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A liposome-based assay for cancer biomarker detection: exploring the correlation between platelet-derived microvesicles and NSCLC-associated miRNAs

Nanoscale, 2024, Advance Article
DOI: 10.1039/D4NR03704A, Paper
Mohamed Aimene Benariba, Kanza Hannachi, Sha Zhu, Yuting Zhang, Xiaoli Wang, Nandi Zhou
This research reveals a significant correlation between PMVs and their associated miRNA. Additionally, the liposome-based assay demonstrates enhanced sensitivity with calcium-induced platelet activation.
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Aptamer-functionalized Nucleic Acid Nanotechnology for Biosensing, Bioimaging and Cancer Therapy

Nanoscale, 2024, Accepted Manuscript
DOI: 10.1039/D4NR04360J, Review Article
Xiaofang Zheng, Zhiyong Huang, Qiang Zhang, Guoli Li, Minghui Song, Ruizi Peng
Nucleic acids have enabled to fabricate self-assemblies and perform dynamic operations. Among different functional nucleic acids, aptamers can specifically bind to wide range of targets including proteins, viral antigens, living...
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Applications of peptide-based nanomaterials in targeting cancer therapy

Biomater. Sci., 2024, 12,1630-1642
DOI: 10.1039/D3BM02026F, Review Article
Beilei Sun, Limin Zhang, Mengzhen Li, Xin Wang, Weizhi Wang
To meet the precise diagnosis and treatment as well as reduce systemic toxicity and side effects, self-assembled peptides are applied to the targeting therapy, including targeting theranostics, nanocarrier delivery, immunotherapy, and combination therapy.
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Self-assembled nanodrug delivery systems for anti-cancer drugs from traditional Chinese medicine

Biomater. Sci., 2024, 12,1662-1692
DOI: 10.1039/D3BM01451G, Review Article
Qiao Li, Yuan Lianghao, Gao Shijie, Wang Zhiyi, Tang Yuanting, Chen Cong, Zhao Chun-Qin, Fu Xianjun
In this review, we have summarized the common self-assembled mechanism of NSMs-based SANDDSs. Meanwhile, the potential applications for cancer treatment and future development prospects are also prospected.
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Free drug and ROS-responsive nanoparticle delivery of synergistic doxorubicin and olaparib combinations to triple negative breast cancer models

Biomater. Sci., 2024, 12,1822-1840
DOI: 10.1039/D3BM01931D, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Robert J. Cavanagh, Patrícia F. Monteiro, Cara Moloney, Alessandra Travanut, Fatemeh Mehradnia, Vincenzo Taresco, Ruman Rahman, Stewart G. Martin, Anna M. Grabowska, Marianne B. Ashford, Cameron Alexander
Combinations of the topoisomerase II inhibitor doxorubicin and the poly (ADP-ribose) polymerase inhibitor olaparib offer potential drug–drug synergy for treatment of triple negative breast cancers (TNBC) both in free drug form and when delivered by oxidation-responsive nanoparticles.
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Ferroptosis and ferroptosis-inducing nanomedicine as a promising weapon in combination therapy of prostate cancer

Biomater. Sci., 2024, 12,1617-1629
DOI: 10.1039/D3BM01894F, Review Article
Mengjun Huang, Qiliang Teng, Fei Cao, Jinsheng Huang, Jun Pang
Existing treatments could be sensitized by targeting the ferroptosis pathway in prostate cancer.
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Light-inducible nanodrug-mediated photodynamic and anti-apoptotic synergy for enhanced immunotherapy in triple-negative breast cancer

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00083H, Paper
Jing Huang, Xingliang Liu, Minzhao Lin, Zecong Xiao, Xintao Shuai
An ROS-labile nanodrug co-encapsulating Ce6 and a Bcl-2 inhibitor enabled PDT and reversed apoptotic resistance, demonstrating a potent inhibitory effect on tumor growth.
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Photothermal therapy: a novel potential treatment for prostate cancer

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00057A, Review Article
Zirui Dong, Kaming Xue, Anushikha Verma, Jian Shi, Zhihao Wei, Xiaotian Xia, Keshan Wang, Xiaoping Zhang
This review discussed photothermal therapy from basic information to its circumstances and potential in protate cancer treatment.
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Telomerase: a nexus between cancer nanotherapy and circadian rhythm

