The social media giant has partnered with leading contractors alongside tech industry leaders to facilitate government adoption of its AI technology

Reports say TSMC notified Chinese chip design companies it would suspend 7 nanometer or below chips for AI and GPU customers beginning Nov. 11

Antibodies are widely used as cancer therapeutics, but their current use is limited by the low number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine kinase-like orphan receptor 2 (ROR2), is normally expressed only during embryogenesis and is tightly down-regulated in postnatal healthy tissues. However, it is up-regulated in a diverse set of hematologic and solid malignancies, thus ROR2 represents a candidate antigen for antibody-based cancer therapy. Here we describe the affinity maturation and humanization of a rabbit mAb that binds human and mouse ROR2 but not human ROR1 or other human cell-surface antigens. Co-crystallization of the parental rabbit mAb in complex with the human ROR2 kringle domain (hROR2-Kr) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)-focused mutagenesis and selection. The affinity-matured rabbit mAb was then humanized by complementarity-determining region (CDR) grafting and framework fine tuning and again co-crystallized with hROR2-Kr. We show that the affinity-matured and humanized mAb retains strong affinity and specificity to ROR2 and, following conversion to a T cell–engaging bispecific antibody, has potent cytotoxicity toward ROR2-expressing cells. We anticipate that this humanized affinity-matured mAb will find application for antibody-based cancer therapy of ROR2-expressing neoplasms.

From Wednesday 26 March 2014 WorldBridge will no longer be providing visa services for applicants applying for a UK visa from the US. The visa processing service, which until how has been provided by WorldBridge, will be provided by VFS Global from ...

Most of the projections of the cost of meeting climate change mitigation targets hinge crucially upon assumptions made about the cost and timing of the development of breakthrough technologies. This paper seeks to uncover attributes of inventions – as reflected in patent data – which serve as "leading indicators" of subsequent technological and market development in climate change mitigation technologies.

Behavioural insights have the potential to enhance the effectiveness of financial literacy and investor education initiatives. This IOSCO/OECD report explores the extent to which they are being used, reviews the available literature and presents various approaches for policy makers and practitioners to consider when seeking to change financial behaviour.

This report provides a review of recent firm-level and plant-level surveys containing questions on environmental policies, innovation practices or performance which are relevant for environmental policy analysis and assessment. We specifically focus on the core element that relates environmental policies to environmental and economic performance, namely the adoption of innovative practices and environmental innovations by firms.

This paper describes MOLES 1.0, an integrated land-use and transport model developed with Object-Oriented Programming principles in order to combine selected characteristics from Spatial Computable General Equilibrium and microsimulation models. MOLES 1.0 models the links between urban land use, mobility patterns, urban economic activities and their environmental impacts, in particular air pollution and emissions of greenhouse gases.

This paper explores the consequences on the labour markets of structural changes induced by decarbonisation policies. These policies are likely going to have consequences on labour-income distribution given i) existing rigidities in the labour markets, and ii) their different impacts on sectors and on job categories.

In yester years, only the business organizations with huge financial backing were able to initiate the process of custom software development. This condition immediately changed when positive remarks on the usage of these applications...

This document outlines the current status of and available guidance documents/tools on the application, use and presentation of PRTR data in OECD member countries and the Commission for Environmental Co-operation based on the results of a survey conducted in November 2011.

This document provides information on the sources, use patterns, and potential release pathways of chemicals used in the manufacture of thermal and carbonless copy paper. It presents approaches for estimating the environmental releases of and occupational exposures to additives and components used in thermal and carbonless copy paper coatings.

This new Advisory Document replaces the 1995 consensus document on the Application of the Principles of GLP to Computerised Systems. It retains all of the key text from the original 1995 document, but includes new text to reflect the current state-of-the art in this field.

