The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

The present invention relates to fusion proteins comprising an antibody, functional fragment or functional derivative thereof having specific binding affinity to either the extracellular domain of oncofetal fibronectin (ED-B) or at least one of the extracellular domains of oncofetal tenascin fused to a cytokine selected from the group consisting of IL-10, IL15, IL-24 and GM-CSF, functional fragments and functional derivatives thereof. The invention is also directed to the use of at least one of said fusion proteins for the manufacture of a medicament. In particular, the invention concerns the use of said medicament for the treatment of tumors or chronic inflammatory diseases such as atherosclerosis, arthritis and psoriasis.

Plant viral vectors have great potential in rapid production of proteins, but no simple. Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes.

A disk drive unit includes a rotor configured to rotate a disk accommodated within a disk accommodating space and set thereon, a fixed body configured to rotatably support the rotor, a fluid dynamic pressure generating part provided between the fixed body and the rotor, and a plurality of ring-shaped members, provided in an overlapping manner along a direction of a rotational axis of the rotor within a space that communicates the disk accommodating space and a gas-liquid interface of the lubricant, and covering a gap between the rotor and the fixed body.

A rotating body includes a cylindrical rotating member and bearings located at the ends located in the axial direction of the rotating member. In the rotating body, at least one of the bearings includes a metal inner ring portion having a bearing hole and a resin outer ring portion having first and second portions. The first portion is fitted into the rotating member. The second portion protrudes in the axial direction from the rotating member, surrounds the outer peripheral surface of the inner ring portion, has an outer diameter larger than that of the rotating member, and is in contact with an opposing object opposing the rotating member so as to maintain a specified size of a gap by which the rotating member and the opposing object are spaced apart from each other. The outer and inner ring portions are integrally molded.

The present invention provides a polymerizable compound represented by the following formula (I), a polymerizable composition that includes the polymerizable compound and an initiator, a polymer obtained by polymerizing the polymerizable compound or the polymerizable composition, and an optically anisotropic article that includes the polymer. The polymerizable compound, polymerizable composition, and polymer have a practical low melting point, exhibit an excellent solubility in a general-purpose solvent, can be produced at low cost, and may produce an optical film that achieves uniform conversion of polarized light over a wide wavelength band, and an optically anisotropic article.

The present description relates to an olefin block copolymer preferably useful to form nonslip pads due to excellences in elasticity and heat resistance, and a sheet-shaped molded body comprising the olefin block copolymer The olefin block copolymer includes a plurality of blocks or segments, each of which includes an ethylene or propylene repeating unit and an α-olefin repeating unit at different weight fractions. The olefin block copolymer satisfies a defined relationship when a load of 5 to 10 kg is applied to a sheet-shaped molded body of the block copolymer for 12 hours or longer at a temperature of 60° C. or higher, and then removed.

A lipstick case lipstick body lift seat anti-slipped structure includes a lipstick case, an outer tube, a lift seat with an opening facing upward, and a lipstick body. A plurality of anti-slipped blocking grooves is formed on an upwardly inclined side of each of the two inclined guiding grooves. The outer tube is sleeved on an outer side of the small diameter guiding tube, and a spiral guiding groove is disposed on an inner wall of the outer tube concavely. The lipstick body is sleeved in the lift seat. Two lift guiding columns are disposed on an outer wall of the lift seat protrudingly for engaging with the inclined guiding grooves correspondingly and pressing into the spiral guiding groove. An anti-slipped blocking portion is protrudingly disposed on an outer diameter of each of the lift guiding columns corresponding to the anti-slipped blocking grooves.

A medical device for blood flow restoration and/or for use as an implantable member in a human vessel includes a self-expanding member, a guidewire, and a connection mechanism. The self-expanding member includes a plurality of cells and filaments having specific ranges of thicknesses, widths, and heights. The self-expanding member can take on a volume-reduced coiled form with overlapped edges, and can generate optimal radial forces against a vessel wall and/or thrombus when deployed and expanded.

