era Generation of sulfones utilizing β-sulfinyl esters as masked aryl sulfinates under redox-neutral conditions By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00238E, CommunicationYixin Zhang, Zhu Yang, Hongjun Yang, Xuefeng Li, Lu YangA method for generation of SVI sulfones from β-sulfinyl esters (SIV) under transition-metal-free non-oxidative mild conditions is presented.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
era Not exclusively the activity, but the sweet spot: a dehydrogenase point mutation synergistically boosts activity, substrate tolerance, thermal stability and yield By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, 22,3009-3018DOI: 10.1039/D4OB00211C, PaperYu-Ke Cen, Lin Zhang, Yue Jiang, Xiang-Fu Meng, Yuan Li, Chao Xiang, Ya-Ping Xue, Yu-Guo ZhengA single-point mutation of 7α-HSDH achieved the highest activity and synergistically improved substrate tolerance, thermal stability, cofactor affinity, and conversion rate.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
era Photogenerated chlorine radicals activate C(sp3)–H bonds of alkylbenzenes to access quinazolinones By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, 22,2968-2973DOI: 10.1039/D4OB00129J, CommunicationXin-Yao Pan, Gui-Xia Sun, Fang-Ping Huang, Wen-Jian Qin, Qing-Hu Teng, Kai WangAn Fe-catalyzed visible-light induced condensation of alkylbenzenes with anthranilamides has been developed.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
era A phosphamide nucleotide analog: a substrate for polymerase synthesis of DNA By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, 22,2963-2967DOI: 10.1039/D4OB00089G, CommunicationJiong Meng, Qiaqia Guo, Xiaona Zhai, Song Yang, Shuai Wang, Pengcheng Wang, Debin JiA phosphamide nucleotide analog (dNTPγNH2) exhibited higher stability than dNTPs and can be recognized by DNA polymerases in PCR.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
era Revisiting Biginelli-like Reactions: Solvent Effects, Mechanisms, Biological Applications and Correction of Several Literature Reports By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00272E, PaperBrenno A. D. Neto, Pedro Beck, Arthur Leitão, Yasmin Santana, Jose R. Correa, Carime Vitória da Silva Rodrigues, Daniel Machado, Guilherme Matos, Luciana Machado Ramos, Claudia Cristina Gatto, Carlos Kleber Z. Andrade, Sarah CaldasThis study critically reevaluates reported Biginelli-like reactions using a Kamlet-Abboud-Taft-based solvent effect model. Surprisingly, structural misassignments were discovered in certain multicomponent reactions, leading to the identification of pseudo three-component derivatives...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
era New Generation of Highly Reactive Allylborating Agents For Cu(I)-Catalyzed Allylation of Chiral Sulfinylimines By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00291A, PaperMichael S. Alexeev, Tatyana V. Strelkova, Michail M. Ilyin, Jr., Yulia V. Nelyubina, Ivan A. Bespalov, Michael Medvedev, Victor N Khrustalev, Nikolai KuznetsovThe implementation of selective catalytic processes with highly active reagents is an attractive strategy that meets modern principles of sustainable development of chemistry. In the current study, we for the...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
era Sustainable preparation of 2-acylbenzothiazoles under the cooperation of ionic liquids and microwave irradiation By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00315B, PaperShoushun Wang, Mengjie Liu, Yiyuan Yue, Xiude Hu, Yalin Zhang, Guodong Shen, Ruiguo Dong, Lilong Shi, Bing Yu, Xianqiang HuangA series of 2-acylbenzothiazole derivatives were sustainably synthesized for the first time under the cooperation of ionic liquids and microwave irradiation, metal- and extra-additives-free conditions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
era Deep tech is helping airlines sustain operations during Covid By www.thehindubusinessline.com Published On :: Mon, 24 Jan 2022 09:51:21 +0530 Integrated biometric-enabled frameworks for real-time test results, travel details and vaccine status are key to making air travel safe Full Article Flight Plan
era Insolvency of aircraft operator: default remedies. By www.thehindubusinessline.com Published On :: Sun, 17 Apr 2022 20:19:27 +0530 India should adopt Cape Town Convention as part of the domestic legal framework. Full Article Flight Plan
era Apple Intelligence launches the iPhone into the AI era By www.thehindu.com Published On :: Tue, 29 Oct 2024 08:26:09 +0530 Apple has released a free software update that will inject its first dose of artificial intelligence into its iPhone 16 line-up as the trendsetting company tries to catch up with technology’s latest craze Full Article Technology
