Bermuda Skyport and Aecon Airport Constructors have chosen the artists to display works in the new passenger terminal building when it opens next year. The winners are: Christina Hutchings, Daniel DeSilva, Edwin Smith, Jahday Ford, Jonathan Northcott, JP Rouja, Michele Smith, Milton Hill, Otto Trott, Vaughan & Amy Evans, William Gringley and Zoe Dyson Hedstrom. “The […] (Click to read the full article)

The City of Hamilton invites the public to an ‘All things Hamilton’ art exhibition opening at the Bermuda Society of Arts in City Hall at 5:00pm on Friday, January 17th; which is another public celebration to recognize the 225th anniversary of the Corporation of Hamilton. A call for artwork was launched in November and more […] (Click to read the full article)

“With so many people adversely affected by this crisis, everyone must step in to play their part,” OBA Leader Craig Cannonier said. Mr. Cannonier said, “I want to thank the Governor for his help in arranging a special flight from the UK to bring Bermudians home – it will mean a great deal to those […] (Click to read the full article)

“It is important to support, as much as we can, our local businesses,” OBA Leader Craig Cannonier said, adding that “I am happy to give my backing to the new #ChooseBDA campaign.” Mr. Cannonier said, “While the health of Bermudians is paramount, it is obvious to everyone by now that this is going to be […] (Click to read the full article)

The Bermuda Entertainment Union [BEU] said they “vehemently denounce” the remarks made by local entertainer Tony Brannon, while Mr Brannon has apologized for his remarks and said that he understands he “must work on anti-racism and regain the communities trust.” This comes after Mr Brannon referred to members of the Government as “cockroaches” on social […] (Click to read the full article)

Bermuda’s Hayley Francis Cann, a certified music therapist who now resides in Canada, will be hosting a book launch signing for her new book Mandy’s Mom, The Music Therapist on Saturday, March 14 at the Long Story Short Bookstore in St. Georges from 3.00pm to 4.30pm. The event poster says, “Bermuda’s own Hayley Francis Cann […] (Click to read the full article)

Noting his “unacceptable comments,“ Felix Tod said that he will no longer perform alongside Tony Brannon. Mr Tod said, “In light of Tony Brannon’s unacceptable comments, I have made the choice to no longer perform alongside him. For me, The Big Chill was not only about entertainment, but also about equality. “It has been a great […] (Click to read the full article)

There are four people in custody that police believe were “involved in the shootings,” Police Commissioner Stephen Corbishley said, adding that “there are other arrests planned.” The Commissioner’s comments follow after the spate of gun violence on Monday, which saw the police respond to four separate firearms incidents in 24 hours. According to the police, the […] (Click to read the full article)

[Written by Don Burgess] A 51-year-old Hamilton Parish man admitted importing more than $120,000 worth of cannabis resin into Bermuda. Appearing in Magistrates Court, Michael Johnson pleaded guilty to one count of drug importation after customs officers at the L.F. Wade International Airport in a package with his name on it. The package had arrived as […] (Click to read the full article)

The Bermuda Shakespeare Schools Festival [BSSF] is getting set to host their seventh annual event on the occasion of William Shakespeare’s 450th birthday. The event’s 2014 programme focuses on youth, culture, and creativity and will take place at the Earl Cameron Theatre at City Hall from October 21 through October 23, 2014. The event’s opening […] (Click to read the full article)

“Landlords must work with their tenants to try and provide some relief as the economy faces huge disruption due to Covid-19,” according to the Leader of the One Bermuda Alliance, Craig Cannonier. Mr. Cannonier said, “For the immediate survival of many small to medium sized Bermudian businesses, rent relief could be vital. Many buildings have […] (Click to read the full article)

Governor John Rankin today [Oct 25] launched the annual Poppy Appeal to raise funds for war veterans and their families. Mr Rankin bought the first poppy from Bermuda Legion welfare case worker Carol Everson and two woman veterans of World War Two, Isobel Flood, 94, who served with the Royal Canadian Air Force and Betty […] (Click to read the full article)