An elongate inserter has a distal end releasably connected to an expandable interbody fusion device and a proximal end including a trigger actuator. The interbody fusion device comprises a superior endplate and an inferior endplate that are movable in an expansion direction relative to each other in the intradiscal space. The inserter includes a lifting platform and an elevator that define cooperatively engaging ramps and ramps surfaces that upon operation of the trigger actuator cause the superior and inferior endplates to move relatively away from each other. A driver is supported by the inserter for pushing an insert into the expanded device between the superior and inferior endplates.

A rotary-driven tool for cutting machining, in particular a drilling tool with a cutting body and a holder with a shaft piece is disclosed, with at least a cutter and a dovetail-shaped region on the cutting body and a matching dovetail recess on the holder. The cutting body can only be inserted in the holder laterally to a longitudinal axis of the holder. In order to fix the cutting body, opposing flank sections of the dovetail recess, between which the dovetail-shaped region fits can be moved over each other by means of a screw connection in the holder and on fixing the cutting body said body is subjected to a force on the axial direction by the screw connection. In one aspect, the cutting body is a cutting head and the axial force is exclusively generated by the dovetail-shaped region in cooperation with the dovetail recess in the holder.

A cutting tool has at least one cutting tool support pad. The cutting tool support pad includes two opposing primary surfaces, each primary surface includes an abutment surface and at least one convex contact surface. For each primary surface, the at least one contact surface extends outwardly further than the abutment surface.

A method and apparatus for dating a body sample, such as blood, includes taking at least one spectroscopic measurement of the sample at at least two predetermined positions in the spectrum having spectral characteristics corresponding to at least two predetermined substances present in the sample that have a time varying relationship with each other. A measured relative concentration of each of the predetermined substances is then determined from the measurement, and the measured relative concentrations of the two predetermined substances is compared with a known variation of the relative concentrations of the two predetermined substances over time. A good fit of the measured relative concentrations to the known variation of the relative concentrations is then determined, so as to provide an indication of the age of the sample. Alternatively, instead of measuring the relative concentrations of each of the predetermined substances, the rate of change of the relative concentrations is determined.

Disclosed herein are antibody-nanoparticle conjugates that include two or more nanoparticles (such as gold, palladium, platinum, silver, copper, nickel, cobalt, iridium, or an alloy of two or more thereof) directly linked to an antibody or fragment thereof through a metal-thiol bond. Methods of making the antibody-nanoparticle conjugates disclosed herein include reacting an arylphosphine-nanoparticle composite with a reduced antibody to produce an antibody-nanoparticle conjugate. Also disclosed herein are methods for detecting a target molecule in a sample that include using an antibody-nanoparticle conjugate (such as the antibody-nanoparticle conjugates described herein) and kits for detecting target molecules utilizing the methods disclosed herein.

The present invention relates to shaped bodies made of fiber-reinforced ceramic composites and comprising a core zone and at least one covering layer which has a coefficient of thermal expansion which is higher than that of the core zone. The covering layer is an SiC-rich covering layer and is divided into segments which are separated from the adjacent segments by gaps or bridging zones of a material which is different from the material of the segments. The invention also relates to a process for producing such shaped bodies by infiltration of an intermediate body with molten silicon and their use for friction disks, in vehicle construction or as protective plates.

Disclosed is a method of increasing lean body mass and reducing fat body mass in infants, said method comprising administration to an infant, term or preterm, a nutritional formula comprising a source of DHA and ARA. It has been found that the administration of DHA and ARA, or a source thereof, in infants can increase lean body mass and reduce fat body mass, when compared to an unsupplemented control formula, without impacting the total overall growth of the infant. This method is especially useful in preterm infants.

