Javanese Gamelan-New and Traditional:An afternoon of Javanese Gamelan featuring a variety of works for traditional gamelan instruments.Midiyanto, director Admission to all Noon Concerts is free. Registration is recommended at music.berkeley.edu/register.Safety The UC Berkeley Department of Music is committed to the health and safety of our students, staff, and patrons. Measures to protect concertgoers and musicians will be informed by state, local, and UC Berkeley Public Health policies and are subject to change. Social distancing, masks, and proof of COVID 19 vaccination may be required. UC Berkeley does not promise or guarantee that all patrons or employees on site are vaccinated. Unvaccinated individuals may be present as a result of exemptions, exceptions, fraudulent verification, or checker error. None of these precautions eliminate the risk of exposure to COVID-19. Registration is strongly encouraged for noon concerts at music.berkeley.edu/register.Accessibility If you require an accommodation for effective communication (ASL interpreting/CART captioning, alternative media formats, etc.) or information about campus mobility access features in order to fully participate in this event, please contact the Hertz Hall Manager at 510.642.4864 or hertzhallmgr@berkeley.edu. with as much advance notice as possible and at least 7-10 days in advance of the event. Facebook: @ucbmusicdept Instagram: @ucberkeleymusic  Twitter @ucbmusicdept Youtube: Berkeley Music YouTube channel

If American Evangelical Christians want any moral legs to stand on in the sexuality debate, we must own up to our sordid racial past.

On September 15, 2021, US Defense Secretary Lloyd Austin ordered all military personnel, Defense Department civilian officials and contractors to report any symptoms of Havana syndrome, a mysterious disease that affected US diplomatic missions in many countries around the world. Reference: The mysterious disease manifested itself for the first time in 2016 in Havana, Cuba, where it literally wiped out the staff of the US Embassy. The victims reported that at first they heard strange grinding and ringing sounds, and then they either lost consciousness, or began to experience severe migraines, dizziness and disorientation. The diplomatic mission had to be closed, and the personnel had to be repatriated. At least 59 Americans in Cuba and China have been screened or treated for the unknown illness. The total number of patients amounts to at least 130 people.

Timur Ivanov, Russian Deputy Defence Minister, was arrested on April 23 in the case of bribery. He will remain in custody before June 2024. A Moscow court sent Deputy Defence Minister Timur Ivanov to a pre-trial detention centre. He was arrested for two months, until June 23. Ivanov was charged under Part 6 of Art. 290 of the Criminal Code (receiving a bribe on an especially large scale). According to investigators, Ivanov entered into a "criminal conspiracy with third parties to commit a crime and received a large bribe in the form of property services provided during contracting and subcontracting works for the needs of the Defence Ministry.”

Russia's fibre optic controlled Knyaz Vandal (Prince Vandal) drone struck a column of the Armed Forces of Ukraine (AFU) in the Kursk region of Russia. The attack was captured on video. The recording shows the drone flying at high speed over an asphalt road. It slows down and descends slightly when approaching an intersection. Several Ukrainian vehicles with ammunition can be seen driving in its direction. Knyaz Vandal flies up to one of the vehicles and crashes into it to explode.  Fiber optic controlled UAVs are a revolutionary weapon. According to military analyst and co-founder of Vatfor information and analytical project, Sergey Poletayev, drones controlled via fibre optic appeared as part of the scientific and technological revolution. The invention of such drones can be compared to the advent of artillery.

When flying at full speed, Russia's state-of-the-art Avangard hypersonic vehicle is invisible to radar. “This is the only hypersonic unit in the world that can be used at intercontinental range and has a speed of Mach 28. In a nutshell, this is  a vehicle to deliver conventional or nuclear weapons that flies in the form of a fireball as its surface heats up to colossal temperatures at such speed producing plasma on the surface of the vehicle,” Yuri Knutov military expert, director of the Museum of Air Defense Forces Yuri Knutov told lenta.ru publication.  Plasma absorbs electromagnetic radiation making the unit invisible to radar, the expert added. 

PPDS, the exclusive global provider of Philips professional displays, has announced that Telelogos software has been approved as the very first remote device management solution for the new Philips Tableaux range of Advanced Colour ePaper displays.

According to Forbes, the global smart retail market size is expected to grow at a CAGR of 29.1% by 2030. DENSO accompanies retailers into the future with RFID.

By Jeremy Landau, freelance writer.

Retail's dynamic environment is seeing a real shift, driven by the integration of advanced software solutions. This goes beyond a mere technological upgrade – it's about completely transforming the customer experience.

In anticipation of the upcoming Retail Technology Show 2024 in London, scheduled between April 24th and the 25th, Advantech is showcasing the next generation of products targeted to this industry.

Avantra, provider of AIOps and automation solutions for SAP environments, was a prominent participant at the recent SAP Sapphire events held in Orlando and Barcelona. The company unveiled its latest AI capabilities and highlighted its pivotal role in enabling organizations to transition from manual operations to advanced automation.

Couchbase, Inc., the cloud database platform company, has launched Capella Columnar on AWS, which helps organisations streamline the development of adaptive applications by enabling real-time data analysis alongside operational workloads within a single database platform.

Virginia Tech communication professor Megan Duncan discusses why United States presidential candidates Donald Trump and Kamala Harris focused on podcasts in their voter outreach, and what benefits such media bring.

[Sports] :
The North Korean women's football team defeated the world's top ranked U.S. squad in the semifinals of the 2024 FIFA U-20 Women's World Cup under way in Colombia, moving a step closer to winning their third World Cup title. North Korea claimed a one-nil victory over the U.S. in the ...

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On the morning of October 18, at Yeoido KBS HallKBS WORLD Radio filmed K-pop stars making their way to attend rehearsals for Music Bank.

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The structure of Ni3V2O8 was studied using X-ray diffraction at temperatures of 299 and 1323 K. No phase transition at high temperature is observed. The variation in V—O bond length is small as compared with the Ni—O bond due to its high rigidity.

Nickel orthovanadate is a promising material with potential applications in energy storage and photocatalytic devices. The crystal structure of Ni3V2O8 at 299 (3) K and 1323 (8) K was studied using X-ray powder diffraction. The sample was a single-phase orthorhombic kagome-staircase-Ni3(VO4)2-type structure (space group Cmca) at both temperatures. The phase purity and morphology was studied using energy-dispersive X-ray spectroscopy and scanning electron microscopy. The refined unit-cell parameters at 299 (3) K are a = 5.93384 (4) Å, b = 11.38318 (7) Å and c = 8.23818 (5) Å, and at 1323 (8) K are a = 6.02077 (7) Å, b = 11.48838 (7) Å and c = 8.32611 (9) Å. The obtained results indicate thermal expansion anisotropy, with a largest expansivity along a. Variations in Ni—O and V—O bonds with temperature are observed. The variation in the Ni—O bond is about one order higher in magnitude than that of the V—O bond, signifying the high rigidity of V—O bonds. The unit-cell size variations with rising effective ionic volume of the divalent A ion in the A3B2O8 family [A = Ni, Mg, Zn, Co, Mn (experimental data) and also A = Cu, Cd (theoretical data), B = V or As] are analyzed. Based on experimental and theoretical data, trends within the family are observed and the unit-cell size for reported solid solution of nickel (87%) and copper (13%) mixture in (Ni1–xCux)3V2O8 are predicted. Predictions are also provided for some hypothetical A3B2O8 ternary compound and solid solutions.