Earlier today [May 8], Governor John Rankin and the Minister of National Security Wayne Caines visited Warwick Camp to mark the 75th Anniversary of VE [Victory in Europe] Day, the end of the Second World War in Europe. The Governor said, “Current circumstances mean that we cannot mark the event with a parade or a […] (Click to read the full article)

With the aim to “create a global leader in corporate and fiduciary services, fund administration and capital markets”, Ocorian and Estera announced that they will merge, with the enlarged business operating under the Ocorian name. A spokesperson said, “We are delighted to announce the combination of the Ocorian and Estera businesses to create a global […] (Click to read the full article)

[Updated] The police held a press conference this afternoon [Aug 27] regarding the fatal stabbing of 25-year-old Danshun Swann early this morning in Southampton. Earlier today, Police Media Relations Manager Dwayne Caines said, “The Bermuda Police Service responded to a report of an incident that took place at 12:10am on Monday outside of Southampton Rangers Sports Club. “Upon police […] (Click to read the full article)

Today is the one year anniversary of the murder of Danshun Swann, and the police continue their investigation, with detectives renewing their appeal for witnesses to come forward. A police spokesperson said, “The 27th of August is the one year anniversary of the murder of Mr. Danshun Swann. “Danshun was stabbed to death on South Road […] (Click to read the full article)

Public-use airports, metropolitan planning organizations (MPOs), and local land-use/ transportation planning agencies all have independent yet interrelated planning processes bound by legal and policy requirements to ensure compatibility. This means that they should work cooperatively to solve joint transportation challenges in the most effective and efficient manner. The TRB Airport Cooperative Research Program's ACRP Research Report 216: Guidebook for Assessing Collaborative Planning Efforts Among Airp...

TRB’s Airport Cooperative Research Program (ACRP) Legal Research Digest 16: Procurement of Airport Development and Planning Contracts provides guidance on how to determine which requirements apply to any given procurement process. The report also includes an overview of the consequences for noncompliance with procurement laws or regulations in order to help airports better understand the inherent risks associated with various funding sources.

TRB’s Airport Cooperative Research Program (ACRP) Report 106: Being Prepared for IROPS: A Business-Planning and Decision-Making Approach describes a process to help justify airport planning, and funding decisions (capital, and operations and maintenance) related to supporting irregular operations (IROPS) contingency planning. The report presents a structured approach to quantifying the lifecycle economic value of proposed IROPS mitigation alternatives through a spreadsheet-based business-planning and dec...

TRB’s Airport Cooperative Research Program (ACRP) Research Report 200: Using GIS for Collaborative Land Use Compatibility Planning Near Airports offers guidance for using Geographic Information Systems (GIS) as a collaboration tool to encourage compatible land use around airports. The report is designed to help airport and community planners seeking to work together to protect existing and future airport development as well as maintain safety and improve quality of life for those living and working near ...

Global business and tourism depend heavily on the efficient operation of airports and movement of passengers, baggage, and cargo across many areas. With increasing demand and connectivity requirements for airports comes the need for more sophisticated simulation and modeling tools to validate design assumptions. Furthermore, airport design and planning decisions have significant impacts on policy and major capital improvement decisions, which can be supported by simulation and modeling tools at many leve...

Incompatible land uses can threaten the safe utility of airports and expose people living and working nearby to potentially unacceptable levels of noise or safety risk. At the state level, all 50 states have enacted some form of airport zoning legislation since the 1950s. The majority of states (90 percent) have enacted laws mandating or enabling local governments to adopt, administer, and enforce airport zoning regulations. The TRB Airport Cooperative Research Program's ACRP Research Report 206: Guidebo...

Hello Internet! In This Episode: Erin and Weer’d discuss the recent spree killing in Canada, and the conspicuous lack of information on it; David talks about gun parts that are great to have around; Weer’d interviews Logan Metesh of High … Continue reading →

The unmanned aircraft systems (UAS) industry is on the cutting edge of aviation innovation. Airports, including tenants and contractors, are discovering the benefits of UAS to their operations and bottom line. Yet, with the diversity of UAS applications at airports, there has been a lack of relevant industry data on this topic to inform the airport industry on current practices. The TRB Airport Cooperative Research Program's ACRP Synthesis 104: Current Landscape of Unmanned Aircraft Systems at Airports s...

