Environ. Sci.: Processes Impacts, 2024, Advance Article
DOI: 10.1039/D4EM00525B, Paper

Naomi Y. Chang, Clara M. A. Eichler, Elaine A. Cohen Hubal, Jason D. Surratt, Glenn C. Morrison, Barbara J. Turpin
Per and polyfluoroalkyl substances (PFAS) are ubiquitous in the indoor environment, resulting in indoor exposure. Inhalation and ingestion dominate.
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Faraday Discuss., 2024, Accepted Manuscript
DOI: 10.1039/D4FD00047A, Paper

Open Access

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Naomi Elstone, Emily Shaw, Karina Shimizu, Joshua Lai, Bruno Demé, Paul Lane, Matthew L Costen, Kenneth G McKendrick, Sarah Elizabeth Youngs, Sarah E. Rogers, Jose Nuno Canongia Lopes, Duncan W Bruce, John M. Slattery
As part of an ongoing study of the structure and properties of mixtures of ionic liquids in which one component has a hydrocarbon chain and the other a semiperfluorocarbon chain,...
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Inorg. Chem. Front., 2024, 11,8130-8138
DOI: 10.1039/D4QI02088J, Research Article

Bei-Bei Zhang, Wen-Ye Gao, Wei Xu, Liang Ma, Wenlong Liu, Ru-Ling Tang, Sheng-Ping Guo
The acentric Ce(IV) fluoride NH₄Ce₃F₁₃ is systematically studied, exhibiting the strong SHG effect (1.2 × KDP) and high LIDTs (39 × AGS). It also possesses the largest band gap among NLO materials containing Ce(IV).
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Inorg. Chem. Front., 2024, 11,8025-8036
DOI: 10.1039/D4QI01804D, Research Article

Fangyuan Yu, Qifa Lin, Xiangfu Zeng, Ping Zhou, Xiao Wu, Cong Lin, Chunlin Zhao, Min Gao, Tengfei Lin, Xingan Jiang, Laihui Luo, Qiwei Zhang
Sr/Er was codoped in KNN ceramics to induce the coexistence of O and T phases, resulting in improving optical transparency, maintaining moderate ferroelectricity, inducing excellent PC behavior and fluorescence temperature sensing performance.
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Inorg. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QI02162B, Research Article

Ni-Ya Li, Xin-Yu Wang, Pei-Xuan Zhang, Ning-Ning Zou, Wen Qiu, Yu-Fei Xing, Yun-Jian Wang, Xiao-Yan Tang, Dong Liu
A unique coordination polymer can transform between comb-like and ladder-like bistable structures through reversible single-crystal-to-single-crystal photoreaction and exhibit photo-switchable fluorescence.
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Lab Chip, 2024, 24,1965-1976
DOI: 10.1039/D3LC01007D, Paper

Wei-Jen Soong, Chih-Hung Wang, Chihchen Chen, Gwo-Bin Lee
We devised an innovative method for automated sorting of extracellular vesicles (EVs) employing optically-induced dielectrophoresis on an integrated microfluidic chip. EVs of three distinct size categories could be isolated in 1 h at a purity of 86%.
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Lab Chip, 2024, 24,2017-2024
DOI: 10.1039/D3LC01050C, Paper

Samantha Bourg, Karol Rakotozandriny, Ivan T. Lucas, Emmanuel Letavernier, Christian Bonhomme, Florence Babonneau, Ali Abou-Hassan
The successful formation of a carbonated apatite coating inside a micrometer channel is described, which was used to investigate its role on the formation of calcium oxalate crystals in the context of kidney stones.
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Lab Chip, 2024, 24,1918-1929
DOI: 10.1039/D3LC00793F, Paper

Lauren M. Delong, Colby E. Witt, Madison Pennell, Ashley E. Ross
Here, we have developed a 3D printed microfluidic device capable of oxygen gradient formation within intestinal tissue slices ex vivo. The device is open-welled and compatible with external electrochemical recording during tissue analysis.
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Lab Chip, 2024, 24,2058-2068
DOI: 10.1039/D3LC00942D, Paper

Xiaoming Chen, Mo Shen, Shun Liu, Chungang Wu, Liangliang Sun, Zhipeng Song, Jishun Shi, Yulong Yuan, Yong Zhao
We develop a novel microfluidic impedance cytometer for analysis of marine microalgae by inserting ground flat-end cylindrical electrodes into microchannels.
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Lab Chip, 2024, 24,1977-1986
DOI: 10.1039/D3LC01017A, Paper

