u.s.

Bedsores Can Cause Serious Harm — Are U.S. Nursing Homes Hiding Cases?

Title: Bedsores Can Cause Serious Harm — Are U.S. Nursing Homes Hiding Cases?
Category: Health News
Created: 8/17/2022 12:00:00 AM
Last Editorial Review: 8/18/2022 12:00:00 AM




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Efficacy and Toxicity of [177Lu]Lu-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer: Results from the U.S. Expanded-Access Program and Comparisons with Phase 3 VISION Data

The phase 3 VISION trial demonstrated that [177Lu]Lu-PSMA-617 prolonged progression-free survival and overall survival (OS) in prostate-specific membrane antigen [PSMA]–positive metastatic castration-resistant prostate cancer (mCRPC) patients who progressed on taxane-based chemotherapy and androgen receptor–signaling inhibitors (ARSIs). The U.S. expanded-access program (EAP; NCT04825652) was opened to provide access to [177Lu]Lu-PSMA-617 for eligible patients until regulatory approval was obtained. This study aimed to evaluate the efficacy and safety profile of [177Lu]Lu-PSMA-617 within the EAP and compare the results with those from the VISION trial. Methods: Patients enrolled in the EAP at 4 institutions in the United States with available toxicity and outcome data were included. Outcome measures included OS, a prostate-specific antigen (PSA) response rate (RR) of at least 50%, and incidences of toxicity according to Common Terminology Criteria for Adverse Events version 5.0. Differences in baseline characteristics, outcome data, and toxicity between the EAP and VISION were evaluated using t testing of proportions and survival analyses. Results: In total, 117 patients with mCRPC who received [177Lu]Lu-PSMA-617 within the EAP between May 2021 and March 2022 were eligible and included in this analysis. Patients enrolled in the EAP were more heavily pretreated with ARSI (≥2 ARSI regimens: 70% vs. 46%; P < 0.001) and had worse performance status at baseline (Eastern Cooperative Oncology Group score ≥ 2: 19% vs. 7%; P < 0.001) than VISION patients. EAP and VISION patients had similar levels of grade 3 or higher anemia (18% vs. 13%; P = 0.15), thrombocytopenia (13% vs. 8%; P = 0.13), and neutropenia (3% vs. 3%; P = 0.85) and similar PSA RRs (42% vs. 46%; P = 0.50) and OS (median: 15.1 vs. 15.3 mo; P > 0.05). Conclusion: Patients with PSMA-positive mCRPC who received [177Lu]Lu-PSMA-617 within the EAP were later in their disease trajectory than VISION patients. Patients enrolled in the EAP achieved similar PSA RRs and OS and had a safety profile similar to that of the VISION trial patients.




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U.S. Imaging Costs: Michal Horny Talks with Ken Herrmann and Johannes Czernin About the Changing Contribution of Medical Imaging to Health Care Costs




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U.S., Japan agree to maximize diplomatic pressure on North Korea

Monitor in Tokyo shows news of North Korea firing a ballistic missile on July 4. File photo by Toru Hanai/Reuters

TOKYO — U.S. and Japanese diplomats agreed Tuesday to maximize pressure on North Korea to resolve tensions over its nuclear program, while citing the need to be prepared for the worst if diplomacy fails.

U.S. Deputy Secretary of State John Sullivan, after meeting his Japanese counterpart, Shinsuke Sugiyama, told reporters that the focus at the State Department is still on diplomacy to solve the problem and eventually denuclearize the Korean Peninsula.

“We must, however, with our allies in Japan and South Korea and elsewhere, be prepared for the worst should diplomacy fail,” he said. The U.S. must be prepared to defend itself and its allies, he said.

Sugiyama, briefing reporters separately, reiterated Japan’s support for President Donald Trump’s policy of keeping all options open, but stressed the need for a diplomatic solution by bolstering cooperation among Japan, U.S. and South Korea, as well as via cooperation with China and Russia.

The two diplomats will join their South Korean counterpart in Seoul for further talks Wednesday on North Korea.

READ MORE: Rex Tillerson says continue diplomacy with North Korea ‘until first bomb drops’

The talks come as the U.S. and South Korea hold joint naval drills this week. They regularly conduct joint exercises, though North Korea condemns them as an invasion rehearsal.

North Korea’s deputy U.N. ambassador warned on Monday that the situation on the peninsula “has reached the touch-and-go point and a nuclear war may break out any moment.”

