Irina Tishelman from Sonatype will present a talk "Automate or Die - DevSecOps in the Age of Software Supply Chain Attacks" at the November 14, 2019 nycdevops meetup.

The meetup meets at the Stack Overflow office in NYC.

https://www.meetup.com/nycdevops/events/265281451/

You don't want to miss this one!

McDonald’s knows exactly where its beef is. The fast food chain’s CEO on Thursday expressed full confidence in the burger joint’s meat supply.

McDonald’s knows exactly where its beef is. The fast food chain’s CEO on Thursday expressed full confidence in the burger joint’s meat supply.

During the coronavirus crisis, food producers, distributors and retailers in California, producer of much of the U.S. food supply, scramble to adapt.

Primary Responsibility: Overall accountability for designing supply chain solution proposals to support revenue growth. Work with a cross-functional team to create compelling proposals for solutions that add value to the customers' supply chains and meet Americold's financial guidelines. E

For decades, even centuries, we British have prided ourselves on being the free-est people in the world, subject only to the laws passed by our democratically elected parliament. But can we really go on preaching what has now become a canard?

Simon Bogg says it took him 10 days to make the sculpture in tribute to the "absolute legend".

A Canadian grocery chain says its introducing a fleet of intelligent grocery carts that scan and weigh products as customers place them in the cart.

In line with new evolving computer technologies, a lot of issues previously found complicated are now seen as an easygoing task, for example, e-commerce, contactless payment, secured online transactions, and ride-hailing. All thanks to blockchain, a new technology that massively revitalized all-around sectors, equipping the financial industry with enhanced solutions with less or no additional […]

The post 6 Industries Blockchain Technology Will Revolutionize appeared first on ReadWrite.

Ian McKee, founder and CEO of Singapore-based Vuulr, explains the value of blockchain technology—and the threat it poses to the structure of traditional digital advertising.

Corporate Members Event Webinar

Professor Ian Goldin, Professor of Globalisation and Development, University of Oxford; Director, Oxford Martin Programme on Technological and Economic Change

Further speakers to be announced.

Gijs den Besten
Sep 1, 2013; 54:2325-2340
Reviews

Corporate Members Event Webinar

Professor Ian Goldin, Professor of Globalisation and Development, University of Oxford; Director, Oxford Martin Programme on Technological and Economic Change

Further speakers to be announced.

• Django Unchained Review
• Discussion on Tarantino: The Director
• What We Watched: Not Much
• What Game Jason Loves? A: Tokyo Jungle

It.s often a challenge to get from Point A to Point B in normal circumstances, but after a disaster it can be almost impossible to transport food, water, and clothing from the usual supply points to the people in desperate need. A new mathematical model employs probability and nonlinear programming to design supply chains that have the best chance of functioning after a disaster. For each region or country, the model generates a robust chain of supply and delivery points that can respond to the combination of disruptions in the network and increased needs of the population. Math also helps medical agencies operate more efficiently during emergencies, such as an infectious outbreak. Fluid dynamics and combinatorial optimization are applied to facility layout and epidemiological models to allocate resources and improve operations while minimizing total infection within dispensing facilities. This helps ensure fast, effective administering of vaccines and other medicines. Furthermore, solution times are fast enough that officials can input up-to-the-minute data specific to their situation and make any necessary redistribution of supplies or staff in real time. For More Information: Supply Chain Network Economics: Dynamics of Prices, Flows, and Profits, Anna Nagurney, 2006.

D. V. Gusak and E. V. Karnaukh
Theor. Probability and Math. Statist. 99 (2020), 77-89.
Abstract, references and article information

Here is some insight into the first ever blockchain advert

Inter-α-inhibitor is a proteoglycan essential for mammalian reproduction and also plays a less well-characterized role in inflammation. It comprises two homologous “heavy chains” (HC1 and HC2) covalently attached to chondroitin sulfate on the bikunin core protein. Before ovulation, HCs are transferred onto the polysaccharide hyaluronan (HA) to form covalent HC·HA complexes, thereby stabilizing an extracellular matrix around the oocyte required for fertilization. Additionally, such complexes form during inflammatory processes and mediate leukocyte adhesion in the synovial fluids of arthritis patients and protect against sepsis. Here using X-ray crystallography, we show that human HC1 has a structure similar to integrin β-chains, with a von Willebrand factor A domain containing a functional metal ion-dependent adhesion site (MIDAS) and an associated hybrid domain. A comparison of the WT protein and a variant with an impaired MIDAS (but otherwise structurally identical) by small-angle X-ray scattering and analytical ultracentrifugation revealed that HC1 self-associates in a cation-dependent manner, providing a mechanism for HC·HA cross-linking and matrix stabilization. Surprisingly, unlike integrins, HC1 interacted with RGD-containing ligands, such as fibronectin, vitronectin, and the latency-associated peptides of transforming growth factor β, in a MIDAS/cation-independent manner. However, HC1 utilizes its MIDAS motif to bind to and inhibit the cleavage of complement C3, and small-angle X-ray scattering–based modeling indicates that this occurs through the inhibition of the alternative pathway C3 convertase. These findings provide detailed structural and functional insights into HC1 as a regulator of innate immunity and further elucidate the role of HC·HA complexes in inflammation and ovulation.

