En 6 AM Hoy por Hoy, se conectó William Dávila Valeri, Hijo del Líder opositor Williams Dávila, quien habló del estado de salud de su padre luego de estar internado en el hospital y sobre la situación que están pasando en este momento.

Jorge Emilio Rey confirmó que los menores se encuentran en recuperación, tras el accidente en el que 5 jóvenes perdieron la vida 

Carlos Fernando Galán, alcalde de Bogotá, hizo hincapié en cuáles son las principales causas de las inundaciones en la Autopista Norte 

En 6AM de Caracol Radio se conectó Cecilia Rico Torres, Directora de Gestión de Impuestos de la DIAN, quien habló sobre la importancia de la factura electrónica y por qué hay más de 27.000 establecimientos sin facturación electrónica en sus operaciones

Connor Bedard's former coach says the World Junior hockey phenom is something special; how Buffalo is rallying together after Damar Hamlin's near death on the football field; how the bid to keep Prince Harry's memoir from leaking plays into the hype; seriously though, what exactly is Ozempic?; Toronto bartender mixes alcohol-free cocktails for Dry January and beyond; why BioNTech's plan to ship prefabricated mRNA vaccine factories to Rwanda is controversial; and more.

“We cannot direct the wind, but we can adjust the sails,” Dolly Parton once said. In the face of uncertainty and disruption, all we can do is adapt. This rings especially true for the logistics industry, which has been subject to major disruption over the last five years. Here, Dave Walsha, sales and marketing director at drive system supplier EMS, explores how robotics could streamline internal logistics operations.

The dessert is a Fig & Ash mainstay, a dessert so beloved that on the rare occasion Hughes takes it off the menu, "people complain."

Shaun Ross discusses his #InMySkinIWin movement.

Hold the Turkey, bring on the fists.

Public Policy expert Dr. Amara Enyia says it's Pres. Biden.

Hidden sources reveal true character.

It’s time for MJ to put her foot down.

The ‘Fuels Bill 2022′ will move the “responsibility for the regulation of fuels under the auspices of the Regulatory Authority,” Deputy Premier & Minister of Home Affairs Walter Roban said in the House of Assembly. The Minister said, “The Fuels Bill seeks to make the Regulatory Authority responsible for not only the regulation of the […]

Police Constable Jermari Belboda was convicted, in Magistrates’ Court, of sexual assault in relation to an incident which took place in 2018. Stephen Corbishley, Commissioner of Police stated, “PC Belboda remains suspended from duty pending the completion of the disciplinary process, which has been on hold until the resolution of the criminal process.” Related Stories […]

“The Department of Environment and Natural Resources is “currently investigating a major incident on the property of an exclusive private club, which has significantly impacted a large stand of protected mangroves,” Minister Walter Roban said, adding that a group of healthy mature red mangroves “which were 30-40 foot high, were cut to 4 foot stumps.” “Mangroves also […]

Clarien’s new interns, Maya Dean, Chelsea Correira, and David Goonewardene, made a “significant impact” this summer with their fresh ideas, the company said. A spokesperson said, “As we embrace the final weeks of summer, Clarien is proud to introduce our latest team members—interns Maya Dean, Chelsea Correira, and David Goonewardene—who have spent the past few weeks […]

The 2024 Bermuda Billfish Blast — part of the Bermuda Triple Crown — was held this week, with one of the notable catches being a 636lb blue marlin, caught on ‘Debaitable.’ The event website notes, “For decades, the blue-purple waters off the island nation of Bermuda have attracted anglers from around the world to pursue […]

Bermuda motorcycle racer Aeziah Divine has described competing at the Monster Energy Grand Prix MotoGP at the Silverstone GP Circuit last weekend as an “unforgettable experience.” Racing in the R&G Talent Cup round four, Divine was representing the Sencat Talent Team/Mortimer Racing – Victoria House Academy for the second successive round of the Moto3 class […]