Kim In Ryong told the U.N. General Assembly’s disarmament committee that North Korea has been subjected to a direct nuclear threat from the United States and has the right to possess nuclear weapons in self-defense.

He pointed to military exercises and what he called a U.S. plan to stage a “secret operation aimed at the removal of our supreme leadership.”

Kim’s speech follows increasingly tough U.N. sanctions. Russian President Vladimir Putin said his country is curtailing economic, scientific and other ties with North Korea in line with U.N. sanctions, and the European Union announced new sanctions as well.

The post U.S., Japan agree to maximize diplomatic pressure on North Korea appeared first on PBS NewsHour.




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U.S.-backed Syrian forces recapture Raqqa from Islamic State group

Fighters of Syrian Democratic Forces celebrate after Raqqa in Syria was liberated from Islamic State militants on Oct. 17. Photo by Erik De Castro/Reuters

U.S.-backed Syrian Democratic Forces announced Tuesday that they had captured the city of Raqqa from Islamic State militants.

“Everything is finished in Raqqa, our forces have taken full control of Raqqa,” SDF spokesman Talal Sello told AFP. A formal declaration would be announced after operations to clear any remaining sleeper cells and to remove landmines in the city were completed, Sello added.

The move is a major setback for the Islamic State which considered Raqqa the de-facto capital of its self-declared caliphate. It comes on the third anniversary of the global effort to defeat ISIS.

Raqqa was the first provincial capital to fall from government control in March 2013 after it was captured by a rebel army. The army included both Syrian opposition groups and more hard line  parties including al-Nusra and the Islamic State.

A civilian government  that was established in the city divided two months later, and less than a year later ISIS recaptured Raqqa and named the the capital of their caliphate.

About 900 civilians have been killed since the the start of the five-month operation, including 570 people in coalition air raids, according to the Syrian Network for Human Rights. The Britain-based Syrian Observatory for Human Rights put the civilian death toll at 1,130 people. American journalist James Foley was beheaded in the mountains south of the city.

SDF fighters pulled down the Islamic State’s black flag from the city’s National Hospital near the city’s stadium, according to a Reuters report.

Special presidential envoy for the Global Coalition to Defeat ISIS Brett McGurk said in August that the U.S. would attempt to perform a “stabilization” in Raqqa — including demining, removing rubble from major pathways to allow trucks and equipment through, and “basic electricity, sewage, water, the basic essentials to allow populations to come back to their home.”

It is not clear when the 300,000 civilians who have fled Raqqa since April during the operation will be able to return.

The post U.S.-backed Syrian forces recapture Raqqa from Islamic State group appeared first on PBS NewsHour.




u.s.

British Nonprofit Worked With U.S. To Censor America




u.s.

Trump Is the Most Resilient Politician in U.S. History

Unknown host Charlie Stone analyzes Trump's unprecedented victory with Obama Homeland Security Secretary, Jeh Johnson




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Food recalls in the U.S. spike due to Listeria, Salmonella and allergens

An in-depth analysis in the United States, covering 2002 to 2023, reveals that biological contamination and allergens are the leading causes of food recalls. The study, recently published in the Journal of Food Protection, examined more than 35,000 food and beverage recalls overseen by the U.S. Food and Drug Administration... Continue Reading




u.s.

Donald Trump and Elon Musk: Could U.S. election's odd couple unleash a small-government revolution?

The appointment of a political outsider like Musk could help Trump cut regulations and rein in government bureaucracy, even if the moves are unpopular




u.s.

U.S. Chip Revival Plan Chooses Sites



Last week the organization tasked with running the the biggest chunk of U.S. CHIPS Act’s US $13 billion R&D program made some significant strides: The National Semiconductor Technology Center (NSTC) released a strategic plan and selected the sites of two of three planned facilities and released a new strategic plan. The locations of the two sites—a “design and collaboration” center in Sunnyvale, Calif., and a lab devoted to advancing the leading edge of chipmaking, in Albany, N.Y.—build on an existing ecosystem at each location, experts say. The location of the third planned center—a chip prototyping and packaging site that could be especially critical for speeding semiconductor startups—is still a matter of speculation.

“The NSTC represents a once-in-a-generation opportunity for the U.S. to accelerate the pace of innovation in semiconductor technology,” Deirdre Hanford, CEO of Natcast, the nonprofit that runs the NSTC centers, said in a statement. According to the strategic plan, which covers 2025 to 2027, the NSTC is meant to accomplish three goals: extend U.S. technology leadership, reduce the time and cost to prototype, and build and sustain a semiconductor workforce development ecosystem. The three centers are meant to do a mix of all three.