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00024B, Minireview
Pramit Kumar Ghosh, Maddila Jagapathi Rao, Chandra Lekha Putta, Sandipan Ray, Aravind Kumar Rengan
The use of nanoparticles for identifying and suppressing telomerase presents promising opportunities for anticancer strategies, particularly in relation to circadian regulation.
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Optimization of lipid assisted polymeric nanoparticles for siRNA delivery and cancer immunotherapy

Biomater. Sci., 2024, 12,2057-2066
DOI: 10.1039/D3BM02071A, Paper
Song Lin, Houjin Jing, Xiaojiao Du, Xianzhu Yang, Jun Wang
A siRNA delivery system was developed using clinically approved mPEG-b-PLGA, cationic lipid and ionizable lipid for siRNA delivery and cancer immunotherapy.
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Correction: A Y1 receptor ligand synergized with a P-glycoprotein inhibitor improves the therapeutic efficacy of multidrug resistant breast cancer

Biomater. Sci., 2024, 12,2165-2166
DOI: 10.1039/D4BM90022G, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Yinjie Wang, Zhenqi Jiang, Bo Yuan, Yuchen Tian, Lingchao Xiang, Yanying Li, Yong Yang, Juan Li, Aiguo Wu
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Correction: Hindering the unlimited proliferation of tumor cells synergizes with destroying tumor blood vessels for effective cancer treatment

Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM90033B, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ya Liu, Yajun Xu, Ying Wang, Jianlin Lv, Kun Wang, Zhaohui Tang
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Andhra govt. to launch cancer screening for all above 18

In the three-level screening, ASHAs and ANMs will visit houses and conduct initial tests; those with symptoms will be sent to village health clinics for examination by a medical officer, who will refer patients in need of more tests to medical colleges




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Merck partners with Moderna to test KRas cancer vaccines in humans

The pair hopes to stimulate the immune system to tackle tumors bearing mutant KRas proteins, one of cancer’s toughest targets




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Periwinkle gives up its cancer-busting secrets

Key enzymes in complex biosynthesis could enable alkaloid production




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Controlling CAR-T: How scientists plan to make the engineered T cell therapy safer, and work for more cancers

CAR T-cell therapy works wonders for some cancer patients. For others, it is a death sentence. To make the revolutionary therapy work for more people, scientists must devise better ways to control it




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Merck and Moderna sign cancer vaccine deal




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Accent Therapeutics launches to target the epitranscriptomic RNA code in cancer

With $40 million series A funding, the start-up will develop inhibitors of proteins that make chemical modifications to RNA




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Grail raises more funds to advance a blood-based cancer test

Flush with another $300 million, Grail plans to enroll 135,000 people in studies this year to detect circulating tumor-derived DNA




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Celgene to pay Evotec $65 million in cancer drug pact




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Experimental cancer cell therapies have nearly doubled in six months

A new report from the Cancer Research Institute highlights the U.S. and China as cell therapy leaders




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The difficult search for the right recipe in cancer immunotherapy

With so many ingredients on hand, can the oncology community figure out how to sensibly and efficiently combine checkpoint inhibitors with other drugs?




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AbbVie invests in switchable CAR-T therapies for cancer

The drug company is partnering with Calibr to develop universal CAR T-cells directed to different tumors via antibody switches




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Ferreting out why some cancer drugs struggle to shrink tumors

Study shows how stopping one enzyme could help drugs treat an important class of cancers more effectively




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Untangling the CRISPR cancer scare

News reports linking the gene-editing technology to cancer are the latest in a series of hyped alarms due to be tested in humans soon




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AbbVie invests in switchable CAR-T therapies for cancer

The drug company is partnering with Calibr to develop universal CAR T cells directed to different tumors via antibody switches




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Chemistry in Pictures: Simulating cancer




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Paper describing piperlongumine anticancer activity retracted

Some coauthors dissent from withdrawal of report, for which key findings have been independently confirmed




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Paper describing piperlongumine anticancer activity retracted

Some coauthors dissent from withdrawal of report, for which key findings have been independently confirmed




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Phosphorylation at different sites of cancer-related enzyme leads to different shape changes

Recent work might have implications for drug development




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‘It’s been the toughest year of our lives’: Cycling legend Chris Hoy on terminal cancer




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Cancer Drugs Fund requires further reform




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Johnson & Jonson to pay $72M for cancer death linked to talcum powder

Company accused of failing to warn consumers that its talc-based products could cause cancer




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The cancer cluster of Piketon, Ohio

How the legacy of the Cold War poisons people still




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Venom as a cure? Intriguing prospects in treating cancer, diabetes, pain...


