RJD leader says the contest in Bihar for the Lok Sabha election is with the BJP; he adds that the real issues are inflation, poverty, unemployment, education

Ranveer is loud, but not shrill, notes Subhash K Jha.As in singing, in acting holding your pitch in the higher notes is a Himalayan task.Ranveer resides on the highest notes of the musical mountain and still manages to be coherent, fluent and persuasive.

This little snippet can come in handy when you need to serve a different header on a per page basis. All you need to do is create a new header file – header-yourfilename.php and then put in some logic in your desired template file. In my case I have a header file called header-home.php and in my homepage template I ... Read more

The post Load a Different Header in WordPress appeared first on Web Design Weekly.

New findings could help researchers and governments decide which trees to prioritise for protection

‘Yaavarum Kaelir’ stands out for its erudite host and an impressive line-up of speakers

How is enterprise education different from entrepreneurship education? Why do students need both?

2024 seems to be the year museums are making room for the narratives of misunderstood women — from Yoko Ono and Naomi Campbell, to Salvador Dalí’s wife and muse

It might be politically incorrect to say this, but America isn’t ready to embrace cricket yet

Swiggy’s B2C operations account for 61 per cent of revenue and its B2B supply chain segment contributes a substantial 39 per cent, marking a key distinction from Zomato’s business structure

A spot shortage of the analytical sample holder affects some scientists

With so many ingredients on hand, can the oncology community figure out how to sensibly and efficiently combine checkpoint inhibitors with other drugs?

Recent work might have implications for drug development

Is it an old SUV in a new body? Or a new SUV in old body? Rajesh Karkera test-drives the next-gen Tata Safari aka Gravitas and comes away impressed.

Smooth engine, plush interiors, great suspension that handle dodgy roads with ease, futuristic design elements that have little by way of competition in the market -- it's all there, says Pavan Lall.

Two shows launched by Vijay TV and Zee Tamil feature actors performing daredevil stunts

This tough, no-frills SUV sure has an air of indestructibility about it thanks to the body-on-frame chassis

Urmelesh Swami from Saharanpur, Uttar Pradesh and Pankaj Singh from the UAE have made lovely Diwali memories.

The Covid-19 lockdown has given the midfielder the chance to show his acting skills outside the Southampton changing room

Nathan Redmond hustles towards the camera, suited up, fedora jauntily perched and when he starts to lip-sync, the voice is that of Carter – the character played by Chris Tucker in Rush Hour 3. It is the scene involving him, Master Yu and Mi and, for those who have not seen it, has Carter getting into a word-play tangle as he questions Yu and Mi. “Who are you? Yu. No, not me, you. Yes, I am Yu.” It goes from there.

Related: 'People's lives depend on it': the sacked English defender left in limbo | Sid Lowe

The Guardian’s former political editor revisits humiliating prime ministerial resignations from Robert Peel to David Cameron

Both Brexit camps claim Sir Robert Peel, the Tory moderniser whose 1846 resignation crisis most resembles May’s. But he had succeeded where she failed. Determined to cut food prices for industrial workers, Peel pushed through repeal of protectionist Corn Laws with opposition help. In retaliation, rightwing enemies defeated his Irish Coercion bill. Peel resisted Queen Victoria’s appeal to stay, but grateful crowds cheered him as he walked to the Commons to resign. He slipped out by a side door, but was spotted and cheered home. Divided Tories lost office for 20 years.

You may have form the idea that celebrities are the trendiest person ever, no matter their dressing-up or making-up. Thus keep an eye on what they look is a wise means to keep pace with trend. How to make themselves different from other...

Deglobalisation should make investors think twice about betting on index tracker funds

Robert Jenrick says trial in Isle of Wight will inform decision making on technology

The state-owned airline, which suspended regular passenger flights in March reported a 21% rise in profit for its financial year that ended on March 31

Wood Ants Store Short- And Long-Term Memories on Different Sides of Their Brains  ScienceAlert

Since the Middle Ages, alchemists have sought to transmute elements, the most famous example being the long quest to turn lead into gold. Now, Princeton University theorists have proposed a different approach to this ancient ambition — just make one material behave like another. The researchers demonstrate that any two systems can be made to look alike, even if just for the smallest fraction of a second.

Williams driver George Russell is enjoying sim racing online while Formula 1 is suspended but admits he doesn't get the same sense of speed or fear.

12 November 2014 , Volume 90, Number 6

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.