The first edition of this report, in 2009, provided a comprehensive industry reference for the management of airport deicing runoff. The second edition has been wholly updated to reflect the latest industry practices. The TRB Airport Cooperative Research Program's ACRP Research Report 14: Deicing Planning Guidelines and Practices for Stormwater Management Systems, second edition , explores a wide array of practices designed to provide for the practical, cost-effective control of runoff from aircraft and ...

The introduction of unmanned aircraft systems (UAS) has presented a wide range of new safety, economic, operational, regulatory, community, environmental, and infrastructure challenges to airports and the National Airspace System. These risks are further complicated by the dynamic and shifting nature of UAS technologies. The pre-publication draft of ACRP Research Report 212: Airports and Unmanned Aircraft Systems, Volume 1: Managing and Engaging Stakeholders on UAS in the Vicinity of Airports provides gu...

With the coronavirus disease (COVID-19) pandemic hitting the transportation industry hard, TRB’s catalog of research on infectious disease and other biological threats to people and transportation systems is crucial in helping to advise transportation professionals. Transportation officials must be prepared to know how to minimize the consequences to their communities. In regards to biothreats, a recent National Academies of Sciences, Engineering, and Medicine report suggests that there are advantages to...

TRB’s Airport Cooperative Research Program (ACRP) Research Report 200: Using GIS for Collaborative Land Use Compatibility Planning Near Airports offers guidance for using Geographic Information Systems (GIS) as a collaboration tool to encourage compatible land use around airports. The report is designed to help airport and community planners seeking to work together to protect existing and future airport development as well as maintain safety and improve quality of life for those living and working near ...

Global business and tourism depend heavily on the efficient operation of airports and movement of passengers, baggage, and cargo across many areas. With increasing demand and connectivity requirements for airports comes the need for more sophisticated simulation and modeling tools to validate design assumptions. Furthermore, airport design and planning decisions have significant impacts on policy and major capital improvement decisions, which can be supported by simulation and modeling tools at many leve...

Major technological and security changes in the aviation industry over the past 20 years have forced airport leaders and aviation stakeholders to think of new research ideas that will improve the planning and development of policies and new models that foster growth of air service, incorporate new airport and customer technology, revise airport business models, and better interact with neighboring communities. ACRP (Airport Cooperative Research Program) Web-Only Document 39: Policy and Planning Issues Ro...

Introduction of unmanned aircraft systems (UAS) will pose safety, economic, operational, regulatory, community, environmental, and infrastructure challenges to airports. These risks are further complicated by the dynamic nature of UAS technological development. Experiences and lessons learned from recent major aviation system changes demonstrate the critical importance of ensuring that airports have the resources needed to avoid adverse impacts and maximize benefits as early as possible. This pre-publica...

Environmental regulations have long required airports to undertake review of many actions associated with planning and development. More recently, airports have embraced sustainability as a means for ensuring the long-term viability and community benefits of their facilities. The TRB Airport Cooperative Research Program's ACRP Research Report 209: Integrating Sustainability Planning and the Environmental Review Process is designed for airport industry practitioners who are interested in gaining a better ...

Incompatible land uses can threaten the safe utility of airports and expose people living and working nearby to potentially unacceptable levels of noise or safety risk. At the state level, all 50 states have enacted some form of airport zoning legislation since the 1950s. The majority of states (90 percent) have enacted laws mandating or enabling local governments to adopt, administer, and enforce airport zoning regulations. The TRB Airport Cooperative Research Program's ACRP Research Report 206: Guidebo...

The series was previously scheduled to roll out Thursday, April 2 on sibling Science Channel.

The Society for Laboratory Automation and Screening (SLAS) announced the winners of its annual New Product Awards Monday afternoon at the 9th Annual SLAS International Conference and Exhibition in San Diego, CA, USA.