Venom as a cure? Intriguing prospects in treating cancer, diabetes, pain...


(Third column, 21st story, link)





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Bariatric Surgery Cuts Cancer Risk by 80% in Obese Patients: Study

According to a new Canadian study morbidly obese patients who have surgery to reduce their stomach size could lower their risk of developing cancer by about 80 per cent.




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Mother who battled NHS over brain cancer treatment for her son separates from her husband

Few relationships would be immune to the pressures wrought by their ordeal: the strain of caring for their desperately sick child, their brief life as fugitives, the draining legal battles.




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Boy, 4, who beat coronavirus and battled rare cancer is allowed outside for first time in two months

Essex cancer patient Archie Wilks, four, (right) was allowed outdoors for a family walk after testing negative for coronavirus. He walked through fields with his twin brother Henry (left) and parents.




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Mother who battled NHS over brain cancer treatment for her son separates from her husband

Few relationships would be immune to the pressures wrought by their ordeal: the strain of caring for their desperately sick child, their brief life as fugitives, the draining legal battles.




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Breast cancer cases surge as cervical dips

Fewer women in India now suffer from cervical cancer - counted among the worst of killers. However, breast cancer cases have shot up alarmingly.




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Explained: Study claims fatality rate among lung cancer patients due to coronavirus is high

New York, May 04: A new study in the United States has estimated the number of fatality rate among patients suffering from cancer patients infected with the deadly coronavirus. This study is described as the largest study has found out that




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Veteran Doordarshan Anchor Malvika Marathe Passes Away At 53 Due To Brain Cancer

The field of film and television in India has lost a number of gems in the past few days. In another setback, revered Doordarshan presenter Malvika Marathe breathed her last on May 7, 2020.  The anchor and actress was 53.   Malvika




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Veteran Doordarshan Anchor Malvika Marathe Passes Away At 53 Due To Brain Cancer

The field of film and television in India has lost a number of gems in the past few days. In another setback, revered Doordarshan presenter Malvika Marathe breathed her last on May 7, 2020.  The anchor and actress was 53.   Malvika




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15 Herbs and Spices In Cancer Prevention and Treatment

Cancer is a major disease worldwide in both developed as well as developing countries. According to a study, in the year 2008, there were around 7.6 million deaths worldwide due to cancer. [1] The WHO estimate the count to rise above




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Thyroid Cancer: Causes, Symptoms, Risk Factors, Diagnosis, Treatment And Prevention

Thyroid cancer is the cancer of the thyroid gland which is found at the neck's front just below Adam's apple. The thyroid gland is a butterfly-shaped gland with two lobes, one at each side joined by a narrow tissue called the




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COVID-19 And Breast Cancer: Does It Increase The Risk Of Developing Coronavirus Infection?

The coronavirus cases around the globe are at 2,995,757, with 207,022 deaths reported and 881,845 recoveries. The virus outbreak that began in 2019 continues to cause casualties, while health experts around the globe are extensively working on developing a vaccine and




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Rishi Kapoor Passes Away Of Acute Myeloid Leukaemia: Know More About This Cancer

Veteran actor Rishi Kapoor (67) passed away on Thursday at 8:45 a.m after a long battle with leukaemia. This Bollywood star was diagnosed with the disease two years back in 2018 and has undergone a bone marrow treatment in the US




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New treatment option for young women with hormone-sensitive breast cancer

A drug used for treating breast cancer, known as exemestane, is more effective than a common breast cancer prevention drug, tamoxifen, in preventing breast cancer recurrence in young women who also receive post-surgical treatment to suppress ovarian function. The combined results of the Tamoxifen and Exemestane Trial and Suppression of Ovarian Function Trial were presented at the 2014 ASCO Annual Meeting in Chicago.




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Study reveals early family history-based screening of colorectal cancer may help in diagnosis




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As hospitals close, cancer patients take to helplines

As hospitals close, cancer patients take to helplines