NEWS – As the holiday season approaches, Creality is thrilled to launch its biggest-ever Black Friday event! From October 21 to December 3 on the Creality Store and November 21 to December 2 on Amazon, enjoy record-low prices on an extensive range of 3D printers and accessories. Whether you’re a 3D printing enthusiast or a […]

REVIEW – There seems to be a number of different form factors popping up with projectors recently. Very slim projectors, portable cubes, and today’s variation which looks more like a spotlight than a projector at first glance. The XGODY Gimbal 3 projector looked like a fun projector to try out and looked very portable. Read […]

Modula 5 mg is a medication that contains Tadalafil, which is commonly used to treat erectile dysfunction (ED) and symptoms of benign prostatic hyperplasia (BPH). It works by increasing blood flow to the penis during sexual activity, which helps achieve and maintain an erection. For individuals with diabetes, Tadalafil can generally be used safely, but some factors should be considered when choosing the right formulation: Factors to Consider for Individuals with Diabetes: Impact on Blood Sugar: Tadalafil itself doesn’t directly affect blood sugar levels, but individuals with diabetes need to manage their overall health, including blood sugar levels, when using medications for ED. It’s important to monitor blood glucose levels regularly while on Tadalafil. Formulation of Modula 5 mg: Modula 5 mg is typically available in tablet form. The tablet formulation is suitable for people with diabetes, as it is not known to contain sugar or carbohydrates that could directly affect blood sugar. Oral tablets like Modula 5 mg are often preferred because they allow for controlled, consistent dosing. Side Effects: People with diabetes may be more prone to certain side effects, such as dizziness, headaches, or blurred vision. These side effects are more common in individuals who have other underlying conditions (such as cardiovascular issues) that may co-occur with diabetes. It's important to start with a lower dose, like 5 mg, and adjust based on tolerance and effectiveness, in consultation with a healthcare provider. Cardiovascular Health: Diabetes often comes with an increased risk of heart disease, which is also a concern when using medications like Tadalafil. It’s crucial to consult a healthcare provider to ensure that there are no contraindications with any existing heart conditions before starting MODULA 5 MG. Other Medications: People with diabetes may be on other medications to manage their condition, such as insulin or oral medications for blood sugar control. Tadalafil can interact with certain medications, especially nitrates (used for chest pain), leading to dangerous drops in blood pressure. Therefore, it is essential to ensure that Modula 5 mg doesn’t interact with any other ongoing treatments. Recommendation for People with Diabetes: Modula 5 mg (Tadalafil) in its tablet formulation is generally a suitable option for individuals with diabetes, provided they are managing their blood sugar levels effectively and have discussed the use of this medication with their healthcare provider. If there are concerns about side effects or interactions with other medications, starting with a lower dose or exploring other alternative treatments for ED may be recommended. Key Takeaways: Modula 5 mg (Tadalafil) is safe for most individuals with diabetes, but it's crucial to check for potential interactions with diabetes medications. Monitoring blood sugar and blood pressure regularly while using Tadalafil is essential for safety. Always consult a healthcare provider to ensure the medication is appropriate based on your medical history and current treatments. If you have specific concerns, such as interactions with your diabetes medications or heart conditions, consulting with your doctor is the best course of action before starting any treatment.

1. Apple reportedly releasing a wall-mounted smart home tablet in 2025 - and yes, it does AI  Yahoo Finance Australia
2. Apple’s next device might make your home a lot smarter  Sydney Morning Herald
3. Apple's Next Big Move Could Be Home Security Cameras  PCMag AU

Sevenoaks slider Lizzy Yarnold says the fact Britain has no real purpose built tracks is the main reason behind British success in the sport

The habitable zone is a useful concept in astrobiology, but it can sometimes paint an over-simplified picture of planetary habitability.

The post How to Use a Graphics Tablet to Edit Photos: 10 Powerful Tips appeared first on Digital Photography School. It was authored by John McIntire.