New York gets extreme ultraviolet lithography

NSTC plans to direct $825 million into the Albany project. The site will be dedicated to extreme ultraviolet lithography, a technology that’s essential to making the most advanced logic chips. The Albany Nanotech Complex, which has already seen more than $25 billion in investments from the state and industry partners over two decades, will form the heart of the future NSTC center. It already has an EUV lithography machine on site and has begun an expansion to install a next-generation version, called high-NA EUV, which promises to produce even finer chip features. Working with a tool recently installed in Europe, IBM, a long-time tenant of the Albany research facility, reported record yields of copper interconnects built every 21 nanometers, a pitch several nanometers tighter than possible with ordinary EUV.

“It’s fulfilling to see that this ecosystem can be taken to the national and global level through CHIPS Act funding,” said Mukesh Khare, general manager of IBM’s semiconductors division, speaking from the future site of the NSTC EUV center. “It’s the right time, and we have all the ingredients.”

While only a few companies are capable of manufacturing cutting edge logic using EUV, the impact of the NSTC center will be much broader, Khare argues. It will extend down as far as early-stage startups with ideas or materials for improving the chipmaking process “An EUV R&D center doesn’t mean just one machine,” says Khare. “It needs so many machines around it… It’s a very large ecosystem.”

Silicon Valley lands the design center

The design center is tasked with conducting advanced research in chip design, electronic design automation (EDA), chip and system architectures, and hardware security. It will also host the NSTC’s design enablement gateway—a program that provides NSTC members with a secure, cloud-based access to design tools, reference processes and designs, and shared data sets, with the goal of reducing the time and cost of design. Additionally, it will house workforce development, member convening, and administration functions.

Situating the design center in Silicon Valley, with its concentration of research universities, venture capital, and workforce, seems like the obvious choice to many experts. “I can’t think of a better place,” says Patrick Soheili, co-founder of interconnect technology startup Eliyan, which is based in Santa Clara, Calif.

Abhijeet Chakraborty, vice president of engineering in the technology and product group at Silicon Valley-based Synopsys, a leading maker of EDA software, sees Silicon Valley’s expansive tech ecosystem as one of its main advantages in landing the NSTC’s design center. The region concentrates companies and researchers involved in the whole spectrum of the industry from semiconductor process technology to cloud software.

Access to such a broad range of industries is increasingly important for chip design startups, he says. “To design a chip or component these days you need to go from concept to design to validation in an environment that takes care of the entire stack,” he says. It’s prohibitively expensive for a startup to do that alone, so one of Chakraborty’s hopes for the design center is that it will help startups access the design kits and other data needed to operate in this new environment.

Packaging and prototyping still to come

A third promised center for prototyping and packaging is still to come. “The big question is where does the packaging and prototyping go?” says Mark Granahan, cofounder and CEO of Pennsylvania-based power semiconductor startup Ideal Semiconductor. “To me that’s a great opportunity.” He points out that because there is so little packaging technology infrastructure in the United States, any ambitious state or region should have a shot at hosting such a center. One of the original intentions of the act, after all, was to expand the number of regions of the country that are involved in the semiconductor industry.

But that hasn’t stopped some already tech-heavy regions from wanting it. “Oregon offers the strongest ecosystem for such a facility,” a spokesperson for Intel, whose technology development is done there. “The state is uniquely positioned to contribute to the success of the NSTC and help drive technological advancements in the U.S. semiconductor industry.”

As NSTC makes progress, Granahan’s concern is that bureaucracy will expand with it and slow efforts to boost the U.S. chip industry. Already the layers of control are multiplying. The Chips Office at the National Institute of Standards and Technology executes the Act. The NSTC is administered by the nonprofit Natcast, which directs the EUV center, which is in a facility run by another nonprofit, NY CREATES. “We want these things to be agile and make local decisions.”




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U.S. Watchdog Report: China Holds More Meetings with Taliban than Any Other Country


The office of the U.S. Special Inspector General for Afghanistan Reconstruction (SIGAR), a federal watchdog agency, revealed in its regular report that China has held more than 200 meetings with Taliban terrorists since their return to power, Afghanistan's Tolo News reported this weekend.

The post U.S. Watchdog Report: China Holds More Meetings with Taliban than Any Other Country appeared first on Breitbart.




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‘Laapataa Ladies’ rebrands to ‘Lost Ladies’ as Kiran Rao and Aamir Khan begin Oscar campain in the U.S.