The L-edge EXAFS of the entire set of lanthanide oxides were collected and modeled, taking into consideration the aggregation of inequivalent absorbing sites, geometric parameterization of the crystal lattice and multielectron excitation removal.

In the title compound, the tellurium(VI) and vanadium(V) atoms are statistically disordered over two of the ten metal-atom sites in the unprotonated [TeV9O28]5– heteropolyanion.

In recent years, China's advanced light sources have entered a period of rapid construction and development. As modern X-ray detectors and data acquisition technologies advance, these facilities are expected to generate massive volumes of data annually, presenting significant challenges in data management and utilization. These challenges encompass data storage, metadata handling, data transfer and user data access. In response, the Data Organization Management Access Software (DOMAS) has been designed as a framework to address these issues. DOMAS encapsulates four fundamental modules of data management software, including metadata catalogue, metadata acquisition, data transfer and data service. For light source facilities, building a data management system only requires parameter configuration and minimal code development within DOMAS. This paper firstly discusses the development of advanced light sources in China and the associated demands and challenges in data management, prompting a reconsideration of data management software framework design. It then outlines the architecture of the framework, detailing its components and functions. Lastly, it highlights the application progress and effectiveness of DOMAS when deployed for the High Energy Photon Source (HEPS) and Beijing Synchrotron Radiation Facility (BSRF).

A state-of-the-art multilayer deposition system with a 4200 mm-long linear substrate translator housed within an ultra-high vacuum chamber has been developed. This instrument is engineered to produce single and multilayer coatings, accommodating mirrors up to 2000 mm in length through the utilization of eight rectangular cathodes. To ensure the quality and reliability of the coatings, the system incorporates various diagnostic tools for in situ thickness uniformity and stress measurement. Furthermore, the system features an annealing process capable of heating up to 700°C within the load-lock chamber. The entire operation, including pump down, deposition and venting processes, is automated through user-friendly software. In addition, all essential log data, power of sputtering source, working pressure and motion positions are automatically stored for comprehensive data analysis. Preliminary commissioning results demonstrate excellent lateral film thickness uniformity, achieving 0.26% along the translation direction over 1500 mm in dynamic mode. The multilayer deposition system is poised for use in fabricating periodic, lateral-graded and depth-graded multilayers, specifically catering to the beamlines for diverse scientific applications at Diamond Light Source.

Beauveriolides, including the main beauveriolide I {systematic name: (3R,6S,9S,13S)-9-benzyl-13-[(2S)-hexan-2-yl]-6-methyl-3-(2-methyl­prop­yl)-1-oxa-4,7,10-tri­aza­cyclo­tridecane-2,5,8,11-tetrone, C27H41N3O5}, are a series of cyclo­depsipeptides that have shown promising results in the treatment of Alzheimer's disease and in the prevention of foam cell formation in atherosclerosis. Their crystal structure studies have been difficult due to their tiny crystal size and fibre-like morphology, until now. Recent developments in 3D electron diffraction methodology have made it possible to accurately study the crystal structures of submicron crystals by overcoming the problems of beam sensitivity and dynamical scattering. In this study, the absolute structure of beauveriolide I was determined by 3D electron diffraction. The cyclo­dep­si­peptide crystallizes in the space group I2 with lattice parameters a = 40.2744 (4), b = 5.0976 (5), c = 27.698 (4) Å and β = 105.729 (6)°. After dynamical refinement, its absolute structure was determined by comparing the R factors and calculating the z-scores of the two possible enanti­omorphs of beauveriolide I.

The validation of structural models obtained by macromolecular X-ray crystallography against experimental diffraction data, whether before deposition into the PDB or after, is typically carried out exclusively against the merged data that are eventually archived along with the atomic coordinates. It is shown here that the availability of unmerged reflection data enables valuable additional analyses to be performed that yield improvements in the final models, and tools are presented to implement them, together with examples of the results to which they give access. The first example is the automatic identification and removal of image ranges affected by loss of crystal centering or by excessive decay of the diffraction pattern as a result of radiation damage. The second example is the `reflection-auditing' process, whereby individual merged data items showing especially poor agreement with model predictions during refinement are investigated thanks to the specific metadata (such as image number and detector position) that are available for the corresponding unmerged data, potentially revealing previously undiagnosed instrumental, experimental or processing problems. The third example is the calculation of so-called F(early) − F(late) maps from carefully selected subsets of unmerged amplitude data, which can not only highlight the location and extent of radiation damage but can also provide guidance towards suitable fine-grained parametrizations to model the localized effects of such damage.

Vancomycin is a glycopeptide antibiotic that for decades has been a mainstay of treatment for persistent bacterial infections. However, the spread of antibiotic resistance threatens its continued utility. In particular, vancomycin-resistant enterococci (VRE) have become a pressing clinical challenge. Vancomycin acts by binding and sequestering the intermediate Lipid II in cell-wall biosynthesis, specifically recognizing a d-alanine-d-alanine dipeptide motif within the Lipid II molecule. VRE achieve resistance by remodeling this motif to either d-alanine-d-lactate or d-alanine-d-serine; the former substitution essentially abolishes recognition by vancomycin of Lipid II, whereas the latter reduces the affinity of the antibiotic by roughly one order of magnitude. The complex of vancomycin bound to d-alanine-d-serine has been crystallized, and its 1.20 Å X-ray crystal structure is presented here. This structure reveals that the d-alanine-d-serine ligand is bound in essentially the same position and same pose as the native d-alanine-d-alanine ligand. The serine-containing ligand appears to be slightly too large to be comfortably accommodated in this way, suggesting one possible contribution to the reduced binding affinity. In addition, two flexible hydroxyl groups – one from the serine side chain of the ligand, and the other from a glucose sugar on the antibiotic – are locked into single conformations in the complex, which is likely to contribute an unfavorable entropic component to the recognition of the serine-containing ligand.