Regular readers will know that I've been hanging out for the "market allocation" parts of the proposed Cannabis Legalisation and Control Bill, which will be the subject of a referendum this year.
While most media outlets ran inane stories last year on how many joints 14 grams added up to, it was clear to anyone who took the subject seriously that the questions of who would get to produce and sell cannabis and how licences would be awarded were vastly more important. And we've had to wait for answers to those.
Well, they're here. And it's very good news. From…

The PHP development team announces the immediate availability of PHP 7.2.30. This is a security release.All PHP 7.2 users are encouraged to upgrade to this version.For source downloads of PHP 7.2.30 please visit our downloads page, Windows source and binaries can be found on windows.php.net/download/. The list of changes is recorded in the ChangeLog.

Levodopa-induced dyskinesia (LID) poses a significant health care challenge for Parkinson’s disease (PD) patients. Amantadine is currently the only drug proven to alleviate LID. Although its efficacy in treating LID is widely assumed to be mediated by blockade of N-methyl-D-aspartate (NMDA) glutamate receptors, our experiments demonstrate that at therapeutically relevant concentrations, amantadine preferentially blocks inward-rectifying K+ channel type 2 (Kir2) channels in striatal spiny projection neurons (SPNs) — not NMDA receptors. In so doing, amantadine enhances dendritic integration of excitatory synaptic potentials in SPNs and enhances — not antagonizes — the induction of long-term potentiation (LTP) at excitatory, axospinous synapses. Taken together, our studies suggest that the alleviation of LID in PD patients is mediated by diminishing the disparity in the excitability of direct- and indirect-pathway SPNs in the on state, rather than by disrupting LTP induction. This insight points to a pharmacological approach that could be used to effectively ameliorate LID and improve the quality of life for PD patients.

Elevated pressure in the pancreatic gland is the central cause of pancreatitis following abdominal trauma, surgery, endoscopic retrograde cholangiopancreatography, and gallstones. In the pancreas, excessive intracellular calcium causes mitochondrial dysfunction, premature zymogen activation, and necrosis, ultimately leading to pancreatitis. Although stimulation of the mechanically activated, calcium-permeable ion channel Piezo1 in the pancreatic acinar cell is the initial step in pressure-induced pancreatitis, activation of Piezo1 produces only transient elevation in intracellular calcium that is insufficient to cause pancreatitis. Therefore, how pressure produces a prolonged calcium elevation necessary to induce pancreatitis is unknown. We demonstrate that Piezo1 activation in pancreatic acinar cells caused a prolonged elevation in intracellular calcium levels, mitochondrial depolarization, intracellular trypsin activation, and cell death. Notably, these effects were dependent on the degree and duration of force applied to the cell. Low or transient force was insufficient to activate these pathological changes, whereas higher and prolonged application of force triggered sustained elevation in intracellular calcium, leading to enzyme activation and cell death. All of these pathological events were rescued in acinar cells treated with a Piezo1 antagonist and in acinar cells from mice with genetic deletion of Piezo1. We discovered that Piezo1 stimulation triggered transient receptor potential vanilloid subfamily 4 (TRPV4) channel opening, which was responsible for the sustained elevation in intracellular calcium that caused intracellular organelle dysfunction. Moreover, TRPV4 gene–KO mice were protected from Piezo1 agonist– and pressure-induced pancreatitis. These studies unveil a calcium signaling pathway in which a Piezo1-induced TRPV4 channel opening causes pancreatitis.

