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MRI-Guided Radiation Therapy Reduces Long-Term Side Effects for Patients with Prostate Cancer

After a comprehensive two-year follow-up, researchers at the UCLA Health Jonsson Comprehensive Cancer Center found that MRI-guided stereotactic body radiotherapy (SBRT) for prostate cancer significantly reduced long-term side effects and improved quality of life, particularly in bowel and sexual health, compared to conventional CT-guided treatment.




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Sylvester Cancer Researchers Share Findings in Oral Presentations at the ASH 2024 Annual Meeting & Exposition - Tip Sheet

Research findings from Sylvester Comprehensive Cancer Center and the Miller School of Medicine at the University of Miami will be presented at the Annual Meeting & Exposition of the American Society of Hematology in San Diego, Dec. 7-10.




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Sylvester Cancer Tip Sheet: Researchers Present Posters at the 66th ASH Annual Meeting & Exposition

Hematology researchers from Sylvester Comprehensive Cancer Center and the Miller School of Medicine at the University of Miami are authors or co-authors on more than 70 posters to be presented at the Annual Meeting & Exposition of the American Society of Hematology in San Diego, Dec. 7-10. Links to each abstract are included in this tip sheet.




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Treatment Advances, Predictive Biomarkers Stand to Improve Bladder Cancer Care

Recent advances in bladder cancer treatments may offer hope of curative care to more patients, including those with high-risk localized, muscle-invasive disease, according to a New England Journal of Medicine editorial published by Matthew Milowsky, MD, FASCO, a bladder cancer expert at UNC School of Medicine and UNC Lineberger Comprehensive Cancer Center.




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Vaccine Shows Promise Against Aggressive Breast Cancer

A small clinical trial shows promising results for patients with triple-negative breast cancer who received an investigational vaccine designed to prevent recurrence of tumors. Conducted at Washington University School of Medicine in St. Louis with a therapy designed by WashU Medicine researchers, the trial is the first to report results for this type of vaccine -- known as a neoantigen DNA vaccine -- for breast cancer patients.




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Treatment Advances, Predictive Biomarkers Stand to Improve Bladder Cancer Care

Recent advances in bladder cancer treatments may offer hope of curative care to more patients, including those with high-risk localized, muscle-invasive disease, according to a New England Journal of Medicine editorial published by Matthew Milowsky, MD, FASCO, a bladder cancer expert at UNC School of Medicine and UNC Lineberger Comprehensive Cancer Center.




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Vaccine Shows Promise Against Aggressive Breast Cancer

A small clinical trial shows promising results for patients with triple-negative breast cancer who received an investigational vaccine designed to prevent recurrence of tumors. Conducted at Washington University School of Medicine in St. Louis with a therapy designed by WashU Medicine researchers, the trial is the first to report results for this type of vaccine -- known as a neoantigen DNA vaccine -- for breast cancer patients.




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Bio blog: Melbourne cancer research partnership led by Australian icons

La Trobe University in Melbourne will bring its world-class scientific expertise to the newly launched Olivia Newton-John Cancer Research Institute (ONJCRI).





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Galen (129-216 AD) in China: cancer / crab

I just received the following book:  P.N. Singer and Ralph M. Rosen, eds., The Oxford Handbook of Galen (New York:  Oxford University Press, 2024).  The volume has 29 chapters, the last of which is "Galen in Premodern Tibet and China: Impressions and Footprints" (pp. 658-674) by Dror Weil and Ronit Yoeli-Tlalim.  Naturally, this chapter is […]




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Cancer Patients in England Denied Access to Drugs Over Price Standoff




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'I found out I had cancer when 36 weeks pregnant'

After a Caesarean section, Laura Hudson had to endure chemotherapy and have a mastectomy.




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Full House star Dave Coulier reveals diagnosis with ‘very aggressive’ cancer

Actor, who played Joey Gladstone on the hit ABC sitcom, said he is currently undergoing rounds of chemotherapy




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Charity wants testing of prostate cancer high risk

Prostate Cancer Research acknowledges more accurate tests would be needed to justify screening all men.




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AI-Driven Liquid Biopsy Enhances Early Detection of Ovarian Cancer

Highlights: AI-powered liquid biopsy detects ovarian cancer early Combines DNA fragment analysis and biomarkers




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Want to Prevent Prostate Cancer Naturally? Try Button Mushroom Supplement

An investigational white button mushroom supplement shows promise in slowing and even preventing the spread of prostate cancer among men participating




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AI-Driven Liquid Biopsy Enhances Early Detection of Ovarian Cancer

A breakthrough AI-powered liquid biopsy combining cell-free DNA and protein biomarkers improves early detection of ovarian cancer, aiding in accurate screening.




