and strategy get harder.

Do we call it a library, a folder, a collection, a workspace, a section, a category, a topic? How about a document, page, file, entry, article, worksheet? And.. what's the difference? While these kinds of decisions might not be front and center when working out designs for a product or feature, they can impact a lot.

For starters, having clear definitions for concepts helps keep teams on the same page. When engineering works on implementing a new object type, they're aligned with what design is thinking, which is what the sales team is pitching potential customers on. Bringing a product to life is hard enough, why complicate things by using different terms for similar things or vice versa?

Inconsistent terms are obviously also a comprehension issue for the people using our products. "Here's it's called a Document, there it's called an Article. Are those the same?" Additionally, undefined terms often lead to miscellaneous bins in our user interfaces. "What's inside Explore?" When the definition of objects and actions isn't clear, what choice do we have but to drop them into vague sounding containers like Discover?

The more a product gets developed (especially by bigger teams) the more things can diverge because people's mental model of what terms mean can vary a lot. So it's really useful to proactively put together a list of the objects and actions that make up an application and draft some simple one-liner definitions for each. These lists almost always kick off useful high-level discussions within teams on what we're building and for who. Being forced to define things requires you to think them through: what is this feature doing and why?

And of course, consistent labels also ease comprehension for users. Once people learn what something means, they'll be able to apply that knowledge elsewhere -instead of having to contend with mystery meat navigation.




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A wedding, funeral – and moving on

Celebrity Chef Gaggan Anand on food philosophies and handling fame




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Resisting neoliberal schooling [electronic resource] : dismantling the rubricization and corporatization of higher education / edited by Anthony J. Nocella II.

New York : Peter Lang , 2024.




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Protests against the screening of ‘The Kerala Story’ in Kochi

The screenings at two other multiplexes in Kochi were cancelled




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Uttar Pradesh declares The Kerala Story tax-free, CM Yogi to watch with entire cabinet

Uttar Pradesh becomes the second State after Madhya Pradesh to make the controversial film tax-free




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Vijay Deverakonda, Mrunal Thakur team up for a Telugu film

Mrunal Thakur signs her third Telugu film, which also brings together the hit trio Vijay Deverakonda, Parasuram Petla and Gopi Sunder once again




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Anand Deverakonda: Vaishnavi Chaitanya’s character is the soul of ‘Baby’

‘Baby’ is the most emotional film he has done so far, says actor Anand Deverakonda, while asserting that it’s a gender-sensitive film with Vaishnavi Chaitanya’s character as its backbone




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How cyberattackers tried to execute a $15-million ransomware attack

Maze operators use virtual machines to spread the ransomware



  • Computers & Laptops

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HP launches new generation of AI-powered Spectre laptops in India



  • Computers & Laptops

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Absent history : the untold story of Special Branch Operations in Singapore, 1915-1942 / Ban Kah Choon.

Singapore : Horizon Books, 2002.




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A field guide to tropical reef fishes of the Indo-Pacific / Gerald R. Allen ; illustrated by Roger Swainston & Jill Ruse.

Tokyo ; Rutland, Vermont ; Singapore : Tuttle Publishing, 2020.




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Flora und Fauna in fantastischen Welten : Symposium 2019 in Bonn = Flora and fauna in fantastic worlds / herausgegeben von Denise Burkhard, Marion Gymnich und Dieter Petzold in Verbindung mit Adelheid Kegler [and five others].

Berlin : Peter Lang, [2020]




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The real thing : Reflections on a literary form / Terry Eagleton.

New Haven ; London : Yale University Press, [2024]




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Silent operas = (Wusheng xi) / by Li Yu ; edited by Patrick Hanan.

Hong Kong : Research Centre for Translation, Chinese University of Hong Kong, 1990.




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A new literary history of modern China / edited by David Der-Wei Wang.

Cambridge, Massachusetts : The Belknap Press of Harvard University Press, 2017.




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Anthology of Japanese literature from the earliest era to the mid-nineteenth century / compiled and edited by Donald Keene.

New York : Grove Press, 1960.




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Modern Japanese literature : an anthology / compiled and edited by Donald Keene.

New York : Grove Press, 1960.




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Dawn to the West : Japanese literature of the modern era / Donald Keene.

New York : Henry Holt and Company, 1987.