Historically, children with end-stage renal disease who initiated chronic dialysis during the first year of life were far less likely to survive or successfully receive a kidney transplant compared with those who initiated chronic dialysis at older ages.

In recent years, survival has improved markedly among children who initiate chronic peritoneal dialysis at <1 year of age. Among those infants who initiate dialysis after the neonatal period and later undergo kidney transplantation, graft survival has improved as well. (Read the full article)

Educators are changing instructional priorities, altering lessons, and working on ways to help teachers grow professionally, all in an effort to raise math achievement.

Rick talks with Larry Rosenstock, education icon, the founder and CEO of High Tech High, and recent recipient of the WISE Prize for Education, about what he's learned after a half century in education.

A record 62 clubs from 50 countries have entered the 2019/20 edition: see who is aiming for Vienna.

Equipping teachers to help transgender students feel safe and included requires special training, advocates say.

Twenty-two students recently graduated from Penn College at Wellsboro’s practical nursing program, the first to fulfill their requirements at a facility dedicated in May.

Even before the recent news of the season’s first confirmed spotted lanternfly hatches in the Philadelphia region, homeowners in many parts of Pennsylvania were gearing up for their annual battle with the destructive pest.

Ibrexafungerp (formerly SCY-078) is a semisynthetic triterpenoid and potent (1->3)-β-D-glucan synthase inhibitor. We investigated the in vitro activity, pharmacokinetics, and in vivo efficacy of ibrexafungerp (SCY) alone and in combination with anti-mould triazole isavuconazole (ISA) against invasive pulmonary aspergillosis (IPA). The combination of ibrexafungerp and isavuconazole in in vitro studies resulted in an additive and synergistic interactions against Aspergillus spp. Plasma concentration-time curves of ibrexafungerp were compatible with linear dose proportional profile. In vivo efficacy was studied in a well established persistently neutropenic NZW rabbit model of experimental IPA. Treatment groups included untreated rabbits (UC) and rabbits receiving ibrexafungerp at 2.5(SCY2.5) and 7.5(SCY7.5) mg/kg/day, isavuconazole at 40(ISA40) mg/kg/day, or combinations of SCY2.5+ISA40 and SCY7.5+ISA40. The combination of SCY+ISA produced in vitro synergistic interaction. There was significant in vivo reduction of residual fungal burden, lung weights, and pulmonary infarct scores in SCY2.5+ISA40, SCY7.5+ISA40, and ISA40-treatment groups vs that of SCY2.5-treated, SCY7.5-treated and UC (p<0.01). Rabbits treated with SCY2.5+ISA40 and SCY7.5+ISA40 had prolonged survival in comparison to that of SCY2.5-, SCY7.5-, ISA40-treated or UC (p<0.05). Serum GMI and (1->3)-β-D-glucan levels significantly declined in animals treated with the combination of SCY7.5+ISA40 in comparison to those treated with SCY7.5 or ISA40 (p<0.05). Ibrexafungerp and isavuconazole combination demonstrated prolonged survival, decreased pulmonary injury, reduced residual fungal burden, lower GMI and (1->3)-β-D-glucan levels in comparison to those of single therapy for treatment of IPA. These findings provide an experimental foundation for clinical evaluation of the combination of ibrexafungerp and an anti-mould triazole for treatment of IPA.

The local bourse inched higher on Wednesday as global stocks took a breather following consecutive sessions of weakness.

Global markets rallied on the back of optimism that most governments were gearing up to at least partially reopen their economies following lockdowns to prevent the spread of the coronavirus.

On the currency market, the rand traded softer against the greenback as it slipped to a session low of R18.77/$.

OBJECTIVES:

Our first aim was to examine baseline differences in body dissatisfaction, depression, and anxiety symptoms by gender, age, and Tanner (ie, pubertal) stage. Our second aim was to test for changes in youth symptoms over the first year of receiving gender-affirming hormone therapy. Our third aim was to examine potential differences in change over time by demographic and treatment characteristics. Youth experiences of suicidal ideation, suicide attempt, and nonsuicidal self-injury (NSSI) are also reported.

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To help teachers remotely engage their students during the coronavirus crisis, Penn State’s Holocaust, Genocide and Human Rights Education Initiative has released its first set of free learning resources.

Apple's new $4,999 Pro Display XDR monitor (and its $1,000 stand) may sound mighty expensive on the surface. It has the potential to upend a whole industry, however—it's made to compete with panels five to ten times the price. We have one in-house, and here are our first impressions.

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Nedbank, FirstRand and Anglo Platinum have received the highest scores in the Public Investment Corporation's new corporate governance rating system.

