Platform.sh removes a major pain point for developers: having to invest time in managing servers, virtual machines, or containers. Instead, Platform.sh enables developers to focus 100% of their time on their code. Since the beginning, Platform.sh has provided instant cloning capability, so dev teams can work on perfect copies of their production sites in the cloud for every Git branch. Now, in partnership with Lando, we’re extending that capability to the desktop.

Xdebug is an indispensable tool for every PHP developer. PHP’s favorite real-time debugger, it supports breakpoints, more detailed debug output, and deeper introspection of PHP code to determine just what it’s doing (and what it’s doing wrong). Sadly, it comes at a huge cost in performance, though, making it unsuitable for production. Not on Platform.sh, though. Xdebug is now available on all Grid environments, secure and without a performance loss.

The platforms, providers, and infrastructures which together make up the contemporary Internet play an increasingly central role in the business of governing human societies. Although the software engineers, administrators, business professionals, and other staff working at these organisations may not have the institutional powers of state organisations such as law enforcement or the civil service, … Continue reading Three Paper Thursday: The role of intermediaries, platforms, and infrastructures in governing crime and abuse →

It's like three buses showing up at once carrying $8bn

India’s largest mobile carrier, Jio, has just scored a third new investor in three weeks!…

IBM today announced that CipherHealth, a SaaS healthcare provider, has deployed IBM Power Systems™ infrastructure to run its technology platform that helps healthcare providers reduce re-admissions and improve the patient experience by providing effective patient engagement from pre-hospitalization through to post-discharge. The move to the new infrastructure has halved CipherHealth’s monthly infrastructure costs, and improved its data processing times by nearly 90 percent.

IBM and Sesame Workshop today announced that Georgia’s Gwinnett County Public Schools, one of the nation’s top urban school districts, has completed an initial pilot of the industry’s first cognitive vocabulary learning app, built on the IBM and Sesame intelligent play and learning platform. The new platform, powered by IBM Cloud, enables an ecosystem of software developers, researchers, educational toy companies, and educators to tap IBM Watson cognitive capabilities and Sesame Workshop’s early childhood expertise to build engaging experiences to help advance children’s education and learning. The cognitive vocabulary app is one of the first of many cognitive apps, games, and educational toys that will be built over time on this new platform, as a result of the two companies’ collaboration announced last year.

IBM today announced that IBM Watson Internet of Things (IoT) has been named a Leader in the IDC MarketScape: Worldwide IoT Platforms 2017 Vendor Assessment (Doc # US42033517, July 2017). The report highlights IBM’s Watson IoT Platform on IBM Cloud, which today is being used by thousands of clients and partners across six continents including BMW, KONE, HARMAN and more.

IBM announced today that Acrow, one of Australia’s leading suppliers of scaffolding and formwork for the construction industry, has selected IBM and IT Easy , to implement a total infrastructure refresh built around IBM Cloud, mobile, and network technology.

IBM today announced new offerings to its Watson Data Platform, including data cataloging and data refining, which is designed to make it easier for developers and data scientists to analyze and prepare enterprise data for AI applications, regardless of its structure or where it resides. By improving data visibility and helping to better enforce data security policies, users can now connect and share data across public and private cloud environments.

Bank of Montreal (BMO), CaixaBank, Commerzbank and Erste Group have joined an initiative launched by UBS and IBM in 2016 to build a new global trade platform based on blockchain technology. This new platform, called Batavia, is built to be openly accessed by organisations of all sizes anywhere in the world, and can support trade finance for transactions across all modes of trade, whether goods are being transported by air, land or sea.

As companies look to embrace Artificial Intelligence (AI) to gain competitive advantage and increase productivity, IBM today unveiled a new data science and machine learning platform and an elite consulting team to help them accelerate their AI journeys.

IBM today announced it is building an industry-first insurance platform on the IBM Cloud that aims to improve the processes and economics for new product development, underwriting, and benefits delivery.

IBM announced today that Portland Software, one of New Zealand’s fastest growing technology companies, has created a fully integrated employee benefits administration platform on IBM Cloud.

ANZ, Commonwealth Bank, IBM Scentre Group and Westpac have jointly launched a live pilot for Lygon, a new digital platform using blockchain technology to transform the way businesses obtain and manage bank guarantees that are often required as part of a retail property lease.

Customer transaction and processing time reduced with the new digital engagement

ASL to benefit from IBM Cloud and IBM PureApplication to deliver for secure real time payments for NPP Australia

We study the trade-offs faced by Internet Service Providers (ISPs) that serve as platforms through which consumers access both television and internet services. As online streaming video improves, these providers may respond by attempting to steer consumers away from streaming video toward their own TV services, or by attempting to capture surplus from this improved internet content. We augment the standard mixed bundling model to demonstrate the trade-offs the ISP faces when dealing with streaming video, and we show how these trade-offs change with the pricing options available to the ISP. Next, we use unique household-level panel data and the introduction of usage-based pricing (UBP) in a subset of markets to measure consumers' responses and to evaluate quantitatively the ISP's trade-offs. We find that the introduction of UBP led consumers to upgrade their internet service plans and lower overall internet usage. Our findings suggest that while steering consumers towards TV services is possible, it is likely costly for the ISP and therefore unlikely to be profitable. This is especially true if the ISP can offer rich pricing menus that allow it to capture some of the surplus generated by a better internet service. The results suggest that policies like UBP can increase ISPs' incentive to maintain open access to new internet content.

The Times has begun using a new commenting platform for its online articles.