An integrated control valve body and hydraulic pump for an automatic transmission includes a control valve body having a plurality of control valves and passageways and an internal cavity having an inlet and an outlet, a pump rotor received within the internal cavity and having a plurality of radially and axially extending slots, radially moveable vanes and a shaft, and a device for transferring drive energy from a drive shaft extending between an output of a torque converter and an input of the transmission to the shaft of the hydraulic pump. The device for transferring drive energy may be a pair of chain sprockets and a chain, a pair of spur or helical gears or other inter-axis power transfer components and may affect a speed increase or reduction.

An exchangeable lens includes: a mount unit at which a camera body is detachably engaged; a plurality of drive target members, conditions of which change as a drive force is applied thereto; an initialization unit that executes initialization processing for each of the plurality of drive target members; an initialization status transmission unit that transmits initialization statuses, each indicating a status of the initialization processing executed for one of the drive target members, to the camera body via a first transmission path over predetermined first cycles; and a drive condition transmission unit that transmits a drive condition of at least one drive target member among the plurality of drive target members to the camera body via a second transmission path different from the first transmission path over predetermined second cycles different from the predetermined first cycles.

An aspect of the present invention provides an interchangeable lens camera having a camera body and a lens unit that is freely attachable and detachable to the camera body. In the interchangeable lens camera, a communications unit in the camera body sends via communications terminals (MT_MOSI and MT_MISO) an INTR_BUSY control instruction that instructs whether to make notification with a busy signal (INTR_BUSY signal) for any operation out of a plurality of types of operations that can be executed, and the lens unit or camera body communications unit sets the busy signal (INTR_BUSY) to an ON state (low level) only during the period of operation of the type indicated by the INTR_BUSY control instruction.

The present invention relates to an anti-human α9 integrin antibody. More particularly, the present invention relates to: a monoclonal antibody, a chimeric antibody, a humanized antibody and a human antibody that specifically recognize human α9 integrin; a hybridoma cell that produces the monoclonal antibody; a method for producing the monoclonal antibody; a method for producing the hybridoma cell; a therapeutic agent comprising the anti-human α9 integrin antibody; a diagnostic agent comprising the human α9 integrin antibody; and a method for screening for a compound that inhibits the activity of human α9 integrin.

The present invention relates to a composition comprising at least three primary antibodies or fragments thereof, wherein the at least three antibodies or fragments thereof binds specifically to at least three different proteins, and wherein the at least three different proteins are AMCAR, CK 5/6, and HMWC. Methods for using the composition in diagnosis, prognosis, and assessing efficacy of treatment is further included as well as kits comprising said composition, and optionally, instructions of its use.

A cask cushioning body includes an end-surface side member (2) in which a plurality of plates (21, 22) made of steel are formed at a distance between plate surfaces of the plates (21, 22) that face each other, and in which the plate surfaces of the plates (21, 22) are arranged along an end surface (100a) of a cask (100), and a circumferential-surface side member (3) that forms a cylindrical body (31) made of steel, one end of which is connected to a periphery of the end-surface side member (2), and that is arranged along an end-portion outer-circumferential surface (100b), wherein an impact absorber (4) that absorbs an impact by deforming is provided outside of the end-surface side member (2) and the circumferential-surface side member (3).

A three way catalyst includes an extruded solid body having by weight: 10-100% of at least one binder/matrix component; 5-90% of a zeolitic molecular sieve, a non-zeolitic molecular sieve or a mixture of any two or more thereof; and 0-80% optionally stabilised ceria. The catalyst also includes at least one precious metal and optionally at least one non-precious metal, wherein: (i) the at least one precious metal is carried in one or more coating layer(s) on the body surface; (ii) at least one metal is present throughout the body and at least one precious metal is carried in one or more coating layer(s) on a body surface; or (iii) at least one metal is present throughout the body, is present in a higher concentration at a body surface, and at least one precious metal is carried in one or more coating layer(s) on the body surface.