era Out-of-pocket expenditure on health in Kerala is highest in country despite increased State investments By www.thehindu.com Published On :: Sun, 20 Oct 2024 18:13:50 +0530 National Health Accounts figures show the per capita out-of-pocket expenditure on health in Kerala stands at ₹7,889. However, Kerala also tops the list when it comes to the per capita government spending on health, at ₹4,338 Full Article Health
era Rapid assessment of pulse polio campaign shows high vaccine coverage, highlights gaps in Chennai By www.thehindu.com Published On :: Tue, 22 Oct 2024 15:41:02 +0530 Chennai accounted for nearly 21% of the non-vaccinated children, highlighting the gaps in an urban area and the need for targeted community outreach Full Article Chennai
era Should men be allowed into operation theatres when their wives are having a baby? Doctors weigh in after YouTuber’s video sparks controversy By www.thehindu.com Published On :: Tue, 22 Oct 2024 21:52:17 +0530 YouTuber Irfan recently posted a video on social media that showed him cutting the umbilical cord of his newborn, in the operation theatre of a private hospital in Chennai; consent of the medical personnel involved to being videoed was another aspect doctors say needs discussion Full Article Health
era What is stereotactic radiation therapy for prostate cancer? How does it compare to other treatments? By www.thehindu.com Published On :: Mon, 28 Oct 2024 17:06:09 +0530 Stereotactic radiotherapy uses high doses of radiation to target and kill cancer cells; it uses newer machines that can deliver very focused radiation beams Full Article Health
era Bridging the gap in mental healthcare services: NGOs launch dementia clinics in Hyderabad’s slums By www.thehindu.com Published On :: Tue, 29 Oct 2024 00:15:10 +0530 India continues to grapple with a dearth of mental healthcare services, even as the number of persons with dementia is expected to rise over the next two decades Full Article Hyderabad
era Ayushman Bharat: All seniors above 70 can avail health coverage except those in Delhi, West Bengal By www.thehindu.com Published On :: Tue, 29 Oct 2024 14:16:54 +0530 Senior citizens eligible for PM-JAY regardless of income; Ayushman Vaya Vandana card will help cut out-of-pocket health spends; on Ayurveda Day, PM launches initiatives to validate traditional herbal medicine, promote Indian medical systems Full Article India
era Glioblastoma: why immunotherapy may offer hope for brain cancer patients By www.thehindu.com Published On :: Tue, 05 Nov 2024 09:15:00 +0530 Recent trials have shown that immunotherapy can safely be delivered through injections into the cerebrospinal fluid; scientists are now exploring how to adapt these methods to penetrate the tumour more effectively Full Article Health
era 'Scale at which this scam operates is shocking' By www.rediff.com Published On :: Wed, 03 Jan 2024 10:13:00 +0530 'There is an eminently fertile ground that perpetrators must be finding in our society.' Full Article
era The Girl From Laapataa Ladies, Heeramandi By www.rediff.com Published On :: Mon, 06 May 2024 15:02:42 +0530 'I joined Heeramandi's shoot right after completing Laapataa Ladies.''When I landed on the Heeramandi sets, I was like "Oh my God!" because this was for the first time I was seeing such a huge set in my life.' Full Article Pratibha Ranta Laapataa Ladies Heeramandi Pratibha Ranta Interview Kiran Rao Aamir Khan Sanjay Leela Bhansali Rediff Interview
era 'Heeramandi wasn't another sex scene' By www.rediff.com Published On :: Thu, 16 May 2024 12:10:40 +0530 'While I was performing it, I had a weird feeling that people would love it because it's so bizarre.' Full Article
era Role of soft skills in industrial and product design career success: Preparing next generation of designers By www.dnaindia.com Published On :: Wed, 30 Oct 2024 07:07:00 GMT Kushal Karwa, a thought leader in design education, emphasizes the need for integrating soft skills training into career preparation programs to help young designers thrive in real-world environments. Full Article Technology
era Expert clinic director successfully implements half-hour scheduling system, boosting therapist productivity By www.dnaindia.com Published On :: Mon, 04 Nov 2024 09:24:00 GMT As word spread about the success of the half-hour schedule, some early adopters became curious after the clinic director and the team showcased the benefits. Full Article Technology
era Empowering Pharma with AI, Analytics: Accelerating Drug Discovery, Optimizing Healthcare Outcomes By Rajesh Munirathnam By www.dnaindia.com Published On :: Mon, 04 Nov 2024 12:06:35 GMT While AI is making significant strides in healthcare, it is also transforming other industries, such as insurance. Full Article Technology
era Kanak Rele was a doyenne of Mohiniyattam who redefined and reinterpreted the traditional dance form of Kerala By www.thehindu.com Published On :: Thu, 23 Feb 2023 15:45:43 +0530 In her passing, Mohiniyattam has lost a crusader who widened its repertoire and gave it a new aesthetics rooted in Kerala Full Article Dance