An X-ray absorption spectroscopy (XAS) electrochemical cell was used to collect high-quality XAS measurements of N-truncated Cu:amyloid-β (Cu:Aβ) samples under near-physiological conditions. N-truncated Cu:Aβ peptide complexes contribute to oxidative stress and neurotoxicity in Alzheimer's patients' brains. However, the redox properties of copper in different Aβ peptide sequences are inconsistent. Therefore, the geometry of binding sites for the copper binding in Aβ4–8/12/16 was determined using novel advanced extended X-ray absorption fine structure (EXAFS) analysis. This enables these peptides to perform redox cycles in a manner that might produce toxicity in human brains. Fluorescence XAS measurements were corrected for systematic errors including defective-pixel data, monochromator glitches and dispersion of pixel spectra. Experimental uncertainties at each data point were measured explicitly from the point-wise variance of corrected pixel measurements. The copper-binding environments of Aβ4–8/12/16 were precisely determined by fitting XAS measurements with propagated experimental uncertainties, advanced analysis and hypothesis testing, providing a mechanism to pursue many similarly complex questions in bioscience. The low-temperature XAS measurements here determine that CuII is bound to the first amino acids in the high-affinity amino-terminal copper and nickel (ATCUN) binding motif with an oxygen in a tetragonal pyramid geometry in the Aβ4–8/12/16 peptides. Room-temperature XAS electrochemical-cell measurements observe metal reduction in the Aβ4–16 peptide. Robust investigations of XAS provide structural details of CuII binding with a very different bis-His motif and a water oxygen in a quasi-tetrahedral geometry. Oxidized XAS measurements of Aβ4–12/16 imply that both CuII and CuIII are accommodated in an ATCUN-like binding site. Hypotheses for these CuI, CuII and CuIII geometries were proven and disproven using the novel data and statistical analysis including F tests. Structural parameters were determined with an accuracy some tenfold better than literature claims of past work. A new protocol was also developed using EXAFS data analysis for monitoring radiation damage. This gives a template for advanced analysis of complex biosystems.

Here, the novel technique of extended-range high-energy-resolution fluorescence detection (XR-HERFD) has successfully observed the n = 2 satellite in manganese to a high accuracy. The significance of the satellite signature presented is many hundreds of standard errors and well beyond typical discovery levels of three to six standard errors. This satellite is a sensitive indicator for all manganese-containing materials in condensed matter. The uncertainty in the measurements has been defined, which clearly observes multiple peaks and structure indicative of complex physical quantum-mechanical processes. Theoretical calculations of energy eigenvalues, shake-off probability and Auger rates are also presented, which explain the origin of the satellite from physical n = 2 shake-off processes. The evolution in the intensity of this satellite is measured relative to the full Kα spectrum of manganese to investigate satellite structure, and therefore many-body processes, as a function of incident energy. Results demonstrate that the many-body reduction factor S02 should not be modelled with a constant value as is currently done. This work makes a significant contribution to the challenge of understanding many-body processes and interpreting HERFD or resonant inelastic X-ray scattering spectra in a quantitative manner.

The title compound, (C4H12N)[V(C12H8N4O2)O2]·H2O, was synthesized via aerial oxidation on refluxing picolinohydrazide with ethyl picolinate followed by addition of VIVO(acac)2 and di­ethyl­amine in methanol. It crystallizes in the triclinic crystal system in space group Poverline{1}. In the complex anion, the dioxidovanadium(V) moiety exhibits a distorted square-pyramidal geometry. In the crystal, extensive hydrogen bonding links the water mol­ecule to two complex anions and one di­ethyl­ammonium ion. One of the CH2 groups in the di­ethyl­amine is disordered over two sets of sites in a 0.7:0.3 ratio.

The structure of polymeric catena-poly[2-amino­benzimidazolium [[dioxidovanadium(V)]-μ-oxido]], {(C7H8N3)2[V2O6]}n, has monoclinic symmetry. The title compound is of inter­est with respect to anti­cancer activity. In the crystal structure, infinite linear zigzag vanadate (V2O6)2− chains, constructed from corner-sharing VO4 tetra­hedra and that run parallel to the a axis, are present. Two different protonated 2-amino­benzimidazole mol­ecules are located between the (V2O6)2– chains and form classical N—H⋯O hydrogen bonds with the vanadate oxygen atoms, which contribute to the cohesion of the structure.

In the title compound, (C5H7N2)5[TeV9O28], the tellurium and vanadium atoms are statistically disordered over two of the ten metal-atom sites in the [TeV9O28]5– heteropolyanion. The anions stack along [100] and are extended into a three-dimensional supra­molecular network through N—H⋯O and weak C—H⋯O hydrogen bonds involving the self-assembled 2-amino­pyridinium penta­mers, which are linked by C—H⋯π and π–π stacking inter­actions. The most important contributions to the Hirshfeld surface arise from O⋯H/H⋯O (54.8%), H⋯H (17.8%) and C⋯H/H⋯C (13.4%) contacts.

Van Vleck modes describe all possible displacements of octahedrally coordinated ligands about a core atom. They are a useful analytical tool for analysing the distortion of octahedra, particularly for first-order Jahn–Teller distortions, but determination of the Van Vleck modes of an octahedron is complicated by the presence of angular distortion of the octahedron. This problem is most commonly resolved by calculating the bond distortion modes (Q2, Q3) along the bond axes of the octahedron, disregarding the angular distortion and losing information on the octahedral shear modes (Q4, Q5 and Q6) in the process. In this paper, the validity of assuming bond lengths to be orthogonal in order to calculate the Van Vleck modes is discussed, and a method is described for calculating Van Vleck modes without disregarding the angular distortion. A Python package for doing this, VanVleckCalculator, is introduced and some examples of its use are given. Finally, it is shown that octahedral shear and angular distortion are often, but not always, correlated, and a parameter η is proposed as the shear fraction. It is demonstrated that η can be used to predict whether the values will be correlated when varying a tuning parameter such as temperature or pressure.

From the historical roots of metalworking to the forefront of modern nanotechnology, functional materials have played a pivotal role in transforming societies, and their influence is poised to persist into the future. Encompassing a wide array of solid-state materials, spanning semiconductors to polymers, molecular crystals to nanoparticles, functional materials find application in critical sectors such as electronics, computers, information, communication, bio­technology, aerospace, defense, environment, energy, medicine and consumer products. This feature article delves into diverse instances of functional materials, exploring their structures, their properties and the underlying mechanisms that contribute to their outstanding performance across fields like batteries, photovoltaics, magnetics and heterogeneous catalysts. The field of structural sciences serves as the cornerstone for unraveling the intricate relationship between structure, dynamics and function. Acting as a bridge, it connects the fundamental understanding of materials to their practical applications.

The first Federation of European Biochemical Societies Advanced Course on macromolecular crystallization was launched in the Czech Republic in October 2004. Over the past two decades, the course has developed into a distinguished event, attracting students, early career postdoctoral researchers and lecturers. The course topics include protein purification, characterization and crystallization, covering the latest advances in the field of structural biology. The many hands-on practical exercises enable a close interaction between students and teachers and offer the opportunity for students to crystallize their own proteins. The course has a broad and lasting impact on the scientific community as participants return to their home laboratories and act as nuclei by communicating and implementing their newly acquired knowledge and skills.