Aamir Khan recently kicked off the campaign at New York’s Indian restaurant, The Bungalow, where he was joined by Kiran Rao and hosted by chef Vikas Khanna




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Larocque's early goal propels Canada to 4-1 win over U.S. to take lead in Rivalry Series

​​​​​​​Jocelyne Larocque scored less than 4 minutes into the game, Sarah Nurse added a goal midway through the first period and Canada cruised to a 4-1 win over the United States in Boston on Sunday to take a 2-1 lead in the five-game Rivalry Series.




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Sinner beats Fritz at ATP Finals in rematch of U.S. Open championship

Top-ranked Jannik Sinner made it two wins in two matches before his home fans at the ATP Finals, beating Taylor Fritz 6-4, 6-4 on Tuesday. Earlier, Daniil Medvedev moved back into contention with a 6-2, 6-4 victory over Alex De Minaur.



  • Sports/Olympics/Summer Sports/Tennis

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A U.S. jury awards former Iraqi detainees $42 million for Abu Ghraib prison abuse

The jury also decided to hold a Virginia-based military contractor responsible for contributing to the torture and mistreatment of detainees at the notorious Iraqi prison two decades ago.




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10 Dirtiest Cities in the U.S. (L.A. Shockingly Isn't One of Them)

Living in a city offers a lot of excitement and opportunity on a daily basis, but it also comes with some downsides like pollution, trash and health risks. So, which cities have it worst? LawnStarter did a deep dive on this very topic to uncover the dirtiest cities in the U.S.




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The Tallest Mountain in the U.S. and 7 Close Contenders

Although most of the highest mountains in the world are in Asia (looking at you, Mount Everest and Himalayas), the United States is home to some of the most breathtaking and impressive mountain ranges in the world.




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What Are the Biggest Lakes in the U.S.?

The United States is home to some truly spectacular lakes. Whether considering the massive Great Lakes themselves or deep alpine gems like Lake Tahoe, with its crystal-clear waters, America is well-stocked with many sizable bodies of water.




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The Coldest State in the U.S. Is Below Freezing on Average

The United States has a wide range of climate zones, from the subtropical to the arctic. On the low end of the thermometer, there are plenty of options for a deep winter chill. Here, we look at a couple different ways to determine the coldest state in the U.S. — and by both definitions, there's one winner.




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Trump Might Not Lead a U.S. Retreat from the World Stage After All

His early personnel choices indicate his incoming administration would be willing to use sticks as well as carrots to deal with Russia.




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Feeling anxious about the U.S. election results? Elmo says, 'Stop scrolling, take a deep breath'

Canadians are watching the U.S. election results with trepidation, knowing they have no control over the outcome that will still affect them. Polling shows Vice-President Kamala Harris and former president Donald Trump are neck-and-neck. 




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From Beyoncé to brat summer, celeb endorsements and viral moments didn't matter much in this U.S. election

While buzzy social media moments, massive celebrity endorsements and viral memes were everywhere during the U.S. election campaign, those who study social media and pop culture say it's likely that smaller social media interactions had a larger impact on the outcome.




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'Grueling and arduous': A look back at Canada-U.S. relations during the first Trump presidency

Canadian political leaders are congratulating Donald Trump on winning back the U.S. presidency — a victory that raises questions about what Canada-U.S. relations will look like over the next four years.




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U.S. Federal Reserve cuts interest rates again

The U.S. Federal Reserve cut interest rates by a quarter of a percentage point on Thursday. Policymakers took note of a job market that has "generally eased," while inflation continues to move toward the central bank's two per cent target.




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Ottawa to reinstate Arctic ambassador as it faces challenges from U.S., Russia and China in region

Ottawa is finalizing its long-awaited Arctic foreign policy with Inuit leaders for release before the end of the year, as Canada braces for a second Trump presidency and increasing threats to its sovereignty from China and Russia.




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Former U.S. commerce secretary says he 'can't imagine' Trump would tax Canadian energy

Donald Trump's former commerce secretary says he 'can't imagine' the U.S. president-elect would want to tax Canadian energy, despite campaign promises about imposing a global tariff when he takes office in January.




u.s.

Trudeau says Canada and the U.S. will 'do good things together' with Trump in the White House

Prime Minister Justin Trudeau sounded an upbeat note Tuesday on the prospect of working with U.S. president-elect Donald Trump, saying Canada has dealt with his trade threats before and can do so again.