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Want to Prevent Prostate Cancer Naturally? Try Button Mushroom Supplement

Food as Medicine to Fight Prostate Cancer: White button mushroom supplement can keep prostate cancer at bay.




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India hosts senior cancer physicians, policymakers from Bay of Bengal countries

India hosted senior cancer physicians and policymakers from BIMSTEC countries during the annual meeting of National Cancer Grid (NCG) held at Mumbai's Tata Memorial Hospital.




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New treatment option for young women with hormone-sensitive breast cancer

A drug used for treating breast cancer, known as exemestane, is more effective than a common breast cancer prevention drug, tamoxifen, in preventing breast cancer recurrence in young women who also receive post-surgical treatment to suppress ovarian function. The combined results of the Tamoxifen and Exemestane Trial and Suppression of Ovarian Function Trial were presented at the 2014 ASCO Annual Meeting in Chicago.




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Chemical synthetic approaches to mimic the TRAIL: promising cancer therapeutics

RSC Med. Chem., 2024, 15,3639-3651
DOI: 10.1039/D4MD00183D, Review Article
Abdullah-Al Masum, Shin Aoki, Md. Mahbubur Rahman, Yosuke Hisamatsu
TRAIL induced apoptosis signalling by death receptors (DR4/DR5).
The content of this RSS Feed (c) The Royal Society of Chemistry




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Furoxan–piplartine hybrids as effective NO donors and ROS inducers in PC3 cancer cells: design, synthesis, and biological evaluation

RSC Med. Chem., 2024, 15,3778-3794
DOI: 10.1039/D4MD00281D, Research Article
Carolyne Brustolin Braga, Julio Cesar Milan, Matheus Andrade Meirelles, Bruno Zavan, Guilherme Álvaro Ferreira-Silva, Ester Siqueira Caixeta, Marisa Ionta, Ronaldo A. Pilli
A novel hybrid integrating piplartine with a furoxan moiety exhibited a sub-micromolar IC50 and extraordinary selectivity for PC3 cells, which was associated with its capacity to release NO, generate ROS, induce DNA damage, and trigger apoptosis.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Pyridinyl 4-(2-oxoalkylimidazolidin-1-yl)benzenesulfonates and their hydrochloride salts as novel water soluble antimitotic prodrugs bioactivated by cytochrome P450 1A1 in breast cancer cells

RSC Med. Chem., 2024, 15,3728-3745
DOI: 10.1039/D4MD00476K, Research Article
Vincent Ouellette, Chahrazed Bouzriba, Atziri Corin Chavez Alvarez, Quentin Bruxelles, Geneviève Hamel-Côté, Sébastien Fortin
New water soluble antimitotic CYP1A1-activated prodrugs named PYRAIB-SOs and their hydrochlorides targeting breast cancers.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Prediction of synergistic gemcitabine-based combination treatment through a novel tumor stemness biomarker NANOG in pancreatic cancer

RSC Med. Chem., 2024, 15,3853-3861
DOI: 10.1039/D4MD00165F, Research Article
Jiongjia Cheng, Ting Zhu, Shaoxian Liu, Jiayu Zhou, Xiaofeng Wang, Guangxiang Liu
The synergistic effect observed in gemcitabine-based combination therapies targeting pancreatic cancer stem cells was correlated with the inhibiting effect on the expression of stemness-related gene NANOG.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling

RSC Med. Chem., 2024, 15,3746-3758
DOI: 10.1039/D4MD00122B, Research Article
Open Access
Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong Li
We designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy

RSC Med. Chem., 2024, 15,3912-3912
DOI: 10.1039/D4MD90040E, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex Joseph
The content of this RSS Feed (c) The Royal Society of Chemistry




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Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00610K, Research Article
Open Access
Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina Marzano
In this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....
The content of this RSS Feed (c) The Royal Society of Chemistry




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Cancer Drugs Fund requires further reform




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Oncologist stabbed at Chennai govt hospital ‘by 26-year-old whose mother is undergoing cancer treatment’ - The Indian Express