Geological samples are inherently multi-scale. Understanding their bulk physical and chemical properties requires characterization down to the nano-scale. A powerful technique to study the three-dimensional microstructure is X-ray tomography, but it lacks information about the chemistry of samples. To develop a methodology for measuring the multi-scale 3D microstructure of geological samples, correlative X-ray micro- and nanotomography were performed on two rocks followed by scanning electron microscopy with energy-dispersive spectroscopy (SEM-EDS) analysis. The study was performed in five steps: (i) micro X-ray tomography was performed on rock sample cores, (ii) samples for nanotomography were prepared using laser milling, (iii) nanotomography was performed on the milled sub-samples, (iv) samples were mounted and polished for SEM analysis and (v) SEM imaging and compositional mapping was performed on micro and nanotomography samples for complimentary information. Correlative study performed on samples of serpentine and basalt revealed multiscale 3D structures involving both solid mineral phases and pore networks. Significant differences in the volume fraction of pores and mineral phases were also observed dependent on the imaging spatial resolution employed. This highlights the necessity for the application of such a multiscale approach for the characterization of complex aggregates such as rocks. Information acquired from the chemical mapping of different phases was also helpful in segmentation of phases that did not exhibit significant contrast in X-ray imaging. Adoption of the protocol used in this study can be broadly applied to 3D imaging studies being performed at the Advanced Light Source and other user facilities.

Source: Streetwise Reports 10/22/2024

The growth of artificial intelligence, the need for more computer data centers, the eventual adoption of electric vehicles (EVs), and the need for more net-zero power means a renaissance in nuclear power is underway.

Just last month, Microsoft Corp. (MSFT:NASDAQ) announced a deal with Constellation Energy Group (CEG:NYSE) to restart and buy all of the power from one of the shut-down reactors at its infamous Three Mile Island plant in Pennsylvania and the Biden administration also announced a plan to restart the Palisades plant in Michigan.

"Biden has called for a tripling of U.S. nuclear power capacity to fuel energy demand that is accelerating in part due to expansion of power-hungry technologies like artificial intelligence and cloud computing," Valerie Volcovici wrote for Reuters on Oct. 8.

The administration also wants to develop small nuclear reactors (SMRs) for certain applications.

All of this is putting the metal needed to power nuclear energy, uranium, front and center. Prices for the element have started rising, with nuclear fuel trading at US$83.30 per pound last Thursday, a level not seen since 2007, according to a report by Daily Finland on Friday.

Uranium prices are expected to move higher by the end of this quarter, when Trading Economics' global macro models and analyses forecast uranium to trade at US$84.15 per pound, Nuclear Newswire reported on Oct. 3. In another year, the site estimates that the metal will trade at US$91.80 per pound.

The Catalyst: Surging Demand

The engine driving the prices is a "fundamental global shortage" of uranium driven by surging demand, said Andre Leibenberg, chief executive officer of Yellow Cake, which is focused on providing exposure to uranium's spot price.

The demand is stemming not only from a growing recognition of nuclear power's role in the future energy mix, but also from its critical importance in supporting the AI boom and the development of data centers, he wrote in a company update last week, according to Mining Weekly.

According to the report, Liebenberg noted that the primary mine supply of 140 million pounds was significantly trailing behind global demand of more than 180 million pounds a year.

In the European Union, a "lack of clarity" about Russian uranium imports is holding back investment in new enrichment plants, according to Reuters.

Russia supplied more than 25% of European and American enriched uranium before the start of the Ukraine war in February 2022, the report said.

Since then, "the U.S. implemented a ban on imports of enriched uranium from Russia in August, with some exemptions, but in Europe, different countries have taken different approaches," muddying the waters.

Complicating matters is a hint in September that Russian President Vladimir Putin might embargo exports of the vital element to the west.

Citi, in a note to clients, said utilities have been stockpiling Russian uranium, but an embargo would make it "hard to replace" supplies of the metal in the next two years.

"Russia supplies close to 12% of U3O8 (known as yellow cake), 25% of UF6 (uranium hexafluoride) and 35% of EUP (enriched uranium product) to international markets," the bank said, according to Forbes. "While the largest share of these supplies goes to China and in supplying nuclear reactors that were built by Russia's Rosatom, we believe that at-risk supplies are exports to the U.S. or Western Europe."

The consequences of what could happen without more nuclear power can be seen in the U.K., where the number of reactors is shrinking. Four of five of them are expected to close in the next couple of years, which could "stretch the grid to the limit."

"As Britain's reactor fleet shrivels, the amount of nuclear capacity will fall from six gigawatts (GW) today to just 1.2 GW by 2028 or soon after," Jonathan Leake and Matt Oliver wrote for The Telegraph last week. "Along with rising demand from power-hungry data centers and technologies of the future, it will make it even harder to keep the lights on when wind and solar generation is low."

Small Nuclear Reactors (SMRs)

SMRs are another possible solution for some medium-sized energy needs. They have been operational for dozens of years in submarines and other long-distance ocean-going craft.

"They can be manufactured in factories and then rapidly erected on-site," Dominic Frisby wrote for his newsletter, The Flying Frisby, on Oct. 13. They are scalable, and that flexibility "aids manufacture, transportation, and installation while reducing construction time and costs."

A 440-megawatt (MW) SMR would produce about 3.5 terawatt hours (TWh) of electricity per year, enough for 1.2 million homes, Frisby noted.

SMRs produce electricity that can easily be adjusted to meet the constant, everyday needs of the grid (baseload), and they can also ramp up or down to follow changes in demand throughout the day, the author wrote. They spin in sync with the grid, so they help keep everything stable.

"When they're running, they act like a steady hand, providing momentum that makes it easier to manage sudden changes in electricity supply or demand," he wrote.

'Bucket Loads of Power' Needed

All of this equates for a bright future for the metal, he said.

"Guess what? AI requires bucket loads of power," Frisby wrote. "That's why Microsoft recently agreed to pay Constellation Energy, the new owner of America's infamous nuclear power station, Three Mile Island, a sizeable premium for its energy. There is cheaper wind and solar power to be had in Pennsylvania, but it isn't as reliable as nuclear 24 hours a day. It's not just AI. The widespread political desire to rid ourselves of fossil fuels means the world needs electricity, and fast."

Chris Temple, publisher of The National Investor, recently noted that with the Three Mile Island deal, "uranium/nuclear power is BACK!"

"I've watched as the news has continued to point to uranium being in the early innings of this new bull market," Temple wrote. "Yet the markets have been yawning . . . until now."

What follows are several uranium explorers and producers that could benefit from this upswing for investors looking to take advantage.

Baselode Energy Corp.

Baselode Energy Corp. (FIND:TSX.V; BSENF:OTCQB) controls 100% of about 273,000 hectares for exploration in the Athabasca Basin area in northern Saskatchewan, Canada.[OWNERSHIP_CHART-10321]

The company said it discovered the ACKIO near-surface, high-grade uranium deposit in September 2021. ACKIO measures greater than 375 meters along strike, greater than 150 meters wide, and is comprised of at least 11 separate zones. Mineralization starts as shallow as 28 meters beneath the surface and continues down to about 300 meters depth beneath the surface, with the bulk of mineralization occurring in the upper 120 meters, Baselode said. ACKIO remains open to the west and south and along the Athabasca sandstone unconformity to the east and south.

Earlier this month, the company reported positive uranium assay results from three drill holes of its 2024 drill program at ACKIO.