A first panel includes an engaging section configured to engage with an engaged section so as to allow displacement of the engaged section according to swinging of a hood between a closed position and an open position and restrict the swinging of the hood in a state where an opening section is opened. The engaging section engages with the engaged section such that the engaged section is detachable by being displaced in a predetermined first direction. The machine main body further includes an auxiliary supporting section provided in a machine room and configured to restrict, by detachably supporting the engaged section detached from the engaging section, the swinging of the hood in a state where the opening section is opened.

The invention relates to a handle (2) for an openable body section of a vehicle, including: an actuator (20) such as a lever, which is movably mounted between an inoperative position of the actuator and a position for unlocking the openable body section, and a locking member (36), such as a lock bolt, which is designed to occupy an inoperative position in which same locks the actuator (20) in the inoperative position of the actuator.

The invention relates to an assemblage of two pieces of bodywork (1, 2) each having a flange (5, 6) for pressing against the flange of the other piece. Each flange carries at least one tongue (11, 12) extending towards the other piece. A fastener member (20) is suitable for engaging around the tongues so to prevent them from moving relative to one another once said two pieces of bodywork are in a predetermined position in which they are united flange against flange. The invention also provides the pieces of bodywork constituting said assemblage.

A battery operated hand held device for use in handling or controlling livestock, particularly cattle, swine, sheep and horses. This invention provides a novel alternative to conventional electric livestock prods, which deliver an electric shock to the animal. While operating on the principle of external stimulus to invoke a flight response, this invention relies on vibration and/or sound rather than painful electric shock. This unique mode of action satisfies the needs in the livestock industry for low stress handling equipment and techniques with the welfare of the animal as a priority.

A paired row opener has a furrowing tip arranged to be selectively supported on a body of the opener. The furrowing tip includes a knife portion and a pair of wing portions extending rearwardly and outwardly therefrom where are separable together from the opener body. A pair of deflector wings are integrally formed on the opener body above inner edges of the respective wing portions which are abutted with the opener body so as to deflect disturbed soil away from a seam between the inner edge of the wing portions and the opener body. An insulated mounting block is fastened onto a rear bracket of the opener body which receives an anhydrous ammonia delivery tube therethrough so permit optional delivery of anhydrous ammonia at a location which is insulated and spaced rearwardly from the opener body.

An interface between a receptacle body and an insert designed, in particular, as a tool or workpiece insert, comprises a receptacle body (2) having a cylindrical receiving bore (4), which is circumscribed by a first plane surface (6) extending at a right angle to the bore axis and in which a first cone surface (9) is arranged, said first cone surface being coaxial with the bore axis and being arranged so that its tapered end faces toward the plane surface. The insert (3) has a pin (15) that is disposed to be plugged into the receiving bore (4) and is circumscribed by a second plane surface (22). At an axial distance from the second plane surface (22), said pin has a second cone surface (22), the tapered end of said second cone surface being arranged so as to face toward the second plane surface. With the pin (15) inserted in the receiving bore (4), the two plane surfaces are in superimposed contact while the two cone surfaces (9, 22) can be biased relative to each other by limited twisting of the insert relative to the receptacle body.

The invention relates to an energy-efficient apparatus driven by compressed air and equipped with a dual piston function for tensioning, or clamping, or centering, or punching, or welding, or clinching, for use in body construction in the automotive industry. The apparatus is driven by a pressurized fluid, in particular by compressed air. It is shown how a significant amount of operating costs can be saved while, at the same time, conserving the environment and consuming a low amount of pressurized fluid, in particular compressed air. In addition, the pivoting angle of a toggle joint assembly and thus of an apparatus connected thereto, for example, a tensioning arm of a toggle tensioning apparatus, can be continuously adjusted in both directions while, at the same time, adjusting a sampling device using sensors, for example, microswitches, or inductive switches, or pneumatic switches, or limit switches.

A yttria sintered body is provided which includes yttria as a principal ingredient and 5 to 40 vol. % silicon nitride, and which exhibits enhanced corrosion resistance and mechanical strength.