Photo editing is simpler than ever thanks to the power of a graphics tablet! Explore our top 10 tips to level up your skills. If you’re just getting started with post-processing and retouching, you’re probably using a mouse and keyboard combo. You can get by with this setup, sure. But when the tasks become more […]

The post How to Use a Graphics Tablet to Edit Photos: 10 Powerful Tips appeared first on Digital Photography School. It was authored by John McIntire.

IKEA hacks that go viral? It’s often the simplest ideas, brilliantly executed, mixed with a healthy dose of “It’s so easy, even you can do it” appeal. The latest sensation comes from Ayse Balci of @interiorundco, whose stylish DIY project has been turning heads on Instagram, amassing an impressive 115,000 likes and counting. Have you seen it yet? It’s a fantastic DIY project that transforms the popular and affordable 13 3/4″ LACK side table into a stylish chrome cube side […]

The post How a Basic IKEA Table Became a Viral Sensation (So Easy Anyone Can DIY It) appeared first on IKEA Hackers.

My search for the perfect sideboard has been going on for like ever. Like many home decor enthusiasts, I found myself caught between my champagne taste and lemonade budget – until I came across @interiorxlifestyle‘s IKEA hack. She transformed the affordable IKEA GURSKEN nightstands into a sophisticated storage sideboard that may just be the thing I’m looking for. On its own, a single hacked GURSKEN might not amount to much. But when you place five of these hacked beauties in […]

The post The $20 IKEA Bedside Table That Became a Luxury Sideboard appeared first on IKEA Hackers.

If you love pasta, but don’t often find suitable gluten-free alternatives in restaurants, Charlie's Table gluten-free products may be the answer for you. In fact, this craft pasta and pasta flour blend not only caters to the gluten intolerant, but is free of the top nine food allergens.[...]

In honor of his parents, Chemistry Nobel Laureate David MacMillan has founded The May and Billy MacMillan Foundation to provide educational opportunities for financially disadvantaged students in Scotland.

PivotTables are a powerful tool to calculate, summarize, and analyze data that lets you see comparisons, patterns, and trends in your data. This session will introduce participants PivotTables and their functionality. We will also discuss creating PivotCharts, a graphical representation of a data summary displayed in a PivotTable.

eLab Accelerator Info Table

On the off chance that you are a well-being cognizant voyager or a rec center goer, what you should have is the Best Portable Blender.

The post 15 Best Portable Blender While Traveling 2024 – Top Portable Kitchen Machine appeared first on Star Two.