BACKGROUND Neurofibroma/schwannoma hybrid nerve sheath tumors (N/S HNSTs) are neoplasms associated with larger nerves that occur sporadically and in the context of schwannomatosis or neurofibromatosis type 2 or 1. Clinical management of N/S HNSTs is challenging, especially for large tumors, and established systemic treatments are lacking.METHODS We used next-generation sequencing and array-based DNA methylation profiling to determine the clinically actionable genomic and epigenomic landscapes of N/S HNSTs.RESULTS Whole-exome sequencing within a precision oncology program identified an activating mutation (p.Asp769Tyr) in the catalytic domain of the ERBB2 receptor tyrosine kinase in a patient with schwannomatosis-associated N/S HNST, and targeted treatment with the small-molecule ERBB inhibitor lapatinib led to prolonged clinical benefit and a lasting radiographic and metabolic response. Analysis of a multicenter validation cohort revealed recurrent ERBB2 mutations (p.Leu755Ser, p.Asp769Tyr, p.Val777Leu) in N/S HNSTs occurring in patients who met diagnostic criteria for sporadic schwannomatosis (3 of 7 patients), but not in N/S HNSTs arising in the context of neurofibromatosis (6 patients) or outside a tumor syndrome (1 patient), and showed that ERBB2-mutant N/S HNSTs cluster in a distinct subgroup of peripheral nerve sheath tumors based on genome-wide DNA methylation patterns.CONCLUSION These findings uncover a key biological feature of N/S HNSTs that may have important diagnostic and therapeutic implications.FUNDING This work was supported by grant H021 from DKFZ-HIPO, the University Cancer Center Frankfurt, and the Frankfurt Research Funding Clinician Scientist Program.

We're still waiting to hear news about Apple Card's performance relative to the major card issuers, but that hasn't stopped Samsung from announcing plans to launch an "innovative" debit card as part of a new mobile-first money management platform the company has been developing over the last year.


Announced on Thursday in a blog post by Samsung Pay vice-president Sang Ahn, the forthcoming debit card is in partnership with finance company SoFi and will be backed by a cash management account.

"In 2020, Samsung Pay will be expanding our service from being a rewarding way to shop and pay, to also being a rewarding way to manage money," writes Ahn. "Over the past year we have been busy developing a mobile-first money management platform. Our vision is to help consumers better manage their money so that they can achieve their dreams and goals. Now more than ever, mobile financial services and money management tools will play an even bigger role in our daily lives while also opening up new possibilities."

The debit card is scheduled to launch this summer. Other than that, Samsung hasn't offered any details on how it will work, but expect it to integrate with Samsung's existing mobile payment system.

Launched in August 2019, ‌Apple Card‌ is a credit card linked to Apple Pay and built into the Wallet app on iPhone. Apple partnered with Goldman Sachs to launch the card, and in October the investment bank hailed it as "the most successful credit-card launch ever." Nine months later, neither Apple nor Goldman Sachs has offered any concrete details on its performance.

During the global health crisis, Apple has introduced an ‌Apple Card‌ Assistance Program that allows ‌‌Apple Card‌‌ holders to skip their March and April payments without incurring interest charges for that billing cycle. For more details on how the card works, check out our comprehensive Apple Card guide.
This article, "Samsung Announces 'Innovative' Debit Card Launching this Summer" first appeared on MacRumors.com

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Disney has announced that it will be producing a new Robin Hood movie.

Yes, that Robin Hood.

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After being elected in 2008 on "hope and change", "change you can believe in", and "change the way Washington works", President Obama now says that he cannot change Washington from the inside? Then why should we re-elect him in 2012? Continue reading →

The Town of Berlin Connecticut continues to raise property taxes in the face of a never-ending recession. The Berlin Property Owners Association has been speaking out against these increases in property taxes. Recorded herein are four speeches by residents of the Town of Berlin at the first Town Council meeting subsequent to the Town Council's approval of an increase in property taxes, resulting from giving raises to virtually all town employees, who are already very well compensated. Continue reading →

A year ago this month the U.S. Department of Justice announced that the banking giant JPMorgan Chase would avoid criminal charges by agreeing to pay $13 billion to settle claims that it had routinely overstated the quality of mortgages it … Continue reading →

CNN Brianna Keilar interviews Senator Bernie Sanders on State of the Union May 17 2015. Senator Bernie Sanders says the American people want and deserve a serious debate on the serious issues facing our country today instead of merely the same old, endless 30 second, ad hominem, attack ads. Continue reading →