The Alumni Spotlight is a monthly feature in Bridges, highlighting College of Education alumni who are making a difference in the lives of the people around them. This edition features Rob Longwell-Grice, who draws upon personal experience to help students who are also the first in their families to pursue a college degree.

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Behavioral economics applies key principles from psychology and economics to address obstacles to behavior change. The important topic of pediatric firearm injuries has not yet been explored through a behavioral economic lens. Pediatric firearm-related injuries are a significant public health problem in the United States. Despite American Academy of Pediatrics guidelines advising that firearms be stored unloaded, in a locked box or with a locking device, and separate from ammunition, estimates suggest that ~4.6 million children live in homes with at least 1 loaded and unlocked firearm. In this article, we use behavioral economic theory to identify specific cognitive biases (ie, present bias; in-group, out-group bias; and the availability heuristic) that may influence parental decision-making around firearm storage. We illustrate situations in which these biases may occur and highlight implementation prompts, in-group messengers, and increased salience as behaviorally informed strategies that may counter these biases and subsequently enhance safe firearm storage. We also describe other opportunities to leverage the behavioral economic tool kit. By better understanding the individual behavioral levers that may impact decision-making around firearm storage, behavioral scientists, pediatric providers, and public health practitioners can partner to design and test tailored interventions aimed at decreasing pediatric firearm injuries. Further empirical study is warranted to identify the presence of specific biases and heuristics and determine the most effective behavior change strategies for different subpopulations.

As the wife of former President George H.W. Bush, she used the bully pulpit of her office as first lady to advance the issue on behalf of both for children and parents.

Lyon have become the first team to 100 UEFA women's club games, adding to their many records.

Nine stadiums across eight cities will host games at UEFA Women's EURO 2021 in England.

CNA Staff, Mar 25, 2020 / 07:11 pm (CNA).- The Italian bishop of a missionary region of Ethiopia is the first Catholic bishop known to have died of the global coronavirus pandemic. He died March 25.

Bishop Angelo Moreschi, 67, was the leader of Ethiopia’s Apostolic Vicariate of Gambella, a missionary region of 25,000 Catholics in the western part of the country. He died Wednesday in the Italian city of Brescia, in the Lombardy region that has become the European epicenter of the pandemic.

A member of the Salesians of Don Bosco religious order, Moreschi had been a missionary in Ethiopia since 1991. He was ordained a bishop in January 2010.

“The Salesian community mourns the death of the Apostolic Vicar of Gambella (Ethiopia), namely Msgr. Angelo Moreschi, SDB, who died today, March 25, in Brescia (Italy) due to the coronavirus,” the Salesians of Don Bosco said in a statement released through the order’s information bureau.
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The secretary general of Ethiopia’s bishops’ conference announced the news in the country, announced conveying “deep condolences to the Clergy, religious, bereaved family and the lay faithful in the Apostolic Vicariate of Gambella.”

To the mourning people of the Gambella vicariate, the country’s bishops pledged the “closeness and prayers of members of the Catholic Bishops’ Conference of Ethiopia and the entire Catholic Church in Ethiopia. May his soul rest in peace.”

Bishop Moreschi was renowned in Ethiopia for his pastoral ministry to the service of young people and the poor. In the local dialect, he was afforded the title “Abba,” meaning “Father.”

“In his mission as prefect and then as apostolic vicar, he continued to embody the Salesian focus in helping children, accompanying them by his practical spirit and his strong apostolic zeal,” the Salesians of Don Bosco stated.

“In his visits to the villages, they still remember when the Salesian arrived with a battered SUV - or by motorboat in the villages along the Baro river when the roads were flooded - and he immediately began to distribute multi-vitamin biscuits to malnourished children.”

Bishop Moreschi died “after serving the young, the poor and his flock of souls as a Salesian for 46 years, as a priest for 38, and as a bishop for over 10,” the Salesians said.

More than 60 priests have died in the ongoing coronavirus pandemic, which has claimed more than 21,000 lives globally. Several bishops have contracted the virus.

 

This story was first reported by ACI Africa, CNA's African news partner. It has been adapted by CNA.

 

The new NUC is taking all sorts of forms at CES 2020, but none is as slick or as snazzy as Razer's early stab at this power-packed mini-PC platform.

The 64 entrants are confirmed, 32 in the UEFA Champions League path and 32 in the domestic champions path to be drawn on Tuesday.

To view more press releases, please visit http://ir.wintrust.com/news.aspx?iid=1024452.

To view more press releases, please visit http://ir.wintrust.com/news.aspx?iid=1024452.

After a fire devastates a Bangladesh slum, the OM team distributes food, cooking items, plastic tarps and hope to hurting families.

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Starting at $249, Samsung's Galaxy Watch Active 2 offers optional LTE connectivity, enhanced fitness features, and a fashion-forward design for wrists big and small.