  1. Oncologist stabbed at Chennai govt hospital ‘by 26-year-old whose mother is undergoing cancer treatment’  The Indian Express
  2. Video: Chennai man calmly walks away after stabbing doctor, wipes knife  India Today
  3. Indian Medical Association condemns brutal attack on doctor in Chennai  The New Indian Express
  4. Daylight assault on doctor inside Chennai hospital leaves medical fraternity in shock  The Hindu
  5. 'No law and order': BJP, AIADMK attack ruling DMK after government doctor stabbed in Chennai  The Times of India




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Association between second-hand smoke exposure and lung cancer risk in never-smokers: a systematic review and meta-analysis

Background

Lung cancer ranks as the leading cause of cancer-related deaths worldwide. There is evidence that second-hand smoke (SHS) exposure is a risk factor for the development of lung cancer in never-smokers. This systematic review and meta-analysis aims to provide the most accurate quantification of the association between SHS exposure and lung cancer risk in never-smokers.

Materials and methods

Through the use of an innovative method to identify original publications, we conducted a systematic review of the literature, with corresponding meta-analysis, of all epidemiological studies evaluating the association between SHS exposure and lung cancer risk among never-smokers, published up to May 2023. Pooled relative risks were obtained using random-effects models. Dose–response relationships were derived using log-linear functions or cubic splines.

Results

Out of 126 identified eligible studies, 97 original articles were included in the meta-analysis. The pooled relative risk for lung cancer for overall exposure to SHS was 1.24 (95% CI 1.16–1.32, number of articles, n=82). Setting-specific relative risks were 1.20 (95% CI 1.12–1.28, n=67) for SHS exposure at home, 1.38 (95% CI 1.28–1.62, n=30) at a workplace, 1.37 (95% CI 1.22–1.53, n=28) at home or a workplace and 1.27 (95% CI 1.11–1.44, n=24) in nonspecified settings. The risk of lung cancer significantly increased with the duration, intensity and pack-years of SHS exposure.

Conclusions

This meta-analysis shows that exposure to SHS increases by more than 20% the risk of lung cancer among never-smokers, providing definitive evidence of the association between SHS exposure and lung cancer risk.




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Full House star Dave Coulier reveals diagnosis with ‘very aggressive’ cancer

Actor, who played Joey Gladstone on the hit ABC sitcom, said he is currently undergoing rounds of chemotherapy




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Treatment Outcomes of Persistent Radiation-Induced Alopecia in Patients With Cancer




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Local Rare Cancer Foundation Hosts Gathering of World Experts

The FLC Scientific Summit will be held at the Hyatt Regency Greenwich on April 24 – 26.




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Emerging Scientists Awarded Hopper-Belmont Foundation Grants to Fund Critical Pancreatic and Ovarian Cancer Research

Five of the nation's most innovative early-career cancer researchers receive Hopper-Belmont Inspiration Award




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Cancer

Title: Cancer
Category: Diseases and Conditions
Created: 7/4/2000 12:00:00 AM
Last Editorial Review: 6/10/2022 12:00:00 AM




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Federal Court Orders EPA to Re-examine Whether Roundup Causes Cancer

Title: Federal Court Orders EPA to Re-examine Whether Roundup Causes Cancer
Category: Health News
Created: 6/20/2022 12:00:00 AM
Last Editorial Review: 6/20/2022 12:00:00 AM




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Cancer-Fighting Foods: Resveratrol, Green Tea, and More

Title: Cancer-Fighting Foods: Resveratrol, Green Tea, and More
Category: Slideshows
Created: 5/19/2010 3:06:00 PM
Last Editorial Review: 8/26/2022 12:00:00 AM




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Cervical Cancer (Cancer of the Cervix)

Title: Cervical Cancer (Cancer of the Cervix)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 5/9/2022 12:00:00 AM