era Risk Management: Learning to tackle operational surprises By www.thehindubusinessline.com Published On :: Tue, 23 Jun 2015 22:31:50 +0530 Knowing what can go wrong is key to getting things done right Full Article New Manager
era Hierarchy of desire in organisations By www.thehindubusinessline.com Published On :: Thu, 17 Jan 2019 10:36:57 +0530 Full Article New Manager
era Realigning HR in the post-Covid era By www.thehindubusinessline.com Published On :: Fri, 12 Jun 2020 16:06:13 +0530 Handling the organisation’s ‘resources’ in a ‘humane’ manner is the way forward for HR Full Article New Manager
era Cooperatives are the solution for hunger, farmers’ woes: Brazil Agriculture Minister By www.thehindu.com Published On :: Thu, 02 Nov 2023 20:37:59 +0530 Minister Carlos Fávaro offers transfer of technology to India to boost cooperative production Full Article Agri-Business
era Centre increases Fair and Remunerative Price of sugarcane; will be in force from October 1 By www.thehindu.com Published On :: Thu, 22 Feb 2024 00:23:52 +0530 Minister Anurag Thakur says the decision will benefit 5 crore farmers, including family members, and lakhs of other persons involved in the sugar sector Full Article India
era PM Modi lauds role of cooperatives in farmers’ welfare By www.thehindu.com Published On :: Sat, 24 Feb 2024 12:29:43 +0530 PM Modi made his comments while inaugurating the pilot project of “world’s largest grain storage plan”, which is being done across 11 States Full Article India
era Guaranteed MSP is an ethical imperative By www.thehindu.com Published On :: Wed, 20 Mar 2024 01:53:11 +0530 Farmers hardly get 30% of the price paid by the consumers. This will increase if MSP is guaranteed Full Article Comment
era Ask LukeW: Text Generation Differences By www.lukew.com Published On :: Fri, 21 Jun 2024 00:00:00 +0000 As the number of highly capable large language models (LLMs) released continues to quickly increase, I added the ability to test new models when they become available in the Ask Luke conversational interface on this site. For context there's a number of places in the Ask Luke pipeline that make use of AI models to transform, clean, embed, retrieve, generate content and more. I put together a short video that explains how this pipeline is constructed and why if you're interested. Specifically for the content generation step, once the right content is found, ranked, and assembled into a set of instructions, I can select which large language model to send these instructions to. Every model gets the same instructions unless they can support a larger context window. In which case they might get more ranked results than a model with a smaller context size. Despite the consistent instructions, switching LLMs can have a very big impact on answer generation. I'll leave you to guess which of these two answers is powered by OpenAI's GPT-4 and which one comes from Antrhopic's new (this week) Claude 3.5 Sonnet. Some of you might astutely point out that the instruction set could be altered in specific ways when changing models. Recently, we've found the most advanced LLMs to be more interchangeable than before. But there's still differences in how they generate content as you can clearly see in the example above. Which one is best though... could soon be a matter of personal preference. Thanks to Yangguang Li and Sam for the dev help on this feature. Full Article
era A Proliferation of Terms By www.lukew.com Published On :: Tue, 23 Jul 2024 00:00:00 +0000 When working through the early stages of a product design, it's common that labels for objects and actions emerge organically. No one is overly concerned about making these labels consistent (yet). But if this proliferation of terms doesn't get reined in early, both product design and strategy get harder. Do we call it a library, a folder, a collection, a workspace, a section, a category, a topic? How about a document, page, file, entry, article, worksheet? And.. what's the difference? While these kinds of decisions might not be front and center when working out designs for a product or feature, they can impact a lot. For starters, having clear definitions for concepts helps keep teams on the same page. When engineering works on implementing a new object type, they're aligned with what design is thinking, which is what the sales team is pitching potential customers on. Bringing a product to life is hard enough, why complicate things by using different terms for similar things or vice versa? Inconsistent terms are obviously also a comprehension issue for the people using our products. "Here's it's called a Document, there it's called an Article. Are those the same?" Additionally, undefined terms often lead to miscellaneous bins in our user