The OECD Conference on Genome Editing: Applications in Agriculture – Implications for Health, Environment and Regulation will explore the regulatory considerations raised by genome edited products, with the aim to favour a coherent policy approach to facilitate innovation involving genome editing. More information on the programme and the speakers.

ab with 01 CRAN 1583 of 2020 (Via Video Conferencing)

In the matter of : an application for bail under Section 439 of the Code of Criminal Procedure filed on 19.04.2020 in connection with Bally Police Station Case No. 25 of 2018 dated 01.03.2018 under Sections 195(A)/506/509/427/34 of the Indian Penal Code.

And In Re :- Bikash Pandey @ Vikash Pandey @ Vicky ... Petitioner.

Mr. Achin Jana ... For the Petitioner. Mr. R. Roy Chowdhury Mr. T. K. Ghosh Mr. P. Bose ... For the State

ab with 02 CRAN1420 of 2020 (Via Video Conferencing)

In the matter of : an application for bail under Section 439 of the Code of Criminal Procedure filed in connection with Egra P.S. Case No. 194 of 2020 dated 21.03.2020 under Sections 341/354A/427 of the Indian Penal Code, 1860 of Protection of Children from Sexual Offences Act, 2012.

And In Re :- Laltu Jana ... Petitioner. Sk. Sahjahan Ali ... For the Petitioner. Mr. R. Roy Chowdhury Mr. T. K. Ghosh Mr. P. Bose ... For the State

The application Jessica Ennis-Hill made for a SportsAid grant as a 15-year-old has been revealed by the organisation's Twitter account on the day she announced her retirement.

Archives, Room Use Only - HD9685.G7 B69 1986

Archives, Room Use Only - TK5266.H47 1897

Archives, Room Use Only - TF627.P74 1863

Archives, Room Use Only - KF228.M674 U55 1860

Archives, Room Use Only - QC517.C85 1821

Archives, Room Use Only - TK5118.M7 H37 1854

Archives, Room Use Only - Q164.J85 1829

Archives, Room Use Only - TK151.B43 1901

Archives, Room Use Only - TK5262.R46 1924

Archives, Room Use Only - QC611.H46 1831

Trial run of software will be conducted

A portable IR fiber laser-heating system, optimized for X-ray emission spectroscopy (XES) and nuclear inelastic scattering (NIS) spectroscopy with signal collection through the radial opening of diamond anvil cells near 90°with respect to the incident X-ray beam, is presented. The system offers double-sided on-axis heating by a single laser source and zero attenuation of incoming X-rays other than by the high-pressure environment. A description of the system, which has been tested for pressures above 100 GPa and temperatures up to 3000 K, is given. The XES spectra of laser-heated Mg0.67Fe0.33O demonstrate the potential to map the iron spin state in the pressure–temperature range of the Earth's lower mantle, and the NIS spectra of laser-heated FeSi give access to the sound velocity of this candidate of a phase inside the Earth's core. This portable system represents one of the few bridges across the gap between laser heating and high-resolution X-ray spectroscopies with signal collection near 90°.

British Geological Survey submits application for geoenergy observatory in Cheshire  ThinkGeoEnergy

Reductive cyclization of 1,3,5-triphenyl- and 3-(2-meth­oxy­phen­yl)-1,5-di­phenyl­pentane-1,5-diones by zinc in acetic acid medium leads to the formation of 1,2,4-tri­phenyl­cyclo­pentane-1,2-diol [1,2,4-Ph3C5H5-1,2-(OH)2, C23H22O2, (I)] and 4-(2-meth­oxy­phen­yl)-1,2-di­phenyl­cyclo­pentane-1,2-diol [4-(2-MeOC6H4)-1,2-Ph2C5H5-1,2-(OH)2, C24H24O3, (II)]. Their single crystals have been obtained by crystallization from a THF/hexane solvent mixture. Diols (I) and (II) crystallize in ortho­rhom­bic (Pbca) and triclinic (Poverline{1}) space groups, respectively, at 150 K. Their asymmetric units comprise one [in the case of (I)] and three [in the case of (II)] crystallographically independent mol­ecules of the achiral (1R,2S,4r)-diol isomer. Each hydroxyl group is involved in one intra­molecular and one inter­molecular O—H⋯O hydrogen bond, forming one-dimensional chains. Compounds (I) and (II) have been used successfully as precatalyst activators for the ring-opening polymerization of ∊-caprolactone.