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Chromotherapy in Cancer

In 2007, I posted two articles on this site suggesting that cancer had something to do with the energy mechanism of the human body. I am coming back to this through a comment on one of those articles by Viorel Bungau, a family medical doctor in Romania. The two previous articles are: Cancer and ATP: The Photon Energy Pathway Could cancer be a functional deviation of the cellular energy production mechanism that is open to correction by relatively simple means instead of a genetic mutation that is passed down through cell division? Heinrich Kremer, MD, says that this is indeed the case. His hypothesis of a photon-mediated cellular energy pathway may turn out to substantially add to our understanding of what cancer is, and why such natural substances as curcumin may be effective cancer fighting agents. Cancer: The ATP-Photon Hypothesis Could cancer be a result of the functional degradation of a cellular photon absorption pathway that is basic to the production of ATP, the cellular energy molecule? And could tumor cells merely be executing an age-old survival program they retained from the time of unicellular existence? An interesting new hypothesis of cancer causation spells out why some cells all of a sudden start dividing to form tumors, and how that urge to sustained growth could likely be 'switched off. Chromotherapy: The healing power of colors (image found here) Here (with some minor edits) is what Dr Bungau originally posted as a comment on the second article... CHROMOTHERAPY IN CANCER Dear Professor, Medical practitioner, I am passionate about cancer research. After years of study, we came to a hypothesis to be verified experimentally in collaboration with a field center. After many attempts (direct approach), no one has agreed to do this experiment. Please help make this research proposal possible. If proven true, it would change the medical approach to diagnosis and treatment of cancer and beyond. Yours sincerely, Dr.Viorel Bungau...




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American Cancer Society Homepage

American Cancer Society HomepageThe mothership- American Cancer Society Homepagemore info hereOriginally Posted on 11/06/2005 21:40:06Content source: http://bobrboobd.blogspot.com/2004_04_13_bobrboobd_archive.html#108192415493448834




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Has The Cure For Cancer Been Here All Along?

Has The Cure For Cancer Been Here All Along?by: Jane JarvisCancer treatment and medication is a multi-billion dollar industry--so why would hospitals and pharmaceutical companies want a cure?Have you ever heard of a doctor giving someone with stage 4 or 5 cancer a 90-100% chance of success at beating the disease? I didn't think so. Well, there is a way you can beat these dismal odds. If you, a




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The Diet Cancer Story

Robert MorgenCopyright 2005 by http://www.organicgreens.us and Loring Windblad. This article may be freely copied and used on other web sites only if it is copied complete with all links and text intact and unchanged except for minor improvements such as misspellings and typos.My wife has had 10 tumors removed from her breasts. The first two and the last two (1 each breast each occurrence) were




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Lycopene Effective with Prostate Cancer Treatment

by: Darin IngelsMen with prostate cancer who take supplemental lycopene in addition to surgical removal of the testicles may experience less active disease, less bone pain, and live longer than those who only have surgical removal of the testicles, according to a new study in British Journal of Urology International (2003;92:375–8). This is exciting news for millions of men who have to undergo




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Overall Risk of Cancer Cut By 37%...

by: Warren MatthewsWhat do you think about this? * Overall cancer risk reduced by 37% * Overall reduction in cancer mortality rates by 50% * 30% reduction of colorectal cancer.Sounds like the sort of claims someone standing on a soapbox trying to sell snake oil would make... but SURPRISE... these statements are coming from the mainstream... and the results are from simple natural




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W.H.O. gets cancer

by: Simon MitchellBelow The World Health Organisation (W.H.O.) summarise what we know about cancer from scientific research:Cancer is largely preventable: by stopping smoking, providing healthy food and avoiding the exposure to carcinogens.Some of the most frequent cancer types are curable by surgery, chemotherapy or radiotherapy. The chance of cure increases substantially if cancer is detected




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Cancer Is An Energy

by: Simon MitchellEinstein, a genius scientist of the 20th century, and central to the new energy physics, stated that ‘a problem cannot be solved by the same mind set that created it’. Cancer is a case in point. Cancer is a dis-ease that stems partly from the products of the mechanistic, anthropomorphic and exploitative philosophy at the heart of our culture, which we tend to ignore. Its




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New Drug Offers Hope to Cancer Patients

by: ARA Content(ARA) - A decade ago, research into angiogenesis-inhibiting compounds was still in a relative state of infancy. The principle itself was not new -- as far back as the early '70s, there was speculation that human cancer tumors could not grow beyond a few millimeters in diameter without obtaining their own blood supply. But opinion was still divided in the scientific




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New Findings on the Role of Glutathione in Cancer

by: Priya F ShahCancer cells and normal cells are known to respond differently to nutrients and drugs that affect glutathione status.Numerous studies have shown that tumor cells have elevated levels of glutathione levels, which confers resistance to chemotherapy drugs.One of the challenges of cancer therapy is how to deplete tumor cells of glutathione, so as to make them more vulnerable to the




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Breast Cancer Fighting Nutrients and Which Foods Contain Them

Foods to eat that contain nutrients that may help to prevent breast cancer.




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What Are the 5 Warning Signs of Prostate Cancer

Key indicators that may signal the presence of prostate cancer. Early detection and treatment of this disease to significantly improve the chances of successful outcomes.