BEST DEALS ON GAMING LAPTOPS:

• MSI - Modern 15 15.6" Laptop — $749

• ASUS - ROG G531GT 15.6" Gaming Laptop — $999.99

• Dell - G3 15.6" Gaming Laptop — $999.99

My first gaming laptop cost $1,500 more than 10 years ago, and that was considered affordable. It wasn't a top-of-the-line model, but it wasn't a slouch either, sporting one of the better mid-tier graphics cards and a reliable processor/RAM combination.  

But my, how things have changed.

Today, you can go on Amazon and find plenty of laptops for less than $1,000 that would have been at least $1,500 a few years ago, thus opening doors to people who want to try out PC gaming for themselves. (And if it's Prime Day or Black Friday or Cyber Monday, you can expect deal prices to dip even lower.) But sorting through all of the options and deciding which is best presents its own unique challenge. Read more...

BEST FITNESS TRACKER DEALS:

• Fitbit - Charge 3 Activity Tracker + Heart Rate — $99.95 (save $30)

• Garmin - Forerunner 645 Music GPS Heart Rate Monitor Running Watch — $449.99

• 3Plus - HR Activity Tracker + Heart Rate — $49.99

Wellness is a buzzy word lately. Over the past few years, we’ve seen a surge in all things health, wellness, and spirituality. Juice bars are popping up, boutique studios are becoming more accessible, and essential oils are chilling us out. Self-care is becoming more of the norm too, but amidst all this hype, it can be challenging to find the right routine that promotes good exercise, sleep, vitals, and mindset.  Read more...

BEST PILLOW DEALS:

• Sealy - Essentials Molded Bed Pillow — $19.99

• Beautyrest Latex Pillow with Removable Cover —  $39.88

• Samsonite - Long Memory Foam Pillow — $24.99

Achieving a good night’s sleep isn’t always easy. Busy schedules, frequent stress, and bad rest environments can be culprits for sleep troubles. And it’s more common than you think. 

According to the American Sleep Association, 50 to 70 million U.S. adults have a sleep disorder. If your sleepless nights are taking a toll on your health, it might be time for you to buy a new pillow. 

Digital marketing is fast-paced with trends and new updates to existing systems continuously popping out. That’s why it is important to stay up-to-date with the latest strategies that can be beneficial in reaching new audiences. Keeping up to date with the marketing trends will also help a business stay ahead of their competition. The best […]

The post Five of the Best B2B Content Marketing Trends That Are Proven Effective To Gain New Clients appeared first on Dumb Little Man.

After spending two months living in Mérida and years of trips traveling through the Yucatán Peninsula, I’ve finally put together the best itinerary for two weeks in Mexico. Most travelers go to Mexico to lie on the beach for a week, maybe go on an excursion to a ruin or a cenote, and head straight …

Two Weeks in Mexico: The BEST Yucatán Road Trip Itinerary Read More »

The post Two Weeks in Mexico: The BEST Yucatán Road Trip Itinerary appeared first on Adventurous Kate.

For those long, long travel days when you can't be bothered to change your socks ... you need the odorless, antibacterial MP Magic Socks.

The post Are These “Magic” Socks the Best Odorless Socks for Travelers? appeared first on Vagabondish.

When someone mentions “Peru,” images of bucolic mountain pastures, ancient Incan ruins, and verdant Amazonian jungle are probably the first thing that pop into your mind. But this beautiful South American nation boasts miles and miles of gorgeous Pacific coastline, and it is also home to some amazing beaches. Let’s take a look at some of best beaches Peru has to offer.

Cabo Blanco: Arguably the most famous beach along Peru’s 2,500 kilometers of coastline, Cabo Blanco is routinely hailed as one the best surf spots in the world. When Peruvian surfer Gordo Barreda was scouting the area for great waves, he randomly paid a visit to the village, where he stumbled upon the now famous Peruvian Pipeline. A hollow, powerful left-hanging wave, it is arguably one of the best places to catch a wave on the continent’s entire Pacific coastline. Even before Barreda’s famous discovery, this fishing hamlet long enchanted visitors with its small-town charm and thriving fishing industry. In the 1950s and 1960s, fishermen routinely made the trek to Cabo Blanco in search of the area’s legendary large marlin. The famous writer Ernest Hemmingway spent several months here during the filming of the movie adaptation of his novel “The Old Man and the Sea.” During his stay, he reportedly caught a 700-pound marlin.

Mancora: Once a quaint fishing village, Mancora has exploded onto Peru’s backpacker scene as a major hub in the last decade or so. Located right in the middle of Peru’s sunniest and warmest region, you can relax on beautiful beaches during the day and then party the night away. Mancora is great for travelers on a budget, and cheap hostels abound.