Located on the Caribbean coast, Cozumel has some of the most stunning beaches in the world. It’s not just the turquoise waters and soft sandy beaches that attract tourists from all over the world. The island is also known for its spectacular sunsets, painting the sky in vibrant colors of orange, pink and red, and promising a magical end to every day. Looking for the perfect sunset spot Seeing the sunset, however, is only half the experience. It can escalate from a simple natural phenomenon to an unforgettable memory where you choose to see it. Enter the quintessential beach bar. These getaways dot Cozumel’s beaches, each offering a different climate and different temperatures. It is important to choose the right one. With the perfect cocktail in hand, it can mean the difference between a beautiful sunset and an extraordinary sunset. Choosing where to stumble in the evening light isn’t just about finding the best spot. It’s about the atmosphere, the drinks, the service, and how the sound of the waves matches the music in the background. It is a form of art. And we’re here to guide you through it. Unveiling the Top 10 Beach Bars in Cozumel for Stunning Sunsets Cozumel, a gem in the Caribbean, is famed not just for its crystal-clear waters and vibrant marine life but also for its spectacular sunsets that paint the sky in shades of orange, pink, and purple. Among the best ways to enjoy these magical moments is from the comfort of the island’s best beach bars. Here’s a countdown to the top 10 beach bars in Cozumel for those unforgettable sunset views. 10. The Sunset Lounge Description: Nestled on the quieter side of the island, The Sunset Lounge offers a laid-back vibe with hammocks and cozy seating. Their signature cocktail, the “Caribbean Sunset”, combines local fruits with aged rum. Ambiance: Chill and intimate Unique Feature: A private pier for sunset gazers Best Time for Sunsets: Arrive an hour before sunset for the perfect spot. Interesting Fact: The Sunset Lounge was once a private retreat before opening its doors to the public. 9. Ocean Vibes Bar Description: A vibrant spot where live music and ocean views create a lively atmosphere. Their “Blue Horizon” cocktail is a must-try. Ambiance: Festive and musical Unique Feature: Live bands every evening Best Time for Sunsets: The party starts in the late afternoon, leading up to sunset. Interesting Fact: Ocean Vibes Bar holds a record for hosting the longest-running beach party on the island. 8. Coral Reef Inn Description: More of a cozy inn with a spectacular beach bar, it’s known for its extensive tequila selection and the “Mayan Mule” cocktail. Ambiance: Rustic and cozy Unique Feature: An underwater-themed bar top Best Time for Sunsets: Just as the dusk settles in. Interesting Fact: Its signature bar top features real corals and artifacts found in Cozumel’s waters. 7. Sunset Paradise Description: This bar offers panoramic views of the ocean, making it a prime spot for sunset watching. Their specialty is the “Paradise Punch”. Ambiance: Romantic and serene Unique Feature: Elevated decks for an unobstructed view Best Time for Sunsets: Half an hour before sunset is ideal. Interesting Fact: The bar’s location was chosen specifically for its unobstructed sunset views. 6. Azure Sky Bar Description: Famous for its signature “Azure Martini” and a sophisticated atmosphere. It’s a favorite among luxury travelers. Ambiance: Elegant and upscale Unique Feature: An infinity pool that blends with the ocean horizon Best Time for Sunsets: Right as the sun begins to dip below the horizon. Interesting Fact: The bar was designed by a renowned architect who wanted to capture the essence of the ocean in every element. 5. La Cazuela del Mar Description: Known for its seafood cuisine, this bar’s “Seaside Sangria” is a refreshing accompaniment to the stunning views. Ambiance: Casual and friendly Unique Feature: A menu that changes daily based on the catch of the day Best Time for Sunsets: Early evening to enjoy dinner with the show. Interesting Fact: The owner is a former fisherman who shares tales of the sea with guests. 4. The Horizon Club Description: Overlooking the highest point on the island, this bar offers not just cocktails, like their “Horizon Spritz”, but also a breathtaking view of the entire bay. Ambiance: Exclusive and private Unique Feature: A telescope for star-gazing post-sunset Best Time for Sunsets: An hour before sunset to appreciate the changing colors. Interesting Fact: It stood as a historical lookout post in the 18th century. 3. Pirate’s Hideaway Description: With a fun pirate theme, this bar serves a “Treasure Chest” cocktail filled with rum and tropical fruits. Ambiance: Fun and thematic Unique Feature: Authentic pirate memorabilia Best Time for Sunsets: As the sun starts its descent, to capture the golden hour. Interesting Fact: The bar is rumored to be built on an actual pirate hideout. 2. Moonlit Mirage Description: Offering serenity alongside inventive cocktails like the “Moonlit Mojito”, this bar is perfect for a tranquil sunset. Ambiance: Quiet and reflective Unique Feature: Moonlight reflection pools Best Time for Sunsets: Moments before the sun meets the horizon. Interesting Fact: The reflection pools are a nod to the ancient Mayan practices of moon gazing. 1. The Majestic View Description: Crowned as the best beach bar for sunsets in Cozumel, The Majestic View marvels with its “Cosmic Colada”, an interplay of local spices and coconut rum. Ambiance: Breathtaking and unforgettable Unique Feature: A cliff-top location that offers a 360-degree view of the surrounding landscape and ocean. Best Time for Sunsets: Be there an hour early to catch the gradual change in scenery. Interesting Fact: It’s said that on certain evenings, the conditions create a green flash phenomenon just as the sun sets. Each of these beach bars in Cozumel offers a unique experience for sunset seekers. From the vibrant and lively to the serene and intimate, there’s a spot for every kind of traveler looking to capture the essence of Cozumel’s sunsets. Whether you’re there for the cocktails, the company, or just the views, these bars are sure to make your evenings in Cozumel unforgettable. Additional Tips for the Perfect Sunset Experience Best Sunset Watching Practices To guarantee you don’t miss out on the splendid Cozumel sunset: Ideal Arrival Time: Aim to arrive at least an hour before the expected sunset time. This allows you to secure the best viewing spot. Photography Tips: Use a low ISO setting to avoid grainy photos. Set your camera to a small aperture (high f-number) for a deeper depth of field. Utilize the golden hour filter on photo apps for an enhanced effect. Local Etiquette and Tips Being mindful of local customs and practices enhances the experience: Local Customs: Always ask for permission before taking photos of the locals or private properties. Happy Hour Info: Many beach bars offer ‘happy hour’ specials 1-2 hours before sunset, making it a great time to enjoy discounted drinks as you wait for the sunset. Map and Directions While a detailed map cannot be displayed here, all mentioned beach bars are located along Cozumel’s western coast, facing the Caribbean Sea, ideal for sunset views. You can easily find them marked on any local map provided by the tourist offices in Cozumel. Transport Options: Taxi: Readily available and reasonably priced. Ensure to agree on the fare before the ride. Rentals: Scooters and cars are available for rent if you prefer exploring at your own pace. Public Transport: Buses and colectivos (shared vans) run frequently along the main road, offering an economical way to travel. conclusion Cozumel’s beach bars not only offer delicious drinks and a lively atmosphere, but also some of the most spectacular sunsets in the Caribbean. Remember to arrive early, be mindful of local customs, and don’t forget your camera to capture amazing scenes. Whether you want a romantic evening, a quiet solo getaway, or a fun night out with friends, these bars offer the perfect setting. We encourage all visitors to explore these areas and discover the natural beauty and unique local hospitality that Cozumel offers. And once you soak in the unique sunset, be sure to share your experience or personal tips to help your fellow travelers make the most of their Cozumel trip.