Liyu Dai, Xiaomin Wu, Huimin Hou, Zhifeng Hu, Yukai Lin, Zhiping Yuan
Cuboid pump systems driven by liquid metal multi-droplets using pillars to restrain the motion of droplets are designed, which achieve a significant increase in the flow rate of the pump.
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Lab Chip, 2024, 24,2107-2121
DOI: 10.1039/D3LC01075A, Paper

Open Access

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Wannes Verbist, Jolien Breukers, Sapna Sharma, Iene Rutten, Hans Gerstmans, Lotte Coelmont, Francesco Dal Dosso, Kai Dallmeier, Jeroen Lammertyn
A novel platform, called SeParate, enabling accurate multiplex droplet sorting by integrating serial and parallel sorting principles for three model systems with increasing complexity and intra-subpopulation variation in fluorescence intensities.
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Lab Chip, 2024, 24,1833-1866
DOI: 10.1039/D4LC00089G, Critical Review

Sasikala Apoorva, Nam-Trung Nguyen, Kamalalayam Rajan Sreejith
Wearable devices are increasingly popular in health monitoring, diagnosis, and drug delivery. Advances allow real-time analysis of biofluids like sweat, tears, saliva, wound fluid, and urine.
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Lab Chip, 2024, 24,1947-1956
DOI: 10.1039/D3LC00656E, Paper

Open Access

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Klaudia Staskiewicz, Maria Dabrowska-Zawada, Lukasz Kozon, Zofia Olszewska, Lukasz Drewniak, Tomasz S. Kaminski
Novel microfluidic technique for functional selection of biosurfactant-producing microorganisms. Single bacterial cells are encapsulated into picoliter droplets for clonal cultivation and passively sorted at high throughput by interfacial tension.
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Lab Chip, 2024, 24,1867-1874
DOI: 10.1039/D3LC00796K, Perspective

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Umut A. Gurkan, David K. Wood, Dorn Carranza, Luke H. Herbertson, Scott L. Diamond, E. Du, Suvajyoti Guha, Jorge Di Paola, Patrick C. Hines, Ian Papautsky, Sergey S. Shevkoplyas, Nathan J. Sniadecki, Vamsee K. Pamula, Prithu Sundd, Asif Rizwan, Pankaj Qasba, Wilbur A. Lam
In this perspective article, we present the state of the microfluidic field regarding current limitations and propose future directions and new approaches for the field to advance lab-on-a-chip technologies closer to translation and clinical use.
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Lab Chip, 2024, 24,2094-2106
DOI: 10.1039/D3LC01082A, Paper

Open Access

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Claudia Olaizola-Rodrigo, Sujey Palma-Florez, Teodora Ranđelović, Clara Bayona, Mehran Ashrafi, Josep Samitier, Anna Lagunas, Mònica Mir, Manuel Doblaré, Ignacio Ochoa, Rosa Monge, Sara Oliván
A novel methodology utilizing plasma surface treatment enables the construction of cell culture chambers featuring abutment-free patterns, facilitating the precise distribution of shear stress.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC00743J, Tutorial Review

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Olivia M. Young, Xin Xu, Sunandita Sarker, Ryan D. Sochol
This Tutorial Review highlights strategies for leveraging the micron-to-submicron-scale additive manufacturing technique, “direct laser writing”, to enable 3D microfluidic technologies.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC00891F, Paper

Yu-Hsiang Hsu, Wen-Chih Yang, Yi-Ting Chen, Che-Yu Lin, Chiou-Fong Yang, Wei-Wen Liu, Subhashree Shivani, Pai-Chi Li
The DC-MPS device uses a velocity V-clamp to create a partition with a steep concentration gradient for simultaneously developing vasculogenic vessels and a tumor. It enables vessel–tumor interaction to develop a tumor model with angiogenic vessels.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC00933E, Paper

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Huynh Quoc Nguyen, Van Dan Nguyen, Vu Minh Phan, Tae Seok Seo
The COVID-19 pandemic greatly impacted the in vitro diagnostic market, leading to the development of new technologies such as point-of-care testing (POCT), multiplex testing, and digital health platforms.
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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00118D, Paper

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Jiaheng Li, Lok Ting CHU, Hogi Hartanto, Guihuan Guo, Lu LIU, Jianpeng WU, Minghui Wu, Chenyu Cui, Gaobo Wang, Wengang LIU, Hoi Kwan Kwong, Siying WU, Ting-Hsuan Chen
Mucosal antibodies at the upper respiratory tract are the earliest and most critical responders to prevent respiratory infections, providing an indication to rapidly evaluate immune protection. Here, we report a...
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC01101A, Paper