There is provided a vehicle body structure that can improve collision performance at the time of a rear collision. The vehicle body structure includes first and second crash boxes that are provided at rear ends of rear side members. Further, the second crash boxes are disposed at positions different from the positions of the first crash boxes in a vertical direction of the vehicle. The second crash boxes, which are disposed at the positions different from the positions of the first crash boxes, can absorb a load applied from bumper reinforcement of another vehicle. Since a load at the time of a rear collision is absorbed by the second crash boxes, it is possible to suppress the deformation of a trunk that is provided at the rear portion of a vehicle body.

A panel member having a U-shaped cross section includes step portions at an upper face portion and a lower face portion, and a distance, in a vehicle longitudinal direction, of the step potions from a panel member formed substantially in a flat-plate shape, is configured such that the distance at a central portion, in the vehicle width direction, of a bumper reinforcement is the maximum and the distance decreases gradually toward an outward direction of the vehicle. Accordingly, the vehicle-body structure which can properly ensure the bending strength and also attain the light weight of the bumper reinforcement, improving the load transmission from the bumper reinforcement to crash cans, can be provided.

A first projection portion projecting outward, in a vehicle width direction, from a front side frame is provided. A front end of the first projection portion is located at the same position, in the vehicle longitudinal direction, as a connection portion of a crash can to the front side frame or located in back of the connection portion. An outward side face of the first projection portion is configured to slant rearward and inward in a plan view. The first projection portion and a power unit are arranged to overlap each other in the vehicle longitudinal direction. Accordingly, an impact transmitted to a vehicle-compartment side in a small overlap collision can be reduced, restraining repair costs of the crash can broken in a low-speed collision as well as maintaining appropriate design flexibility of a vehicle-body front portion.

A coupler body for a railcar coupler, said coupler body comprising at least one central datum feature that does not wear during coupler use.

The moving body separating device includes a separating device main body, which separates an upstream-side moving body disposed on a base plate to be movable in a straight-line direction and a downstream-side moving body connected to the upstream-side moving body on the base plate at a prescribed separating point when moving to a downstream side. The separating device main body includes a rotary body for pushing out the downstream-side moving body towards the downstream side through a rotary action, a supporting shaft held by the upstream-side moving body for supporting the rotary body to be freely rotatable, and an original-position returning spring held by the supporting shaft for returning the rotary body to an original position. A protrusion member which applies a rotary pressure force to the rotary body is fixed at a prescribed separating point on the base plate by corresponding to one end part of the rotary body.

An improved coupler body having an area of increased material in the upper lock chamber.

A toy projectile launcher assembly has the form of a crossbow. The crossbow only launches the safety projectiles that are provided. The launcher body has a handle at a first end and diverging support arms at an opposite second end. An adjustment mechanism is contained within the launcher body for selectively adjusting the length of the launcher body. The crossbow has diverging support arms. Bow arms are attached to the support arms. The bow arms pivot from retracted positions to extended positions when a projectile is loaded into the toy crossbow. The toy crossbow has elastic loops that can only engage specialized safety projectiles with side. Furthermore, the trigger mechanism can only engage the safety projectiles provided with the toy. Projectiles without a specific tab and keyhole cannot be loaded into the toy crossbow.

A dispenser system for delivering various combinations of dispersants to a body of water with the various combinations of dispersants supplied to the body of water through the interchanging of dispensing cartridges which are attachable to a main dispensing cartridge where a condition for interchanging of dispensing cartridges may be triggered by an event.

A multiple nozzle body including a plurality of discharge nozzles for arranging on the liquid line of an agricultural crop sprayer, wherein the liquid line can be connected to the supply line of the multiple nozzle body, wherein the supply line opens out in a distribution space, wherein a plurality of connecting lines that respectively lead to a discharge nozzle branch off from the distribution space, wherein a shut-off element that is respectively assigned to a connecting line and is formed as a shut-off valve is assigned to the distribution space, wherein one or more connecting lines can be optionally connected to and/or shut off from the supply line by means of the shut-off element of the shut-off valves, which can be actuated by means of a switchable actuating element.