The Times has launched a new, more interactive commenting platform on latimes.com.

Amid coronavirus, Platform begins curbside pickup for wine, CBD.

They may not be classics, but people are watching and talking about 'Trolls World Tour,' 'The Platform' and 'Onward.'

Economics professors Susan Harmeling and Nico Voigtländer break down Netflix's social allegory "The Platform," exploring how the Spanish thriller is even more resonant in wake of the coronavirus pandemic.

One of the fastest ways for a startup to grow has always been to ride on the shoulders of a successful platform: from Microsoft/OSS in software to AWS in cloud computing to iOS/Android in mobile to Facebook/Twitter/Pinterest in social to … Continue reading →

Nokia World, London - Having jumped off of a burning platform and into Redmond’s arms – a story that I (partially) broke on TechCrunch back in February this year – Nokia this morning finally took the wraps off its much anticipated entry into the Windows Phone world with two new devices: The flagship Lumia 800 [...]

velocityconf: Free webcast from our friends at @citrix 5/29 http://t.co/IOeY4U0wUP Learn to consolidate 40 load balancers and ADCs into single platform

Alumni inspired by the scientific response to the SARS outbreak are developing a platform to help researchers collaborate on global challenges.

(Institute for Operations Research and the Management Sciences) New research to be published in the INFORMS journal Management Science has found popular rideshare platforms exhibit racial and other biases that penalize under-represented minorities and others seeking to use their services.

We finally get the IoT acronym the pod has been waiting for as we discuss Bitcoin and 17th century Dutch finance. Charlotte Jee informs Henry Burrell, David Price and Scott Carey.

Scott then leads us down the winding road of the so-called platform wars, in a week when Google blocked the Amazon Echo Show from streaming YouTube. Is this a bump in the road or will services be cut from rival hardware?

And finally, led by David, the pod discusses its favourite tech of the year and what you might consider buying for friends and family for Christmas.

See acast.com/privacy for privacy and opt-out information.

Bile acids (BAs) serve multiple biological functions, ranging from the absorption of lipids and fat-soluble vitamins to serving as signaling molecules through the direct activation of dedicated cellular receptors. Synthesized by both host and microbial pathways, BAs are increasingly understood as participating in the regulation of numerous pathways relevant to metabolic diseases, including lipid and glucose metabolism, energy expenditure, and inflammation. Quantitative analyses of BAs in biological matrices can be problematic due to their unusual and diverse physicochemical properties, making optimization of a method that shows good accuracy, precision, efficiency of extraction, and minimized matrix effects across structurally distinct human and murine BAs challenging. Herein we develop and clinically validate a stable-isotope-dilution LC/MS/MS method for the quantitative analysis of numerous primary and secondary BAs in both human and mouse biological matrices. We also utilize this tool to investigate gut microbiota participation in the generation of structurally specific BAs in both humans and mice. We examine circulating levels of specific BAs and in a clinical case-control study of age- and gender-matched type 2 diabetes mellitus (T2DM) versus nondiabetics. BAs whose circulating levels are associated with T2DM include numerous 12α-hydroxyl BAs (taurocholic acid, taurodeoxycholic acid, glycodeoxycholic acid, deoxycholic acid, and 3-ketodeoxycholic acid), while taurohyodeoxycholic acid was negatively associated with diabetes. The LC/MS/MS-based platform described should serve as a robust, high-throughput investigative tool for studying the potential involvement of structurally specific BAs and the gut microbiome on both physiological and disease processes.

2 July 2014 , Volume 90, Number 4

Youyi Zhang, Jeffrey S. Morris, Shivali Narang Aerry, Arvind U. K. Rao, Veerabhadran Baladandayuthapani.

Source: The Annals of Applied Statistics, Volume 13, Number 3, 1957--1988.

Abstract:
Technological innovations have produced large multi-modal datasets that include imaging and multi-platform genomics data. Integrative analyses of such data have the potential to reveal important biological and clinical insights into complex diseases like cancer. In this paper, we present Bayesian approaches for integrative analysis of radiological imaging and multi-platform genomic data, where-in our goals are to simultaneously identify genomic and radiomic, that is, radiology-based imaging markers, along with the latent associations between these two modalities, and to detect the overall prognostic relevance of the combined markers. For this task, we propose Radio-iBAG: Radiomics-based Integrative Bayesian Analysis of Multiplatform Genomic Data , a multi-scale Bayesian hierarchical model that involves several innovative strategies: it incorporates integrative analysis of multi-platform genomic data sets to capture fundamental biological relationships; explores the associations between radiomic markers accompanying genomic information with clinical outcomes; and detects genomic and radiomic markers associated with clinical prognosis. We also introduce the use of sparse Principal Component Analysis (sPCA) to extract a sparse set of approximately orthogonal meta-features each containing information from a set of related individual radiomic features, reducing dimensionality and combining like features. Our methods are motivated by and applied to The Cancer Genome Atlas glioblastoma multiforme data set, where-in we integrate magnetic resonance imaging-based biomarkers along with genomic, epigenomic and transcriptomic data. Our model identifies important magnetic resonance imaging features and the associated genomic platforms that are related with patient survival times.

If you are looking for a well-designed Linux distro that is far from mainstream, loaded with performance features not found elsewhere, check out the 2020 upgrade of the MakuluLinux Core distro. It could change your perspective on what a daily computing driver should offer. Developer Jacque Montague Raymer recently released the 2020 edition of MakuluLinux Core OS.