Notably, drill hole AK24-119 intersected 0.28% U3O8 over 21.0 meters, including a high-grade section of 1.55% U3O8 over 1.5 meters at a depth of 141 meters. While drill hole AK24-118 returned 0.59% U3O8 over 8.5 meters, including 1.25% U3O8 over 1.5 meters at a depth of 153 meters.

"These results strengthen our confidence in ACKIO," Chief Executive Officer James Sykes said in a release. "It's remarkable that, just over three years after discovering ACKIO, we're still achieving better-than-expected grades and widths."

Baselode expects further assay results from the remaining 40 drill holes to be released after quality review and approval.

David Talbot, Managing Director at Red Cloud Securities, noted in a September 17 report that drilling at ACKIO "continued to expand the mineralized footprint at Pods 1, 6, and 7," highlighting that "thirteen holes reported composite intervals of anomalous radioactivity between 11m and 42m in thickness."

In his report, Talbot rated the stock as a Buy and further projected the potential for "8-10-12 million pounds of U3O8 at a grade of ~0.3% U3O8," which aligns with typical grades found in the southeastern part of the Athabasca Basin.

According to Refinitiv, Baselode has institutions holding 23.26% with Alps Advisors holding the bulk of it with 17.94%, followed by Vident Investment Advisory LLC at 2.97%. Management and Insiders hold 1.59%. The rest is retail.

The company has a market cap of CA$20.05 million, with 131.51 free float shares. It trades in the 52-week range between CA$0.10 and CA$0.61.

Uranium Energy Corp.

According to its website, Uranium Energy Corp. (UEC:NYSE AMERICAN) is America's "largest and fastest growing supplier of uranium."[OWNERSHIP_CHART-402]

The company said it is advancing the next generation of low-cost, environmentally friendly in-situ recovery (ISR) mining uranium projects in the United States and high-grade conventional projects in Canada. It has two production-ready ISR hub and spoke platforms in South Texas and Wyoming.

Additionally, Uranium Energy Corp. said it has diversified uranium holdings with one of the largest physical uranium portfolios of U.S. warehoused U3O8; a major equity stake in Uranium Royalty Corp., the only royalty company in the sector; and a Western Hemisphere pipeline of resource stage uranium projects.

Most recently, the company announced it was expanding its U.S. uranium production capacity by acquiring Rio Tinto Plc.'s Sweetwater Plant and a portfolio of Wyoming uranium assets.

On September 25, Temple of The National Investor noted that UEC was "upgraded back to Buy" following recent uranium market news. He pointed to UEC's acquisition of the Wyoming uranium assets as a catalyst, emphasizing that uranium is "in the early innings of this new bull market."

Jeff Clark of The Gold Advisor, in his September 26 update, called the acquisition a "significant move," noting that it consolidated a large portfolio of uranium assets under UEC's control, positioning the company for rapid growth. He also highlighted the company's strategic advantage with "53,000 additional acres for exploration," reinforcing UEC's potential to ramp up production.

According to Reuters, Uranium Energy has a market cap of US$3.48 billion and 411.41 million shares outstanding. It trades in a 52-week range of US$4.06 and US$8.66.

About 2% of UE is help by management and insiders, Reuters noted. The largest portion, 77.58%, is held by institutional investors. The rest is in retail.

Terra Clean Energy Corp.

Formerly Tisdale Clean Energy Corp., Terra Clean Energy Corp. (TCEC:CSE; TCEFF:OTC; T1KC:FSE), a Canadian-based uranium exploration and development company, is currently developing the South Falcon East uranium project, which holds a 6.96-million-pound inferred uranium resource within the Fraser Lakes Zone B uranium/thorium deposit, located in the Athabasca Basin region of Saskatchewan.[OWNERSHIP_CHART-10935]

Representing a portion of Skyharbour Resources Ltd.'s existing South Falcon Project, Terra Clean Energy's project covers approximately 12,464 hectares and lies 18 kilometers outside the Athabasca Basin, approximately 50 kilometers east of the Key Lake Mine.

Recently, the company announced a comprehensive exploration program set for Winter 2025 at its South Falcon East Uranium Project. The work will focus on extending the mineralized footprint at the Fraser Lakes B Uranium Deposit and includes about 2,000 meters of infill and step-out drilling designed to verify existing mineralized zones and identify additional targets.

In a release, Chief Executive Officer Alex Klenman described the initiative as "a unique setup for a Canadian microcap, offering multiple paths to significant value creation." This US$1.5 million project will involve TerraLogic Exploration Inc., operating out of SkyHarbour's McGowan Lake Camp with helicopter support.

According to Reuters, management and insiders hold 4.62% of Terra Clean Energy. Of those, Alex Klenman holds the most, with 4.37%.

Strategic Investors hold 12.03%, with Planet Ventures Inc holding the most at 7.40%. The rest is retail.

Terra Clean Energy has a market cap of CA$2.98 million and a 52-week range of CA$0.05 to CA$0.22.

North Shore Uranium Ltd.

North Shore Uranium Ltd. (NSU:TSX) said it is working to become a major force in exploration for economic uranium deposits at the eastern margin of the Athabasca Basin.[OWNERSHIP_CHART-10945]

The company said it is running exploration programs at its Falcon and West Bear properties and evaluating opportunities to complement its portfolio of uranium properties.

Falcon consists of 15 mineral claims, the company said. Four of them comprise 12,791 hectares and are 100%-owned by the company. The remaining 11 claims totaling 2,908 hectares are subject to an option agreement with Skyharbour Resources Ltd. Under the terms of the option agreement, North Shore has the option to earn up to 100% interest in the 11 claims by completing certain payments.

Earlier this month, the company announced details of its target generation efforts at its Falcon uranium project at the eastern margin of Saskatchewan's Athabasca Basin. The company said it has identified 36 uranium targets across three zones.

"We have a great pipeline of targets to choose from for our next drill program at Falcon," said President and Chief Executive Officer Brooke Clements. "Our Zone 2 has attracted the interest of uranium explorers in the past, and we believe there is potential to make a significant uranium discovery using new data and interpretation."

Earlier this month, North Shore announced it had received a Crown Land Work permit for the full 55,700-hectare Falcon project. Issued by the Saskatchewan Ministry of Environment, it authorizes the company to conduct mineral exploration activities, including prospecting and ground geophysics, trail and drill site clearing, line cutting, the drilling of up to 75 exploration drill holes, and the storage of drill core. The permit expires in July 2027.

Insiders and founding investors own approximately 45% of the issued and outstanding shares. Clements himself owns 3.6% or 1.33M shares, Director Doris Meyer has 2.11% or 0.78M shares, and Director James Arthur holds 1.58% or 0.58M shares. According to North Shore, 14.92M shares (40.5%) held by six founding investors are subject to a voluntary pooling agreement that restricts the disposition of these shares before October 19, 2026.

Most of the rest is with retail, as the institutional holdings are minor.