Kotaro Hama
Apr 1, 2020; 61:523-536
Patient-Oriented and Epidemiological Research

X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder caused by deleterious mutations in the ABCD1 gene. The ABCD1 protein transports very long-chain FAs (VLCFAs) from the cytosol into the peroxisome where the VLCFAs are degraded through β-oxidation. ABCD1 dysfunction leads to VLCFA accumulation in individuals with X-ALD. FAs are activated by esterification to CoA before metabolic utilization. However, the intracellular pools and metabolic profiles of individual acyl-CoA esters have not been fully analyzed. In this study, we profiled the acyl-CoA species in fibroblasts from X-ALD patients and in ABCD1-deficient HeLa cells. We found that hexacosenoyl (26:1)-CoA, but not hexacosanoyl (26:0)-CoA, was the most abundantly concentrated among the VLCFA-CoA species in these cells. We also show that 26:1-CoA is mainly synthesized from oleoyl-CoA, and the metabolic turnover rate of 26:1-CoA was almost identical to that of oleoyl-CoA in both WT and ABCD1-deficient HeLa cells. The findings of our study provide precise quantitative and metabolic information of each acyl-CoA species in living cells. Our results suggest that VLCFA is endogenously synthesized as VLCFA-CoA through a FA elongation pathway and is then efficiently converted to other metabolites, such as phospholipids, in the absence of ABCD1.

When users are defined in multiple groups associated with grid options set mappings, the first grid option set that is returned by the metadata search chain takes precedence. Only one grid options set mapping is used

Branched chain amino acids (BCAAs) are associated with the progression of obesity-related metabolic disorders, including T2DM and non-alcoholic fatty liver disease. However, whether BCAAs disrupt the homeostasis of hepatic glucose and lipid metabolism remains unknown. In this study, we observed that BCAAs supplementation significantly reduced high-fat (HF) diet-induced hepatic lipid accumulation while increasing the plasma lipid levels and promoting muscular and renal lipid accumulation. Further studies demonstrated that BCAAs supplementation significantly increased hepatic gluconeogenesis and suppressed hepatic lipogenesis in HF diet-induced obese (DIO) mice. These phenotypes resulted from severe attenuation of Akt2 signaling via mTORC1- and mTORC2-dependent pathways. BCAAs/branched-chain α-keto acids (BCKAs) chronically suppressed Akt2 activation through mTORC1 and mTORC2 signaling and promoted Akt2 ubiquitin-proteasome-dependent degradation through the mTORC2 pathway. Moreover, the E3 ligase Mul1 played an essential role in BCAAs/BCKAs-mTORC2-induced Akt2 ubiquitin-dependent degradation. We also demonstrated that BCAAs inhibited hepatic lipogenesis by blocking Akt2/SREBP1/INSIG2a signaling and increased hepatic glycogenesis by regulating Akt2/Foxo1 signaling. Collectively, these data demonstrate that in DIO mice, BCAAs supplementation resulted in serious hepatic metabolic disorder and severe liver insulin resistance: insulin failed to not only suppress gluconeogenesis but also activate lipogenesis. Intervening BCAA metabolism is a potential therapeutic target for severe insulin-resistant disease.

Mandeep Bajaj
Nov 1, 2005; 54:3148-3153
Metabolism

Blockchain is the digital technology that underpins cryptocurrencies such as bitcoin, and has been proposed as the digital panacea of our times. But Leeza Osipenko, from the London School of Economics, has thought about how it could actually be used in clinical trials, and what else would need to change in our regulatory environment to make that...

Marc Prentki
Mar 1, 1996; 45:273-283
Original Article

Invitation Only Research Event

2 September 2015

This paper explores the potential of using public procurement policy to promote the uptake of sustainable food products in order to reduce imports of agricultural products associated with deforestation.

28 January 2016

Private-sector commitments and government policies, a loss of support for biofuels, and health concerns over the consumption of palm oil and beef, are factors that may help to restrict the further expansion of agricultural land into forest areas.