Electron diffraction tomography (EDT) has gained increasing interest, starting with the development of automated electron diffraction tomography (ADT) which enables the collection of three-dimensional electron diffraction data from nano-sized crystals suitable for ab initio structure analysis. A basic description of the ADT method, nowadays recognized as a reliable and established method, as well as its special features and general applicability to different transmission electron microscopes is provided. In addition, the usability of ADT for crystal structure analysis of single nano-sized crystals with and without special crystallographic features, such as twinning, modulations and disorder is demonstrated.

The room-temperature experiment has been revisited for macromolecular crystallography. Despite being limited by radiation damage, such experiments reveal structural differences depending on temperature, and it is expected that they will be able to probe structures that are physiologically alive. For such experiments, the humid-air and glue-coating (HAG) method for humidity-controlled experiments is proposed. The HAG method improves the stability of most crystals in capillary-free experiments and is applicable at both cryogenic and ambient temperatures. To expand the thermal versatility of the HAG method, a new humidifier and a protein-crystal-handling workbench have been developed. The devices provide temperatures down to 4°C and successfully maintain growth at that temperature of bovine cytochrome c oxidase crystals, which are highly sensitive to temperature variation. Hence, the humidifier and protein-crystal-handling workbench have proved useful for temperature-sensitive samples and will help reveal temperature-dependent variations in protein structures.

Microcrystal delivery methods are pivotal in the use of serial femtosecond crystallography (SFX) to resolve the macromolecular structures of proteins. Here, the development of a novel technique and instruments for efficiently delivering microcrystals for SFX are presented. The new method, which relies on a one-dimensional fixed-target system that includes a microcrystal container, consumes an extremely low amount of sample compared with conventional two-dimensional fixed-target techniques at ambient temperature. This novel system can deliver soluble microcrystals without highly viscous carrier media and, moreover, can be used as a microcrystal growth device for SFX. Diffraction data collection utilizing this advanced technique along with a real-time visual servo scan system has been successfully demonstrated for the structure determination of proteinase K microcrystals at 1.85 Å resolution.

A new temperature-controllable humidifier for X-ray diffraction has been developed. It is shown that the humidifier can successfully maintain protein crystal growth at a temperature lower than room temperature.

An algorithm, based on the matching of q-vectors pairs, is combined with three-dimensional pattern matching using a nearest-neighbors approach to index Laue and monochromatic serial crystallography data recorded on small unit cell samples.

Hot spots of mercury pollution in aquatic sediments and soils can contaminate local food webs and threaten ecosystems, but cleaning them up can be expensive […]

The post Toxicity of mercury hot spots can be reduced with application of activated carbon, researchers discover appeared first on Smithsonian Insider.

A new aspherical scattering factor formalism has been implemented in the crystallographic least-squares refinement program SHELXL. The formalism relies on Gaussian functions and can optionally complement the independent atom model to take into account the deformation of electron-density distribution due to chemical bonding and lone pairs. Asphericity contributions were derived from the electron density obtained from quantum-chemical density functional theory computations of suitable model compounds that contain particular chemical environments, as defined by the invariom formalism. Thanks to a new algorithm, invariom assignment for refinement in SHELXL is automated. A suitable parameterization for each chemical environment within the new model was achieved by metaheuristics. Figures of merit, precision and accuracy of crystallographic least-squares refinements improve significantly upon using the new model.

UK-based banks have received around 100,000 applications in a single day after The Bounce Back Loans scheme for small businesses was released.