The post 10 Best Beach Bars in Cozumel for Unforgettable Sunsets appeared first on Geeky Traveller.

The following article, Check out the Leftist Notables Who Have NOT Donated to Harris, was first published on The Black Sphere.

What's up rich Leftists? Do you know something you're not telling the minions of your party?

Continue reading Check out the Leftist Notables Who Have NOT Donated to Harris ...

A 'hybrid model' for hosting the Champions Trophy will not be accepted by Pakistan, according to its Cricket Board chairman Mohsin Naqvi.

The following article, ‘Utterly Unacceptable’: After Helping Trump Win, Elon Musk Makes Crucial Endorsement For Senate Majority Leader, was first published on Conservative Firing Line.

Despite a landslide victory for Donald Trump and his “Make America Great Again” agenda last week, a ferocious battle has suddenly broken out in the U.S. Senate over who will be the chamber’s new leader, with some saying outgoing Majority Leader Mitch McConnell is trying to thwart the plans of the president-elect. “What the hell …

Continue reading ‘Utterly Unacceptable’: After Helping Trump Win, Elon Musk Makes Crucial Endorsement For Senate Majority Leader ...

The first battle cry has sounded ahead of the showdown at Twickenham on Saturday, with English winger Tommy Freeman reckoning that the Springboks are 'still human' and 'still playing the same game'.

China Needs to Make the Belt and Road Initiative More Transparent and Predictable Expert comment sysadmin 29 April 2019

The global infrastructure project must move beyond mish-mash of opaque bilateral deals

As China welcomes dozens of world leaders to Beijing for its second Belt and Road forum, it has one simple aim: relaunching President Xi Jinping’s controversial global infrastructure drive.