A sound absorbing body includes a fibrillated part fibrillated into fiber form, and an unfibrillated part that is not fibrillated into fiber form. The unfibrillated part is dispersed inside the single sound absorbing body.

A printing device includes a case, a printing unit arranged inside the case, and a sound absorbing body arranged inside the case. The sound absorbing body has parts with different densities including a dense part with a higher density and a non-dense part with a lower density. The non-dense part includes a fibrillated part that is fibrillated into fiber form, and an unfibrillated part that is not fibrillated into fiber form.

A sound absorbing body includes parts of different densities including a plurality of non-dense parts of lower density and a plurality of dense parts of higher density. The non-dense parts and the dense parts are alternately laminated obliquely.

An ice maker has an ice-making vessel having a cylindrical shape, a cooling means, a block ice making mold which is placed inside, and an agitator. The mold includes a main mold body having a plurality of connected L-shaped plates projected radially outward from the central axis; a base plate which is joined to each L-shaped plate, and the top side of the L-shaped plates form a screw insertion part of the mold body such that the agitator fits between the L-shaped plates at a second end of the central axis.

A one-piece ice chest cover for changing the appearance of an ice chest includes a flexible main pocket portion having a front side, two lateral sides, and a back side forming a main pocket opening for receiving a main body of the ice chest. It also includes a flexible lid pocket portion formed of an inner portion configured to face an inner-facing surface of a lid of the ice chest and an outer portion for covering an outer-facing surface of the lid. The lid pocket portion may include a lid pocket opening sized smaller than a size of the main pocket opening. The lid pocket opening may be sized to receive a portion of the lid of the ice chest. The outer portion of the lid pocket portion may be connected to the back side of the main pocket portion so that the ice chest cover flexes when the lid is pivoted to open and close the ice chest.

A body, such as a pick tool for cutting coal, includes a steel substrate and a hard face structure fused to the steel substrate. The hard face structure includes at least 1 weight percent Si, at least 5 weight percent Cr and at least 40 weight percent W. Substantially the balance of the hard face structure includes carbon and an iron group metal M selected from Fe, Co, Ni and alloy combinations of these elements. The hard face structure includes a plurality of elongate or platelike micro-structures having a mean length of at least 1 micron, a plurality of nano-particles having a mean size of less than 200 nanometers, and a binder material.

Provided is a method of potentiating immunity or preventing or treating an immune-related disease comprising administering an anti-Ang2 antibody or an antigen-binding fragment thereof to a subject in need thereof.

Provided is a method of decreasing blood sugar level or preventing and/or treating a hyperglycemia-related disease, including administering an anti-Ang2 antibody or an antigen-biding fragment thereof to a subject in need thereof.

Provided in some embodiments are antibodies comprising a heavy chain having no native interchain cysteine amino acids, a light chain having no native interchain cysteine amino acids, and having no native interchain disulphide linkages between the heavy chain and the light chain. Also provided in certain embodiments are antibodies comprising a heavy chain having no native interchain cysteine amino acids, a light chain having no native interchain cysteine amino acids, and having no native interchain disulphide linkages between the heavy chain and the light chain where the native interchain cysteine amino acids have been replaced by amino acids having no thiol moiety.

A collision risk calculation device includes: a movement information obtaining unit that obtains a speed and a movement direction of an obstacle; and a risk map generator that generates a risk map indicating a range within which the obstacle can exist after one unit of time and degree of risk of collision of an own vehicle with the obstacle within the range, on a basis of the speed and the movement direction of the obstacle obtained by the movement information obtaining unit, wherein the risk map generator changes the range in left and right directions with respect to a traveling direction of the obstacle, on a basis of the speed of the obstacle in the traveling direction.