Wei Wang, Jaime de la Fuente Diez, Nicolas Delsuc, Juan Peng, Riccardo Spezia, Rodolphe Vuilleumier, Yong Chen
A new method uses piezoelectric and microfluidic tuning to study vibrational polaritons in liquids under flow. This enables modifying cavity length adjustments and flexibility in experimental setups.
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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D3LC01066J, Paper

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Artur Davletshin, Wen Song
Fluid-solid interactions in nanoporous materials underlie processes fundamental to nature and the engineered environment, including the thermochemical transformation of argillaceous materials during high-level nuclear waste disposal. Operando fluid-solid resolution at...
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Lab Chip, 2024, 24,2176-2192
DOI: 10.1039/D3LC00912B, Paper

Open Access

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Priscilla Delgado, C. Alessandra Luna, Anjana Dissanayaka, Oluwamayokun Oshinowo, Jesse J. Waggoner, Sara Schley, Todd Fernandez, David R. Myers
This activity enables students to construct geometrically complex microfluidics at their desk with no specialized equipment. It can be easily transported, and helped students significantly improve their understanding of miniaturization science.
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Lab Chip, 2024, 24,2193-2201
DOI: 10.1039/D3LC00979C, Paper

Bingbing Zhang, Jinxin Fu, Maohua Du, Kai Jin, Qi Huang, Jiahao Li, Dongping Wang, Siyi Hu, Jinhua Li, Hanbin Ma
Advancing active-matrix digital microfluidics through polar coordinates for precise concentration gradients. Demonstrated with chip photography, concentration gradient solution demo, and efficiency comparison.
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Lab Chip, 2024, 24,2253-2261
DOI: 10.1039/D3LC01053H, Paper

Ziran Ye, Ping Lu, Yiben Chen, Zhixian Xu, Haixia Huang, Mingjia Zhi, Zi Ang Chen, Bo Yan
We present an efficient approach for the consecutive synthesis of Au–TiO₂ nanocomposites with controlled morphologies in a microfluidic chip.
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Lab Chip, 2024, 24,2280-2286
DOI: 10.1039/D3LC00822C, Paper

Mingwei Zhao, Jing Yang, Zhenqing Li, Yuan Zeng, Chunxian Tao, Bo Dai, Dawei Zhang, Yoshinori Yamaguchi
Concentration gradient generation and mixed combinations of multiple solutions are of great value in the field of biomedical research.
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Lab Chip, 2024, 24,2317-2326
DOI: 10.1039/D4LC00151F, Paper

Open Access

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Amirreza Gholivand, Olivera Korculanin, Knut Dahlhoff, Mehrnaz Babaki, Timo Dickscheid, Minne Paul Lettinga
Taking microfluidics to the third dimension causes scrambling of memory effects in blood flow due to out-of-plane vessel structures.
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Lab Chip, 2024, 24,2347-2357
DOI: 10.1039/D3LC00834G, Paper

Austin Lai, Adam Hawke, Mokhaled Mohammed, Peter Thurgood, Gianmarco Concilia, Karlheinz Peter, Khashayar Khoshmanesh, Sara Baratchi
We created a versatile microfluidic system for studying the effect of arrhythmic flow patterns on endothelial cells in vitro. This system provides unique opportunities to identify the molecular machineries that control endothelial biology in response to arrhythmia.
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Lab Chip, 2024, 24,2327-2334
DOI: 10.1039/D4LC00176A, Paper

Open Access

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Aravind M, Sajan D. George
Adhesive contrast contact lens fabricated by selective lubricant grafting splits tear film on specified zone by secretion and blinking. Integrating the contact lens with the spectroscopic technique offers an efficient platform for biomolecule sensing.
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Lab Chip, 2024, 24,2306-2316
DOI: 10.1039/D3LC01045G, Paper

Sabah H. Al-Jaf, Sameera Sh. Mohammed Ameen, Khalid M. Omer
On-site monitoring of ions in drinking water is essential for safeguarding public health, ensuring high water quality, and preserving the ecological balance of aquatic ecosystems.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00087K, Paper

Mohammad Mahdi Mardanpour, Ayyappasamy Sudalaiyadum Perumal, Zahra Mahmoodi, Karine Baassiri, Gala Montiel-Rubies, Kenneth M. LeDez, Dan V. Nicolau
This study conducted in vitro experimentation using microvascular tissue-like structures to examine the dynamics of interfacial forces leading to gas bubble cessation, with the objective of providing a medical guideline for preventing gas embolism.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00012A, Paper