Since it began five years ago, the Belt and Road Initiative (BRI) has sunk hundreds of billions into port, railway and power projects stretching from south-east Asia to central Europe. But its path has been bumpy, drawing sharp criticism over the ruinous debts that some countries have racked up amid Chinese largesse.

Xi will stress sustainable financing and transparency this week, amid the usual talk of ‘win win’ cooperation. Yet BRI’s problems are structural, not presentational. For any pledges to be meaningful, China must move beyond its present mish-mash of opaque, bilateral deals.

After bad headlines last year, BRI has in fact enjoyed a good run in recent weeks. Malaysia announced it would resume a previously cancelled high-speed rail project, while Italy’s decision to join up last month marked a further European incursion. Indeed, if attendance is any guide to success, BRI looks in fine fettle. The first forum in 2017 attracted 29 world leaders. China says 37 will turn up this week. Phillip Hammond, UK chancellor, arrives hunting deals too, just a day after news that Chinese technology group Huawei will be allowed to help build 5G networks in Britain.

Even so, three interlinked problems remain at the heart of President Xi’s pet project, all of which must be addressed if BRI is to move beyond the pitfalls that have damaged its reputation.

The first and most obvious is debt. Critics allege that China ‘traps’ its BRI partners financially, often pointing to a debt-for-equity deal that handed China control of a port in Sri Lanka. These claims are exaggerated — few other projects have ended up this way. Yet poorer nations from Laos to Tajikistan are still signing up to vastly expensive Chinese schemes that offer poor value for money while straining their public finances.

The second problem is transparency. Despite its grand scale there is still no reliable list of BRI projects, no disclosure of the lending standards China follows, nor even the amount China has invested. Beijing claims more than $1 trillion; independent estimates suggest perhaps a few hundred billion. Either way, it will be hard for China to convince doubters on debts until it is open about the criteria it uses in deciding who to lend to and why.

BRI’s third and most important challenge is its muddled organization. Despite BRI’s image as a centrally run mega-project, China has allowed many deals to be struck locally, via a mix of state-backed companies, public sector banks and freewheeling regional governments. And it is here that the problems began.

Infrastructure deals are notoriously complex, especially for transnational projects like high-speed rail. Renegotiations are common, even for experienced bodies like the World Bank. Yet BRI has repeatedly seen terms negotiated behind closed doors, in countries such as Malaysia and Pakistan, come unstuck in the face of public outcry.

Rather than seeking to trap others with debt, China’s central government more often has to step in to fix dubious projects agreed by underlings lower down the chain.

These negotiations go one of two ways. Either China’s partners complain and win terms, as was true in Malaysia and in Myanmar over a multibillion-dollar deep-sea port. Or, as in the case of Sri Lanka, the renegotiations go in China’s favour, but at the cost of accusations of debt trickery. In both cases China looks bad.

Speaking last year, Xi responded to criticism of BRI by describing it as ‘an open platform for cooperation’. Yet, so far, he has proved resistant to the step that would deliver on that vision — namely turning BRI into an institution with open standards and international partners.

The reasons for his reluctance are obvious. Ending BRI’s reliance on loose bilateral deals would limit Beijing’s room for geopolitical manoeuvre. Yet what might be lost in political flexibility could easily be gained in economic credibility, while avoiding some of the painful renegotiations that have dogged many BRI projects.

At a time when China’s economy is slowing and its current account surplus is shrinking, formalising and institutionalising, BRI could also help avoid wasting scarce public resources on white elephant projects. China even has an easy template in the form of the Asian Infrastructure Investment Bank, the Beijing-based institution that has won plaudits for its project quality and openness since it started in 2016.

Whichever model is chosen, a dose of Chinese-style central planning is called for, along with more openness. Without it, the oddly chaotic and decentralised model pioneered in BRI’s first five years is unlikely to help the project thrive over the next five.

This article was originally published in the Financial Times.

