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Surrogate endpoints for overall survival for patients with metastatic hormone-sensitive prostate cancer in the CHAARTED trial




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African-American men with low-risk prostate cancer treated with radical prostatectomy in an equal-access health care system: implications for active surveillance




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Telomere-based risk models for the early diagnosis of clinically significant prostate cancer




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Exposure to direct-to-consumer advertising is associated with overestimation of benefits regarding ultrahypofractionated radiation therapy for prostate cancer




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Clinical utility of the exosome based ExoDx Prostate(<i>IntelliScore</i>) EPI test in men presenting for initial Biopsy with a PSA 2–10 ng/mL




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MHD surrogate model for convection in electromagnetically levitated molten metal droplets processed using the ISS-EML facility

npj Microgravity, Published online: 16 March 2020; doi:10.1038/s41526-020-0099-7

MHD surrogate model for convection in electromagnetically levitated molten metal droplets processed using the ISS-EML facility




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The HDOCK server for integrated protein–protein docking




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Cobaltaelectro-catalyzed C–H activation for resource-economical molecular syntheses




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Ex situ determination of freely dissolved concentrations of hydrophobic organic chemicals in sediments and soils: basis for interpreting toxicity and assessing bioavailability, risks and remediation necessity




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Author Correction: Guidance for quantitative confocal microscopy




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Cellular thermal shift assay for the identification of drug–target interactions in the <i>Plasmodium falciparum</i> proteome




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High rate of durable remissions post autologous stem cell transplantation for core-binding factor acute myeloid leukaemia in second complete remission




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Phase I trial of maintenance selinexor after allogeneic hematopoietic stem cell transplantation for patients with acute myeloid leukemia and myelodysplastic syndrome




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Rituximab for desensitization during HLA-mismatched stem cell transplantation in patients with a positive donor-specific anti-HLA antibody




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Chromosome 11 open reading frame 30 (C11orf30), calpain small subunit 1 (CAPNS1; CAPN4), signal transducer and activator of transcription 6 (STAT6) and ankyrin repeat domain 27 (ANKRD27) as diagnostic markers for eosinophilic esophagitis (EoE)

Genomewide association studies identified four genes that could serve as diagnostic markers and/or therapeutic targets for EoE.




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Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity




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MicroRNA binding site polymorphism in inflammatory genes associated with colorectal cancer: literature review and bioinformatics analysis




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Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40




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Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy




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Nanomedicines based on nanoscale metal-organic frameworks for cancer immunotherapy




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Universal screening for hepatitis C virus infection should be linked to universal treatment access




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A novel multidimensional reinforcement task in mice elucidates sex-specific behavioral strategies




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A roadmap for development of neuro-oscillations as translational biomarkers for treatment development in neuropsychopharmacology




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Correction: Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression




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Δ<sup>9</sup>-Tetrahydrocannabinol (THC) impairs visual working memory performance: a randomized crossover trial




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Nuclear receptor crosstalk — defining the mechanisms for therapeutic innovation




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Sweet signals — gut–brain circuit for sugar identified




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Combining radiolabelled therapies for neuroendocrine neoplasms




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Author Correction: Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis




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Development of a skin temperature map for dermatomes in individuals with spinal cord injury: a cross-sectional study




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Aerosol box for dentistry




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Special products for specialist cleaning




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Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke




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An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders




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NLRP3 inflammasome activity as biomarker for primary progressive multiple sclerosis




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Mining bacteria for biosensors




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Why Authoritarianism is Bad for Science, But Bigotry is Even Worse

There have been many protests against the Citizenship Amendment Bill (now Act), and there will be many more. This piece of legislation strikes at the heart of the Constitution, seeking to make India another country altogether. It is thus that so many people from so many different walks of life have raised their voices against [...]




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Surgeon’s protection during ophthalmic surgery in the Covid-19 era: a novel fitted drape for ophthalmic operating microscopes




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Evaluation of an AI system for the detection of diabetic retinopathy from images captured with a handheld portable fundus camera: the MAILOR AI study




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Design, implementation, and evaluation of a nurse-led intravitreal injection programme for retinal diseases in Singapore




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Possible consequences of the COVID-19 pandemic on the use of biospecimens from cancer biobanks for research in academia and bioindustry




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Defense Playbook for Campaigns

The 2018 National Defense Strategy (NDS) is predicated on a single organizing principle: America’s military pre-eminence is rapidly eroding. This is not a new concept. For years, experts have warned that the economic and technological advancements of U.S. adversaries, coupled with the 2008 financial crisis and America’s focus on peripheral conflicts, have caused a decline in America’s military dominance. 

In this context, the advances of near-peer competitors such as China and Russia have created plausible “theories of victory” in potential conflicts across Eastern Europe and East Asia. Competitors’ unaddressed improvements in strategic innovation, economic investment, and dual-use technology increases the risk of conflict and strains the U.S. alliance system. It is urgent that the United States reestablish and maintain credible deterrents against these near-peer competitors. After decades of focusing on post-Cold War ‘shaping’ operations, the American military needs to reinvigorate for full spectrum great power competition.

This report is intended as a blueprint on how to begin that process from graduate students at the Belfer Center for Science and International Affairs at Harvard University. Contained inside are 12 memorandums. Each provides a high-level overview and specific recommendations on a key issue of American defense policy. 




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So Do Morals Matter in U.S. Foreign Policy? I Asked the Expert.

In his new book, Do Morals Matter? Presidents and Foreign Policy from FDR to Trump, Joseph S. Nye developed a scorecard to determine how U.S. presidents since 1945 factored questions of ethics and morality into their foreign policy. In an interview, Henry Farrell asked him a few questions to get to the heart of his findings.




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The United States Forgot Its Strategy for Winning Cold Wars

Stephen Walt writes that arguments against U.S. offshore balancing misunderstand history. The strategy that worked against the Soviet Union can work against China.




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Cutoff point estimation for serum vitamin D concentrations to predict cardiometabolic risk in Brazilian children




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StrongKids for pediatric nutritional risk screening in Brazil: a validation study




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We’re In For A Rough Ride With Iran

In a dangerous world, every US use of military force should be backed up by a careful calculation of risks and a strategy to cope with the adversary’s response. Neither risk-balancing nor strategy is apparent in President Trump’s decision to kill Major General Qassem Soleimani, leader of the Quds Force of Iran’s Revolutionary Guard. With that killing — and Iran’s announcement it would exact a “harsh revenge” — there is a real danger the Middle East will slide even further into the fires of war.




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The Global Pandemic Has Spawned New Forms of Activism — and They're Flourishing

The authors have identified nearly 100 distinct methods of nonviolent action that include physical, virtual and hybrid actions.




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The Arctic is Transforming… Can We?

Joel Clement describes how the Arctic is transforming into a warmer, wetter, and less predictable climate state, what the consequences are for the Arctic's indigenous inhabitants, and what measures can be taken to build resilience.




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How to Topple Dictators and Transform Society

Nonviolent resistance scholar Erica Chenoweth explains the key ingredients of successful social movements.