North Shore has 36.84M outstanding shares and currently has a market cap of CA$1.47 million. It has traded in the past 52 weeks between CA$0.04 and CA$0.30 per share.

Skyharbour Resources Ltd.

Skyharbour Resources Ltd. (SYH:TSX.V; SYHBF:OTCQX; SC1P:FSE) has an extensive portfolio of uranium exploration projects in Canada's Athabasca Basin, with 29 projects, 10 of which are drill-ready, covering over 1.4 million acres of mineral claims. In addition to being a high-grade uranium exploration company, Skyharbour utilizes a prospect generator strategy by bringing in partner companies to advance its secondary assets.[OWNERSHIP_CHART-6026]

In an updated research note on July 24, Analyst Sid Rajeev of Fundamental Research Corp. wrote that Skyharbour "owns one of the largest portfolios among uranium juniors in the Athabasca Basin."

"Given the highly vulnerable uranium supply chain, we anticipate continued consolidation within the sector," wrote Rajeev, who reiterated the firm's Buy rating and adjusted its fair value estimate from CA$1.16 to CA$1.21 per share. "Additionally, the rapidly growing demand for energy from the AI industry is likely to accelerate the adoption of nuclear power, which should, in turn, spotlight uranium juniors in the coming months."

Skyharbour acquired from Denison Mines, a large strategic shareholder of the company, a 100% interest in the Moore Uranium Project, which is located 15 kilometers east of Denison's Wheeler River project and 39 kilometers south of Cameco's McArthur River uranium mine. Moore is an advanced-stage uranium exploration property with high-grade uranium mineralization at the Maverick Zone, including highlight drill results of 6.0% U3O8 over 5.9 meters, including 20.8% U3O8 over 1.5 meters at a vertical depth of 265 meters.

Adjacent to the Moore Uranium Project is Skyharbour's Russell Lake Uranium Project optioned from Rio Tinto, which hosts historical high-grade drill intercepts over a large property area with robust exploration upside potential. The 73,294-ha Russell Lake Uranium Property is strategically located in the central core of the Eastern Athabasca Basin of northern Saskatchewan. Skyharbour has recently discovered high-grade uranium mineralization in a new zone at Russell and is carrying out an additional 7-8,000-meter drill campaign across both Russell and Moore.

Management, insiders, and close business associates own approximately 5% of Skyharbour.

According to Reuters, President and CEO Trimble owns 1.6%, and Director David Cates owns 0.70%.

Institutional, corporate, and strategic investors own approximately 55% of the company. Denison Mines owns 6.3%, Rio Tinto owns 2.0%, Extract Advisors LLC owns 9%, Alps Advisors Inc. owns 9.91%, Mirae Asset Global Investments (U.S.A) L.L.C. owns 6.29%, Sprott Asset Management L.P. owns 1.5%, and Incrementum AG owns 1.18%, Reuters reported.

There are 182.53 million shares outstanding with 178 million free float traded shares, while the company has a market cap of CA$89.44 million and trades in a 52-week range of CA$0.31 and CA$0.64.

ATHA Energy Corp.

Atha Energy Corp. (SASK:TSX.V; SASKF:OTCMKTS) is a Canadian mineral company engaged in the acquisition, exploration, and development of uranium assets with a portfolio including three 100%-owned post-discovery uranium projects (the Angilak Project located in Nunavut, and CMB Discoveries in Labrador hosting historical resource estimates of 43.3 million pounds and 14.5 million pounds U3O8 respectively, and the newly discovered basement-hosted GMZ high-grade uranium discovery located in the Athabasca Basin).[OWNERSHIP_CHART-11007]

In addition, the company said it holds the largest cumulative prospective exploration land package (more than 8.5 million acres) in two of the world's most prominent basins for uranium discoveries. ATHA also holds a 10% carried interest in key Athabasca Basin exploration projects operated by NexGen Energy Ltd. and IsoEnergy Ltd.

Technical Analyst Maund considers Atha Energy to be "THE top play in the uranium sector" and has an Immediate Strong Buy rating on it, he wrote in the previously mentioned Oct. 17 report.

The company's 3-, 13- and 26-month charts indicate its stock price had been in a bear market since trading began until September, when it had an upwave or preliminary breakout. This, along with other indicators, including positive accumulation-distribution convergence and high volume, suggest another upleg is expected soon, he said.

"Given the outlook for the uranium price and what Atha Energy has going for it, its stock is astoundingly cheap after its persistent downtrend this year," Maund wrote.

According to Refinitiv, 10 management and insiders own 16.44% of Atha Energy. The Top 5 are Timothy Young with 6.32%, Matthew Mason with 5.8%, Atha Chairman Michael Castanho with 1.16%, and Atha Director Sean Kallir with 0.9%.

Seven institutional investors together hold 9.38%. The Top 3 are Alps Advisors Inc. with 6.26%, Sprott Asset Management LP with 1.3%, and Vident Investment Advisory LLC with 0.8%.

The remaining 74.18% of Atha is in retail.

According to the company, it has 277.9M shares outstanding, 14M options, 4M restricted stock units/performance rights, and 10.2M warrants.

Reuters reports Atha's market cap is CA$208.42 million, and its 52-week range is CA$0.46−$1.42 per share.

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Important Disclosures:

1. Skyharbour Resources Ltd. and Terra Clean Energy Corp. are billboard sponsors of Streetwise Reports and pay SWR a monthly sponsorship fee between US$4,000 and US$5,000. In addition, Terra Clean Energy has a consulting relationship with Street Smart an affiliate of Streetwise Reports. Street Smart Clients pay a monthly consulting fee between US$8,000 and US$20,000.
2. As of the date of this article, officers and/or employees of Streetwise Reports LLC (including members of their household) own securities of North Shore Uranium Ltd., Uranium Energy Corp., and Terra Clean Energy.
3. Steve Sobek wrote this article for Streetwise Reports LLC and provides services to Streetwise Reports as an employee.
4. This article does not constitute investment advice and is not a solicitation for any investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Each reader is encouraged to consult with his or her personal financial adviser and perform their own comprehensive investment research. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company.

For additional disclosures, please click here.

( Companies Mentioned: SASK:TSX.V; SASKF:OTCMKTS, FIND:TSX.V; BSENF:OTCQB, NSU:TSX, SYH:TSX.V; SYHBF:OTCQX; SC1P:FSE, TCEC:CSE; TCEFF:OTC; T1KC:FSE, UEC:NYSE AMERICAN, )

Source: Streetwise Reports 10/24/2024

Skyharbour Resources Ltd. (SYH:TSX.V; SYHBF:OTCQX; SC1P:FSE) announced that it has completed its earn-in requirements for a 51% interest at its co-flagship Russell Lake Uranium Project in the central core of Canada's Eastern Athabasca Basin in Saskatchewan.

The company and Rio Tinto have formed a joint venture (JV) to further explore the property, with Skyharbour holding 51% ownership interest and Rio Tinto holding 49%.