Virtual Roundtable: The Economic Implications of COVID-19 on Asia 2 April 2020 — 11:00AM TO 12:00PM Anonymous (not verified) 27 March 2020 Chatham House | 10 St James's Square | London | SW1Y 4LE

The COVID-19 pandemic is likely to have a damaging economic impact on Asia, potentially the most serious since the financial crisis two decades ago. While early estimates suggest that a recession is inevitable, differing countries in Asia are generally deploying modest fiscal and monetary measures. This is true even in China, compared with the ‘whatever it takes’ approach pursued by Europe and America.

How effective will these measures be in reviving growth and in easing the pain, particularly on the poor in developing countries in Asia? Is Asia witnessing a sudden but temporary halt in economic activity rather than a prolonged slowdown? At this virtual roundtable, the speakers will consider the likelihood of a recovery for trade in the region and will explore what lessons can be learned from countries like Singapore, who seem to be successfully managing the health and economic aspects of COVID-19.

This event is online only. After registering, you will receive a follow-up confirmation email with details of how to join the webinar.

Hasmik Keshishian
Dec 1, 2007; 6:2212-2229
Research

Shao-En Ong
May 1, 2002; 1:376-386
Research

W Gamble
Nov 1, 1978; 19:1068-1070
Articles

A seat at the table – why inclusivity matters in global governance 10 May 2021 — 1:30PM TO 3:00PM Anonymous (not verified) 22 April 2021 Online

Exploring the changing dynamics of global cooperation and the role inclusivity can play in building collaborative action.

Please click on the below link to confirm your participation and receive your individual joining details from Zoom for this event. You will receive a confirmation email from Zoom, which contains the option to add the event to your calendar if you so wish.

The scale of today’s global challenges demand collaborative and coordinated action. But deepening geopolitical competition is threatening multilateralism while growing inequality and social tensions continue to undermine public confidence in the ability of international institutions to deliver.

Into this challenging environment, add the complexity and sheer pace of many global challenges such as the climate crisis and the proliferation of new technologies – issues that cannot be addressed effectively by governments alone.

• How do global institutions and mechanisms need to adapt to address the demands for a fairer distribution of power between states and to engage the diverse set of actors essential today for effective solutions?
• What can be learnt from existing initiatives that bring together governments, civil society, private sector, cities, next generation leaders and other stakeholders?
• And what are the political obstacles to greater inclusivity?

This event supports the launch of a synthesis paper from Chatham House’s Inclusive Governance Initiative.

Stop codon read-through (SCR) is a process of continuation of translation beyond a stop codon. This phenomenon, which occurs only in certain mRNAs under specific conditions, leads to a longer isoform with properties different from that of the canonical isoform. MTCH2, which encodes a mitochondrial protein that regulates mitochondrial metabolism, was selected as a potential read-through candidate based on evolutionary conservation observed in the proximal region of its 3' UTR. Here, we demonstrate translational read-through across two evolutionarily conserved, in-frame stop codons of MTCH2 using luminescence- and fluorescence-based assays, and by analyzing ribosome-profiling and mass spectrometry (MS) data. This phenomenon generates two isoforms, MTCH2x and MTCH2xx (single- and double-SCR products, respectively), in addition to the canonical isoform MTCH2, from the same mRNA. Our experiments revealed that a cis-acting 12-nucleotide sequence in the proximal 3' UTR of MTCH2 is the necessary signal for SCR. Functional characterization showed that MTCH2 and MTCH2x were localized to mitochondria with a long t1/2 (>36 h). However, MTCH2xx was found predominantly in the cytoplasm. This mislocalization and its unique C terminus led to increased degradation, as shown by greatly reduced t1/2 (<1 h). MTCH2 read-through–deficient cells, generated using CRISPR-Cas9, showed increased MTCH2 expression and, consistent with this, decreased mitochondrial membrane potential. Thus, double-SCR of MTCH2 regulates its own expression levels contributing toward the maintenance of normal mitochondrial membrane potential.