Vichayito: If you want great beaches without a slew of rowdy partiers, Vichayito is an excellent option. Situated about 7 kilometers to the south of Mancora, this is an ideal spot for families. The water is ideal for swimming and kite surfing, and the beaches are clean and quiet.

Punta Hermosa: Just an hour drive from Peru’s capital, Punta Hermosa is popular with Limeños looking for a summer retreat from the city. While not as spectacular as the beaches of Paracas or Mancora, Punta Hermosa’s proximity to Lima makes it a great option for looking for a quick weekend escape from the city.

Asia: Peru’s most opulent beach, Asia is all about glitz and glamour. The upper echelons of Peruvian society have luxurious summer homes at this beach resort town, making it a hub of wealth. The beaches are great, but what really make Asia stand out are its high-end restaurants, luxury shopping center, and dazzling nightclubs.

Paracas: The Paracas National Reserve boasts some of Peru’s most dramatic desert landscape. Here, enormous sand dunes and dramatic sandstone rock formations meet the azure waters of the Pacific. The reserve, which consists of a total of 335,000 hectares of tropical desert on the Paracas Peninsula, is intended to preserve the area’s rich marine ecosystem as well as protect its unique cultural heritage (the site was of great significance to the Paracas, a pre-Colombian indigenous group that inhabited the area between roughly 800 BC and 1000 BC). There are no formal hotels within the reserve, though there are many sites popular with beach campers.

If you are looking for more luxurious accommodations, they can certainly also be found. Though beach destinations to the north of the country often attract the majority of tourist attention, it is Paracas where you will find the most luxurious beach vacations Peru has to offer. Just a few miles from the park’s entrance, you will find Hotel Paracas, a Luxury Collection Resort complete with 5-star accommodations, three pools, and a luxury spa.

Marcona: For those really looking to get off of Peru’s beaten tourist trail, we recommend a visit to the rugged, windswept beaches of Marcona, located roughly 8 hours south of Lima. The waters here can be quite cold year-round thanks to the Humboldt current, which brings water up from Antarctica along the Pacific coast of Chile and southern Peru. But the cold temperatures mean that waters are teeming with marine life. With any bit of luck, visitors might catch a glimpse of one of the zone’s enormous seal colonies. The beaches are known for their dramatic rock formations and rough surf, but they are a great place for those looking for options totally free of tourists.

So they you have it, our pick of the best Peruvian beaches. Happy adventuring in Peru!

• Top 10 Films of 2012
• Movies We Wish We Saw In Theatres
• Most Overrated Movie
• Guilty Pleasure
• Biggest Disappointment
• Best Movie Poster
• Most Memorable Scene
• Best Movie You Saw In 2012 That Didn't Come Out In 2012

Many chemicals and cellular processes cause oxidative stress that can damage lipids, proteins, or DNA (1). To quickly sense and respond to this ubiquitous threat, organisms have evolved enzymes that neutralize harmful oxidants such as reactive oxygen species and electrophilic compounds (including xenobiotics and their breakdown products) in cells.These antioxidant enzymes include GSH S-transferase (GST),2 NADPH:quinone oxidoreductase 1, thioredoxin, hemeoxygenase-1, and others (2, 3). Many of these proteins are commonly expressed in cells exposed to oxidative stress.The antioxidant response element (ARE) is a major regulatory component of this cellular stress response. The ARE is a conserved, 11-nucleotide-long DNA motif present in the 5'-flanking regions of many genes encoding antioxidant proteins. The laboratory of Cecil Pickett (Fig. 1) at the Merck Frosst Centre for Therapeutic Research in Quebec discovered ARE, a finding reported in the early 1990s in two JBC papers recognized as Classics here (4, 5).jbc;295/12/3929/F1F1F1Figure 1.Cecil Pickett (pictured) and colleagues first described the ARE motif, present in the 5' regions of many genes whose expression is up-regulated by oxidative stress and xenobiotics. Photo courtesy of Cecil Pickett.ARE's discovery was spurred in large part by Pickett's career choice. After completing a PhD in biology and a 2-year postdoc at UCLA in the mid-1970s, he began to work in the pharmaceutical industry.Recruited to Merck in 1978 by its then head of research and development (and later CEO), Roy Vagelos, “I became interested in how drug-metabolizing enzymes were induced by various xenobiotics,” Pickett says.According to Pickett, Vagelos encouraged researchers at the company...

Medicine has long been a rewarding career, but doctors say the profession needs to overcome the frustrations of working in the NHS to ensure it remains so. During the Big Debate at BMJ Live in London last week six speakers argued for and against the motion, “This house believes that medicine is the best career in the world.” After presentations...

As England’s presumed consent law for 2020 clears parliament, Veronica English, head of medical ethics and human rights at the BMA, say that evidence from Wales and other countries shows that it could increase transplantation rates. But Blair L Sadler, physician and senior adviser to California State University, consider such legal changes a...