This summer, Skyharbour announced that in the first phase of drilling it had found what was historically the best uranium intercept mineralization at the project when hole RSL24-02 at the recently identified Fork Target returned a 2.5-meter-wide intercept of 0.721% U3O8 at a relatively shallow depth of 338.1 meters, including 2.99% U3O8 over 0.5 meters at 339.6 meters.

The second phase of drilling included three holes totaling 1,649 meters, with emphasis "at the MZE (M-Zone Extension) target, approximately 10 km northeast of the Fork target, identified prospective faulted graphitic gneiss accompanied by anomalous sandstone and basement geochemistry," Skyharbour said.

"The discovery of multi-percent, high-grade, sandstone-hosted uranium mineralization at a new target is a major breakthrough in the discovery process at Russell — something that hasn't been seen before at the project with the potential to quickly grow with more drilling," President and Chief Executive Officer Jordan Trimble said at the time.

ANT Survey, Upcoming Drilling Program

The company also announced on Thursday that it had completed an Ambient Noise Tomography (ANT) survey in preparation for further drilling at the Russell Lake Project, set to commence in the fall. The survey used Fleet Space Technologies' Exosphere technology to acquire 3D passive seismic velocity data over the highly prospective Grayling and Fork target areas, where previous drilling has intersected high-grade uranium mineralization.

"The ANT technology has been successfully employed in mapping significant sandstone and basement structures and associated alteration zones related to hydrothermal fluids pathways in the Athabasca Basin," the company said.

Results from the survey will be used to further refine drill targets for the upcoming drilling program. Skyharbour is fully funded and permitted for the follow-up fall drill campaign consisting of approximately 7,000 metres of drilling at its main Russell and Moore Projects, with 2,500 meters of drilling at Moore and 4,500 meters of drilling at Russell.

A Great Neighborhood

Russell Lake is a large, advanced-stage uranium exploration property totaling 73,294 hectares strategically located between Cameco's Key Lake and McArthur River projects and Denison's Wheeler River Project to the west, and Skyharbour's Moore project to the east.

"Skyharbour's acquisition of a majority interest in Russell Lake creates a large, nearly contiguous block of highly prospective uranium claims totaling 108,999 hectares between the Russell Lake and the Moore uranium projects," the company said.

Most of the historical exploration at Russell Lake was conducted before 2010, prior to the discovery of several major deposits in/around the Athabasca Basin, Skyharbour said.

Notable exploration targets on the property include the Grayling Zone, the M-Zone Extension target, the Little Man Lake target, the Christie Lake target, the Fox Lake Trail target and the newly identified Fork Zone target.

"More than 35 kilometers of largely untested prospective conductors in areas of low magnetic intensity also exist on the property," the company noted.

In an updated research note in July, Analyst Sid Rajeev of Fundamental Research Corp. wrote that Skyharbour "owns one of the largest portfolios among uranium juniors in the Athabasca Basin."

"Given the highly vulnerable uranium supply chain, we anticipate continued consolidation within the sector," wrote Rajeev, who rated the stock a Buy with a fair value estimate of CA$1.21 per share. "Additionally, the rapidly growing demand for energy from the AI (artificial intelligence) industry is likely to accelerate the adoption of nuclear power, which should, in turn, spotlight uranium juniors in the coming months."

The Catalyst: Uranium is 'BACK!'

The growth of AI, new data centers, electric vehicle (EV) adoption, and the need for more net-zero power means more nuclear energy and the uranium needed to fuel it.

Uranium prices are expected to move higher by the end of this quarter, when Trading Economics' global macro models and analyses forecast uranium to trade at US$84.15 per pound, Nuclear Newswire reported on Oct. 3. In another year, the site estimates that the metal will trade at US$91.80 per pound.

Just last month, Microsoft Corp. (MSFT:NASDAQ) announced a deal with Constellation Energy Group (CEG:NYSE) to restart and buy all of the power from one of the shut-down reactors at its infamous Three Mile Island plant in Pennsylvania and the Biden administration also announced a plan to restart the Palisades plant in Michigan.

Chris Temple, publisher of The National Investor, recently noted that with the Three Mile Island deal, "uranium/nuclear power is BACK!"[OWNERSHIP_CHART-6026]

"I've watched as the news has continued to point to uranium being in the early innings of this new bull market," Temple wrote. "Yet the markets have been yawning . . . until now."

Ownership and Share Structure

Management, insiders, and close business associates own approximately 5% of Skyharbour.

According to Reuters, President and CEO Trimble owns 1.6%, and Director David Cates owns 0.70%.

Institutional, corporate, and strategic investors own approximately 55% of the company. Denison Mines owns 6.3%, Rio Tinto owns 2.0%, Extract Advisors LLC owns 9%, Alps Advisors Inc. owns 9.91%, Mirae Asset Global Investments (U.S.A) L.L.C. owns 6.29%, Sprott Asset Management L.P. owns 1.5%, and Incrementum AG owns 1.18%, Reuters reported.

There are 182.53 million shares outstanding with 178 million free float traded shares, while the company has a market cap of CA$88.53 million and trades in a 52-week range of CA$0.31 and CA$0.64.

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Important Disclosures:

1. Skyharbour Resources Ltd. is a billboard sponsor of Streetwise Reports and pays SWR a monthly sponsorship fee between US$4,000 and US$5,000.
2. Steve Sobek wrote this article for Streetwise Reports LLC and provides services to Streetwise Reports as an employee.
3. This article does not constitute investment advice and is not a solicitation for any investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Each reader is encouraged to consult with his or her personal financial adviser and perform their own comprehensive investment research. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company.

For additional disclosures, please click here.

( Companies Mentioned: SYH:TSX.V; SYHBF:OTCQX; SC1P:FSE, )

USGS groundwater and surface water monitoring data contributed to the Pennsylvania Department of Environmental Protection's (PaDEP) November 1, 2024, declarations of drought watches and warnings for 35 Pennsylvania counties.

Source: Streetwise Reports 11/08/2024

Vertex Pharmaceuticals Inc. (VRTX:NASDAQ) has reported a robust financial performance for the third quarter of 2024. The report has demonstrated the company's continued revenue growth and the strengthening of its innovative pipeline. For Q3 2024, Vertex's product revenue reached US$2.77 billion, a 12% increase from the previous year. This was primarily driven by strong demand for its TRIKAFTA®/KAFTRIO® therapies. Based on this momentum, Vertex raised its full-year product revenue guidance to a range of US$10.8 billion to US$10.9 billion, citing a solid trajectory in its cystic fibrosis (CF) portfolio and expected future launches.

In Q3, the company made notable advancements in its pipeline. Three programs have begun moving into Phase 3 clinical development: suzetrigine in diabetic peripheral neuropathy (DPN), povetacicept in IgA nephropathy (IgAN), and VX-880 in type 1 diabetes (T1D). Vertex is also preparing for the launch of two potential treatments in early 2025, with PDUFA dates set for January 2 for the vanzacaftor triple therapy for CF and January 30 for suzetrigine, the latter being a pain medication in a new therapeutic class aimed at reducing reliance on opioids.