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In 2024’s Record-Hottest Year, U.S. Voters Will Decide Climate’s Path Forward

Global temperatures through September point to 2024 besting 2023 as the hottest year on record. How many future years set records depends in part on the outcome of the 2024 U.S. presidential election




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How the 2024 Election Could Change Access to Health Care in the U.S. and Influence Global Nuclear Policies

The outcome of the 2024 U.S. presidential election could reshape policies from health care at home to nuclear proliferation abroad




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How the 2024 Election Could Change Access to Education in the U.S. and Influence Global Climate Change Decisions

The outcome of the 2024 U.S. presidential election could set the climate agenda, reshape public education and shift the dynamics of global science collaboration.




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Trump Victory Is a ‘Gut Punch’ to U.S. Climate Action

President-elect Trump vowed to promote fossil fuels, weaken pollution regulations and reverse Biden administration climate efforts




u.s.

What Trump Can—And Probably Can’t—Do to Reverse U.S. Climate Policy

The new president-elect can go beyond just pulling out of the Paris Agreement. But it may be more difficult to roll back clean energy policies




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Five Crucial Trends Facing U.S. Drug Wholesalers in 2024 and Beyond

As regular readers of Drug Channels know, U.S. distribution and dispensing channels for prescription drugs are undergoing significant evolution and consolidation as the changing economics of pharmaceuticals challenge conventional business models.

During this period of volatility, the core business model of the Big Three public pharmaceutical distribution companies—Cardinal Health, Cencora, and McKesson—remains intact. Put simply: Buy low, sell high, collect early, and pay late.

But as I explain below, wholesalers continue to position themselves as essential intermediaries by expanding their industry position and strengthening their economic fundamentals.

Read on for five key pricing, pharmacy, provider, and manufacturer trends that are driving the U.S. drug wholesaling industry.

For even more, check out DCI's new 2024-25 Economic Report on Pharmaceutical Wholesalers and Specialty Distributors, the fifteenth edition of our deep dive into wholesale distribution channels.Click here to download a free report overview (including key industry trends, the table of contents, and a list of exhibits)
Read more »
       




u.s.

'Our Proud Spirited Fellows' The American Navy in U.S. Public Diplomacy with South America

Using the private journals of commission secretaries Henry Marie Brackenridge and Dr. William Baldwin, as well as Captain Sinclair, this chapter will explore the establishment of American naval identity through its diplomatic experiences in South America. It will also exhibit the role of the U.S. Navy in a proto framework of the Monroe Doctrine.




u.s.

211557: Home Minister meets U.S.' Burns

During a 20-minute discussion of Pakistan, Chidambaram asked Burns to treat groups "aimed at India" in the same way we treated "the groups directed against Americans in Afghanistan."




u.s.

U.S. feared LeT attack in India in mid-2009; warned Pakistan

U.S. feared another LeT attack in India in mid-2009, and sought Pakistan's help to ‘disrupt and prevent' it



  • The India Cables

u.s.

U.S. confident of safety of nuclear weapons, despite al-Qaeda presence



  • The India Cables

u.s.

Terror threats keep me awake, Manmohan Singh told U.S. official



  • The India Cables

u.s.

How India kept Kashmir out of U.S. Af-Pak envoy's brief



  • The India Cables

u.s.

226157: Pakistan accepted U.S. military role in counter-insurgency operations




u.s.

207373: U.S. Special Forces embedded with Pakistan Special Services Group and Frontier Corps for operations in NWFP




u.s.

204260: U.S. special forces were embedded with Pakistan troops in 2009 anti-Taliban operations in the North-West Frontier Province




u.s.

Benazir asked U.S. for security, was turned away




u.s.

Pakistan's Punjab turning into hotbed of extremism, U.S. had warned




u.s.

Nawaz Sharif too sought U.S. help to protect himself




u.s.

When in power, people start making money, Maran told U.S. Political Officer

The estranged DMK M.P. spoke about party's corrupt image & predicted its downfall; criticised ‘freebies'; praised Rahul Gandhi; was ‘very downbeat' about United Progressive Alliance's electoral prospects




u.s.

Don't leave Afghanistan, India told U.S.



  • India &amp; Neighbours

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&lsquo;Pakistan's actions at the UN may embolden other member states to oppose U.S. positions'

U.S. Mission in New York raised concerns about Pakistan's voting on key issues such as counterterrorism and human rights




u.s.

We are not as advanced as you are in respect for freedom of religion, Pakistan told U.S.




u.s.

U.S. surprised, happy at SAARC observer offer



  • India-US relations