Test results suggest N95 masks can be safely disinfected through heating 50 times before their filtration efficiency begins to decline.

The best type of fabric for a breathable but effective COVID-19 mask.

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Here's a clue: the governor has said the teachers' unions need to be punched in the face.

Hypertension -- Diet therapy -- Recipes.

Illumination of books and manuscripts, Medieval -- Themes, motives -- Exhibitions.

London : Longman, Rees, Orme, Brown, and Green, 1834.

London : published by S.W. Fores, 1795.

London : printed by W. Wilson, for E. Brewster, and George Sawbridge, at the Bible on Ludgate-Hill, neere Fleet-bridge, 1653.

Alex Ovechkin can lay claim as the best Capitals player to wear No. 8, but what about the rest of the jersey numbers? Who are the best Caps for every number?

Alex Ovechkin can lay claim as the best Capitals player to wear No. 8, but what about the rest of the jersey numbers? Who are the best Caps for every number?

Adam Osękowski.

Source: Bernoulli, Volume 26, Number 3, 1912--1926.

Abstract:
Let $X=(X_{t})_{tgeq 0}in H^{1}$ and $Y=(Y_{t})_{tgeq 0}in{mathrm{BMO}} $ be arbitrary continuous-path martingales. The paper contains the proof of the inequality egin{equation*}mathbb{E}int _{0}^{infty }iglvert dlangle X,Y angle_{t}igrvert leq sqrt{2}Vert XVert _{H^{1}}Vert YVert _{mathrm{BMO}_{2}},end{equation*} and the constant $sqrt{2}$ is shown to be the best possible. The proof rests on the construction of a certain special function, enjoying appropriate size and concavity conditions.

You've got exactly four hours left to take advantage of these heavily discounted prices.

EndeavourOS is a rolling release Arch Linux-based distribution with some handy new features that improve the user experience. This latest version comes with graphical install options and preconfigured desktop environments. Several new in-house utilities improve package management and error reporting. There are lots of installation tips with the Calamares installer, which has a new look and feel.

Why not use quarantine as an opportunity to have your homeschoolers master woodworking or engine repair?

Ready to "switch" things up on your desktop? A mechanical keyboard can make everything click again. Here's a guide to the most common mechanical key types, as well as the top performers in our testing.

Cord cutters have more choices than just Netflix and Hulu. We break down the best video streaming services for your money, whether you're looking to completely replace cable or watch the latest original content on-demand.

Whether you're a casual smartphone shooter or a professional using an SLR, software can get the most out of your images. We help you find the best photo editing software for your needs.

The post The Value of Simulation: Which Design is the Best? appeared first on The SOLIDWORKS Blog.

If the coronavirus breaks as bad we fear, a lot more people are going to be working from home. These business messaging apps can help teams stay in touch, and stay productive, even if they can't come in to the office.

OK, most of us will never be able to enjoy the first growths from Bordeaux, but you don't have to spend a grand on a bottle to realise that when it comes to cabernet and merlot blends, Bordeaux is still the region to beat.

Your iPhone may be well protected against malware, but it can't protect your data as it travels the internet. Installing one of the best iPhone VPN apps can keep your information safe and private, even when you're connected to the web through an insecure Wi-Fi hotspot.

To try and make life a little easier for you when trying to navigate the minefield of skincare, we’ve compiled a list of some of the companies out there making an effort to have cruelty-free products.

If you're yearning for all the gardening shows that have been cancelled, you can still be inspired by exploring gorgeous virtual gardens now and throughout the summer, from the comfort of your armchair.

Inexpensive tablets can make great ebook readers, video players, or web browsers, and some of our top picks are well below the $100 mark. Here's how to find the right balance of price and features.

Can't get your hands on your own iPad? Kids love tablets, but which is the right one for them? Check out our top picks to keep your kids educated and entertained.

Tablets are great for playing games, reading, homework, keeping kids entertained in the back seat of the car, and a whole lot more. Whether you're looking for an Android or Apple slate, here's what to consider, along with reviews of the best tablets we've tested.

If Scotland really does have such fabulous seafood, why do ordinary citizens find it so hard to tap into this much eulogised catch? The problem has been that subsequent governments have fixated on international exports, not food for citizens.

Our list of the best iPad apps can transform your iPad, iPad mini, or iPad Pro into the ultimate tablet computer for work and play.

Sick of the same-old on-screen keyboard you get with iOS? Download and install a new one and experience keyboard nirvana.

A South African working abroad, able to save R36 000 per month, hopeful that he will continue these earnings, seeks the best investment strategy. Investment expert Elian Wiener responds.

Email marketing software offers quick and easy tools that can help you grow your business, and we've tested the best of them.

Valor Collegiate Academies has been in the top 5 percent of Tennessee schools on growth and achievement every year since it started in 2014. But Tom visited Valor because of the well-regarded Valor Compass, a holistic human-development program.