interfaces. "What's inside Explore?" When the definition of objects and actions isn't clear, what choice do we have but to drop them into vague sounding containers like Discover? The more a product gets developed (especially by bigger teams) the more things can diverge because people's mental model of what terms mean can vary a lot. So it's really useful to proactively put together a list of the objects and actions that make up an application and draft some simple one-liner definitions for each. These lists almost always kick off useful high-level discussions within teams on what we're building and for who. Being forced to define things requires you to think them through: what is this feature doing and why? And of course, consistent labels also ease comprehension for users. Once people learn what something means, they'll be able to apply that knowledge elsewhere -instead of having to contend with mystery meat navigation. Full Article
era A wedding, funeral – and moving on By www.thehindubusinessline.com Published On :: Thu, 25 Apr 2019 16:31:55 +0530 Celebrity Chef Gaggan Anand on food philosophies and handling fame Full Article Luxe
era Resisting neoliberal schooling [electronic resource] : dismantling the rubricization and corporatization of higher education / edited by Anthony J. Nocella II. By darius.uleth.ca Published On :: New York : Peter Lang , 2024. Full Article
era Protests against the screening of ‘The Kerala Story’ in Kochi By www.thehindu.com Published On :: Fri, 05 May 2023 12:40:29 +0530 The screenings at two other multiplexes in Kochi were cancelled Full Article Kerala
era Uttar Pradesh declares The Kerala Story tax-free, CM Yogi to watch with entire cabinet By www.thehindu.com Published On :: Tue, 09 May 2023 10:44:48 +0530 Uttar Pradesh becomes the second State after Madhya Pradesh to make the controversial film tax-free Full Article Entertainment
era Vijay Deverakonda, Mrunal Thakur team up for a Telugu film By www.thehindu.com Published On :: Wed, 14 Jun 2023 14:15:22 +0530 Mrunal Thakur signs her third Telugu film, which also brings together the hit trio Vijay Deverakonda, Parasuram Petla and Gopi Sunder once again Full Article Movies
era Anand Deverakonda: Vaishnavi Chaitanya’s character is the soul of ‘Baby’ By www.thehindu.com Published On :: Tue, 11 Jul 2023 14:47:39 +0530 ‘Baby’ is the most emotional film he has done so far, says actor Anand Deverakonda, while asserting that it’s a gender-sensitive film with Vaishnavi Chaitanya’s character as its backbone Full Article Movies
era How cyberattackers tried to execute a $15-million ransomware attack By www.thehindubusinessline.com Published On :: Wed, 23 Sep 2020 14:43:49 +0530 Maze operators use virtual machines to spread the ransomware Full Article Computers & Laptops
era HP launches new generation of AI-powered Spectre laptops in India By www.thehindubusinessline.com Published On :: Tue, 14 Jun 2022 16:00:49 +0530 Full Article Computers & Laptops
era Absent history : the untold story of Special Branch Operations in Singapore, 1915-1942 / Ban Kah Choon. By encore.st-andrews.ac.uk Published On :: Singapore : Horizon Books, 2002. Full Article
era A field guide to tropical reef fishes of the Indo-Pacific / Gerald R. Allen ; illustrated by Roger Swainston & Jill Ruse. By encore.st-andrews.ac.uk Published On :: Tokyo ; Rutland, Vermont ; Singapore : Tuttle Publishing, 2020. Full Article
era Flora und Fauna in fantastischen Welten : Symposium 2019 in Bonn = Flora and fauna in fantastic worlds / herausgegeben von Denise Burkhard, Marion Gymnich und Dieter Petzold in Verbindung mit Adelheid Kegler [and five others]. By encore.st-andrews.ac.uk Published On :: Berlin : Peter Lang, [2020] Full Article
era The real thing : Reflections on a literary form / Terry Eagleton. By encore.st-andrews.ac.uk Published On :: New Haven ; London : Yale University Press, [2024] Full Article
era Silent operas = (Wusheng xi) / by Li Yu ; edited by Patrick Hanan. By encore.st-andrews.ac.uk Published On :: Hong Kong : Research Centre for Translation, Chinese University of Hong Kong, 1990. Full Article
era A new literary history of modern China / edited by David Der-Wei Wang. By encore.st-andrews.ac.uk Published On :: Cambridge, Massachusetts : The Belknap Press of Harvard University Press, 2017. Full Article
era Anthology of Japanese literature from the earliest era to the mid-nineteenth century / compiled and edited by Donald Keene. By encore.st-andrews.ac.uk Published On :: New York : Grove Press, 1960. Full Article
era Modern Japanese literature : an anthology / compiled and edited by Donald Keene. By encore.st-andrews.ac.uk Published On :: New York : Grove Press, 1960. Full Article
era Dawn to the West : Japanese literature of the modern era / Donald Keene. By encore.st-andrews.ac.uk Published On :: New York : Henry Holt and Company, 1987. Full Article