Anna L. Butterworth, Matin Golozar, Zachary Estlack, Jeremy McCauley, Richard A. Mathies, Jungkyu Kim
This work presents the design, fabrication, and automation of our space flight-format microfabricated sample processing and capillary electrophoresis analysis instrument.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC01052J, Paper

Wenxin Wang, Yiyuan Liu, Zhikai Yao, Dengbo Chen, Yue Tang, Jingwei Cui, Jiangjiang Zhang, Hong Liu, Zikai Hao
A depression-on-gut-chip (DoGC) is prepared and enables extended co-culture of aerobic human intestinal epithelial cells and anaerobic gut microbiota, and allows direct study of interactions between human gut microbiota and depression.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00159A, Paper

Lixue Liang, Xueying Wang, Dong Chen, Palaniappan Sethu, Guruprasad A. Giridharan, Yanxia Wang, Yu Wang, Kai-Rong Qin
The best pulsation frequency mode of the RBP would be one that changes every 2–3 times of the cardiac cycle. The proposed in vitro microfluidic model could provide an effective platform to select the best working mode of the RBP for heart failure.
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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00291A, Paper

Nana Jin, Fan Jiang, Fengzhen Yang, Ying Ding, Ming Liao, Yanbin Li, Jianhan Lin
A colorimetric biosensor was elaboratively designed for fast, sensitive and multiplex bacterial detection on a single microfluidic chip using immune magnetic nanobeads for specific bacterial separation, immune gold@platinum palladium nanoparticles...
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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D3LC00941F, Paper

Shizheng Zhou, Tianhui Chen, Edgar S. Fu, Liuyong Shi, Teng Zhou, Hong YAN
The composition of species and the physiological status of microalgal cells serve as significant indicators for monitoring marine environments. Symbiotic with corals, Symbiodiniacea are more sensitive to the environmental response....
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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D3LC01125A, Paper

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  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Houda Shafique, Vahid Karamzadeh, Geunyong Kim, Molly L. Shen, Yonatan Morocz, Ahmad Sohrabi Kashani, David Juncker
The fabrication of microfluidic devices has progressed from cleanroom manufacturing to replica molding in polymers, and more recently to direct manufacturing by subtractive (e.g., laser machining) and additive (e.g., 3D...
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00132J, Paper

Oriana G. Chavez-Pineda, Roberto Rodriguez-Moncayo, Alan M. Gonzalez-Suarez, Pablo E. Guevara-Pantoja, Jose L. Maravillas-Montero, Jose L. Garcia-Cordero
A microfluidic platform isolates leukocytes from blood efficiently, offering diagnostic and immunotherapeutic potential. Enhanced by a handheld pressure controller, it enables near-patient testing and integration with downstream assays.
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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00075G, Paper

Abdul Basit Zia, Justin Farrell, Ian G. Foulds
The paper demonstrates an adaptation of a 3D printer (Prusa Mini+) with novel modules to develop a droplet generation system that generates combinatorial droplets from a standard 96 well plate....
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC90040E, Correction

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Olivia M. Young, Xin Xu, Sunandita Sarker, Ryan D. Sochol
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00009A, Paper

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Bastián Carnero, Yago Radziunas-Salinas, Bruno K. Rodiño-Janeiro, Sylvana Varela Ballesta, M. Teresa Flores-Arias
The proposed hybrid technique for passive straight micromixer manufacturing by combining pulsed laser ablation and stereolithographic 3D printing.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00193A, Paper

Marti Z. Hua, Shenmiao Li, M. S. Roopesh, Xiaonan Lu
A QD-MIP based microfluidic device to detect mycotoxin in food.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00016A, Paper

Ethan J. Lockhart, Lisa F. Horowitz, Adán Rodríguez, Songli Zhu, Tran Nguyen, Mehdi Mehrabi, Taranjit S. Gujral, Albert Folch
A microfluidic platform was developed that hydrodynamically traps microdissected cuboids for selective drug treatments and isolates conditions with thermoplastic valves.
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React. Chem. Eng., 2024, Advance Article
DOI: 10.1039/D4RE00203B, Paper

Xi-Bao Zhang, Yin-Ning Zhou, Hao Chen, Zheng-Hong Luo, Liyang Zhou, Guojun Yu, Wenwu Liu, Shiping Zhu
A reactor's heat transfer efficiency can be significantly enhanced and the fluid temperature uniformity can be controlled through introducing cooling water in the agitator and regulating the flow ratio of cooling water in the agitator and jacket.
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Soft Matter, 2024, 20,2969-2977
DOI: 10.1039/D4SM00204K, Paper

Rounak Bhattacharyya, Bhaskar Sen Gupta
Phase separation of segregating fluid mixtures in the presence of quenched disorder.
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