GAAP and Non-GAAP net income both reached US$1.0 billion, largely driven by increased product revenue, which offset rising R&D and SG&A expense. This was s due to investments in global commercialization and late-stage clinical development. For Q3, Vertex's combined R&D and SG&A expenses were US$1.2 billion and US$1.1 billion, respectively, an increase from last year attributed to new global program advancements and upcoming launch support.

Vertex's cash position remained strong, with US$11.2 billion in cash, cash equivalents, and marketable securities as of September 30. The decline from US$13.7 billion at the end of 2023 primarily reflects the acquisition of Alpine Immune Sciences and share repurchases under the company's buyback program.

A Look At Biotechnology and Pharma

The U.S. Pharmaceuticals Report for 2024 by Nova One Advisor detailed the size and growth trajectory of the U.S. pharmaceutical market. Valued at US$602.19 billion in 2023, the sector is projected to exceed US$1 trillion by 2033. The report pointed to a "high healthcare expenditure provided by government bodies" as a primary growth driver, further bolstered by the aging population's demand for advanced treatments.

In an October 24 article, The Investing News Network reported on a dynamic landscape within the biotechnology sector. The report highlighted advancements in AI-powered drug discovery. Despite a cautious investment climate, interest remained strong in AI's potential to reshape healthcare, with venture capital investment reaching US$6.59 billion. At the HealthTech Ignite conference, Susie Roberts from Relay Therapeutics expressed confidence, noting, "We will definitely see AI design drugs in the next 10 years."

On November 4, Yahoo! Finance shared insights from MIT professors Andrew Lo and Dennis Whyte. They emphasized that biotechnology's rapid advancement over the past five decades offers valuable lessons for future innovation. In their research paper, Lo and Whyte proposed initiatives to accelerate biotechnology's growth, underscoring the importance of "reducing risk and uncertainty" to foster a robust investment ecosystem that supports groundbreaking discoveries.

Catalysts Driving Vertex Pharma

According to Vertex's November 2024 investor presentation, the company sees multiple growth catalysts over the next few years. Vertex aims to meet its goal of achieving "five launches in five years," focusing on expanding the treatable patient base in CF with vanzacaftor triple, addressing critical needs in sickle cell disease (SCD) and beta thalassemia (TDT) with CASGEVY, and launching suzetrigine for acute pain management.

Additionally, Vertex expects its expansive R&D pipeline to support long-term growth. This includes pivotal clinical trials for VX-880 in T1D, povetacicept in IgAN, and NaV1.8 pain inhibitors like suzetrigine, indicating a commitment to treating a range of chronic and life-threatening conditions with limited therapeutic options.

By driving advancements in CF therapies, diversifying its portfolio with novel pain treatments, and pursuing accelerated approvals for renal and blood-related disorders, Vertex is strategically positioning itself to sustain growth and achieve several near-term milestones.

What Are Experts Saying About Vertex?

In a November 5, 2024, H.C. Wainwright & Co. update, the analysts highlighted promising data from Vertex's recent Phase 2 trial for suzetrigine, which showed encouraging reductions in pain intensity. [OWNERSHIP_CHART-4085]

The analysts noted that suzetrigine's peripheral nervous system-specific mechanism could potentially address "a significant, unmet medical need worldwide" in non-opioid pain management. They set a price target of US$600.00, projecting Vertex's continued growth from its strong cystic fibrosis franchise and pipeline expansion.

From the November 7 Kingswood Capital Partners report, analysts noted Vertex Pharmaceuticals' "sustained execution" in advancing product development programs and achieving robust operating margins, enabling "continued, significant investments" in both its pipeline and commercial capabilities. The firm maintained a "Buy" rating with a 12-month target price of US$550.00, attributing this outlook to Vertex's deep cash resources and historical successes in clinical trials.

Ownership and Share Structure

According to Refinitiv, 95.44% of Vertex Pharmaceuticals is held by Institutions. The top among them are Capital World Investors at 10.37%, The Vanguard Group at 8.88%, BlackRock Institutional Trust with 5.49%, State Street Global Advisors (US) with 4.55%, and Fidelity Management and Research with 4.11%. Strategic Investors hold .12%. The rest is retail.

The company's market cap is US$129,395.59 million with 257.07 million free float shares. The 52 week range is US$341.90–$510.64.

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Important Disclosures:

1) James Guttman wrote this article for Streetwise Reports LLC and provides services to Streetwise Reports as an employee.

2) This article does not constitute investment advice and is not a solicitation for any investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Each reader is encouraged to consult with his or her personal financial adviser and perform their own comprehensive investment research. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company.

For additional disclosures, please click here.

( Companies Mentioned: VRTX:NASDAQ, )

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The growth of artificial intelligence, the need for more computer data centers, the eventual adoption of electric vehicles (EVs), and the need for more net-zero power means nuclear power, and the uranium needed to fuel it, is seeing a resurgence. Here are some options to make the situation work for your portfolio.

Skyharbour Resources Ltd. (SYH:TSX.V; SYHBF:OTCQX; SC1P:FSE) has completed its earn-in requirements for a 51% interest at the Russell Lake Uranium Project in the central core of Canada's Eastern Athabasca Basin in Saskatchewan. This comes as the need for more net-zero power is sparking a rebirth of the nuclear industry.

Enhancements include an auto-fill feature, the ability to search on a business or landmark name, and links to both Google and Bing maps.

Recent strides in biotechnology offer the promise of new and innovative applications -- from edible vaccines to protein-based electronics components.

High schools that successfully engage students in learning have many things in common.

On average, Americans die sooner and experience higher rates of disease and injury than people in other high-income countries, says a new report from the National Research Council and Institute of Medicine.

A new report from the National Academies of Sciences, Engineering, and Medicine identifies six promising practices to improve health care for individuals with social risk factors for poor health care outcomes, such as people who are in a low socio-economic position, reside in disadvantaged neighborhoods, identify as a racial or ethnic minority, or possess limited health literacy.

A new report from the National Academies of Sciences, Engineering, and Medicine says that Medicare’s value-based payment programs could take into account social risk factors – such as low socio-economic position, residence in disadvantaged neighborhoods, or race and ethnicity – but any proposal to do so will entail both advantages and disadvantages that need to be carefully considered.

The burdens of poor health and the benefits of good health and well-being are inequitably distributed in the U.S. due to factors that range from poverty and inadequate housing to structural racism and discrimination, says a new report from the National Academies of Sciences, Engineering, and Medicine.

The U.S. DRIVE Partnership – a government-industry partnership that fosters the development of precompetitive and innovative technologies for clean and efficient light-duty vehicles – has made significant progress in many technical areas including advanced combustion technologies, durability and cost of hydrogen fuel cells, and electric drive systems such as motors, power electronics, and batteries, says a new report by the National Academies of Sciences, Engineering, and Medicine.

Synthetic biology expands the possibilities for creating new weapons — including making existing bacteria and viruses more harmful — while decreasing the time required to engineer such organisms, concludes a new report by the National Academies of Sciences, Engineering, and Medicine.