About 2.1 million immigrants work in jobs growing, harvesting, processing, and selling food in the United States, serving an essential role in feeding America. While immigrants accounted for 17 percent of all civilian employed workers in the United States between 2014-18, they played an outsized role in food production, making up 22 percent of workers in the U.S. food supply chain. They represent far larger shares in certain food-related occupations, and in particular states, as this infographic shows.

OBJECTIVE

A recent publication questioned the integrity of insulin purchased from U.S. retail pharmacies. We sought to independently validate the method used, isotope dilution solid-phase extraction (SPE) liquid chromatography mass spectrometry (LC-MS), and expand analysis to two U.S. Pharmacopeia (USP) methods (high-performance LC with ultraviolet detection and LC-MS).

Paris : G. Steinheil, 1890.

L. F. South, A. N. Pettitt, C. C. Drovandi.

Source: Bayesian Analysis, Volume 14, Number 3, 773--796.

Abstract:
Sequential Monte Carlo (SMC) methods for sampling from the posterior of static Bayesian models are flexible, parallelisable and capable of handling complex targets. However, it is common practice to adopt a Markov chain Monte Carlo (MCMC) kernel with a multivariate normal random walk (RW) proposal in the move step, which can be both inefficient and detrimental for exploring challenging posterior distributions. We develop new SMC methods with independent proposals which allow recycling of all candidates generated in the SMC process and are embarrassingly parallelisable. A novel evidence estimator that is easily computed from the output of our independent SMC is proposed. Our independent proposals are constructed via flexible copula-type models calibrated with the population of SMC particles. We demonstrate through several examples that more precise estimates of posterior expectations and the marginal likelihood can be obtained using fewer likelihood evaluations than the more standard RW approach.

Recent literature has highlighted that international trade is mostly priced in a few key vehicle currencies, and is increasingly dominated by intermediate goods and global value chains (GVCs). Taking these features into account, this paper reexamines the business cycle dynamics of international trade and its relationship with monetary policy and exchange rates.

Bank for International Settlements BIS Working Papers by David Cook and Nikhil Patel

Penn State Mont Alto unveiled its new project and supply chain management degree in response to a local and global need.

Apple is shifting a substantial portion of its current AirPods production from China to Vietnam, and appears to be considering a release schedule later than previously predicted for an AirPods refresh.

Suboptimal brain development and increased risk of cognitive deficits are well documented in very low birth weight children. Supplementation with docosahexaenoic acid and arachidonic acid has been associated with positive cognitive effects.

This follow-up study of a randomized controlled trial of supplementation with docosahexaenoic acid and arachidonic acid to very low birth weight infants is the first report on both cognition and brain macrostructure measured with MRI. No cognitive or neuroanatomical effects were detected at 8 years. (Read the full article)

Rachel Hooker, who will graduate May 9 with a 3.99 GPA in supply chain and information systems, has been selected as the Smeal College of Business’ spring 2020 supply chain and information systems student marshal.

When we interviewed supply chain expert Chris Tyas a few weeks prior to the COVID-19 pandemic, we had no idea that his 40 years of experience and knowledge in the consumer product goods (CPG) industry would soon have a profound impact on the supply chain and efforts to keep supplies [...]

The importance of the supply chain during the COVID-19 crisis was published on SAS Voices by Nancy Rudolph

DOVER (March 18, 2020) – Maintaining the supply of food and fiber for our citizens, especially during times of an emergency, is of paramount importance. Our poultry industry plays a critical role in feeding our citizens and supplying an abundant, healthy source of protein. “It is extremely important that the entire vertically integrated chain of […]

States Will Aggregate Demand for PPE, Medical Equipment and Testing on a Regional Basis Regional Supply Chains Will Help Realize Better Pricing, Delivery and Reliability of PPE and Medical Equipment for States   WILMINGTON, Del. – Amid the ongoing COVID-19 pandemic, Delaware Governor John Carney, New York Governor Andrew M. Cuomo, New Jersey Governor Phil Murphy, […]

With the country remaining under a lockdown due to coronavirus, the supply chain of essential goods has been disrupted, but, the same has also presented the government with an opportunity to identify and plug those gaps.

The latest news and developments

The need of the hour is to promote remote working and expand gig economy, speakers at a Niti Aaayog-organised Webinar said.

The Energy Web Foundation (EWF) this week announced that it has launched the world’s first public, open-source, enterprise-grade blockchain tailored to the energy sector: the Energy Web Chain (EW Chain). As a refresher, blockchain allows for peer-to-peer energy market transactions.